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Glinus lotoides ethanolic extract alleviates LPS-induced anxiety and depression-like behavior by modulating antioxidant and inflammatory biomarkers in rats

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Asian Pacific Journal of Tropical Biomedicine 2022年第2期12卷 78-86页

作者： Ambreen Mehmood Awan Wafa Majeed Faraza Javed Bilal Aslam asra iftikhar Hafiza Arooj Kanwal Sobia Fiaz Institute of Physiology and Pharmacology University of AgricultureFaisalabadPakistan Department of Pharmacology Faculty of Pharmacythe Islamia University of BahawalpurBahawalpurPakistan Department of Pharmacy University of FaisalabadFaisalabadPakistan Department of Pharmacy University of AgricultureFaisalabadPakistan

Objective:To explore the protective role of Glinus lotoides ethanolic extract in a depression model through modulating oxidant/antioxidant enzyme system and inflammatory ***:Phytochemical constituents of Glinus lotoides ethanolic extract were evaluated qualitatively and quantitatively along with *** were divided into six *** normal control and the intoxicated groups received normal saline,and the standard group received imipramine,while the remaining groups received 100,300,and 500 mg/kg Glinus lotoides ethanolic *** groups received treatments for 14 ***(LPS)were then administered i.p.(0.83 mg/kg)to all groups except the normal control *** 24 h,anxiety and depression-like behaviors were evaluated by performing behavioral analysis(open field,tail suspension,forced swim,sucrose preference test),and determining total oxidant status,total antioxidant capacity,catalase,and biochemical parameters[malondialdehyde,glutathione,superoxide dismutase,tumor necrosis factor(TNF)-alpha and interleukin(IL)-6].Results:Phytochemical studies confirmed the presence of phenols and flavonoids and HPLC analysis showed the presence of gallic acid,quercetin,chlorogenic,and caffeic *** oxidant status was significantly decreased,while total antioxidant capacity was significantly increased in the Glinus lotoides ethanolic extract treated ***,Glinus lotoides ethanolic extract diminished malondialdehyde,IL-6,and TNF-alpha levels,while increasing superoxide dismutase,catalase,and glutathione ***:Glinus lotoides ethanolic crude extract shows significant antidepressant activity by modulating oxidative and biochemical parameters that supports its folkloric use in traditional systems of medicine.

关键词： Glinus lotoides Biochemical markers Depression Traditional medicine Nervous system Anxiety Antioxidant Inflammation

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History,epidemiology,vaccine and transmission of coronavirus disease 2019 (COVID-19):a quick review

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Life Research 2021年第3期4卷 9-19页

作者： Rabia Altaf asra iftikhar Rabia Haq Bushra Zahoor Muhammad Zaini Asmawi Mohamed Khadeer Ahamed Basheer Department of Pharmacy The Green International UniversityLahorePakistan Department of Pharmacy The University of FaisalabadPunjabPakistan Department of Family medicine Agha Khan University HospitalKarachiPakistan School of Pharmaceutical Sciences Universiti Sains MalaysiaPenangMalaysia EMAN Research Ltd Level 3/81 Flushcombe RdBlacktown NSW 2148Australia

Coronavirus belonging to family Coronaviridae is a large group of viruses causing respiratory and gastrointestinal *** outbreak of 2019-novel coronavirus has created panic in the whole world after being transmitted from Wuhan,China in December 2019.A large number of people are affected throughout the world that forced a solitary situation in the affected areas confining common people to their homes to prevent its *** receptors in humans for 2019-novel coronavirus are found to be same as for severe acute respiratory syndrome coronavirus,the first human pandemic of 21st century,however,2019-novel coronavirus is highly contagious,virulent and mutable than the severe acute respiratory syndrome *** most attractive site for vaccine development against 2019-novel coronavirus is the spike glycoprotein which is crucial for receptor binding,membrane fusion via conformational changes,virus internalization,and host tissue tropism or spike inactivation through antibody induced *** outbreak was in December 2019,later on at the end of 2020,the mortality ratio decreased that created a sigh of temporary relief in the *** season was considered as one of the sources combating infection and preventing spread of ***,for the last few months,suddenly a huge outrage of new variants of coronavirus disease 2019 are capturing attention of the entire population of earth endangering lives of people irrespective of their ages and *** must focus on the inventions and discoveries of either preventive or therapeutic medicines that precisely target the spike proteins that enable the severe acute respiratory syndrome coronavirus-2’s entry into a host *** this article,we have highlighted various vaccines being approved for emergency use by Federal Investigating Agency to combat the disastrous effects of pandemic on *** variants have created an alarming situation for the health care workers,resear

关键词： Pandemic Severe acute respiratory syndrome coronavirus-2 Social distance Respiratory illness Epitopes S-glycoprotein

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