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Assessment of circulating levels of microRNA-326,microRNA-424,and microRNA-511 as biomarkers for hepatocellular carcinoma in Egyptians

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World Journal of Hepatology 2022年第8期14卷 1562-1575页

作者： Samar Samir Youssef asmaa elfiky Mohamed M Nabeel Hend Ibrahim Shousha Tamer Elbaz Dalia Omran Mohammad Saeed Marie Mohammad A Elzahry Amr Abul-Fotouh Ahmed Hashem Mohamed F Guda Ashraf O Abdelaziz Department of Microbial Biotechnology National Research CentreCairo 1211Egypt Department of Environmental and Occupational Medicine National Research CentreCairo 1211Egypt Department of Endemic Medicine and Hepatogastroenterology Faculty of MedicineCairo UniversityCairo 11562 Egypt Department of Endemic Medicine Faculty of MedicineCairo UniversityCairo 1256Egypt Theodor Bilharz Research Institute Cairo 1256Egypt

BACKGROUND Hepatocellular carcinoma(HCC)is the fifth most common *** expression of microRNAs(miRNAs)-326,miRNA-424,and miRNA-511 has been associated with the diagnosis and prognosis of HCC in different ***,limited information is available regarding their expression in Egyptian HCC *** To assess the role of circulating miRNAs-326,miRNA-424,and miRNA-511 in Egyptian HCC *** This prospective observational study included 70 HCC patients and 25 healthy *** circulating levels of these three miRNAs were evaluated by real-time *** operating characteristic curve analysis was used to test the diagnostic accuracy of micro RNA expression *** All miRNAs were differentially expressed in HCC patients;miRNAs326 and miRNA-424 were upregulated,while miRNA-511 was *** miRNA-326 and miRNA-424 showed sensitivity and specificity of 97%,71.4%,and 52%,60%,respectively,to differentiate HCC from ***,miRNA-326 was associated with survival and could differentiate between Child grades(A vs B);miRNA-424 significantly differentiated early vs intermediate stages of HCC;while miRNA-511 was significantly correlated with response to modified Response Evaluation Criteria in Solid Tumors(m RECIST).CONCLUSION We conclude that miRNA-326,miRNA-424,and miRNA-511 have diagnostic and prognostic roles in Egyptian patients with hepatitis C virus-related HCC and should be considered for better disease management.

关键词： Hepatocellular carcinoma miRNAs-326 miRNA-424 miRNA-511 Modified response evaluation criteria in solid tumors

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SARS-CoV-2 spike behavior in situ:a Cryo-EM images for a better understanding of the COVID-19 pandemic

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Signal Transduction and Targeted Therapy 2020年第1期5卷 326-327页

作者： Alaa M.Ismail Abdo A.elfiky Biophysics Department Faculty of SciencesCairo UniversityGizaEgypt

Most recently in Nature Journal,Ke et *** investigate the SARS-CoV-2 spike in situ by using cryo-electron microscopy(Cryo-EM)to reveal its different conformations,orientations,and distribution over the virion particles.

关键词： particles thoroughly behavior

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The Usage of Social Media and E-Reputation System in Global Supply Chain: Comparative Cases from Diamond &Automotive Industries

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International Journal of Communications, Network and System Sciences 2018年第5期11卷 69-103页

作者： Mostafa Mohamad Mohammed Ali Abdullah Sultan Abdullah Al Shimaa elfiky Salford Business School University of Salford Manchester UK Alliance Manchester Business School University of Manchester Manchester UK ADNEC Corporation Abu Dhabi UAE

The last decade witnesses a heave use of social media-based information systems in different fields of business such as logistics, procurement, and supply chain management. Managing these types of information systems, could help companies to outsource their supply chain functions in a global scale and enhance their competitive advantages. However, the digital performance of these activities inherent risks of inappropriate supplier selection, lack of trust, bounded rationality and uncertainty about the supply conditions (e.g., pricing, shipping and timing). To address such challenges, this research explains how companies use e-reputation systems and social media to select their global trusted suppliers. Based on two-case evidence from British Diamond and Egyptian Automotive companies, the researchers conducted 20 interviews with purchasing and supply chain professionals. Chen & Lin’s reputation system model has been adopted to explain the process of selecting and evaluating a trusted supplier and to inform our data analysis. Our findings referred to the lack of experience among diamond professionals on how to use e-reputation systems and their lack of understanding to the role of social media-based ratings or referrals during the stages of selection suppliers’ discovery and approval. Though, automotive professionals find e-reputation system a strong tool to build goodwill, tacit credibility, competence and predictable trust. Ironically, both cases confirm that supply chain professional use these systems to re-evaluate and reselect their existing suppliers than to extend new supply networks.

关键词： E-Reputation Systems Social Media Global Supply Chain

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