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Liver stiffness as a predictor of hepatocellular carcinoma behavior in patients with hepatitis C related liver cirrhosis

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 22-28页

作者： Sameh A Lashen Mohamed M Elshafei Fahmy H Hablass Eman A Alsayed asmaa a hassan Department of Internal Medicine Faculty of MedicineUniversity of AlexandriaAlexandriaEgypt Department of Radiology Faculty of MedicineUniversity of AlexandriaAlexandriaEgypt Department of Biomedical Informatics and Medical Statistics Medical Research InstituteUniversity of AlexandriaAlexandriaEgypt

Background: Risk strati cation and prognostication of hepatocellular carcinoma (HCC) help to improve patient outcome. Herein we investigated the role of liver stiffness measurement (LSM) in the prediction of HCC behavior. Methods: Totally 121 na ve patients with HCC were included. HCC radiological evaluation and staging were done. LSM was measured using virtual touch quanti cation. Patients were divided into early to intermediate HCC (BCLC-0, A and B) and late HCC (BCLCC and D). HCC was treated according to the BCLC stage. HCC recurrence-free interval was estimated. Results: The mean LSM inside the tumor was signi cantly lower than the peri-tumoral area and the cirrhotic non-cancerous liver parts (P<0.001). In late HCCs stage, the mean LSM inside the tumor and in the peri-tumoral tissue was lower than the corresponding values in the early to intermediate HCCs stage (P<0.001). LSM inside the tumor and in the peri-tumoral tissue negatively correlated with serum AFP, tumor vascular invasion, and stage (P<0.05). The recurrence-free interval was directly correlated to LSM inside the tumor and inversely to LSM in cirrhotic non tumorous liver part. Kaplan-Meier analysis showed that the recurrence-free interval was signi cantly longer in patients with LSM inside the tumor of ≥1.25m/s compared to those with LSM inside the tumor of<1.25m/s. Conclusions: LSM can serve as a potential non-invasive predictor for HCC clinical behavior and the recurrence-free interval following loco-regional treatments.

关键词： Fibrosis Hepatitis C Hepatocellular carcinoma Point shear wave Liver cirrhosis

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Improving outdoor air quality based on building morphology:Numerical investigation

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Frontiers of Architectural Research 2020年第2期9卷 319-334页

作者： asmaa Mohammed hassan Ashraf Abdel Fatah El Mokadem Naglaa Ali Megahed Osama Mahmoud Abo Eleinen Architecture and Urban Planning DepartmentFaculty of EngineeringPort Said UniversityPort SaidEgypt

Due to rapid urbanization around the world,high concentrations of vehicular pollutants have deteriorated the outdoor air quality,which can affect the physical and psychological well-being of *** strategies have been proposed to overcome these harmful impacts by improving the dispersion of air ***,a question arises regarding the potential effects of building morphology on the dispersion of ***,transient three-dimensional Computational Fluid Dynamics(CFD)simulations are performed to examine the effect of building morphology on PM10 *** cases with various prototypes and morphological methods are compared with a simple building form to identify the patterns of PM10 dispersion within a given time sequence under a prevailing inflow *** results indicate that the different designs of building morphology with varying Relative compactness(RC)indicator highlight the importance of considering morphological factors to improve outdoor air *** addition,the proposed prototypes can reduce PM10 concentrations by approximately 30%e90%at specific points in the studied time *** particular,the vertical,horizontal,and grid folded prototypes can be considered more effective as an approximate decrease between 70%and 90%in PM10 concentrations is observed,which reflects the influence of building morphology on improving outdoor air quality.

关键词： Building morphology Morphological methods Outdoor air quality PM10 dispersion CFD simulation

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Green retrofitting of heritage buildings based on(3Ts)framework:An applied case study

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Frontiers of Architectural Research 2024年第4期13卷 776-798页

作者： Alaa O.Shehata asmaa M.hassan Merhan M.Shahda Naglaa A.Megahed Architectural Engineering and Urban Planning Department Faculty of EngineeringPort Said UniversityPort SaidEgypt

Diverse heritage architecture characterizes Port Said in Egypt,reflecting European and Arab *** Canal heritage villas comprise 25%of the total listed heritage buildings in the ***,it is important to retrofit them,aligning with the Sustainable Development Goals(SDGs).By reviewing the previous literature related to the green retrofitting of heritage buildings,the(3Ts)framework can be considered a holistic framework that covers the latest trends due to its three components:targets,tools,and tasks,which help the success of the process through a holistic vision of supporting building information modeling(BIM)technologies and organizing stakeholders’*** paper aims to apply the(3Ts)framework to Suez Canal heritage villas in Port Said,*** applied study is based on how stakeholders perceive their input and decision-making,measuring the climate parameters,proposing several green retrofits,and integrating them into green *** of scenarios is conducted by utilizing the Design Builder simulation ***,the Skelion plugin calculates the photovoltaic system’s(PVs)energy *** results indicated that the total energy savings could reach approximately 12%e74%and nearly 10%e73%CO₂emissions reduction without affecting heritage values.

关键词： Green retrofitting Heritage buildings BIM BES Suez Canal heritage villas Port Said/Egypt

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Effect of cryotherapy on pain management at the puncture site of arteriovenous fistula among children undergoing hemodialysis

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International Journal of Nursing Sciences 2017年第1期4卷 46-51页

作者： Azza Abdel Moghny Attia asmaa Mahfouz hassan Faculty of Nursing Cairo-University11562Egypt

Objective: To evaluate the effectiveness of cryotherapy in managing the pain at the puncture site of Arterio-Venous Fistula (AVF) among children undergoing maintenance hemodialysis (HD).Methods: A one-group pre-post quasi-experiment was performed in two HD centers affiliated with Cairo *** experiment involved 40 children with AVF undergoing *** puncturing,cryotherapy was applied using 2 cm-3 cm pieces of frozen distilled water in a plastic *** was assessed subjectively and objectively in two dialysis sessions before and after cryotherapy.A part from a physiological assessment of vital signs,pain was assessed using the Wong-Baker Faces Pain and the Observed Pain Behavior rating *** research ethics were ***: HD had a median duration of four years,while cryotherapy had a median application time of 8.8 *** Wong-Baker Faces Pain score and almost all observed pain behaviors significantly decreased after *** improvements were observed in respiratory rate before and after needle puncture and in oxygen saturation after needle puncture.A lower skin dryness was observed after cryotherapy (12.5%) than before cryotherapy (52.5%;p < 0.001).Conclusions: Cryotherapy can effectively reduce the venipuncture pain among children with AVF undergoing maintenance ***,the confounding effects of distraction and the non-randomized design used must be both considered when interpreting the *** study recommends the use of cryotherapy in managing needle puncture *** research must adopt a randomized trial design with a placebo to support further the benefits of this procedure.

关键词： Arteriovenous fistula Children Cryotherapy Hemodialysis Pain assessment scales

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SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： hassan M.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nM against JAK2 kinase and 200.9 nM against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nM,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 Molecular docking Molecular dynamics simulation

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Nanosecond pulse and dual-wavelength Q-switched 1.5 μm fiber laser using MAX phase Cr2TiAlC2 saturable absorber

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Optoelectronics Letters 2025年第1期21卷 7-12页

作者： Ahmed Shakir AL-HITI Hiba hassan Department of Electrical Engineering Faculty of Engineering University of Anbar Department of Laser and Optoelectronics Engineering University of Technology-Iraq

We demonstrated a new type of MAX phase material, chromium titanium aluminum carbide（Cr2TiAlC2） polymer film, to generate a passively Q-switched erbium-doped fiber laser（EDFL）. The film thickness was measured to be around 45 μm, which was fabricated using the embedding method with polyvinyl alcohol（PVA） polymer as hoster. The saturable absorber（SA） film demonstrates a dual-wavelength passively Q-switched EDFL which operates at 1 531 nm and 1 560.19 nm, respectively. The Q-switching pulse duration could be varied from 2.46 μs to 770 ns, while the repetition rate varied from 92.76 kHz to 106.6 kHz with an increasing input pumping range from 154 mW to 300 mW. The maximum output power and pulse energy of 15.05 mW and 141.18 nJ were obtained at the maximum input power of 300 mW, respectively.

关键词： Saturable absorbers

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Review of Techniques for Integrating Security in Software Development Lifecycle

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Computers, Materials & Continua 2025年第1期82卷 139-172页

作者： hassan Saeed Imran Shafi Jamil Ahmad Adnan Ahmed Khan Tahir Khurshaid Imran Ashraf College of Electrical and Mechanical Engineering National University of Sciences and Technology(NUST)Rawalpindi46604Pakistan Department of Computer Science Abasyn University Islamabad CampusIslamabad45510Pakistan Military College of Signals National University of Sciences and Technology(NUST)Rawalpindi46600Pakistan Department of Electrical Engineering Yeungnam UniversityGyeongsan38541Republic of Korea Department of Information and Communication Engineering Yeungnam UniversityGyeongsan38541Republic of Korea

Software-related security aspects are a growing and legitimate concern,especially with 5G data available just at our *** conduct research in this field,periodic comparative analysis is needed with the new techniques coming up *** purpose of this study is to review the recent developments in the field of security integration in the software development lifecycle(SDLC)by analyzing the articles published in the last two decades and to propose a way *** review follows Kitchenham’s review *** review has been divided into three main stages including planning,execution,and *** the selected 100 articles,it becomes evident that need of a collaborative approach is necessary for addressing critical software security risks(CSSRs)through effective risk management/estimation *** risks using a numeric scale enables a comprehensive understanding of their severity,facilitating focused resource allocation and mitigation *** a comprehensive understanding of potential vulnerabilities and proactive mitigation efforts facilitated by protection poker,organizations can prioritize resources effectively to ensure the successful outcome of projects and initiatives in today’s dynamic threat *** review reveals that threat analysis and security testing are needed to develop automated tools for the *** estimation of effort required to prioritize potential security risks is a big challenge in software *** accuracy of effort estimation can be further improved by exploring new techniques,particularly those involving deep *** is also imperative to validate these effort estimation methods to ensure all potential security threats are *** challenge is selecting the right model for each specific security *** achieve a comprehensive evaluation,researchers should use well-known benchmark checklists.

关键词： Software development lifecycle systematic literature review critical software security risks national institute of standards and technology DevSecOps open web application security project McGraw’s touch points

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MARIE:One-Stage Object Detection Mechanism for Real-Time Identifying of Firearms

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 279-298页

作者： Diana Abi-Nader hassan Harb Ali Jaber Ali Mansour Christophe Osswald Nour Mostafa Chamseddine Zaki Computer Science Department Faculty of SciencesLebanese UniversityBeirut146404Lebanon College of Engineering and Technology American University of the Middle EastEgaila54200Kuwait Lab-STICC CNRS UMR 6285ENSTA-BretagneBrest29200France

Security and safety remain paramount concerns for both governments and individuals *** today’s context,the frequency of crimes and terrorist attacks is alarmingly increasing,becoming increasingly intolerable to ***,there is a pressing need for swift identification of potential threats to preemptively alert law enforcement and security forces,thereby preventing potential attacks or violent *** advancements in big data analytics and deep learning have significantly enhanced the capabilities of computer vision in object detection,particularly in identifying *** paper introduces a novel automatic firearm detection surveillance system,utilizing a one-stage detection approach named MARIE(Mechanism for Realtime Identification of Firearms).MARIE incorporates the Single Shot Multibox Detector(SSD)model,which has been specifically optimized to balance the speed-accuracy trade-off critical in firearm detection *** SSD model was further refined by integrating MobileNetV2 and InceptionV2 architectures for superior feature extraction *** experimental results demonstrate that this modified SSD configuration provides highly satisfactory performance,surpassing existing methods trained on the same dataset in terms of the critical speedaccuracy *** these innovations,MARIE sets a new standard in surveillance technology,offering a robust solution to enhance public safety effectively.

关键词： Firearm and gun detection single shot multi-box detector deep learning one-stage detector MobileNet inception convolutional neural network

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Secure Channel Estimation Using Norm Estimation Model for 5G Next Generation Wireless Networks

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Computers, Materials & Continua 2025年第1期82卷 1151-1169页

作者： Khalil Ullah Song Jian Muhammad Naeem Ul hassan Suliman Khan Mohammad Babar Arshad Ahmad Shafiq Ahmad Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming650500China Department of Computer Science Abbottabad University of Science and TechnologyHavelianAbbottabad22500Pakistan Department of Computing and Electronics Engineering Middle East CollegeMuscat124Oman Department of CS&IT Pak-Austria Fachhochschule Institute of Applied Sciences and Technology MangHaripur22621Pakistan Industrial Engineering Department College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia

The emergence of next generation networks(NextG),including 5G and beyond,is reshaping the technological landscape of cellular and mobile *** networks are sufficiently scaled to interconnect billions of users and *** in academia and industry are focusing on technological advancements to achieve highspeed transmission,cell planning,and latency reduction to facilitate emerging applications such as virtual reality,the metaverse,smart cities,smart health,and autonomous *** continuously improves its network functionality to support these *** input multiple output(MIMO)technology offers spectral efficiency,dependability,and overall performance in *** article proposes a secure channel estimation technique in MIMO topology using a norm-estimation model to provide comprehensive insights into protecting NextG network components against adversarial *** technique aims to create long-lasting and secure NextG networks using this extended *** viability of MIMO applications and modern AI-driven methodologies to combat cybersecurity threats are explored in this ***,the proposed model demonstrates high performance in terms of reliability and accuracy,with a 20%reduction in the MalOut-RealOut-Diff metric compared to existing state-of-the-art techniques.

关键词： Next generation networks massive mimo communication network artificial intelligence 5G adversarial attacks channel estimation information security

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Response of seed yield and fatty acid compositions for some sunflower genotypes to plant spacing and nitrogen fertilization

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Information Processing in Agriculture 2017年第3期4卷 241-252页

作者： Mohamed Ali Abd EL-Satar asmaa Abd-EL-Halime Ahmed Tamer hassan Ali hassan Oil Crops Research Department Field Crops Research InstituteAgricultural Research Center9 El-Gamaa St.GizaEgypt

A field experiment was conducted at the experiment Farm of Kafr-El-Hamam Research Station,Zagazig,Sharkia Governorate,Agricultural Research Center,Egypt during the two successive summer seasons of 2015 and 2016 to achieve the highest yield and good oil quality of three tested sunflower *** both seasons,the experiment was conducted using the split split plot design in randomized complete block design with three replicates arrangement keeping plant spaces(15,20 and 25 cm apart between hills)in main plots,nitrogen fertilization levels(15,30 and 45 N fad.^-1)in sub plots and sunflower genotypes(Giza 102,Sakha 53 and promising line of L120)in sub sub *** and quality traits were significantly influenced by plant spaces,nitrogen fertilization levels and genotypes as well as interactions in both seasons and their combined *** wider plant spacing of 25 cm seems to be a good compromise between the highest seed yield fad.^-1 and good acid composition of *** increasing of nitrogen fertilization level had a positive reflected on yield and desirable acid composition of *** 53 was ranked in the first order in stem diameter,head diameter,100-seed weight,seed weight plant^-1,flowered late and hence seed yield fad.^-1 as well as seed oil content whereas,Giza 102 characterized with its contained the highest proportion of oleic and linoleic unsaturated fatty *** highest values of head diameter,100-seed weight,seed weight plant^-1 and hence seed yield fad.^-1 as well as the highest proportion of oleic and linoleic unsaturated fatty acids composition were obtained by grown sunflower *** 53 at wider spacing of 25 cm with application of nitrogen fertilization levels of 45 N fad.^-*** and path analyses revealed that 100-seed weight and head diameter had the highest direct and indirect influence on seed weight plant1,at the same time also,oleic acid content and linoleic acid content had the highest direct and indirect effect inf

关键词： Sunflower Plant spacing Nitrogen fertilization Genotypes Seed yield Fatty acids

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