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Comparison of the Hypoglycemic, Hypolipidemic and Hepatoprotective Effects of<i>Asparagus racemosus</i>Linn. in Combination with Gliclazide and Pioglitazone on Alloxan-Induced Diabetic Rats

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Pharmacology & Pharmacy 2017年第2期8卷 52-74页

作者： Abdullah Al Mamun Mahbubul Hossain Md.Sahab Uddin Md.Tanjir Islam Sajjad Hossain Md.Sarwar Hossain Md.Farhad Hossain ataur rahman sujan Mamunur Rashid Md.Mahbubur rahman A.F.M.Towheedur rahman Department of Pharmacy Southeast UniversityDhakaBangladesh School of Biosciences and Veterinary Medicine University of CamerinoCamerinoItaly Department of Physical Therapy Graduate School of Inje UniversityGimhaeKorea Department of Pharmacy University of Asia PacificDhakaBangladesh Department of Pharmacy University of RajshahiRajshahiBangladesh Department of Pharmaceutical Sciences North South UniversityDhakaBangladesh

In recent years, the popularity of medicinal plants as a remedy has been increased manifold due to having minimal adverse effects. The current study aimed to compare the hypoglycemic, hypolipidemic and hepatoprotective effects of the ethanolic extract of Asparagus racemosus (EEAR) Linn. alone and combinedly with conventional antidiabetic agents (gliclazide and pioglitazone) in alloxan-induced diabetic rats. Diabetes was induced in male Wister albino rats by the administration of single intra-peritoneal injection of alloxan monohydrate (120 mg/kg b.w.). Effect of oral administration of two different doses of EEAR (200 and 400 mg/kg b.w.), gliclazide (10 mg/kg b.w.) and pioglitazone (10 mg/70kg/b.w.) alone for 2 weeks and a combination of EEAR (200 mg/kg b.w.) with either gliclazide (10 mg/kg b.w.) or pioglitazone (10 mg/70kg/b.w.) for 2 weeks were examined on hypoglycemic activity on 0th, 5th, 10th and 14th day of treatment. After 2 weeks of treatment, hypolipidemic and hepatoprotective effects were estimated by serum biochemical markers such as total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL), serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate trans-aminases (SGPT) and total protein (TP) with the help of commercially available kits. The survival rate, body weight and organ weight were also measured. Alloxan treatment resulted in persistent hyperglycemia, hyperlipidemia and liver dysfunction in rats. Treatment with EEAR at different doses improved hyperglycemia significantly (p th and 14th day of treatment in a dose-dependent mood when compared to the disease control rats, gliclazide treated rats and pioglitazone treated rats. The combination therapy significantly (p th, 10th and 14th day of treatment as compared to that of disease control rats, gliclazide treated rats and pioglitazone treated rats. Proposed adjunct therapy also markedly (p < 0.001;p

关键词： Diabetes Mellitus Asparagus racemosus Gliclazide Pioglitazone Combination Therapy

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Genome-wide association study of heat stresstolerance traits in spring-type Brassica napus *** controlled conditions

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The Crop Journal 2018年第2期6卷 115-125页

作者： Mizanur Rahaman sujan Mamidi Mukhlesur rahman Department of Plant Sciences North Dakota State UniversityFargoND 58102USA Hudson Alpha Institute for Biotechnology HuntsvilleAL 35806USA

High temperatures have a detrimental effect on growth, development, and yield of Brassica napus. Even a short period of heat stress can lead to yield losses of 15%–20%. A collection of spring-type accessions available in Germplasm Resources Information Network(GRIN)were used to assess the effect of short periods of high-temperature stress at the early flowering stage of B. napus. Two sets of accessions with three replications per set were grown in a greenhouse at 22/18 °C day/night temperatures. Plants from the second set at the 6-day flowering stage were exposed to heat-stress conditions(maximum temperature up to 35 °C) in a plant growth chamber for five days. The heat-stressed plants were then allowed to recover in a greenhouse. Pollen sterility, sterile/aborted pods, and number of pods on main raceme were recorded for both control(set 1) and heat stressed(set 2) *** susceptibility indices for all three traits were calculated and an association-mapping study was conducted using 37,539 Single Nucleotide Polymorphisms(SNPs) to identify genomic regions controlling the heat stress traits. A total of 5, 8, and 7 quantitative trait loci(QTL) were associated with pollen sterility, sterile/aborted pods, and number of pods on main raceme, respectively. Together they explained respectively 46.3%, 60.5%, and 60.6% of phenotypic variation. Candidate genes in the QTL regions included genes associated with flowering, male sterility, pollen abortion, embryo abortion reducing pollen development,and pod development.

关键词： Brassica napus Heat stress Controlled environment QTL

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Genome‐wide association study of heat stress‐tolerance traits in spring‐type Brassica napus *** controlled conditions

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The Crop Journal 2018年第2期 115-125页

作者： Mizanur Rahaman sujan Mamidi Mukhlesur rahman Department of Plant Sciences， North Dakota State University Hudson Alpha Institute for Biotechnology

关键词： BRASSICA NAPUS HEAT stress CONTROLLED environment QTL

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