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Epidemiology and Outcome of Primary Cerebral Lymphoma in Immunocompetent Patients: A Monocentric Study

Open Journal of Modern Neurosurgery 2022年第3期12卷 141-152页

作者： Fatima Ezzahra Rida asmaa harrach Mouna Lamchahab Mohammed Rachid Nissrine Khoubila Siham Cherkaoui Abdellah Madani Meryem Qachouh Department of Hematology and Pediatric Oncology Ibn Rochd University Hospital Center Casablanca Morocco Faculty of Medecine Hassan II University Casablanca Morocco

Primary cerebral lymphoma (PCL) is a form of extranodal non-Hodgkin’s lymphoma with a poor prognosis. Very few cohorts have been reported in the literature. It is a rare form in 1% of extranodal lymphomas, and 3% to 4% of brain tumors. The most common histological type is diffuse large B-cell lymphoma. Survival is improved by combining immunotherapy with chemotherapy. This is a descriptive retrospective study conducted at the Casablanca hematology center over a period of 9 years. The aim of this study was to report our experience by studying the clinical, paraclinical, therapeutic and evolutionary profile of patients with primary cerebral lymphoma. We present a study of 22 patients with PCL. The clinical, radiological and histological findings are shown along with the results of treatment. Patients were aged 25 - 75 years (mean 47 years) with a male predominance (77%). Computed tomography (CT) scans were performed on 16 patients (73%) and Brain magnetic resonance imaging for 16 patients (73%). Typically, lesions were multiple, isodense, and showed uniform enhancement with contrast medium. Immunocytochemical studies demonstrated 21 B-cell and 1 mantle-cell lymphomas. All patients received chemotherapy through high-dose MTX with whole brain radiotherapy (WBRT). After a median follow-up of 19 months, 54% are in complete remission, 32% have died, and 14% are lost to follow-up. Overall survival at 24 months and 36 months were 72% and 52%. The event-free survival at 24 months and 36 months were 60% and 48%. This study was to investigate the clinical features of PCNSL, and evaluate the efficacy of high-dose methotrexate (MTX)-based chemotherapy for immunocompetent Moroccan patients with PCNSL.

关键词： Primary Cerebral Lymphoma (PCL) Retrospective Study Management

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Intramedullary Metastasis of Medulloblastoma: A Case Report

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Open Journal of Modern Neurosurgery 2021年第2期11卷 90-96页

作者： Abderrazzak Bertal Alberic Fabrice Bocco Ismaïl Mahazou asmaa harrach Nihad da Silva Mohamed Yassine Haouas Khadija Ibahioin Said Hilmani Mehdi Karkouri Abdelhakim Lakhdar Department of Neurosurgery Ibn Rochd University Hospital Center Casablanca Morocco Department of Hematology and Pediatric Oncology Ibn Rochd University Hospital Center Casablanca Morocco Department of Pathology Ibn Rochd University Hospital Center Casablanca Morocco Laboratory of Research on Neurologic and Neurosensorial Diseases and Handicap Faculty of Medicine Hassan II University Casablanca Morocco

Medulloblastoma (MB) is a malignant brain tumor with a usual potential for leptomeningeal spread. Intramedullary metastases of MB are rare and there are very few cases reported in the literature. Here, we report the case of an 18-year-old man with intramedullary spinal cord metastasis of MB occurring 9 years after the first diagnosis. The patient presented a 2-month history of progressive weakness in both lower limbs associated with urinary incontinence. Magnetic resonance imaging (MRI) demonstrated a large intramedullary spinal cord tumor extending from T10 to L1. The patient underwent surgical decompression and adjuvant therapy. Histological examination confirmed the diagnosis of classic MB metastasis. Postoperatively, the neurological status was stationary. Intramedullary metastasis of medulloblastoma is rare and difficult to manage with a poor prognosis. Comprehensive studies on the medulloblastoma dissemination mechanisms and clinical trials are needed to assess combined therapeutic approaches on metastases of MB.

关键词： Medulloblastoma Intramedullary Metastasis Classic Spinal Cord

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