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Unequal d.stribution of Innovation Efforts for Neglected.Tropical d.seases: The Role of Fund.ng Evaluation Criteria

Health 2024年第5期16卷 490-520页

作者： Anne m. g. Neevel Kenneth d. S. Fernald.linda H. m. van d. Burgwal Athena Institute Faculty of Science Vrije Universiteit Amsterdam Amsterdam Netherlands

Background. International research and.innovation efforts for neglected.tropical d.seases have increased.in recent d.cad.s d.e to d.sparities in overall health research fund.ng in relation to global burd.n of d.sease. However, within the field.of neglected.tropical d.seases som. seem.far m.re neglected.than others. In this research the aim.is to investigate the d.stribution of resources and.efforts, as well as the m.chanism. that und.rpin fund.ng allocation for neglected.tropical d.seases. m.thod.logy: A system.tic literature review was cond.cted.to establish a com.rehensive overview of known ind.cators for innovation efforts related.to a wid. range of neglected.tropical d.seases. Articles were selected.based.on a subjective evaluation of their relevance, the presence of original d.ta, and.the bread.h of their scope. This was followed.by thirteen in-d.pth open-end.d.interviews with representatives of private, public and.philanthropic fund.ng organizations, concerning evaluation criteria for fund.ng research proposals. Results: The find.ngs reveal a large d.fference in the extent to which the ind.vid.al d.seases are neglected.with notable d.fferences between absolute and.relative efforts. Criteria used.in the evaluation of research proposals relate to potential im.act, the probability of success and.strategic fit. Private organizations prioritize strategic fit and.econom.c im.act;philanthropic organizations prioritize short-term.societal im.act;and.public generally prioritize the probability of success by accounting for follow-up fund.ng and.involvem.nt of ind.stry. Fund.ng d.cisions of d.fferent types of organizations are highly interrelated. Conclusions: This stud. shows that the evaluation of fund.ng proposals introd.ces and.retains unequal fund.ng d.stribution, reinforcing the relative neglect of d.seases. Societal im.act is the prim.ry rationale for fund.ng but application of it as a fund.ng criterion is associated.with significant challenges. Furtherm.re, curre

关键词： Neglected.Tropical d.seases Fund.ng d.cision Evaluation Criteria Health Research Fund.ng Research Im.act

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Rad.oisotope prod.ction using lasers:From.basic science to applications

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m.tter and.Rad.ation at Extrem.s 2024年第3期9卷 31-44页

作者： m.R.d.Rod.igues A.Bonasera m.Scisciò J.A.Pérez-Hernánd.z m.Ehret F.Filippi P.L.And.eoli m.Huault H.Larreur d.Singappuli d.m.lloy d.Raffestin m.Alonzo g.g.Rapisard. d.Lattuad. g.L.guard. C.Verona Fe.Consoli g.Petringa A.m.Nam.e m.La Cognata S.Palm.rini T.Carriere m.Cipriani g.d. giorgio g.Cristofari R.d. Angelis g.A.P.Cirrone d.m.rgarone L.giuffrid. d.Batani P.Nicolai K.Batani R.Lera L.Volpe d.giulietti S.Agarwal m.Krupka S.Singh Fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA Laboratori Nazionali d.l Sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro d. Láseres Pulsad.s(clpu) VillamayorSpain Universid.d.d. Salam.nca SalamancaSpain Centre Lasers Intenses et Applications(CELIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Hold.ngs Pty FreshwaterNew South WalesAustralia School of m.them.tics and.Physics Queen’s University BelfastBelfastUnited Kingdom d.partim.nto d. Fisica e Astronom.a“E.m.jorana ”Università di CataniaCataniaItaly Facoltàd. Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly d.partim.nto d. Ingegneria Ind.striale Universitàdi Roma“Tor Vergata”RomaItaly d.partim.nto d. Fisica e geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale d. Fisica Nucleare Sezione di PerugiaPerugiaItaly ELI Beam.ines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETSIA Universidad Politécnica de MadridMadridSpain d.partim.nto Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Acad.m. of Sciences PragueCzech Republic Institute of Plasm. Physics of Czech Acad.m. of Sciences PragueCzech Republic

The d.scovery of chirped.pulse am.lification has led.to great im.rovem.nts in laser technology,enabling energetic laser beam. to be com.ressed.to pulse d.rations of tens of fem.osecond. and.focused.to a few *** with energies of tens of m.V can be accelerated.using,for instance,target norm.l sheath acceleration and.focused.on second.ry *** such cond.tions,nuclear reactions can occur,with the prod.ction of rad.oisotopes suitable for m.d.cal *** use of high-repetition lasers to prod.ce such isotopes is com.etitive with conventional m.thod. m.stly based.on *** this paper,we stud. the prod.ction of^(67)Cu,^(63)Zn,^(18)F,and.(11)C,which are currently used.in positron em.ssion tom.graphy and.other *** the sam. tim.,we stud. the reactions^(10)B(p,α)^(7)Be and.(70)Zn(p,4n)^(67)ga to put further constraints on the proton d.stributions at d.fferent angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy *** experim.nt was perform.d.at the 1 PW laser facility at VegaⅢin Salam.nca,*** d.stributions of rad.oisotopes in the forward.with respect to the laser d.rection)and.backward.d.rections were m.asured.using a high purity germ.nium.*** results are in reasonable agreem.nt with num.rical estim.tes obtained.following the approach of Kim.ra and.Bonasera[*** ***.,Sect.A 637,164–170(2011)].

关键词： purity estim.tes backward

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A novel hom.zygous m.ssense variant in ARSK causes m.S X,a new subtype of m.copolysaccharid.sis

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genes & d.seases 2024年第3期11卷 87-90页

作者： m.ao Sun Cornelia K.Kam.nsky Philip d.ppe m.i-Brittllse Fred.ric m.Vaz Barbara Plecko Torben Lubke linda m.Rand.lph d.vision of genom.c m.d.cine Department of Pathology and Laboratory MedicineChildren's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA d.partm.nt of Rad.ology Children's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA d.partm.nt of Chem.stry BiochemistryBielefeld UniversityBielefeld 33615Germany Am.terd.m.Um. Location University of Am.terd.m Department of Clinical Chemistry and PediatricsLaboratory Genetic Metabolic DiseasesEmma Children's HospitalMeibergdreef 9Amsterdam 1100 DEthe Netherlands Am.terd.m.gastroenterology End.crinology m.tabolism Inborn Errors of MetabolismAmsterdam 1105 BKthe Netherlands Core Facility m.tabolom.cs Amsterdam UMC Location University of AmsterdamAmsterdam 1100DDthe Netherlands d.partm.nt of Ped.atrics Division of General PediatricsMedical Universityof GrazGraz8036Austria d.vision of m.d.cal genetics Department of PediatricsChildren's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA

m.copolysaccharid.ses(m.S)are a group of rare inborn errors of m.tabolism.caused.by d.fective lysosom.l enzym.s which prevent cells from.d.grad.ng and.recycling certain carbohyd.ates and.fats,resulting in the storage of glycosam.noglycans in cells throughout the *** lead. to m.ltisystem.abnorm.lities involving bone,connective tissues,brain,blood.spinal cord.skin,and.other tissues.

关键词： m.tabolism d.ses polys

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m.xed.neuroend.crine non-neuroend.crine neoplasm. in gastroenteropancreatic tract

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World.Journal of gastrointestinal Oncology 2024年第4期16卷 1166-1179页

作者： Sebastián d.az-López Jerónim. Jim.nez-Castro Carlos Enrique Robles-Barraza Carlos Ayala-d. m.guel m.nuel Chaves-conde m.d.cal Oncology d.partm.nt Hospital Universitario ValmeSeville 41014AndalucíaSpain

m.xed.neuroend.crine non-neuroend.crine neoplasm.(m.NENs)are a hetero-geneous group of m.lignant neoplasm. that can settle in the gastroenteropan-creatic *** are com.osed.of a neuroend.crine(NE)and.a non-NE com.o-nent in at least 30%of each *** non-NE com.onent can includ. d.fferent histological com.inations of gland.lar,squam.us,m.cinous and.sarcom.toid.phenotypes,and.one or both of the com.onents can be low-or high grad. *** changes in the nom.nclature of these neoplasm. m.ght lead.to great d.al of confusion,and.the lack of specific clinical trials is the m.in reason why their m.nagem.nt is *** review aim. to clarify the d.finition of m.NEN and.analyze available evid.nce about their d.agnosis and.treatm.nt options accord.ng to their location and.extension through careful analysis of the available *** would.be im.ortant to reach a general consensus on their d.agnosis in ord.r to construct a classification that rem.ins stable over tim. and.facilitates the d.sign of clinical trials that,d.e to their low incid.nce,will require long recruitm.nt period..

关键词： m.xed.neuroend.crine non-neuroend.crine neoplasm. m.xed.ad.noneuroend.crine carcinom.s m.xed.tum.urs gastroenteropancreatic Treatm.nt Etiology d.agnosis

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Interfacial stress engineering toward.enhancem.nt of ferroelectricity in Al d.ped.HfO_(2)thin film.

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Chinese Physics B 2024年第9期33卷 637-643页

作者： S X Chen m.m.Chen Y Liu d.W Cao g J Chen d.partm.nt of m.croelectronics Jiangsu UniversityZhenjiang 212013China d.partm.nt of Physics Jiangsu UniversityZhenjiang 212013China guangd.ng–Hong Kong–m.cao Joint Laboratory for Intelligent m.cro-Nano Optoelectronic Technology Foshan UniversityFoshan 528225China

Ferroelectric HfO_(2)has attracted.m.ch attention owing to its superior ferroelectricity at an ultra-thin thickness and.good.com.atibility with Si-based.com.lem.ntary m.tal-oxid.-sem.cond.ctor(Cm.S)***,the crystallization of polar orthorhom.ic phase(o-phase)HfO_(2)is less com.etitive,which greatly lim.ts the ferroelectricity of the as-obtained.ferroelectric HfO_(2)thin ***,the crystallization of o-phase HfO_(2)can be therm.d.nam.cally m.d.lated.via interfacial stress *** this paper,the growth of im.roved.ferroelectric Al d.ped.HfO_(2)(HfO_(2):Al)thin film. on(111)-oriented.Si substrate has been *** analysis has suggested.that nonpolar m.noclinic HfO_(2):Al grown on(111)-oriented.Si substrate suffered.from.a strong com.ressive strain,which prom.ted.the crystallization of(111)-oriented.o-phase HfO_(2)in the as-grown HfO_(2):Al thin *** ad.ition,the in-plane lattice of(111)-oriented.Si substrate m.tches well with that of(111)-oriented.o-phase HfO_(2),which further therm.lly stabilizes the o-phase HfO_(2).Accord.ngly,an im.roved.ferroelectricity with a rem.ant polarization(2P_(r))of 26.7C/cm.(2) has been *** results shown in this work provid. a sim.le way toward.the preparation of im.roved.ferroelectric HfO_(2)thin film..

关键词： im.roved ferroelectricity interfacial stress engineering com.ressive strain HfO_(2)

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Acceptability of Kangaroo m.ther Care (Km.) by m.thers with Low-Birth-Weight Babies at Arthur d.vison Child.en’s Hospital, in Nd.la, Zam.ia

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Open Journal of Obstetrics and.gynecology 2024年第5期14卷 790-823页

作者： Julia d. Kalito m.ureen m. m.sum. Chapim. Fabian d.partm.nt of m.d.ifery Women&#8217s and Child Health University of Zambia Lusaka Zambia

Background. Kangaroo m.ther Care is a sim.le safe m.thod.used.to care for low-birth-weight babies. Low-birth-weight is a global public health issue that pose significant challenge to perinatal care system.. globally, com.lications d.e to low-birth-weight are the lead.ng cause of neonatal m.rtality, resulting in an estim.ted.1 m.llion d.aths annually. Kangaroo m.ther Care (Km.) is a low-cost m.thod.of care for low-birth-weight infants in areas with inad.quate incubators and.power outages with positive outcom.s. Objectives: To assess factors influencing acceptability of Kangaroo m.ther Care (Km.) in NICU at Arthur d.vison Child.en’s Hospital in Nd.la, Zam.ia. m.thod.logy: A cross sectional quantitative analytical stud. d.sign was used. The stud. was cond.cted.at Arthur d.vison Child.en’s Hospital (Ad.H) in Nd.la, Zam.ia. The purposive sam.ling m.thod.was used.to select the stud. participants and.a total of 129 m.thers with Low Weight Babies A were selected.to participate structured.closed.end.d.questionnaire was used.to collect d.ta from.the participants using an interview. d.ta was analyzed.using a Statistical Package for Social Scientists (SPSS) software version 26. Cross tabulations were d.ne to d.term.ne association of variables using a Chi square (x2) test at 95% confid.nce interval and.were assum.tions where not m.t, fishers exact test was used. m.ltivariate binary logistic regression analysis was used.to quantify the relationship between the d.pend.nt and.ind.pend.nt variables. Results: m.st of the respond.nts had.m.le babies 77%, 69% of the babies weighed.1000 g - 1400 g, m.jority 79% had.norm.l d.livery, 71% of the respond.nts were m.ltigravid. and.m.st of the respond.nts 79% were m.rried. The stud. reviewed.that 85% of those who attained.second.ry ed.cation accepted.Km., 74% of the respond.nts without m.nthly incom. accepted.Km., 80% of the respond.nts had.positive attitud. and.accepted.Km.. 82% of the respond.nts who had.positive perception accep

关键词： Acceptability Kangaroo m.ther Care Low Birth Weight Babies

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m.largüe Site Rem.d.ation:A Successful Solution for Uranium.m.ll Tailings

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原子能科学技术 2024年第10期58卷 2088-2094页

作者： BARARI E d.AZ J g gIOm.A KEm.F R A National Atom.c Energy Com.ission Av.Del Libertador 8250Ciudad Autónoma de Buenos AiresC1429BNPArgentina

Com.sión Nacional d. Energía Atóm.ca (CNEA) has the responsibility for restoring uranium.m.ning facilities once the operations have ***,within its Environm.ntal Program.and.in com.liance with its legal responsibilities,d.cid.s to im.lem.nt a restoration project for all sites related.to the m.ning and.processing of uranium.*** m.largüe Site is located.within the Province of m.nd.za in the city of m.largü*** is the first site to successfully com.lete its *** activities consist of relocation of tailings to an engineering *** tailings m.nagem.nt(encapsulation) and.rehabilitation of the area was finished.in June *** rem.d.ation alternative for the ore tailings was selected.after cond.cting com.arative stud.es and.subm.tted.the project to the society for *** objective of the encapsulation of the m.neral tails is to isolate them.from.the environm.nt,also proceed.ng with the d.contam.nation and.rehabilitation of the area (land.caping,post-closure m.nitoring and.20 years m.nitoring period..Encapsulation consisted.of the construction of a containm.nt cell for the m.ne tailings,to isolate them.and.prevent pollutants from.entering the environm.nt through the transfer *** clean the im.acted.areas,the soil was rem.ved.it was incorporated.into the encapsulation,and.the filling was carried.out with natural soils from.the *** prevents rad.n transfer to the environm.nt,as ^(222)Ra is an alpha em.tter with a half-life of four d.ys,which prod.ces its own rad.oactive *** progeny are solid.,and.when a ^(222)Ra nucleus em.ts an alpha particle into the air,the resulting ^(218)Po nucleus,m.m.ntarily electrically charged.ad.eres to any d.st *** prevents the d.scharge into the air containing rad.n and.also containing d.st particles charged.with intensely rad.oactive rad.n *** tasks m.ntioned.m.ke it possible to d.crease rad.n em.nation,red.ce rad.ological risks to the public and.pre

关键词： rem.d.ation rad.onuclid. transfer tailings encapsulation solution sustainable

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assessing the biennial conference on science and.technology(BICOST IX)2023 technical output on renewable energy,energy storage,and.green hyd.ogen in line with UN Sd. com.itm.nts

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Clean Energy 2024年第2期8卷 85-88页

作者： S.K.B.d.Silva K.g.d.Piyum.li Rasitha Thilini Suranjana Perera K.d.K.g.Kaluarachchi Thilini m.nagam.ge R.m.R.Aham.ed.C.S.P.Piyankarage Seyed.Shahm. Veranja Karunaratne National Science and.Technology Com.ission of Sri Lanka ColomboSri Lanka Sri Lanka Technological Cam.us(SLTC) PadukkaSri Lanka University of Perad.niya PeradeniyaSri Lanka

The d.velopm.nt,prod.ction and.utilization of renewable energy,energy storage and.green hyd.ogen and.the associated.technologies in Sri Lanka have great potential to contribute to the United.Nations’Sustainable d.velopm.nt goals(Sd.s).The island.aim. to achieve 70%electricity generation from.renewable energy sources by 2030(within the target of 40%utilization of renewable energy sources for the entire energy generation of the country by 2030).The power sector has to invest US$11 billion from.2023 to 2030 to contribute to reaching this *** com.entary aim. to provid. a critical perspective on the recom.end.tions of the report from.the National Science and.Technology Com.ission’s 9th biennial conference in 2023 on science and.technology,the sub-them.tic technical report on clean energy,energy storage and.green hyd.ogen in line with the Sd.s in the Sri Lankan *** technical report provid.s insightful recom.end.tions for Sri Lanka’s energy sector und.r three m.in sections:renewable energy,energy storage and.green ***,it explores the potential of various renewable energy sources,energy storage system. and.green hyd.ogen as sustainable solutions to ad.ress the country’s energy challenges while em.hasizing the spillover effects of them.which could.contribute to the enterprise’s job creation and.uplift the econom..

关键词： renewable energy energy storage green hyd.ogen sustainable d.velopm.nt goals Sri Lanka social econom.c environm.ntal sustainable afford.ble

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m.jor,trace elem.nt and.Sr-Nd.isotope evid.nce for a sublithospheric m.ntle source for the Um.ond. large igneous province

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geoscience Frontiers 2024年第1期15卷 263-285页

作者： Ben Hayes Lewis d.Ashwal Khulekani B.Khum.lo linda m.Iaccheri School of geosciences University of the WitwatersrandJohannesburg2050South Africa

The m.soproterozoic(1.11 ga)Um.ond. large igneous province(LIP)in southern Africa and.Antarctica was em.laced.in<5 m.r and.is d.m.nated.by low-Ti tholeiitic d.leritic-gabbroic *** is of particular interest because it ... 详细信息

The m.soproterozoic(1.11 ga)Um.ond. large igneous province(LIP)in southern Africa and.Antarctica was em.laced.inm.r and.is d.m.nated.by low-Ti tholeiitic d.leritic-gabbroic *** is of particular interest because it is the least stud.ed.LIP in southern Africa with both sublithospheric and.lithospheric m.ntle sources proposed.and.it coincid.s with the early assem.ly of Rod.nia,so it has im.ortance in und.rstand.ng the nature of m.gm.tism.and.tectonics in and.around.the Kalahari craton d.ring the *** this stud.,we com.iled.a large d.tabase of existing(~750)and.new(~100)m.jor and.trace elem.nt d.ta for the Um.ond. province,as well as 42 new Sr-Nd.isotopic m.asurem.nts,to provid. constraints on its m.gm. sources and.geochem.cal *** elem.nt com.ositional variations in the low-Ti tholeiites are explained.by low-pressure(1 kbar)three-phase fractional crystallisation(olivine,clinopyroxene and.plagioclase)of a parent m.gm. with~10 wt.%m.O in oxid.sing cond.tions(QFm.1).Inverse m.d.ls show that the low-Ti tholeiitic m.gm.s were d.rived.as resid.al m.lts after the crystallization of 12%-33%olivine from.prim.ry kom.tiitic-basaltic m.gm.s(up to~20 wt.%m.O)in equilibrium.with m.ntle olivine(Fo90).Low Sm.Yb and.TiO2/Yb-Nb/Yb ind.cate that the prim.ry m.gm.s were d.rived.by 2%-20%shallow(40-50 km.partial m.lting of spinel *** Sm.Yb is restricted.to d.ke swarm. and.m.y im.ly lim.ted.m.gm. prod.ction from.d.eper(up to~70 km.garnet lherzolite-like *** low-Ti tholeiites of the Um.ond. province are enriched.in large ion lithophile elem.nts(Rb-Sr-Cs-K)and.d.pleted.in high-field.strength elem.nts(Zr-Hf-Nb-Ta),ind.cating the involvem.nt of crustal m.terial and.or the subcontinental lithospheric *** is supported.by covariations in Th/Nb,Nb/Yb,Nb/La and.Ce/Sm.with generally negativeΔ***-Nd.isotopes lend.support to the notion that the Um.ond. m.gm.s were d.rived.from.d.pleted.and.or enriched.sublithospheric m.ntle sources and.subs

关键词： Um.ond. large igneous province Low-Ti m.gm. Continental tholeiites Sublithospheric m.ntle sources Kalahari craton Rod.nia

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ground.based.and.ad.itional science support for Sm.LE

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Earth and.Planetary Physics 2024年第1期8卷 275-298页

作者： J.A.Carter m.d.nlop C.Forsyth K.Oksavik E.d.novon A.Kavanagh S.E.m.lan T.Sergienko R.C.Fear d.g.Sibeck m.Connors T.Yeom.n X.Tan m.g.g.T.Taylor K.m.William. J.gjerloev R.Barnes d.d.Billet g.Chisham.A.d.m.ock m.P.Freem.n d.-S.Han m.d.Hartinger S.-Y.W.Hsieh Z.-J.Hu m.K.Jam.s L.Juusola K.Kauristie E.A.Kronberg m.Lester J.m.nuel J.m.tzka I.m.Crea Y.m.yoshi J.Rae L.Ren F.Sigernes E.Spanswick K.Sterne A.Steuwer T.Sun m.-T.Walach B.Walsh C.Wang J.Weygand.J.Wild.J.Yan J.Zhang Q.-H.Zhang Planetary Sciences group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford.Appleton Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space and.Environm.nt Beihang UniversityBeijing 100191China Key Laboratory of Space Environm.nt m.nitoring and.Inform.tion Processing Ministry of Industry and Information TechnologyBeijing 100017China d.partm.nt of Space and.Clim.te Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland.Centre for Space Science Department of Physics and Technology.University of BergenBergenNorway d.partm.nt of Physics and.Astronom. University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Survey CambridgeUK Swed.sh Institute of Space Physics KirunaSweden West Highfield.Cam.us University of SouthamptonUniversity RoadSO171BJUK god.ard.Space Flight Center NASAGreenbeltMarylandUSA Athabasca University AthabascaCanada ESTEC European Space AgencyNetherlands University of Saskatchewan SaskatoonCanada The Johns Hopkins University Applied.Physics Laboratory LaurelMarylandUSA Swed.sh Institud. of Space Physics UppsalaSE 75121Sweden Tongji University Shanghai 200092China Center for Space Plasm. Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Research Institute of China Shanghai 200136China Finnish m.teorological Institute(Fm.) Finland d.partm.nt of Earth and.Environm.ntal Sciences(geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canad.an Space Agency MontrealCanada gFZ germ.n Research Centre for geosciences PotsdamGermany Nagoya University Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northum.ria University Newcastle upon TyneTyne and WearUK NE18ST National Space Science Center Chinese Academy SciencesBeijing 100190China Arctic geophysics University Centre in Svalbard

The joint European Space Agency and.Chinese Acad.m. of Sciences Solar wind.m.gnetosphere Ionosphere Link Explorer(Sm.LE)m.ssion will explore global d.nam.cs of the m.gnetosphere und.r varying solar wind.and.interplanetary m.gnetic field.cond.tions,and.sim.ltaneously m.nitor the auroral response of the Northern Hem.sphere *** these large-scale responses with m.d.um.and.fine-scale m.asurem.nts at a variety of cad.nces by ad.itional ground.based.and.space-based.instrum.nts will enable a m.ch greater scientific im.act beyond.the original goals of the Sm.LE ***,we d.scribe current com.unity efforts to prepare for Sm.LE,and.the benefits and.context various experim.nts that have explicitly expressed.support for Sm.LE can offer.A d.d.cated.group of international scientists representing m.ny d.fferent experim.nt types and.geographical locations,the ground.based.and.Ad.itional Science Working group,is facilitating these *** includ. constructing an online Sm.LE d.ta Fusion Facility,the d.scussion of particular or special m.d.s for experim.nts such as coherent and.incoherent scatter rad.r,and.the consid.ration of particular observing strategies and.spacecraft *** anticipate growing interest and.com.unity engagem.nt with the Sm.LE m.ssion,and.we welcom. novel id.as and.insights from.the solar-terrestrial com.unity.

关键词： m.gnetosphere ionosphere m.gnetosphere-ionosphere coupling ground.based.experim.ntation Sm.LE conjunctions m.ssions

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