检索结果-南通市图书馆

Association between inherited monogenic liver disorders and chronic hepatitis C

World Journal of Hepatology 2014年第2期6卷 92-97页

作者： Linda Piekuse Madara Kreile Agnese Zarina Zane Steinberga Valentina Sondore Jazeps Keiss Baiba Lace astrida krumina Scientific Laboratory of Molecular Genetics Riga Stradins University Latvian Centre of Infectious Diseases Riga East University Hospital Latvian Biomedical Research and Study Centre

AIM:To determine the frequencies of mutations that cause inherited monogenic liver disorders in patients with chronic hepatitis C. METHODS:This study included 86 patients with chronic hepatitis C(55 men, 31 women; mean age at diagnosis, 38.36 ± 14.52 years) who had undergone antiviral therapy comprising pegylated interferon and ribavirin. Viral load, biochemical parameter changes, and liver biopsy morphological data were evaluated in all patients. The control group comprised 271 unrelated individuals representing the general population of Latvia for mutation frequency calculations. The most frequent mutations that cause inherited liver disorders [gene(mutation): ATP7B(H1069Q), HFE(C282Y, H63D),UGT1A1(TA)7, and SERPINA1(PiZ)] were detected by polymerase chain reaction(PCR), bidirectional PCR allele-specific amplification, restriction fragment length polymorphism analysis, and sequencing. RESULTS: The viral genotype was detected in 80 of the 86 patients. Viral genotypes 1, 2, and 3 were present in 61(76%), 7(9%), and 12(15%) patients, respectively. Among all 86 patients, 50(58%) reached an early viral response and 70(81%) reached a sustained viral response. All 16 patients who did not reach a sustained viral response had viral genotype 1. Casecontrol analysis revealed a statistically significant difference in only the H1069Q mutation between patients and controls(patients, 0.057; controls, 0.012; odds ratio, 5.514; 95%CI: 1.119-29.827, P = 0.022). However, the H1069Q mutation was not associated with antiviral treatment outcomes or biochemical indices. The(TA) 7 mutation of the UGT1A1 gene was associated with decreased ferritin levels(beta regression coefficient =-295.7, P = 0.0087). CONCLUSION: Genetic mutations that cause inherited liver diseases in patients with hepatitis C should be studied in detail.

关键词： Hepatitis C Hepatolenticular degeneration(Wilson’s disease) ATP7B SERPINA1 UGT1A1 HFE

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current and future perspectives in the management and treatment of colorectal cancer

引用

World Journal of Clinical Oncology 2025年第2期16卷 9-17页

作者： Sigfredo E Romero-Zoghbi Evita krumina Fernando López-Campos Felipe Couñago Department of Radiation Oncology GenesisCare Talavera de la ReinaToledo 45600Spain Department of Radiation Oncology GenesisCare GuadalajaraGuadalajara 19004Spain Department of Radiation Oncology Hospital Universitario Ramón Y CajalMadrid 28034Spain Department of Radiation Oncology GenesisCare-Hospital Universitario Vithas Madrid La MilagrosaMadrid 28010Spain

In this editorial,we reviewed the article by Fadlallah et al that was recently published in the World Journal of Clinical *** article provided a comprehensive and in-depth view of the management and treatment of colorectal cancer(CRC),one of the leading causes of cancer-related morbidity and mortality *** article analyzed the therapeutic modalities and their sequencing,focusing on total neoadjuvant therapy for locally advanced rectal *** highlighted the role of immunotherapy in tumors with high microsatellite instability or deficient mismatch repair,addressing recent advances that have improved prognosis and therapeutic response in localized and metastatic *** in surgical techniques,advanced radiotherapy,and systemic agents targeting specific mutational profiles are also discussed,reflecting on how they revolutionized clinical *** tumor DNA has emerged as a promising tool for detecting minimal residual disease,prognosis,and therapeutic monitoring,solidifying its role in precision *** review emphasized the importance of technological and therapeutic advancements in improving clinical outcomes and personalizing CRC treatment.

关键词： Colorectal cancer Metastatic colorectal cancer Total neoadjuvant therapy Chemoradiotherapy Colon surgery Rectal surgery Chemotherapy Immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The value of magnetic resonance spectroscopy and diffusion tensor imaging in characterization of gliomas growth patterns and treatment efficiency

引用

Journal of Biomedical Science and Engineering 2013年第5期6卷 518-526页

作者： Anvita Bieza Gaida krumina Department of Radiology Riga East Clinical University Hospital Riga Latvia Department of Radiology Riga Stradins University Riga Latvia

The objective of the study was to assess the usefulness of magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) in detection of vital tumor cell infiltration presence in peritumoral brain areas and determination of biochemical changes in the brain parenchyma after received treatment. 73 patients with present, morphologically conformed brain gliomas and 77 gliomas patients in remission stage after combined therapy underwent magnetic resonance imaging (MRI) including MRS and DTI. Fractional anisotropy (FA) and metabolite ratios—choline/creatine (Cho/Cr), myoinositol/creatine (MI/Cr), lactate-lipid/creatine (LL/Cr), N-acetyl aspartate/creatine (NAA/Cr)—were measured in the tumor, perifocal edema zone, distant and contra-lateral normal appearing white matter. We observed gradual reduction of Cho/Cr, MI/Cr, LL/Cr mean ratios and step-by-step increase of NAA/Cr, FA mean values in the direction from the tumor to the distant and contra-lateral normal-appearing white matter. LL/Cr ratios within distal normal appearing white matter decreased in patients after radiotherapy/chemotherapy. Our study suggests that MRS and DTI in combination with structural MRI sequences enhance vital glial tumor cells areas and possible infiltration border. MRS and DTI quantitative measurements in the glioma peritumoral area reveal pathological changes, despite the normal signal intensity in structural MRI. We suggest that increased LL/Cr ratios and decreased FA values may have the superior implications in the detecting of glial tumors extent along the white matter tracts. NAA/Cr reduction and Cho/Cr increase may provide additional diagnostic value. LL/Cr ratio in distal normal signal intensity area could be used as radiation/chemotherapy effectiveness criteria, as this will reduce after the received treatment and in remission period.

关键词： Glioma Perifocal Zone Treatment Fractional Anisotropy Magnetic Resonance Spectroscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Vitamin D and prostate cancer prevention

引用

World Journal of Clinical Oncology 2024年第6期15卷 691-694页

作者： Evita krumina Abrahams Ocanto Felipe Couñago Department of Radiation Oncology GenesisCare GuadalajaraGuadalajara 19004Spain Department of Radiation Oncology San Francisco de Asís University HospitalGenesisCare MadridMadrid 28002Spain Department of Radiation Oncology Vithas La Milagrosa University HospitalGenesisCare MadridMadrid 28010Spain National Director GenesisCare Spain

Vitamin D is a hot topic nowadays,especially its relationship with cancer ***,vitamin D is associated with bone health principally,but the new research has discovered an impact on immune function and cellular sig-naling,even in same studies talk about a hormone,however,the most important relationship is its implication in cellular processes,inhibiting cancer *** now,the recent studies are oriented about a benefit and a cause-effect relationship between prostate cancer and normal levels of vitamin *** premise opens a lot of questions in this *** editorial highlighted the most important studies in this area.

关键词： Prostate cancer Vitamin D Screening Cancer Prevention

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computed tomography perfusion measurements for definition of lesions in early acute stroke

引用

Open Journal of Clinical Diagnostics 2013年第1期3卷 9-13页

作者： Maija Radzina Gaida krumina Karlis Kupcs Evija Miglane Neurology Department Paula Stradins Clinical University Hospital Riga Latvia Radiology Department Riga Stradins University Riga Latvia

Background: Perfusion computed tomography (CT) is an evolving technique in the diagnosis of acute stroke. After complex deconvolution algorithms, perfusion color maps-cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT)— are produced, they give visual confirmation of perfusion deficit in ischemic area, but some discrepancies exist regarding this technique in reliability of quantitative detection of tissue viability: penumbra (tissue at risk) that surrounds core (necrosis). Purpose: The purpose of this prospective study was to define brain tissue viability grade on the basis of the perfusion CT parameters in acute stroke patients. Material and Methods: Multimodal CT imaging protocol (unenhanced CT of the brain, CT angiography of head and neck blood vessels, followed by brain perfusion CT and 24 hours follow-up brain CT) was performed. Perfusion deficit was detected first visually, with subsequent manual quantitative and relative measurements in affected and contra-lateral hemisphere in 87 patients. Results: Visual perfusion deficit on perfusion CT images was found in 78 cases (38 female, 40 male;mean age 30 - 84 years): penumbra lesion (n = 49) and core lesion (n = 42). Both lesion types were detected by increased MTT on perfusion CT map, penumbra area showed mean values 202.40% (113% - 345% ± 57.17) and core (41% - 320% ± 64.53) in comparison to contra-lateral hemisphere. CBV mean values in penumbra group were increased up to 113.10% (45% - 276% ± 36.29) and in core decreased till 41.82% (3% - 107% ± 27.09). CBF values were decreased up to 65.63% (31% - 137% ± 22) in penumbra lesion and markedly decreased till 25.94% (4% - 79% ± 17.35) in core. Conclusion: Our study shows that perfusion CT measurements relative threshold values are recommended in definition of penumbra and core lesions in acute stroke patients.

关键词： Brain Computed Tomography Perfusion Acute Stroke

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stimulating Effect of Red Beetroot (<i>Beta vulgaris</i>) Juice, Fractioned by Membrane Ultrafiltration, on Iron Absorption in Chicken Intestines

引用

Journal of Biosciences and Medicines 2018年第11期6卷 37-49页

作者： D. Babarykin G. Smirnova G. krumina S. Vasiljeva Z. krumina N. Basova A. Fedotova Institute of Innovative Biomedical Technology Ltd. Riga Latvia Institute of Biology of the University of Latvia Riga Latvia

Iron deficiency is one of the leading risk factors for disability and death worldwide. Targeted iron supplementation with pharmaceuticals is widely used, but oral iron salt ingestion often causes side effects—nausea, vomiting, abdominal pain. The present study demonstrated that red beetroot juice (RBRJ) contains a compound or compound complex with the ability to specifically stimulate duodenal iron absorption, shown in experiments in vitro, in situ and in vivo. The effect does not depend on juice sugar and ascorbic acid concentration. Fractionated RBRJ impact on iron absorption is dose dependent. This phenomenon is described for the first time.

关键词： Iron Intestinal Absorption Red Beetroot Juice Ultrafiltration Chickens

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Production of High-Dispersed Palladium Particles on α-Al2O3 Nanoporous Microgranules by the Extractive-Pyrolytic Method

引用

材料科学与工程（中英文A版） 2013年第2期3卷 104-108页

作者： Vera Serga Lidiya Kulikova Aija krumina Svetlana Chomaj a Konstantin Dubencov Mikhail Maiorov Institute of lnorganic Chemistry Riga Technical University Latvia Faculty of Material Science and Applied Chemistry Riga Technical University Latvia Institute of Physics University of Latvia Latvia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antibacterial Activity of Extracts from Some Bryophytes

引用

Advances in Microbiology 2012年第3期2卷 345-353页

作者： Vizma Nikolajeva Ligita Liepina Zaiga Petrina Guntra krumina Mara Grube Indrikis Muiznieks Faculty of Biology University of Latvia Riga Latvia Institute of Microbiology and Biotechnology University of Latvia Riga Latvia

The antimicrobial activity of aqueous and ethanolic extracts of 11 Bryophyta species and 9 Marchantiophyta species collected in Latvia was tested against Staphylococcus aureus, Escherichia coli and Bacillus cereus. The extract of Lophocolea heterophylla inhibited the growth of B. cereus, but none of the tested extracts inhibited the growth of E. coli. 70% of bryophyte species demonstrated certain activity in relation to S. aureus. In general, 73% of ethanolic extracts and 39% of aqueous extracts exhibited antibacterial activity against S. aureus. The highest degree of antibacterial activity against S. aureus was shown by the ethanolic extract of Dicranum scoparium and aqueous extracts of Atrichum undulatum and Rhytidiadelphus squarrosus. The bactericidal action was not ascertained. For the first time antimicrobial activity has been proved for three moss species—Eurhynchium angustirete, Rhytidiadelphus squarrosus and Rhodobryum roseum, and for two liverwort species Frullania dilatata and Lophocolea heterophylla. Qualitative and quantitative differences of plant extracts were evaluated by FT-IR spectra.

关键词： Bryophyta Marchantiophyta Antimicrobial Activity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Occurrence of Legionella pneumophila in Hot Potable Water in Latvia

引用

Journal of Environmental Science and Engineering(A) 2013年第3期2卷 135-140页

作者： Olga Valcina Daina Pule Svetlana Makarova Angelika krumina Irina Lucenko Aivars Berzins Institute of Food Safety Animal Health and Environment "BIOR" Riga L V-1076 Latvia Department of Infectology and Dermatology Faculty of Medicine Riga Stradins University Riga LV-1006 Latvia The Centre for Disease Prevention and Control Riga LV-1012 Latvia

Legionellae are found in freshwater environments or wet soil, but the major reservoirs are man-made aquatic environments, particularly warm water systems. Our aim was to study the occurrence of Legionella contamination in hot potable water supply systems in apartment and public buildings. Correlations between Legionella spp. positive cases and water source, sampling point and temperature of hot water at the point of consumption were studied. A total of 149 hot water samples were collected in 16 cities and districts of Latvia. Only Legionella pneumophila was isolated. L. pneumophila was found in 63 out of 149 （42%） hot water samples. From all Legionella spp. positive samples, 17% represented L. pneumophila serogroup 1 and 78% L. pneumophila serogroups 2-14 （15）. In 5% of Legionella spp. positive samples, both serogroups 1 and 2-14（15） were isolated. Statistically significant differences were observed in the distribution of L. pneumophila serogroup 1 in samples from various water sources. L. pneumophila was found in 45% of samples from private apartments and in 27% of samples from public buildings. Data analysis confirmed that the temperature of hot water significantly affects the frequency of L. pneumophila positive cases （p 〈 0.05）. Data showed that 85% of consumers received hot water at a temperature below 50°C.

关键词： Legionella pneumophila hot water Latvia.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Red Beet (<i>Beta vulgaris</i>) Impact on Human Health

引用

Journal of Biosciences and Medicines 2019年第3期7卷 61-79页

作者： D. Babarykin G. Smirnova I. Pundinsh S. Vasiljeva G. krumina V. Agejchenko Institute of Innovative Biomedical Technology Riga Latvia Institute of Biology University of Latvia Riga Latvia Baldones lauki Ltd. Steading “Ozolaji” Baldones Region Latvia

The last decade is characterized by an explosive growth of interest in the impact of red beet root on human health. In the review information on the chemical composition and nutritional value of red beet as well as pigments biological effects are presented. Analyzed reports abound on antioxidant, anti-inflammatory and chemo-preventive Beta vulgaris phytochemical activity, its impact on gastrointestinal and cardiovascular system as well as endurance exercise performance. In details the red beet nitrates bioconversion and its role in blood pressure regulation have been described. The first information on red beetroot juice impact on iron metabolism is summarized. Beet processing methods, which led to the appearance of a lot of conventional red beet products, functional food, and dietary supplements, are described. Fractionated red beetroot juice on the molecular mass basis is prospective for senile sarcopenia as well as senile cognitive decline and Alzheimer’s disease prevention. The aim of this review is to discuss red beetroot biological effects and new trends in the studies, targeted on development of new functional food products as well as medicines.

关键词： Red Beetroot Biological Effects Gastrointestinal Tract Iron Absorption Iron Deficiency Anemia Athletes’ Stamina

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：