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Prospective single-blinded single-center randomized controlled trial of Prep Kit-C and Moviprep:Does underlying inflammatory bowel disease impact tolerability and efficacy?

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World Journal of Gastroenterology 2021年第11期27卷 1090-1100页

作者： Waled Mohsen astrid-Jane Williams Gabrielle Wark Alexandra Sechi Jenn-Hian Koo Wei Xuan Milan Bassan Watson Ng Susan Connor Department of Digestive Diseases Gold Coast University HospitalGold Coast4215QueenslandAustralia Department of Gastroenterology and Hepatology Liverpool HospitalSydney 2170New South WalesAustralia South West Sydney Clinical School University of New South WalesSydney 2170New South WalesAustralia Ingham Institute Applied Medical Research Sydney 2170New South WalesAustralia

BACKGROUND Colonoscopy remains the gold standard for detection of colonic *** optimal evaluation depends on adequate bowel *** with inflammatory bowel disease(IBD),require frequent endoscopic assessment for both activity and dysplasia *** commonly used bowel preparations in Australia are Prep Kit-C(Pc)and Moviprep(Mp).Little is known about tolerability,efficacy and safety of split protocols of Mp and Pc in both IBD and non-IBD *** To primary aim was to compare the tolerability,efficacy and safety of split protocols of Mp and Pc in patients having a *** secondary aim was to compare the efficacy,tolerability and safety of either preparation in patients with or without *** Patients were randomized to Pc or Mp bowel *** completed a questionnaire to assess *** was assessed using the Ottawa Bowel Preparation *** electrolytes and renal function were collected one week prior to colonoscopy and on the day of *** Of 338 patients met the inclusion *** 168 patients randomized to Mp and 170 to *** efficacy of bowel preparation(mean Ottawa Bowel Preparation Score)was similar between Mp(5.4±2.4)and Pc(5.1±2.1)(P=0.3).Mean tolerability scores were similar in Mp(11.84±5.4)and Pc(10.99±5.2;P=0.17).125 patients had IBD(73 had Crohn’s Disease and 52 had Ulcerative colitis).Sixtyfour IBD patients were allocated to Mp and 61 to *** non-IBD patients,104 were allocated to Mp and 109 to *** mean tolerability score in the IBD group was lower than the non-IBD group(mean tolerability scores:IBD:10.3±5.1 and non-IBD:12.0±5.3;P=0.01).IBD patients described more abdominal pain with Mp when compared with Pc;(Mp:5.7±4.4 vs Pc:3.6±2.6,P=0.046).Serum magnesium level increased with Pc compared with Mp in all patients(mean increase in mmol/L:Mp:0.03±0.117 and Pc:0.11±0.106;P<0.0001).CONCLUSION In this study,the efficacy,tolerability and safety of Mp and Pc were simila

关键词： Bowel preparation Inflammatory bowel disease Tolerability Efficacy Moviprep Prep Kit-C

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An unusual cause of hematemesis:Goiter

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World Journal of Gastroenterology 2006年第33期12卷 5412-5415页

作者： astrid AM van der Veldt Mohammed Hadithi Marinus A Paul Fred G van den Berg Chris JJ Mul-der Mikael E Craanen Department of Gastroenterology VU University Medical Center Amsterdam The Netherlands Department of Surgery VU University Medical Center Amsterdam The Netherlands Department of Radiology VU University Medical Center Amsterdam The Netherlands

Downhill varices are located in the upper part of the esophagus and are usually related to superior vena cava obstruction. Bleeding from these varices is extremely rare. We describe a 77-year-old patient with hematemesis due to downhill varices as a result of recurrent goiter. A right lobe thyroidectomy was carried out with disappearance of the varices.

关键词： Downhill Esophageal Varices Goiter Hematemesis

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Field Screening of Lesotho and South African Wheat Cultivars for Russian Wheat Aphid Resistance

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Advances in Entomology 2016年第5期4卷 268-278页

作者： astrid Jankielsohn Pitso Masupha Lintle Mohase Crop Protection ARC-Small Grain Institute Bethlehem South Africa Department Crop Protection National University of Lesotho Roma Lesotho Department of Plant Physiology University of the Free State Bloemfontein South Africa

Russian wheat aphid (Diuraphis noxia) is an international wheat pest and was first recorded in South Africa in 1978 in the Bethlehem area in the Eastern Free State. Le-sotho lies adjacent to one of the largest wheat producing areas in South Africa, the Eastern Free State, where winter wheat and facultative types are cultivated under dry land conditions. Wheat (Triticum aestivum L.) is an important crop adapted to all agro-ecological zones of Lesotho. Russian wheat aphid may have a significant impact on wheat yield. No monitoring or pest control is being done in Lesotho and at this stage there is very little information on the Russian wheat aphid resistance of wheat culti-vars cultivated in Lesotho. In view of this it is important to monitor the distribution of Russian wheat aphid biotypes in Lesotho and determine the level of Russian wheat aphid resistance in local Lesotho wheat cultivars. Two local Lesotho wheat cultivars, Bolane and Makalaote were screened together with South African cultivars Elands, Matlabas, Senqu, PAN3379, PAN3118 and SST387, in the glasshouse against all four known biotypes that occur in South Africa. All these cultivars were also planted in 5 m plots in the field at two localities Leribe and Roma in the lowlands of Lesotho. These cultivars were screened in the field for Russian wheat aphid resistance. The predomi-nant Russian wheat aphid biotypes in these areas were also determined. The Lesotho cultivar, Bolane had resistance against RWASA2 in the glasshouse, while Makalaote did not have any Russian wheat aphid resistance in either the glasshouse or field screenings. To contribute to food security an increasing wheat yield potential is a high priority. Russian wheat aphid has been included in the list of important international cereal pests. Russian wheat aphid adapts to changing environments and taking their ecology, distribution, virulence patterns, and variability into account is important in minimizing the gap between actual and attainab

关键词： Russian Wheat Aphid Biotypes Wheat Cultivars Lesotho Field Screening Resistance

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Sperm concentration measurement with a disposable counting chamber

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Asian Journal of Andrology 2018年第5期20卷 525-526页

作者： Mathilde Lemoine Xavier Ferraretto Marie-astrid Llabador-de Royer Achraf Benammar Jacques Darolles Sylvie Epelboin Florence Eustache Catherine Patrat Biology of Reproduction Department Bichat Hospital Paris Nord Val de Seine University Hospitals Public Hospitals of Paris (APHP) Paris 75018 France UFR of Medicine Paris Diderot University PRES Sorbonne Paris Cite Paris 75010 France Espacebio Laboratory of Medical Biology France-Senart-Conseil Montgeron Society Metz 57000 France Gynecology and Obstetrics Department Bichat Hospital Hopitaux Universitaires Paris Nord Val de Seine Public Hospitals of Paris (APHP) Paris 75018 France Biology of Reproduction Department - CECOS Jean Verdier Hospital Paris Seine Saint Denis University Hospital Public Hospitals of Paris (APHP) Bondy 93140 France U1016 INSERM- UMR 8104 CNRS Cochin Institute Paris Descartes University PRES Sorbonne Paris Cite Paris 75014 France Biology of Reproduction Department - CECOS Cochin Hospital Paris Centre University Hospitals Public Hospitals of Paris (APHP) Paris 75014 France

Dear Editor, In its latest edition, the World Health Organization （WHO） provides guidelines regarding the standardization of techniques for the measurement of sperm concentrationI and recommends use of a 100 μm-deep hemocytometer. However, these instructions are not always followed correctly.2 Furthermore, although hemocytometers provide more accurate and consistent results, they present several drawbacks： the chamber must be properly assembled prior to its use so as to ensure that the counts are correct and it needs to be cleaned thoroughly to remove all traces of sperm, which risks breaking the glass coverslip.

关键词： QUALITY-CONTROL VARIABILITY MOTILITY

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NOD2-and disease-specific gene expression profiles of peripheral blood mononuclear cells from Crohn's disease patients

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World Journal of Gastroenterology 2018年第11期24卷 1196-1205页

作者： Holger Schufler Maria Rohde Sarah Rohde astrid Huth Nicole Gittel Hannes Hollborn Dirk Koczan Ane Glass Georg Lamprecht Robert Jaster Department of Medicine II Division of GastroenterologyRostock University Medical CenterRostock 18057Germany Institute of Immunology Rostock University Medical CenterRostock 18057Germany Institute for Biostatistics and Informatics in Medicine and Ageing Research Rostock 18057Germany

AIM To investigate disease-specific gene expression profiles of peripheral blood mononuclear cells(PBMCs) from Crohn's disease(CD) patients in clinical *** Patients with CD in clinical remission or with very low disease activity according to the Crohn's disease activity index were genotyped regarding nucleotidebinding oligomerization domain 2(NOD2),and PBMCs from wild-type(WT)-NOD2 patients,patients with homozygous or heterozygous NOD2 mutations and healthy donors were isolated for further *** cells were cultured with vitamin D,peptidoglycan(PGN) and lipopolysaccharide(LPS) for defined periods of time before RNA was isolated and subjected to microarray analysis using Clariom S assays and quantitative realtime ***2-and disease-specific gene expression profiles were evaluated with repeated measure ANOVA by a general linear *** Employing microarray assays,a total of 267 genes were identified that were significantly up-or downregulated in PBMCs of WT-NOD2 patients,compared to healthy donors after challenge with vitamin D and/or a combination of LPS and PGN(P < 0.05;threshold:≥ 2-fold change).For further analysis by real-time PCR,genes with known impact on inflammation and immunity were selected that fulfilled predefined expression *** a larger cohort of patients and controls,a disease-associated expression pattern,with higher transcript levels in vitamin D-treated PBMCs from patients,was observed for three of these genes,CLEC5 A(P < 0.030),lysozyme(LYZ;P < 0.047) and TREM1(P < 0.023).Six genes were found to be expressed in a NOD2-dependent manner(CD101,P < 0.002;CLEC5 A,P < 0.020;CXCL5,P < 0.009;IL-24,P < 0.044;ITGB2,P < 0.041;LYZ,P < 0.042).Interestingly,the highest transcript levels were observed in patients with heterozygous NOD2 *** Our data identify CLEC5 A and LYZ as CD-and NOD2-associated genes of PBMCs and encourage further studies on their pathomechanistic roles.

关键词： Peripheral blood mononuclear cells Gene expression NOD2 Lysozyme Crohn's disease CLEC5A

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Quality of life, physical performance and nutritional status in older patients hospitalized in a cardiology department

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Journal of Geriatric Cardiology 2020年第7期17卷 410-416页

作者： Matthieu Lilamand Mariannick Saintout Marie Vigan astrid Bichon Laure Tourame Aurélie Brembilla Diet Bernard Iung Dominique Himbert Cédric Laouenan Agathe Raynaud-Simon Assistance Publique Hôpitaux de Paris Nord Department of GeriatricsBichat University HospitalFrance University of Paris France Assistance Publique Hôpitaux de Paris Nord Department of EpidemiologyBiostatistics and Clinical ResearchBichat University HospitalFrance Assistance Publique Hôpitaux de Paris Nord Department of CardiologyBichat University HospitalFrance

Objectives Quality of life(QoL) is a priority outcome in older adults suffering from cardiovascular diseases. Frailty and poor nutritional status may affect the QoL through mobility disorders and exhaustion. The objective of this study was to determine if physical frailty and nutritional status were associated with QoL, in older cardiology patients. Methods Cross sectional, observational study conducted in a cardiology department from a university hospital. Participants(n = 100) were aged 70 and older. Collected data included age, sex, cardiac diseases, New York Heart Association(NYHA) classification, comorbidities(Charlson Index) and disability. A Short Physical Performance Battery(SPPB), including walking speed assessment was performed;handgrip strength were measured as well as Fried’s frailty phenotype. Nutritional status was assessed using the Mini Nutritional Assessment(MNA) and Body Mass Index(BMI), inflammation by C-reactive protein(CRP). QoL was assessed using the EORTC–QLQ questionnaire. Univariate and multivariate analyses were performed to study the associations between all recorded parameters and QoL. Results In participants(mean age: 79.3 ± 6.7 years;male: 59%), Charlson index, arrhythmia, heart failure, NYHA class III-IV, MNA, disability, walking speed, SPPB score, frailty and CRP were significantly associated with QoL in univariate analysis. Multivariate analysis showed that NYHA class III-IV(P < 0.001), lower MNA score(P = 0.03), frailty(P < 0.0001), and higher CRP(P < 0.001) were independently associated with decreased QoL. Conclusions Frailty, nutritional status and inflammation were independently associated with poor QoL. Further studies are needed to assess the efficacy of nutritional and physical interventions on QoL in this population.

关键词： Cardiovascular diseases Frailty Muscle strength Nutrition Older adults Quality of life

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Higher infliximab and adalimumab trough levels are associated with fistula healing in patients with fistulising perianal Crohn’s disease

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World Journal of Gastroenterology 2022年第23期28卷 2597-2608页

作者： Bonita Gu Kavya Venkatesh astrid-Jane Williams Watson Ng Crispin Corte Ali Gholamrezaei Simon Ghaly Wei Xuan Sudarshan Paramsothy Susan Connor South Western Sydney Clinical School University of New South WalesSydney 2170New South WalesAustralia Department of Gastroenterology and Hepatology Liverpool HospitalSydney 2170New South WalesAustralia AW Morrow Gastroenterology and Liver Centre Royal Prince Alfred HospitalSydney 2050New South WalesAustralia Department of Medicine University of NewcastleNewcastle 2308New South WalesAustralia Central Clinical School University of SydneySydney 2050New South WalesAustralia Ingham Institute of Applied Medical Research Sydney 2170New South WalesAustralia Department of Gastroenterology St Vincent’s Hospital SydneySydney 2010New South WalesAustralia St Vincent’s Clinical School University of New South WalesSydney 2010New South WalesAustralia Department of Gastroenterology and Hepatology Concord Repatriation General HospitalSydney 2139New South WalesAustralia Concord Clinical School University of SydneySydney 2139New South WalesAustralia

BACKGROUND Tumor necrosis factor-alpha inhibitors,including infliximab and adalimumab,are effective medical treatments for perianal fistulising Crohn’s disease(CD),but not all patients achieve fistula *** To determine the correlation between perianal fistula healing and closure with infliximab and adalimumab trough *** In this multicentre retrospective study conducted across four tertiary inflammatory bowel disease centres in Australia,we identified CD patients with perianal fistulae on maintenance infliximab or adalimumab who had a trough level within twelve weeks of clinical *** collected included demographics,serum infliximab and adalimumab trough levels(mg/L)within 12 wk before or after their most recent clinical assessment and concomitant medical or surgical *** primary outcome was fistula healing,defined as cessation in fistula *** secondary outcome was fistula closure,defined as healing and closure of all external fistula *** between patients who did or did not achieve fistula healing were compared using the chi-square test,t test or Mann-Whitney U *** One hundred and fourteen patients(66 infliximab,48 adalimumab)were ***-eight(72.7%)patients on maintenance infliximab achieved fistula healing and 18(27.3%)achieved fistula ***-seven(77%)patients on maintenance adalimumab achieved fistula healing and 17(35.4%)achieved fistula *** who achieved fistula healing had significantly higher infliximab and adalimumab trough levels than patients who did not[infliximab:6.4(3.8-9.5)vs 3.0(0.3-6.2)mg/L,P=0.003;adalimumab:9.2(6.5-12.0)vs 5.4(2.5-8.3)mg/L,P=0.004].For patients on infliximab,fistula healing was associated with lower rates of detectable anti-infliximab antibodies and younger *** patients on adalimumab,fistula healing was associated with higher rates of combination therapy with an *** trough levels for patients with and without fistu

关键词： Crohn’s disease Perianal disorders Biologics Inflammatory bowel disease

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Indocyanine green fluorescence angiography during liver and pancreas transplantation: a tool to integrate perfusion statement's evaluation

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Hepatobiliary Surgery and Nutrition 2018年第3期7卷 161-166页

作者： Fabrizio Panaro Enrico Benedetti Guillaume Pineton de Chambrun Hussein Habibeh Piera Leon Hassan Bouyabrine astrid Herrero Francis Navarro Department of General Surgery Division of TransplantationUniversity of Montpellier-College of MedicineSaint Eloi HospitalMontpellier-Cedex 5France Division of Transplantation University of Illinois Hospital and Health Sciences SystemChicagoILUSA Department of Medicine Division of GastroenterologyHospital St.EloiMontpellier University HospitalAugustin Fliche34295-MontpellierFrance

Background: Indocyanine green (ICG) fluorescence imaging is a promising tool for intraoperative decision-making during surgical procedures, in particular to assess organs perfusion. Methods: We used the ICG fluorescence during liver transplantations in six cirrhotic patients to help assessing the graft biliary duct perfusion in order to identify the appropriate level to perform the anastomosis. We also used ICG fluorescence also in five patients receiving kidney-pancreas transplantation to evaluate the perfusion levels of the duodenal stump of the pancreas graft. Results: Follow-up period for the patients was 12 months. The perioperative period was uneventful, no biliary complications such as leaks or stenosis were reported after liver transplantation, no complications of the entero-enteric anastomoses occurred after pancreatic transplantation. Conclusions: ICG fluorescence seems to safely provide important objectifiable perfusion information during organ transplantation procedures that can integrate surgeon's expertise. In fact, detecting intra-operatively perfusion defects, it allows real time modifications on technical strategies potentially useful to reduce the feared risk of anastomotic leakage and consequent severe complications.

关键词： Indocyanine green (ICG) liver pancreas transplantation perfusion

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巴拿马城波尔地区的社区再生研究

巴拿马城波尔地区的社区再生研究

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作者： astrid VALDES 北京交通大学

学位级别：硕士

通过对旅游者和当地居民的调查,本研究调查了巴尔博亚大道作为世界遗产保护区提出的建议。调查显示,游客被古老殖民地建筑的外墙所吸引,这些建筑经过精心修复。相比之下,巴拿马人更多地依赖于新的建筑结构,这些建筑结构促进了该地区的... 详细信息

通过对旅游者和当地居民的调查,本研究调查了巴尔博亚大道作为世界遗产保护区提出的建议。调查显示,游客被古老殖民地建筑的外墙所吸引,这些建筑经过精心修复。相比之下,巴拿马人更多地依赖于新的建筑结构,这些建筑结构促进了该地区的活动和生活方式,并且由于保护而减少了。规划当局主要集中在经济可行性问题上,并赞成增加经济流量的商业活动。因此,巴拿马人认为保护“博物馆化”或使“精英”鼓励旅游业,未能保存真正的遗产并回应社区的实际需求。中美洲主要城市的数量,在1821年独立后成为中美洲共和国的首都,大部分位于殖民地区的内陆地区。巴拿马作为例外,从一开始就把他的首都(巴拿马城)建成海边,作为向南美洲的一个重要贸易点,使其成为独特的一个方面。这项工作侧重于使用定性方法进行实地研究,使用直接观察工具,实地记录和文件审查来分析现场。当电网成为大规模再生的对象时,无论传统特征如何,对城市结构的破坏使得保护过程变得相当困难;与城市原始组织同情的温和转变为核心生存和适当保护提供了巨大潜力。由此,本文提出了一种新的城市保护观,更关注保留旧城的本质,或者保留这个地方的“空间精神”,而不是无论城市如何都无法挽救个别建筑物或空间。他们可以在其中发挥作用和生存的环境。

关键词：城市再生城市保护巴尔博亚大道转型太平洋沿岸

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Ribonucleotide reductases-enzymes with redox-active metal sites and free radicals

Ribonucleotide reductases-enzymes with redox-active metal si...

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中国化学会第26届学术年会

作者： astrid Grslund Dept. of Biochemistry and Biophysics Stockholm University SE-106 91 Stockholm Sweden

＜正＞Ribonucleotide reductases （RNRs） convert ribonucleotides to deoxyribonucleotides, a bottleneck reaction in the metabolism of DNA, required for DNA replication and repair. The RNR enzyme mechanism involves redox active metals and free radicals as active partners. Class I ribonucleotide reductases （RDR）, e.g. in

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