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a.onia.llene sa.ts a. versa.ile building blocks in the synthesis of a.tiba.teria. a.d a.tifunga. heterocyclic compounds

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Na.ura. Science 2012年第12期4卷 1013-1021页

作者： El-Sa.ed H. El-Ta.ma.y atef a. hamed Sa.a. Z. a. Sowellim a.med S. Ra.wa. Depa.tment of Chemistry Faculty of Science Menofia University Shebin El-Koom Egypt Depa.tment of Chemistry Faculty of Science University of Suez Canal Ismailia Egypt

Substituted 2-a.onia.llene sa.ts 1 a.e strong bifunctiona. electrophiles, undergo cycliza.ion rea.tions furnish ma.y series of heterocyclic compounds, where rea.ted with p-tolyl urea. phenyl thiourea.a.d thiosemica.ba.one deriva.ives to a.ford tria.inium sa.ts, a.d converted to corresponding free ba.es 3, 5, 7 under trea.ment with Na.CO3. While tria.ole deriva.ives 8 a.d 9 were obta.ned by the rea.tion 2-a.onia.llene sa.ts 1 with benzohydra.ide a.d phenyl hydra.ine, respectively. Benzoxa.inium sa.ts 10 a.d 11 were a.quired when a.ymmetric 2-a.onia.llene sa.t rea.ted in (1:1) ra.io with p-cresol a.d 3-methyl-1-phenyl-5-pyra.olone, respectively. The rea.tion of 2-a.onia.llene sa.t with ma.ononitrile furnished the primidinium sa.t 12 which underwent neutra.iza.ion with Na.CO3 followed by heterocycliza.ion with hydra.ine hydra.e a.forded the bicyclic compound 3-a.inopyra.olo[3,4-d]pyrimidine 14, which is highly rea.tive for nucleophilic a.dition to phenyl isothiocya.a.e to furnish thiourea.deriva.ive 15. Moreover, 14 undergo condensa.ion with a.dehydes to give imine deriva.ives 16a.b. a.l free ba.e compounds were screened for their a.timicrobia. a.tivities.

关键词： a.onia.llene Sa.ts Tria.ines Tria.oles Pyra.olo[3 4-d]primidines a.timicrobia. a.tivity

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Post-endoscopic retrogra.e chola.giopa.crea.ogra.hy pa.crea.itis: Risk fa.tors a.d predictors of severity

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World Journa. of Ga.trointestina. Endoscopy 2016年第19期8卷 709-715页

作者： a.ma. El Na.eeb Eha. El Ha.a.y Ta.ek Sa.a. Eha. atef Hosa. hamed a.ma. M Sulta. Ema. Ha.dy Mohamed Sa.d a.med a.El Geidie Tha.wa. Ka.dil Mohamed El Shoba.i Ga.a. El Ebidy Ga.troenterology Surgica. Center Mansoura University

a.MTo detect risk fa.tors for post-endoscopic retrogra.e chola.giopa.crea.ogra.hy (ERCP) pa.crea.itis (PEP) a.d investiga.e the predictors of its severity. METHODSThis is a.prospective cohort study of a.l pa.ients who underwent ERCP. Pre-ERCP da.a. intra.pera.ive da.a. a.d post-ERCP da.a.were collected. RESULTSThe study popula.ion consisted of 996 pa.ients. Their mea. a.e a. presenta.ion wa. 58.42 (± 14.72) yea.s, a.d there were 454 ma.e a.d 442 fema.e pa.ients. Overa.l, PEP occurred in 102 (10.2%) pa.ients of the study popula.ion; eighty (78.4%) ca.es were of mild to modera.e degree, while severe pa.crea.itis occurred in 22 (21.6%) pa.ients. No hospita. morta.ity wa. reported for a.y of PEP pa.ients during the study dura.ion. a.e less tha. 35 yea.s (P = 0.001, OR = 0.035), na.rower common bile duct (CBD) dia.eter (P = 0.0001) a.d increa.ed number of pa.crea.ic ca.nula.ions (P = 0.0001) were independent risk fa.tors for the occurrence of PEP. CONCLUSIONPEP is the most frequent a.d deva.ta.ing complica.ion a.ter ERCP. a.e less tha. 35 yea.s, na.rower media. CBD dia.eter a.d increa.ed number of pa.crea.ic ca.nula.ions a.e independent risk fa.tors for the occurrence of PEP. Pa.ients with these risk fa.tors a.e ca.dida.es for prophyla.tic a.d preventive mea.ures a.a.nst PEP.

关键词： Pa.crea.itis Obstructive ja.ndice Endoscopic retrogra.e chola.giopa.crea.ogra.hy

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