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Effect of ezetimibe on the prevalence of cholelithiasis

World Journal of Gastroenterology 2012年第40期18卷 5789-5792页

作者： assaf stein Doron Hermoni Avishay Elis Fred M Konikoff Department of Gastroenterology and Hepatology University of Tel AvivMeir Medical CenterKfar Saba 44281Israel Department of Family Medicine Clalit Health Services SharonNetanya 42470Israel Department of Medicine A University of Tel AvivMeir Medical CenterKfar Saba 44281Israel

AIM:To investigate the prevalence of cholelithiasis among patients treated with ***:A retrospective,case-control study based on computerized medical records from patients of the Clalit Health Services,Sharon-Shomron region,from 2000 to *** 20-85 years of age,who had been treated with ezetimibe and statins or statins only for at least 6 mo,and who had an abdominal ultrasound were included in the *** data included age,gender,ezetimibe treatment duration,presence of hypothyroidism or diabetes,and existence of cholelithiasis as determined by *** were subjects after gallbladder resection,with hemolysis,myeloproliferative or inflammatory bowel diseases,and those treated with ursodeoxycholic acid and *** treated with statins and ezetimibe(study group) were compared to patients treated with statins only(control group).RESULTS:The study group included 25 patients and the control group *** patients in the study were treated with *** study group included 13 males(52%) and 12 females(48%),the control group 76 males(45%) and 92(55%) females(P = 0.544).The groups did not differ in age(mean age:68 ± 8 years,range 53-85 years vs mean age:71 ± 8 years,range 51-85 years;P = 0.153) or in the rate of diabetic and hypothyroid patients [11(44%) vs 57(33%),P = 0.347 in the study group and 5(20%) vs 23(14%),P = 0.449 in the control group,respectively].Patients in the study group were treated with ezetimibe for an average of 798 ± 379 *** was found in 4(16%) patients in the study group and in 33(20%) patients in the control group(P = 0.666).CONCLUSION:Ezetimibe does not appear to influence the prevalence of gallstones.

关键词：患病率胆石症甲状腺功能减退他汀类药物药物治疗平均年龄治疗时间胆囊结石

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Amino acid and mineral digestibility,bone ash,and plasma inositol is increased by including microbial phytase in diets for growing pigs

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Journal of Animal Science and Biotechnology 2024年第2期15卷 699-712页

作者： Liz Vanessa Lagos Mike Richard Bedford Hans Henrik stein Division of Nutritional Sciences University of IllinoisUrbanaIL 61801USA AB Vista Marlborough SN84ANUK

Background The effect of microbial phytase on amino acid and energy digestibility is not consistent in pigs,which may be related to the phytase dosage or the adaptation length to the ***,an experiment was conducted to test the hypotheses that increasing dietary phytase after an 18-day adaptation period:1)increases nutrient and energy digestibility;2)increases plasma P,plasma inositol,and bone ash of young pigs;and 3)demonstrates that maximum phytate degradation requires more phytase than maximum P *** Data indicated that increasing inclusion of phytase[0,250,500,1,000,2,000,and 4,000 phytase units(FTU)/kg feed]in corn-soybean meal-based diets increased apparent ileal digestibility(AID)of Trp(quadratic;P<0.05),and of Lys and Thr(linear;P<0.05),and tended to increase AID of Met(linear;P<0.10).Increasing dietary phytase also increased AID and apparent total tract digestibility(ATTD)of Ca and P(quadratic;P<0.05)and increased ATTD of K and Na(linear;P<0.05),but phytase did not influence the ATTD of Mg or gross *** of plasma P and bone ash increased(quadratic;P<0.05),and plasma inositol also increased(linear;P<0.05)with increasing inclusion of *** concentrations of inositol phosphate(IP)6 and IP5(quadratic;P<0.05),reduced IP4 and IP3(linear;P<0.05),but increased inositol concentrations(linear;P<0.05)were observed in ileal digesta as dietary phytase *** ATTD of P was maximized if at least 1,200 FTU/kg were used,whereas more than 4,000 FTU/kg were needed to maximize inositol *** Increasing dietary levels of phytase after an 18-day adaptation period increased phytate and IP ester degradation and inositol release in the small ***,increasing dietary phytase resulted in improved digestibility of Ca,P,K,Na,and the first 4 limiting amino acids,and in increased concentrations of bone ash and plasma P and *** a corn-soybean meal diet,maximum inositol release requires appr

关键词： Bone ash Inositol Nutrient digestibility Phytase Phytate degradation Pigs

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Effective extraction of polyribosomes from astrocytes enables future discoveries on translation regulation

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Neural Regeneration Research 2025年第4期20卷 1083-1084页

作者： Orna Elroy-stein Sagol School of Neuroscience Tel Aviv UniversityTel AvivIsrael Shmunis School of Biomedicine and Cancer Research George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael

Translation regulation is an important layer of gene expression:Generation of genome-wide expression datasets at multi-omics levels in spatial,temporal,and cell-type resolution is essential for deciphering brain *** of gene expression is a highly dynamic process aiming at the production of precise levels of gene products to guarantee optimal cellular function,in response to physiological *** advances in next-generation sequencing enabled the understanding of epigenomic and transcriptomic dynamic landscapes of different brain regions along development,aging,and disease ***,the correlation of the“transcriptome”with protein levels is poor because numerous mRNAs are subjected to manipulation of their translation efficiency,to warrant a favorable result under certain ***,it is widely accepted that regulation at the translation level is a vital layer of gene *** of actively translated mRNA populations(i.e.,“translatome”)is a more reliable predictor of the“proteome”(Wang et al.,2020).

关键词： translation enable landscape

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Pelleting and particle size reduction of corn increase net energy and digestibility of fiber,protein,and fat in corn-soybean meal diets fed to group-housed pigs

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1751-1760页

作者： Su A Lee Diego A.Rodriguez Chad B.Paulk Hans H.stein Department of Animal Sciences University of IllinoisUrbanaIL 61801USA Department of Grain Sciences and Industry Kansas State UniversityManhattanKS 66506USA

Background Reduction of the particle size of corn increases energy digestibility and concentrations of digestible and metabolizable *** may also reduce particle size of grain,but it is not known if there are interactions between particle size reduction and *** objective of this experiment was to test the hypothesis that particle size reduction and pelleting,separately or in combination,increase N balance,apparent total tract digestibility(ATTD)of fiber and fat,and net energy(NE)in corn-soybean meal diets fed to group-housed *** Six corn-soybean meal-based diets were used in a 3×2 factorial design with 3 particle sizes of corn(i.e.,700,500,or 300μm)and 2 diet forms(i.e.,meal or pelleted).Pigs were allowed ad libitum access to feed and ***-four castrated male pigs(initial weight:29.52 kg;standard diviation:1.40)were allotted to the 6 diets using a 6×6 Latin square design with 6 calorimeter chambers(i.e.,4 pigs/chamber)and 6 *** consumption and CO_(2)and CH_(4)productions were measured during fed and fasting states and fecal and urine samples were *** Regardless of particle size of corn,the ATTD of gross energy(GE),N,and acid-hydrolyzed ether extract(AEE),and the concentration of NE were greater(P<0.05)in pelleted diets than in meal *** of diet form,the ATTD of GE,N,and AEE,and the concentration of NE were increased(linear;P<0.05)by reducing the particle size of corn,but the increase was greater in meal diets than in pelleted diets(interaction;P<0.05).Conclusions Both pelleting and reduction of corn particle size increased nutrient digestibility and NE,but increases were greater in meal diets than in pelleted diets.

关键词： Corn Digestibility Feed technology Net energy Particle size Pelleting

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Colon mucosal neoplasia referred for endoscopic mucosal resection:Recurrence of adenomas and prediction of submucosal invasion

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World Journal of Gastrointestinal Endoscopy 2020年第7期12卷 198-211页

作者： Mamoon Ur Rashid Neelam Khetpal Hammad Zafar Saeed Ali Evgeny Idrisov Yuan Du assaf stein Deepanshu Jain Muhammad Khalid Hasan Department of Internal Medicine Advent Health Graduate Medical EducationOrlandoFL 32804United States Department of Internal Medicine Univerity of Iowa hospitalIowa CityIA 52242United States Department of Gastroenterology University of Oklahoma Health SciencesOklahomaOK 73104United States Center for Interventional Endoscopy AdventHealthOrlandoFL 32803United States

BACKGROUND Endoscopic mucosal resection(EMR)is an effective and minimally invasive alternative to surgery for large polyps and laterally spreading *** morphology and surface characteristics may help predict submucosal invasion of the lesion(SMIL)during endoscopic *** is one of the largest singlecenter studies reporting endoscopic mucosal resection for larger(≥20 mm)colorectal lesions in the United *** To determine the recurrence rate of adenomas and endoscopic features that may predict submucosal invasion of colonic mucosal *** This is a retrospective cohort study of all the patients referred for endoscopic mucosal resection for lesions≥20 mm,spanning a period from January 2013 to February *** main outcome measure was identifying features that may predict submucosal invasion of mucosal lesions and predict recurrence of adenomas on follow-up surveillance colonoscopy performed at 4-6 *** A total of 480 patients with 500 lesions were included in the *** median age was 68(Inter quantile range:14)with 52%*** most common lesion location was ascending colon(161;32%).Paris classification 0-IIa(Flat elevation of mucosa-316;63.2%);Kudo Pit Pattern IIIs(192;38%)and Granular surface morphology(260;52%)were most *** invasion was present in 23(4.6%)out of 500 *** independent risk factors for SMIL were Kudo Pit Pattern IIIL+IV and V(Odds ratio:4.5;P value40 mm).Almost all recurrences(98.8%)were treated endoscopically.

关键词： Endoscopy Polyp Endoscopic mucosal resection Recurrence Submucosal invasion

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Dysregulated microRNAs in type 2 diabetes and breast cancer:Potential associated molecular mechanisms

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World Journal of Diabetes 2024年第6期15卷 1187-1198页

作者： Alex Cleber Improta-Caria Filipe Ferrari João Lucas Penteado Gomes Paloma Brasilio Villalta Úrsula Paula RenóSoci Ricardo stein Edilamar M Oliveira Laboratory of Biochemistry and Molecular Biology of the Exercise Physical Education and Sport SchoolUniversity of São PauloSão Paulo 05508-030Brazil Graduate Program in Cardiology and Cardiovascular Sciences Federal University of Rio Grande do SulHospital de Clínicas de Porto AlegrePorto Alegre 90035003Brazil Laboratory of Metabolic Disorders(Labdime) School of Applied SciencesUniversity of Campinas-UNICAMPCampinas 13484-350Brazil Departments of Internal Medicine Molecular Pharmacology and PhysiologyCenter for Regenerative MedicineUSF Health Heart InstituteMorsani College of MedicineUniversity of South FloridaTampaFL 33602United States

Type 2 diabetes(T2D)is a multifaceted and heterogeneous syndrome associated with complications such as hypertension,coronary artery disease,and notably,breast cancer(BC).The connection between T2D and BC is established through processes that involve insulin resistance,inflammation and other *** this comprehension the specific cellular and molecular mechanisms linking T2D to BC,especially through microRNAs(miRNAs),remain *** are regulators of gene expression at the post-transcriptional level and have the function of regulating target genes by modulating various signaling pathways and biological ***,the signaling pathways and biological processes regulated by miRNAs that are associated with T2D and BC have not yet been *** review aims to identify dysregulated miRNAs in both T2D and BC,exploring potential signaling pathways and biological processes that collectively contribute to the development of BC.

关键词： Type 2 diabetes Breast cancer MicroRNAs Molecular mechanisms

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软件脱碳

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科技纵览 2024年第4期 28-33,4页

作者： RINA DIANE CABALLAR ELIAS stein(图) 不详

软件可能在吞噬世界,同时也在让它升温.2023年12月,来自近200个国家和地区的代表齐聚迪拜参加《联合国气候变化框架公约》第28次缔约方大会(COP28),讨论减少排放的迫切需要.与此同时,COP28网站可持续性评分工具Ecograder的数据表明,其... 详细信息

软件可能在吞噬世界,同时也在让它升温.2023年12月,来自近200个国家和地区的代表齐聚迪拜参加《联合国气候变化框架公约》第28次缔约方大会(COP28),讨论减少排放的迫切需要.与此同时,COP28网站可持续性评分工具Ecograder的数据表明,其网站每加载一个页面会产生3.69克二氧化碳.这个数字似乎很小,但如果该网站1年的浏览量达到每月1万次,其排放量将略高于从旧金山到多伦多的单程航班的排放量.

关键词：《联合国气候变化框架公约》浏览量数据表减少排放可持续性缔约方大会二氧化碳

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Calcium isotope compositions as a means to trace carbonate recycling

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National Science Review 2022年第6期9卷 8-10页

作者： Shichun Huang stein B.Jacobsen Department of Geoscience University of Nevada Department of Earth and Planetary Sciences Harvard University

Marine carbonates, such as sedimentary carbonates and secondary carbonates formed during marine alteration processes, are returned to the mantle at subduction zones, and their fates regulate the global carbon cycle. S... 详细信息

关键词： Carbonates

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‘Smart’copycat mutual funds:on the performance of partial imitation strategies

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Financial Innovation 2022年第1期8卷 2508-2538页

作者： Roberto stein Department of Finance University of Nebraska-Lincoln730 N 14th StLincolnNE 68588USA

Using a novel measure of stock-level trade imitation,we uncover‘smart’copycats:fund managers that use their own information when beneficial,and otherwise imitate other managers’better *** to previous research,we find that these partial imitation strategies lead to ***‘Copycat Score’combines the propensity to imitate and to lead *** at the high and low ends of the score outperform all *** Copycat Score is persistent in time,related to other measures of skill,and a good predictor of fund *** conclude that smart copycatting is another skill of successful fund managers.

关键词： Copycat portfolios Mutual funds Portfolio holdings Fund performance Fund manager skill

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Anorexia nervosa:Outpatient treatment and medical management

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World Journal of Psychiatry 2022年第4期12卷 558-579页

作者： stein Frostad Mette Bentz Department of Mental Health Research Division of PsychiatryHaukeland University HospitalBergen 5021Norway Child and Adolescent Mental Health Centre Capital Region of DenmarkUniversity of CopenhagenCopenhagen 2400Denmark

Anorexia nervosa(AN)is a disabling,costly and potentially deadly *** failure and relapse are common after completing treatment,and a substantial proportion of patients develop severe and enduring *** time from AN debut to the treatment initiation is normally unreasonably *** the past 20 years there has been empirical support for the efficacy of several treatments for ***,outpatient treatment with family-based therapy or individual psychotherapy is associated with good outcomes for a substantial proportion of *** intervention improves outcomes and should be a priority for all *** treatment is usually the best format for early intervention,and it has been demonstrated that even patients with severe or extreme AN can be treated as outpatients if they are medically *** care is more disruptive,more costly,and usually has a longer waiting list than does outpatient *** decision as to whether to proceed with outpatient treatment or to transfer the patient for inpatient therapy may be *** core aim of this opinion review is to provide the knowledge base needed for performing safe outpatient treatment of *** scientific essentials for outpatient treatment are described,including how to assess and manage the medical risks of AN and how to decide when transition to inpatient care is *** following aspects are discussed:early intervention,outpatient treatment of AN,including outpatient psychotherapy for severe and extreme AN,how to determine when outpatient treatment is safe,and when transfer to inpatient healthcare is *** treatments,ethical issues and outstanding research questions are also addressed.

关键词： Anorexia nervosa Outpatient treatment Medical management Outpatient psychotherapy Inpatient healthcare

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