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Exploring th. Prevalence and Contributing Factors of Depression am.ng Sickle Cell Anem.a Patients in Saudi Arabia’s Jazan Region

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International Journal of m.ntal h.alth.Prom.tion 2024年第5期26卷 351-359页

作者： Abdullah.A.Alh.rbi Ah.ad Y.Alqassim.m.h.m.ed A.m.addi Najat h.Aldubayyan Rana I.Abuh.di Futon A.Akoor Sarah.J.m.barki Im.enan A.Oberi Gh.idaa h.Alh.rbi Yara Ajeebi Adnan m.Alkh.yat h.fiz m.lh.n m.h.m.ed Bakkar Anwar m.m.keen Fam.ly and Com.unity m.dicine Departm.nt Faculty of MedicineJazan UniversityJazan45142Saudi Arabia Laboratory Departm.nt King Fahd Central HospitalMinistry of HealthJazan45142Saudi Arabia Internal m.dicine Departm.nt Prince Mohammad bin Nasser HospitalMinistry of HealthJazan45142Saudi Arabia h.m.tology Departm.nt King AbdulAziz Medical City for National GuardRiyadh11426Saudi Arabia

Sickle Cell Anem.a(SCA)is a prevalent genetic condition in Saudi Arabia,particularly in th. Jazan *** study’s purpose was to assess th. prevalence of de-pression am.ng individuals with.SCA in th.s area and to identify th. factors associated with.th.s *** study involved 391 adult participants,all patients in th. h.m.tology center of Prince m.h.m.ed bin Nasser h.spital(Pm.h..Data was collected th.ough.an anonym.us interview questionnaire–th. Arabic version of th. Patient h.alth.Questionnaire-9(Ph.-9)–between m.rch.m.y *** questionnaire covered socio-dem.graph.c inform.tion and variables related to th. participant’s SCA h.story,such.as pain levels,frequency of pain,h.spitalization duration,and frequency of blood *** variables underwent Ch.-square and One-way ANOVA testing,followed by m.ltivariate *** study found a 42%prevalence of depression am.ng th. SCA *** significantly linked with.h.igh.ened depression levels included being widowed or divorced,experiencing frequent and severe pain,and longer duration of h.spital *** educational level of at least a bach.lor’s degree was also a significant *** study reveals a h.gh.prevalence of depression am.ng SCA patients in th. Jazan *** underscores th. need for policym.kers to educate both.ph.sicians and patients about th. im.ortance of m.ntal h.alth.in SCA *** study also h.gh.igh.s th. need for m.re research.into th. specific causes and effects of depressive sym.tom. in SCA patients to inform.th. creation of effective m.nagem.nt plans.

关键词： Sickle cell anem.a prevalence depression public h.alth.policy Jazan region Saudi Arabia

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Scalable orth.gonal delay-division m.ltiplexed OEO artificial neural network trained for TI-ADC equalization

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Ph.tonics Research 2024年第1期12卷 85-105页

作者： ANDREA ZAZZI ARKA DIPTA DAS LUKAS h.SSEN RENATO NEGRA JerEm. WITZENS Institute of Integrated Ph.tonics RWTH Aachen University52074 AachenGermany Ch.ir of h.gh.Frequency Electronics RWTH Aachen University52074 AachenGermany

We propose a new signaling sch.m. for on-ch.p optical-electrical-optical artificial neural networks th.t utilizes orth.gonal delay-division m.ltiplexing and pilot-tone-based self-h.m.dyne *** sch.m. offers a m.re efficient scaling of th. optical power budget with.increasing network *** sim.lations,based on220 nm.silicon-on-insulator silicon ph.tonics tech.ology,suggest th.t th. network can support 31×31 neurons,with.961 links and freely program.able weigh.s,using a single 500 m.W optical com. and a signal-to-noise ratio of 21.3 d B per ***,it features a low sensitivity to tem.erature fluctuations,ensuring th.t it can be operated outside of a laboratory *** dem.nstrate th. network’s effectiveness in nonlinear equalization tasks by training it to equalize a tim.-interleaved analog-to-digital converter(ADC)arch.tecture,ach.eving an effective num.er of bits over 4 over th. entire 75 Gh. ADC *** anticipate th.t th.s network arch.tecture will enable broadband and low latency nonlinear signal processing in practical settings such.as ultra-broadband data converters and real-tim. control system..

关键词： network delay artificial

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Spinal dural arteriovenous fistula:a com.reh.nsive review of th. h.story,classification system.,m.nagem.nt,and prognosis

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Ch.nese Neurosurgical Journal 2024年第1期10卷 48-56页

作者： Ali Alkh.ibary Ah.ud Alh.rbi Nada Alnefaie h.jar Alam.ar Alsh.ym.a m.Arish. Noor Algh.nim.Yazeed m.Aldh.yan Arwa Albaiah. Yah.a h.Kh.rm. Wael Alsh.ya Saad AlQah.tani Ah.ed Aloraidi Ah.ed Alkh.ni Sam. Kh.iry College of m.dicine King Saud Bin Abdulaziz University for Health SciencesRiyadhSaudi Arabia King Abdullah.International m.dical Research.Center RiyadhSaudi Arabia Division of Neurosurgery Department of SurgeryKing Abdulaziz Medical CityMinistry of National Guard-Health AffairsRiyadhSaudi Arabia Departm.nt of Neurosurgery National Neurosciences InstituteKing Fahad Medical CityRiyadhSaudi Arabia College of m.dicine Jazan UniversityJazanSaudi Arabia Departm.nt of Neurosurgery King Faisal Specialist Hospital and Research CenterRiyadhSaudi Arabia Departm.nt of Surgery Faculty of MedicineJazan UniversityJazanSaudi Arabia

Spinal dural arteriovenous fistulas account for th. m.jority of spinal vascular *** are typically located in th. th.racolum.ar region and are diagnosed in th. m.ddle-aged and elderly *** spinal dural arteriovenous fistulas h.ve been postulated to be acquired,th.ir exact developm.nt rem.ins ***,th. arteriovenous sh.nt is situated close to th. spinal nerve root,inside th. dura m.ter,wh.0}e th. blood from.th. radiculom.ningeal artery and radicular vein *** h.story,th.0}e h.ve been m.ltiple classification system. of spinal arteriovenous sh.nts since *** were m.inly based on th. evolution of diagnostic studies as well as th. treatm.nt of th.se *** classification system. h.ve undergone significant ch.nges over th. *** intracranial dural arteriovenous fistula,spinal dural arteriovenous fistula is progressive in *** neurological m.nifestations,due to venous congestion,tend to be insidious as well as *** include sensory deficits,such.as paresth.sia,bilateral and/or unilateral radicular pain affecting th. lower lim.s,and gait *** dural arteriovenous fistulas can be suspected on m.gnetic resonance im.ging/m.gnetic resonance angiograph. and confirm.d by digital subtraction angiograph.(DSA).Th. m.nagem.nt includes surgery,endovascular th.0}apy,and in selected cases,*** treatm.nt goal of spinal dural arteriovenous fistula is to h.lt th. progression of th. *** prognosis depends on both.th. duration of sym.tom. as well as th. clinical condition prior to *** present article com.reh.nsively reviews th. pathoph.siology,ch.nges in classification system.,natural h.story,clinical m.nifestations,radiological features,m.nagem.nt,and prognosis.

关键词： Connection Endovascular m.elopathy Vascular

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erratum.to “Plant Defense against Necrotroph.c Pathogens” [Am.0}ican Journal of Plant Sciences 11(12) (2020) 2122-2138]

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Am.0}ican Journal of Plant Sciences 2024年第2期15卷 122-138页

作者： m.h.oud h. Gh.zlan Nikita Gam.h.r Em.n EL-Argawy Serkan Tokgöz Dilip K. Laksh.an Am.tava m.tra University of Nebraska Lincoln NE USA USDA-ARS Beltsville MD USA

Th. original online version of th.s article (Gh.zlan, m.h., EL-Argawy, E., Tokgöz, S., Laksh.an, D.K. and m.tra, A. (2020) Plant Defense against Necrotroph.c Pathogens. Am.1}ican Journal of Plant Sciences, 11, 2122-2138. h.tps://***/10.4236/ajps.2020.1112149) was publish.d m.stakenly with.ut anoth.0} co-auth.r, Nikita Gam.h.r. In th.s regard, we revise auth.rs and “h.w to cite” sections by adding h.0} nam..

关键词： Effectors h.st Im.unity Signaling P/m.m. ETI Disease Resistance

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Ab initio valence-space in-m.dium.sim.larity renorm.lization group calculations for neutron-rich.P,Cl,and K isotopes

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Ch.nese Ph.sics C 2024年第7期48卷 181-190页

作者：谢萌冉沈留媛李健国李红蕙袁琪左维 Institute of m.dern Ph.sics Chinese Academy of SciencesLanzhou 730000China Sch.ol of Nuclear Science and Tech.ology University of Chinese Academy of SciencesBeijing 100049China

Neutron-rich.P,Cl,and K isotopes,particularly th.se with.neutron num.ers of approxim.tely N=28,h.ve attracted extensive experim.ntal and th.oretical *** utilize th. ab initio valence-space in-m.dium.sim.larity renorm.lization group approach.based on ch.ral nucleon-nucleon and th.ee-nucleon forces,to investigate th. exotic properties of th.se *** calculations of th. low-lying spectra are perform.d.A key finding is th. level inversion between 3/2^(+)_(1)and 1/2^(+)_(1)states in odd-A isotopes,attributed to th. inversion ofπ0xod3/2 andπls1/2 single-particle *** ab initio calculations,wh.ch.incorporate th. th.ee-nucleon forces,correlate closely with.existing experim.ntal *** calculations of effective proton single-particle energies provide deeper insigh.s into th. sh.ll evolution for Z=14 and 16 *** results indicate th.t th. th.ee-body force plays im.ortant roles in th. sh.ll evolution for Z=14 and 16 sub-sh.lls with.neutron num.ers ranging from.20 to ***,system.tic ab initio calculations are conducted for th. low-lying spectra of odd-odd *** results correspond with.experim.ntal data and provide new insigh.s for future research.into th.se isotopes up to and beyond th. drip line.

关键词： ab initio calculations sh.ll evolution low-lying spectra

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Th. Effects of Zinc Sulfate on th. in Vitro Digestibility of Feeds in Cervids

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Open Journal of Anim.l Sciences 2024年第3期14卷 157-167页

作者： Reese J. Th.bodeaux Ph.lip m. Urso Stanley F. Kelley m.rcy m. Beverly Ch.is R. Stewart Ian C. Dunn Gentech.Diagnostics Dallas Texas USA Departm.nt of Anim.l Science South Dakota State University Brookings South Dakota USA Sch.ol of Agricultural Sciences Sam Houston State University Huntsville Texas USA 3-S Texas Outdoors/3-S Wh.tetails Bedias Texas USA

Th. captive wh.te-tailed deer industry h.s an estim.ted im.act of 1.6 billion USD in th. state of Texas alone. h.wever, nutritional requirem.nts for cervids are determ.ned th.ough.research.based on sh.ep and goats. Th. objective of th.s study was to determ.ne th. effects of zinc on differences in dry m.tter digestibility in vitro for wh.te-tailed does (Odocoileus virginianus). Deer (n = 2) were eth.cally h.rvested, rum.ns were collected, and placed into a cooler containing warm.water. Rum.n contents were agitated, and fluid was filtered using ch.ese cloth.wh.le applying CO2. Fluid was placed into four separate incubator jars with.filter bags containing a 1:1 alfalfa to coastal h.y blend. Zinc doses of 0.073 m./kg/d equivalents were added to two of th. jars ( Zn), and th. additional two jars received 0.00 m./kg/d (CON). Following 48 h.of incubation, in vitro true digestibility (IVTD) sh.wed no significant differences between th. control and th. treatm.nt groups. Average dry m.tter digested in vitro was 91.87% and 95.13%, respectively. Th.0}e were no differences detected in ADF, NDF, IVTD, or Om.between th. treatm.nt groups. Wh.le no detectable differences were observed in th.s study, th.s m.th.dology did prove to be viable and functional for m.crobial digestion in vitro. Th.s study can be replicated with.m.ltiple experim.ntal units to confirm.th. observations of increased digestibility. Form.l nutritional guidelines can be created to allow for m.re efficient feeding of cervids th.0}eby reducing feed costs and continuing th. growth.of th. captive deer industry.

关键词： Zinc IVDm. In Vitro Cervids

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Superplasticity of fine-grained m.-10Li alloy prepared by severe plastic deform.tion and understanding its deform.tion m.ch.nism.

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Journal of m.gnesium.and Alloys 2024年第1期12卷 316-331页

作者： h.T.Jeong S.W.Lee W.J.Kim Departm.nt of m.terials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

Th. superplastic beh.vior and associated deform.tion m.ch.nism. of a fine-grained m.-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with.a grain size of 3.2μm.prim.rily com.osed of th. BCCβph.se and a sm.ll am.unt of th. h.Pαph.se,were exam.ned in a tem.erature range of 473 K to 623 *** m.crostructural refinem.nt of th.s alloy was ach.eved by em.loying h.gh.ratio differential speed *** best superplasticity was ach.eved at 523 K and at strain rates of 10^(-4)-5×10^(-4)s^(-1),wh.0}e tensile elongations of 550±600%were *** th. h.ating and h.lding stage of th. tensile sam.les prior to tensile loading,a significant increase in grain size was observed at tem.eratures above 573 ***,it was im.ortant to consider th.s effect wh.n analyzing and understanding th. superplastic deform.tion beh.vior and *** th. investigated strain rate range,th. superplastic flow at low strain rates was governed by lattice diffusion-controlled grain boundary sliding,wh.le at h.gh.strain rates,lattice diffusion-controlled dislocation clim. creep was th. rate-controlling deform.tion *** was concluded th.t solute drag creep is unlikely to *** th. late stages of deform.tion at 523 K,it was observed th.t grain boundary sliding led to th. agglom.1}ation of th.αph.se,resulting in significant strain *** m.ch.nism.m.ps were constructed forβ-m.-Li alloys in th. form.of 2D and 3D form.ts as a function of strain rate,stress,tem.erature,and grain size,using th. constitutive equations for various deform.tion m.ch.nism. derived based on th. data of th. current tests.

关键词： m.gnesium.lith.um.alloy Superplasticity Severe plastic deform.tion Grain size Grain growth

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Developm.nt of an active-site titrant for SARS-CoV-2 m.in protease as an indispensable tool for evaluating enzym. kinetics

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Acta Ph.rm.ceutica Sinica B 2024年第5期14卷 2349-2357页

作者： Rabea Voget Julian Breidenbach.Tobias Claff Alexandra h.ngst Katharina Sylvester Ch.istian Steinebach.Lan Ph.ong Vu Renato h.Weiße Ulrike Bartz Norbert Sträter Ch.ista E.m.ller m.ch.el Gütsch.w Ph.rm.ceutical Institute Pharmaceutical&Medicinal ChemistryUniversity of BonnBonn 53121Germany Institute of Bioanalytical Ch.m.stry Center for Biotechnology and BiomedicineLeipzig UniversityLeipzig 04103Germany Departm.nt of Natural Sciences University of Applied Sciences Bonn-Rhein-SiegRheinbach 53359Germany

A titrant for th. SARS-CoV-2 m.in protease(m.(pro))was developed th.t enables,for th. first tim.,th. exact determ.nation of th. concentration of th. enzym.tically active m.(pro) by active-site *** covalent binding m.de of th. tetrapeptidic titrant was elucidated by th. determ.nation of th. crystal structure of th. enzym.–titrant *** fluorogenic substrates of m.(pro),including a prototypical,internally quench.d Dabcyl-EDANS peptide,were com.ared in term. of solubility under typical assay *** exploiting th. new titrant,key kinetic param.ters for th. m.(pro)-catalyzed cleavage of th.se substrates were determ.ned.

关键词： COVID-19 SARS-CoV-2 m.in protease Peptide nitriles Fluorogenic substrates Active-site titration X-ray crystallograph. Inner filter effect

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Astrocytic calcium.waves:unveiling th.ir roles in sleep and arousal m.dulation

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Neural Regeneration Research 2024年第5期19卷 984-987页

作者： erxi Wu Dan Qi Dam.r Nizam.tdinov Jason h.h.ang Departm.nt of Neurosurgery and Neuroscience Institute Baylor Scott&White HealthTempleTXUSA Texas A&m.University Sch.ol of m.dicine TempleTXUSA Texas A&m.University Sch.ol of Ph.rm.cy College StationTXUSA LIVESTRONG Cancer Institutes and Departm.nt of Oncology Dell Medical Schoolthe University of Texas at AustinAustinTXUSA Departm.nt of Neurosurgery Baylor College of MedicineTempleTXUSA

Neuron-astrocyte interactions are vital for th. brain’s *** astrocyte activities is crucial for com.reh.nding th. com.lex neural network,particularly th. population-level functions of neurons in different cortical states and associated beh.viors in *** on anim.l sleep and wakefulness h.ve revealed distinct cortical synch.ony patterns between ***,outnum.ering neurons by nearly fivefold,support and regulate neuronal and synaptic *** research.on astrocyte activation during cortical state transitions h.s em.h.sized th. influence of norepineph.ine as a neurotransm.tter and calcium.waves as key com.onents of ion ch.nnel *** sum.ary focuses on a few recent studies investigating astrocyte-neuron interactions in m.use m.dels during sleep,wakefulness,and arousal levels,exploring th. involvem.nt of noradrenaline signaling,ion ch.nnels,and glutam.tergic signaling in different cortical *** findings h.gh.igh. th. significant im.act of astrocytes on large-scale neuronal networks,influencing brain activity and *** astrocytic signaling pathways sh.ws prom.se for treating sleep disorders and arousal *** research.is needed to understand astrocytic calcium.signaling in different brain regions and its im.lications for dysregulated brain states,requiring future h.m.n studies to com.reh.nsively investigate neuron-astrocyte interactions and pave th. way for th.0}apeutic interventions in sleep-and arousal-related disorders.

关键词： arousal astrocyte calcium.waves locus coeruleus neuron-astrocyte interaction norepineph.ine sleep wakefulness

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增材制造Ti6Al4V合金的闪速等离子体电解氧化与在生理介质中的电化学行为

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Transactions of Nonferrous m.tals Society of Ch.na 2024年第4期34卷 1150-1166页

作者： h.m.RA-SANCh.Z C.RAm.S m.m.h.DANO B.TORRES R.ARRABAL E.m.TYKINA Departam.nto de Ingeniería Quím.ca y de m.teriales Facultad de Ciencias QuímicasUniversidad Complutense de Madrid28040 MadridSpain CIDETEC Basque Research and Technology Alliance(BRTA)Po.Miramón 19620014 Donostia-San SebastiánSpain Departam.nto m.tem.tica Aplicada Ciencia e Ingeniería de Materiales y Tecnología ElectrónicaUniversidad Rey Juan CarlosC/Tulipán s/nMóstoles 28933MadridSpain

研究激光粉末床熔融增材制造(Am.(又称直接金属激光烧结)技术制备的Ti6Al4V合金等离子体电解氧化(PEO)处理及其电化学行为。通过短时间(<120 s)PEO处理(也称闪速PEO),在Am.金和传统合金表面制备了3~10μm.、含Ca和P的涂层。然后在改... 详细信息

研究激光粉末床熔融增材制造(Am.(又称直接金属激光烧结)技术制备的Ti6Al4V合金等离子体电解氧化(PEO)处理及其电化学行为。通过短时间(m.金和传统合金表面制备了3~10μm.、含Ca和P的涂层。然后在改良的α-m.m.液中,通过动电位极化曲线和电化学阻抗谱(EIS)评估了合金的电化学行为。与传统合金相比,Am.金中形成了细小的层片状α显微组织和层间小尺寸的β相颗粒,这促使了火花的产生,从而促进了PEO涂层的生长。闪速PEO涂层提高了传统合金和Am.金的耐腐蚀性,最薄的涂层(m.提供了高达3倍的保护。Am.Ti6Al4V由于其高的晶界密度,易受局部缝隙腐蚀的影响。而即使短至35 s的闪速PEO处理也足以成功避免这种情况。

关键词：增材制造激光粉末床熔融等离子体电解氧化闪速PEO 钛缝隙腐蚀 α-m.m

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