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Blood diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis

Neural Regeneration Research 2025年第9期20卷 2556-2570页

作者： Yongting lv Hongfu Li Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Medical Genetics and Center for Rare disease Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Nanhu Brain-Computer Interface Institute HangzhouZhejiang Province

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely *** principal pathological alterations of the disease include the selective degeneration of motor neurons in the brain,brainstem,and spinal cord,as well as abnormal protein deposition in the cytoplasm of neurons and glial *** biological markers under extensive scrutiny are predominantly located in the cerebrospinal fluid,blood,and even *** these biomarke rs,neurofilament proteins and glial fibrillary acidic protein most accurately reflect the pathologic changes in the central nervous system,while creatinine and creatine kinase mainly indicate pathological alterations in the peripheral nerves and *** light chain levels serve as an indicator of neuronal axonal injury that remain stable throughout disease progression and are a promising diagnostic and prognostic biomarker with high specificity and ***,there are challenges in using neurofilament light chain to diffe rentiate amyotrophic lateral sclerosis from other central nervous system diseases with axonal *** fibrillary acidic protein predominantly reflects the degree of neuronal demyelination and is linked to non-motor symptoms of amyotrophic lateral sclerosis such as cognitive impairment,oxygen saturation,and the glomerular filtration *** DNA-binding protein 43,a pathological protein associated with amyotrophic lateral sclerosis,is emerging as a promising biomarker,particularly with advancements in exosome-related *** is currently lacking for the value of creatinine and creatine kinase as diagnostic markers;however,they show potential in predicting disease *** the vigorous progress made in the identification of amyotrophic lateral sclerosis biomarkers in recent years,the quest for definitive diagnostic and prognostic biomarke rs remains a formidable *** review summarizes the lat

关键词： amyotrophic lateral sclerosis biomarker blood biomarkers diagnosis glial fibrillary acidic protein neurofilament light chain prognosis TAR DNA-binding protein 43

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The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing Ning Shi lv Qian Wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRp3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

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Co-production of hydrogen, oxygen, and electricity via an integrated solar-driven system with decoupled water electrolyzer and Na-Zn ion battery

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Journal of Energy Chemistry 2025年第1期100卷 621-627页

作者： Fei lv Longjie Liu Jiazhe Wu pengfei Wang Lixia pan Dengwei Jing Yubin Chen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University

Combining water electrolysis and rechargeable battery technologies into a single system holds great promise for the co-production of hydrogen （H2） and ***,the design and development of such systems is still in its ***,an integrated hydrogen-oxygen （O2）-electricity co-production system featuring a bipolar membrane-assisted decoupled electrolyzer and a Na-Zn ion battery was established with sodium nickelhexacyanoferrate （NaNiHCF） and Zn2+/Zn as dual redox *** decoupled electrolyzer enables to produce H2and O2in different time and space with almost 100%Faradaic efficiency at 100 mA ***,the charged NaNiHCF and Zn electrodes after the electrolysis processes formed a Na-Zn ion battery,which can generate electricity with an average cell voltage of 1.75 V at 10 m A *** connecting Si photovoltaics with the modular electrochemical device,a well-matched solar driven system was built to convert the intermittent solar energy into hydrogen and electric energy with a solar to hydrogen-electricity efficiency of 16.7%,demonstrating the flexible storage and conversion of renewables.

关键词： Hydrogen Electricity Decoupled water electrolyzer Na-Zn ion battery Solar energy

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A mild, configurable, flexible CoNi-LDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

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Journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng Wu Hao Gao Qingqing Wang pengfei lv Sam S.Yoon Qufu Wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University School of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-LDH） as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-LDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnSO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 mA h g-1,0.26 mA h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-LDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device

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Recent progress in constructing fluorinated solid-electrolyte interphases for stable lithium metal anodes

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 270-291页

作者： Di Zhang pengfei lv Wei Qin Xin He Yuanhua He Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of ChinaGuanghan 618307China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium metal batteries(LMBs)are emerging as a promising energy storage solution owing to their high energy density and specific ***,the non-uniform plating of lithium and the potential rupture of the solid-electrolyte interphase(SEI)during extended cycling use may result in dendrite growth,which can penetrate the separator and pose significant short-circuit *** a stable SEI is essential for the long-term operation of the ***-rich SEI has garnered significant attention for its ability to effectively passivate electrodes,regulate lithium deposition,and inhibit electrolyte *** the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode *** paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal *** focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI *** instance,combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the *** metals with LiF significantly improves electrochemical performance at the SEI/anode interface,with a necessary focus on reducing electron tunneling ***,incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity,though maintaining structural stability over long cycles remains a critical area for future *** alloys combined with LiF increase surface energy and lithium affinity,challenges such as dendrite growth and volume expansion *** summary,this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

关键词： LiF lithium metal anodes solid-electrolyte interphase interface cycling stability

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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the pI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao Dong Fu Meina Wang Chao Han Zhongyue lv Liang Wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(pI3K) protein kinase B(AKT)

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Lightweight porous silica foams with extreme-low dielectric permittivity and loss for future 6G wireless communication technologies

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Nano Research 2021年第5期14卷 1450-1456页

作者： petra S.pálvölgyi Daniel Sebők Imre Szenti Eva Bozo Henri Ervasti Olli pitkänen Jari Hannu Heli Jantunen Marko E.Leinonen Sami Myllymäki Akos Kukovecz Krisztian Kordas Microelectronics Research Unit Faculty of Information and Electrical EngineeringUniversity of OuluP.O.Box 4500FI-90570OuluFinland Interdisciplinary Excellence Centre Department of Applied and Environmental ChemistryUniversity of SzegedRerrich Béla tér 1H-6720SzegedHungary Centre for Wireless Communications University of OuluP.O.Box 4500FI-90570OuluFinland

In the next generation wireless communication systems operating at near terahertz frequencies, dielectric substrates with the lowest possible permittivity and loss factor are becoming essential. In this work, highly porous (98.9% ± 0.1%) and lightweight silica foams (0.025 ± 0.005 g/cm3), that have extremely low relative permittivity (εr = 1.018 ± 0.003 at 300 GHz) and corresponding loss factor (tan δplate-assisted sol-gel method. After dip-coating the slabs of foams with a thin film of cellulose nanofibers, sufficiently smooth surfaces are obtained, on which it is convenient to deposit electrically conductive planar thin films of metals important for applications in electronics and telecommunication devices. Here, micropatterns of Ag thin films are sputtered on the substrates through a shadow mask to demonstrate double split-ring resonator metamaterial structures as radio frequency filters operating in the sub-THz band.

关键词： low-permittivity materials low-loss dielectrics templated sol-gel synthesis silica foams 6G telecommunication

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Detection of Chlamydophila psittaci from feral pigeons in environmental samples:problems with currently available techniques

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Integrative Zoology 2010年第1期5卷 63-69页

作者： ila GEIGENFEIND Daniel HA AG-WACK ERNAGEL Department of Biomedicine Institute of AnatomyUniversity of BaselBaselSw itzerland

Chlamydophila psittaci(Lillie,1930)Everett et al.,1999,the pathogenic agent of human ornithosis,is widespreadin feral pigeon populations and many cases of transmission from feral pigeons to humans have been *** of the present study was to detect *** in environmental samples to find out more about possibletransmission routes and,therefore,to assess the zoonotic risk for *** samples were collected from nestboxes in a feral pigeon ***,samples were taken from the feather dust film covering the water surface ofpublic fountains where pigeons regularly *** samples were tested for the presence of chlamydial antigenusing an antigen enzyme-linked immunosorbent assay to prove shedding of *** by feral *** testdetects a genus specific lipopolysaccharide in the outer membrane of the chlamydial *** were testedusing the IDEIA pCE Chlamydia Test kit(DakoCytomation)and positive results were verified with IDEIA ChlamydiaBlocking Reagents(DakoCytomation).The IDEIA pCE Chlamydia Test yields a high proportion of positive ***,when IDEIA Chlamydia Blocking was performed,most of the positive results turned out to be negative orcould not be *** conclude that antigen-enzyme-linked immunosorbent assay tests are not suitable fordetecting *** in environmental *** publications where no blocking test was used should bereconsidered critically.

关键词： antigen-enzyme-linked immunosorbent assay Chlamydophila psittaci Columba livia environmen-tal samples zoonosis

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Digital Twins in Industry5.0

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Research 2023年第3期2023卷 1-16页

作者： Zhihan lv Department of Game Design Faculty of ArtsUppsala UniversityUppsalaSweden

This work aims to explore the impact of Digital Twins Technology on industrial manufacturing in the context of Industry 5.0.A computer is used to search the Web of Science database to summarize the Digital Twins in Industry ***,the background and system architecture of Industry 5.0 are ***,the potential applications and key modeling technologies in Industry 5.0 are *** is found that equipment is the infrastructure of industrial scenarios,and the embedded intelligent upgrade for equipment is a Digital Twins primary *** the same time,Digital Twins can provide automated real-time process analysis between connected machines and data sources,speeding up error detection and *** addition,Digital Twins can bring obvious efficiency improvements and cost reductions to industrial *** Twins reflects its potential application value and subsequent potential value in Industry 5.0 through the *** is hoped that this relatively systematic overview can provide technical reference for the intelligent development of industrial manufacturing and the improvement of the efficiency of the entire business process in the Industrial X.O era.

关键词： value intelligent subsequent

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Effect of grain size on mechanical property and corrosion resistance of the Ni-based alloy 690

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Journal of Materials Science & Technology 2018年第9期34卷 1685-1691页

作者： Jinlong lv Fracture and Reliability Research Institute School of Engineering Tohoku University

Mechanical property of coarse grained and nano/ultrafine grained alloy 690 and their corrosion resistance after immersion in high temperature borate buffer solution were investigated. The grain refinement significantly enhances the tensile strength of the alloy 690. In addition, the grain refinement facilitates the formation of the deformation twin which improves the ductility of the alloy 690. It has been found that the grain refinement promotes to form more Cr2 O3 on the surface of the alloy 690 in high temperature borate buffer solution. At the same time, the grain refinement inhibits the formation of spinel type *** hematite type oxides formed on nano/ultrafine grained alloy 690 improves its corrosion resistance in borate buffer solution. The hematite type oxides have a lower concentration of point defect than that of the spinel type oxides, which results in an excellent corrosion resistance of nano/ultrafine grained alloy 690. These results are supported by the Mott-Schottky analysis and the point defect model.

关键词： Alloys Buffer Deformation Electrochemical impedance spectroscopy Electrochemistry Interfaces Nanocrystalline Oxidation

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