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Risk factors associated with progression to intestinal complications of Crohn disease

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Chinese Medical Journal 2019年第20期132卷 2423-2429页

作者： Yusuf Kayar Bulent Baran asli Cifcibasi ormeci Filiz Akyuz Kadir Demir Fatih Besisik Sabahattin Kaymakoglu Department of Gastroenterology Van Education and Research HospitalVan 65100Turkey Department of Gastroenterology Koc UniversityIstanbul 34100Turkey Department of Gastroenterology Istanbul UniversityIstanbul 34065Turkey

Background:Crohn disease is a chronic bowel disease that causes serious complications. Prevalence of Crohn disease is increasing. Studies have shown that the behavior of the disease is not stable and severe complications secondary to behavior change over time have been shown. In this study, we aimed to evaluate the prognostic risk factors associated with phenotypic change in Crohn disease in a Turkish patient ***:Patients followed up from March 1986 to August 2011 were evaluated for demographic and clinical characteristics to determine possible risk factors and initial clinical phenotype of the disease based on the Montreal classification. The cumulative probabilities of developing stricturing or penetrating intestinal complications were estimated using the Kaplan-Meier analysis. Univariate and multivariate Cox-proportional hazard models were used to assess associations between baseline clinical characteristics and intestinal ***:Three hundred and thirty patients (mean age, 30.6 ± 11.1 years;148 female) were included in the study. Mean follow-up duration was 7.4 ± 5.3 years (range: 1.0-25.0 years). At baseline 273 patients had inflammatory-type disease, 57 patients experienced stricturing/penetrating intestinal complications before or at the time of diagnosis. The cumulative probability of developing complicated disease was 37.4% at 5 years, 54.3% at 10 years, 78.8% at 25 years. Independent predictors associated with progression to intestinal complications were current smoking, perianal disease, extra-intestinal manifestations, and location of ***:Location of disease is the most powerful indicator for the development of stenosis and penetrating complications in inflammatory-type disease. Patients with ileal involvement should be considered for more aggressive immunosuppressive therapy.

关键词： complications involvement progression

Treatment of pregnant women with a diagnosis of inflammatory bowel disease

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第4期7卷 490-502页

作者： Sule Poturoglu asli Ciftcibasi ormeci Ali Erkan Duman Department of Gastroenterology Haseki Training and Research Hospital

The frequency of diagnosis of inflammatory bowel disease(IBD) has increased in younger *** this reason,pregnancy in patients with IBD is a topic of interest,warranting additional focus on disease management during this *** main objective of this article is to summarize the latest findings and guidelines on the management of potential problems from pregnancy to the breastfeeding *** is decreased in patients with active *** remission prior to conception will likely decrease the rate of pregnancy-related *** of the drugs used for IBD treatment are safe during both pregnancy and *** exceptions are methotrexate and thalidomide,which are contraindicated in *** necrosis factor agents are not advised during the third trimester as they exhibit increased transplacental transmission and potentially cause immunosuppression in the *** and endoscopic examinations and surgical interventions should be performed only when absolutely *** increases the fetal mortality *** delivery method should be determined with consideration of the disease site and presence of progression or flare *** planning should be a collaborative effort among the gastroenterologist,obstetrician,colorectal surgeon and patient.

关键词：怀孕煽动性的肠疾病 Immunomodulators Biologics 母乳喂养治疗

Current state and clinical outcome in Turkish patients with hepatocellular carcinoma

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World Journal of Hepatology 2018年第1期10卷 51-61页

作者： Omer Ekinci Bulent Baran asli Cifcibasi ormeci Ozlem Mutluay Soyer Suut Gokturk Sami Evirgen Arzu Poyanli Mine Gulluoglu Filiz Akyuz Cetin Karaca Kadir Demir Fatih Besisik Sabahattin Kaymakoglu Department of Gastroenterohepatology Istanbul Faculty of Medicine Istanbul University Department of Internal Medicine Istanbul Faculty of Medicine Istanbul University Department of Gastroenterology Ko? University Hospital Department of Radiology Istanbul Faculty of Medicine Istanbul University Department of Pathology Istanbul Faculty of Medicine Istanbul University

AIM To investigate clinical, etiological, and prognostic features in patients with hepatocellular *** Patients with hepatocellular carcinoma who were followed-up from 2001 to 2011 were included in the study. The diagnosis was established by histopathological and/or radiological criteria. We retrospectively reviewed clinical and laboratory data, etiology of primary liver disease, imaging characteristics and treatments. ChildPugh and Barcelona Clinic Liver Cancer stage was determined at initial diagnosis. Kaplan-Meier survival analysis was done to find out treatment effect on survival. Risk factors for vascular invasion and overall survival were investigated by multivariate Cox regression analyses. RESULTS Five hundred and forty-five patients with hepatocellular carcinoma were included in the study. Viral hepatitis was prevalent and 68 patients either had normal liver or were non-cirrhotic. Overall median survival was 16(13-19) mo. Presence of extrahepatic metastasis was associated with larger tumor size(OR = 3.19, 95%CI: 1.14-10.6). Independent predictor variables of vascular invasion were AFP(OR = 2.95, 95%CI: 1.38-6.31), total tumor diameter(OR = 3.14, 95%CI: 1.01-9.77), and hepatitis B infection( OR = 5.37, 95 % CI : 1.23-23.39). Liver functional reserve, tumor size/extension, AFP level and primary treatment modality were independent predictors of overall survival. Transarterial chemoembolization(HR = 0.38, 95%CI: 0.28-0.51) and radioembolization(HR = 0.36, 95%CI: 0.18-0.74) provided a comparable survival benefit in the real life setting. Surgical treatments as resection and transplantation were found to be associated with the best survival compared with loco-regional treatments(log-rank, P < 0.001).CONCLUSION Baseline liver function, oncologic features including AFP level and primary treatment modality determines overall survival in patients with hepatocellular carcinoma.

关键词： Hepatocellular carcinoma Cirrhosis Alfafetoprotein Prognosis Treatment Survival

Inhibition of Ehrlich ascites carcinoma growth by melatonin:Studies with micro-CT

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Oncology Research 2024年第1期32卷 175-185页

作者： SEHER YILMAZ ZÜLEYHA DOĞANYIĞIT MERT OCAK EVRIM SUNA ARIKAN SÖYLEMEZ asli OKAN OFLAMAZ SÜMEYYE UÇAR ŞÜKRÜATEŞ AMMAD AHMAD FAROOQI Department of Anatomy Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Mechanical and Aerospace Engineering Case Western Reserve UniversityClevelandOhioUSA Department of Histology and Embriology Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Anatomy Faculty of DentistryAnkara UniversityAnkaraTurkey Department of Medical Biology Faculty of MedicineAfyonkarahisar Health Sciences UniversityAfyonTurkey Department of Anatomy Faculty of MedicineErciyes UniversityKayseriTurkey Department of Molecular Oncology Institute of Biomedical and Genetic Engineering(IBGE)IslamabadPakistan

Melatonin is a versatile indolamine synthesized and secreted by the pineal gland in response to the photoperiodic information received by the retinohypothalamic signaling *** has many benefits,such as organizing circadian rhythms and acting as a powerful *** aimed to show the antitumor effects of melatonin in both in vivo and in vitro models through the mammalian target of rapamycin(mTOR)signaling pathway and the Argyrophilic Nucleolar Regulatory Region(AgNOR),using the Microcomputed Tomography(Micro CT).Ehrlich ascites carcinoma(EAC)cells were administered into the mice by subcutaneous *** with solid tumors were injected intraperitoneally with 50 and 100 mg/kg melatonin for 14 *** measurements for the taken tumors were made with micro-CT imaging,immunohistochemistry(IHC),real-time polymerase chain reaction(PCR)and ***,the tumor tissue volume in the Tumor+100 mg/kg melatonin group was significantly lower than that in the other groups in the data obtained from micro-CT *** the IHC analysis,the groups treated with Tumor+100 mg/kg melatonin were compared when the mTOR signaling pathway and factor 8(F8)expression were compared with the control *** was determined that there was a significant decrease(p<0.05).Significant differences were found in the total AgNOR area/nuclear area(TAA/NA)ratio in the treatment groups(p<0.05).Furthermore,there were significant differences between the amount of mTOR mRNA for the phosphatidylinositol 3-kinase(PI3K),AKT Serine/Threonine Kinase(PKB/AKT)genes(p<0.05).Cell apoptosis was evaluated with Annexin V in an in vitro study with different doses of melatonin;It was observed that 100µg/mL melatonin dose caused an increase in the apoptotic cell *** this study,we have reported anti-tumor effects of melatonin in cell culture studies as well as in mice *** characterization of the melatonin-mediated cancer inhibitory effects will be valuable in advanc

关键词： Signaling pathway Apoptosis Real-time PCR AgNOR

What is the impact of capsule endoscopy in the long term period?

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World Journal of Gastrointestinal Endoscopy 2016年第7期8卷 344-348页

作者： asli ormeci Filiz Akyuz Bulent Baran Suut Gokturk Tugrul ormeci Binnur Pinarbasi Ozlem Mutluay Soyer Sami Evirgen Umit Akyuz Cetin Karaca Kadir Demir Sabahattin Kaymakoglu Fatih Besisik Division of Gastroenterohepatology Department of Internal Medicine Istanbul Faculty of Medicine Istanbul University Department of Radiology Medipol University Department of Gastroenterology Yeditepe Univer-sity

AIM: To assess the clinical impact of capsule endoscopy(CE) in the long-term follow-up period in patients with obscure gastrointestinal bleeding(OGIB). METHODS: One hundred and forty-one patients who applied CE for OGIB between 2009 and 2012 were retrospectively analyzed, and this cohort was then questioned prospectively. Demographic data of the patients were determined via the presence of comorbid diseases, use of non-steroidal anti-inflammatory drugs anticoagulant-antiaggregant agents, previous diagnostic tests for bleeding episodes, CE findings, laboratory tests and ***: CE was performed on 141 patients becauseof OGIB. The capsule was retained in the upper gastrointestinal(GI) system in two of the patients, thus video monitoring was not achieved. There were 139 patients [62% male, median age: 72 years(range: 13-93 years) and a median follow-up duration: 32 mo(range: 6-82 mo)]. The overall diagnostic yield of CE was 84.9%. Rebleeding was determined in 40.3%(56/139) of the patients. The rebleeding rates of patients with positive and negative capsule results at the end of the follow-up were 46.6%(55/118) and 4.8%(1/21), respectively. In the multivariate analysis, usage of NSAIDs, anticoagulant-antiaggregant therapies(OR = 5.8; 95%CI: 1.86-18.27) and vascular ectasia(OR = 6.02; 95%CI: 2.568-14.146) in CE were detected as independent predictors of rebleeding. In the univariate analysis, advanced age, comorbidity, and overt bleeding were detected as predictors of ***: CE is a reliable method in the diagnosis of obscure GI bleeding. Negative CE correlated with a significantly lower rebleeding risk in the long-term follow-up period.

关键词： Capsule endoscopy Small bowel Obscure gastrointestinal bleeding Rebleeding

Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction:role on apoptosis,inflammation and oxidative stress

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Food Science and Human Wellness 2022年第5期11卷 1290-1298页

作者： GökselŞener Gözde Karakadıoglu Dilek Ozbeyli Seren Ede Refiye Yanardag Ozlem Sacan asli Aykac Department of Pharmacology Faculty of PharmacyFenerbahce UniversityIstanbul 34758Turkey Department of Pharmacology Institude of Health SciencesMarmara UniversityIstanbul 34854Turkey Department of Medical Pathology Techniques Vocational School of Health ServicesMarmara UniversityIstanbul 34865Turkey Department of Biochemistry Faculty of EngineeringIstanbul Universityş-CerrahpasaIstanbul 34320Turkey Department of Biophysics Faculty of MedicineNear East UniversityNicosia 99138Cyprus

This study was designed to investigate whether Petroselinum crispum(PC)extract has protective effects on the brain in the scopolamine-induced Alzheimer’s disease(AD)rat *** rats were divided into;control,scopolamine(1 mg/kg,i.p.),galantamine(1.5 mg/kg,i.p.)and PC extract(2 g/kg,p.o.)-treated scopolamine *** day 14,the novel object recognition test(NORT)and Morris water maze test(MWMT)were performed and then the rats were ***-induced cognitive impairments observed in the NORT and MWMT,significantly improved with PC extract and galantamine *** reduced M_(1) receptor expression,Bcl-2/Bax ratio,and glutathione levels in the hippocampus and frontal cortex,while malondialdehyde levels,caspase-3/9 expressions,and acetylcholinesterase(AChE)activity were found to be *** the other hand,PC and galantamine treatments reversed these *** conclusion,PC extract has shown an ameliorative effect on the spatial and recognition memory,M_(1) receptor expression,apoptosis,oxidative stress,and increased AChE ***,it was concluded that PC could prevent AD-like conditions and can be used as a functional ***,since animal models do not completely mimic those of humans,based on the data obtained in this study,the importance of PC on human AD should be demonstrated in future studies.

关键词： Petroselinum crispum Apoptosis Spatial memory Recognition memory Oxidative stress M1 receptor

Teaching construction sciences with the integration of BIM to undergraduate architecture students

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Frontiers of Architectural Research 2020年第4期9卷 940-950页

作者： asli Agirbas Department of Architecture Fatih Sultan Mehmet Vokif UniversityIstanbulTurkey

This study aims to test two hypotheses:teaching building information modeling(BIM)in relation to construction scienee provides students with a remarkable understanding of the nature of construction scie nee(Hypothesis 1),and if the student has positive attitude toward the use of the BIM program,then efficiency by which construed on science is taught by its means is improved(Hypothesis 2).Results and process of a case study with a novel teaching methodology were discussed in terms of the benefits of the students.A questionnaire study was conducted on the student group with which the case study was performed to test each student's *** were evaluated *** BIM is integrated with the teaching of basic construction courses within architecture degree programs,the students understood the building system principles simply and *** a result of the statistical analysis,the students find the applied method ***,their attitude toward BIM affects the process.

关键词： Building information modeling(BIM) Architectural education Construction science Student attitudes

Dynamic Recrystallization Behavior of a Fe-Cr-Ni Super-Austenitic Stainless Steel

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Journal of Materials Science & Technology 2009年第5期25卷 603-606页

作者： A.Hoseini asli A.Zarei-Hanzaki School of Metallurgical and Materials Engineering University of Tehran

The super-austenitic stainless steels are extensively utilized in the seamless tubes production for oil extraction industries. Due to the importance of thermo-mechanical processing in the production of these tubes, the dynamic recrystallization （DRX） characteristics of a Cr-Ni super austenitic stainless steel （1.4563） were investigated in the present study. This was performed using the hot compression testing method in the temperature range of 950-1150℃ and the strain rate of 10^-3-10^-1 s^-1. The initiation and evolution of DRX were examined through microstructural analysis. The results indicated that the recrystallized grain formed a necklace type structure at the prior austenite grain boundaries at higher strain rates. In addition, DRX nucleation occurs by bulging and successive strain induced boundary migration （SIBM）.

关键词： Sanicro 28 Dynamic recrystallization Super-austenitic Necklace structure

Beclin1 haploinsufficiency compromises mesenchymal stem cell-offered cardioprotection against myocardial infarction

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Cell Regeneration 2022年第1期11卷 192-202页

作者： Xing Qin Juanjuan Fei Yu Duan asli F.Ceylan Fuyang Zhang Jun Ren Department of Cardiology Xijing HospitalFourth Military Medical UniversityXi’an 710032ShaanxiChina Department of Cardiology and Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital Fudan UniversityShanghai 200032China Department of Medical Pharmacology Ankara Yildirim Beyazit UniversityFaculty of MedicineBilkentAnkaraTurkey Department of Laboratory Medicine and Pathology University of WashingtonSeattleWA 98195USA

Mesenchymal stem cells(MSCs)-based therapy has displayed some promises in ischemia heart diseases although its efficacy may be affected by changes in surrounding *** study evaluated the role of autophagy insuf-ficiency using Beclin1 haploinsufficiency(BECN^(+/−))on intra-myocardial MSC transplantation-evoked effect against myocardial *** MSCs from C57BL/6 mice were labelled with cell-tracker CM Dil and were delivered into LV free wall adjacent to infarct region in wild-type(WT)and BECN^(+/−) recipient mice following ligation of left main coronary artery(MI-MSCs).Ten days following MI,myocardial function was assessed using *** contractility and intracellular Ca^(2+) were monitored using cardiomyocytes from the area-at-risk adjacent to ***-Dil labeled cells were tracked in MSCs recipient mice using fluorescence ***,Masson trichrome staining and Western blot analysis were employed to determine cardiomyocyte area,scar fibrosis,apoptosis and *** insult triggered scar fibrosis,LV chamber dilation,decreased fractional shortening,ejection fraction,cardiomyocyte shortening,maximal velocity of shortening and relengthening as well as prolonged relength-ening,which were abrogated or attenuated by MSCs therapy in WT but not BECN^(+/−)*** decreased intracellular Ca^(2+) rise and decay in response to electrical stimuli without affecting resting intracellular Ca^(2+),which were reconciled by MSCs in WT but not BECN^(+/−) *** further attenuated MI-induced mitochondrial ultrastructural injury,apoptosis,inflammation and autophagy defects in periinfarct area in WT but not BECN^(+/−)***,our results suggested that autophagy insufficiency dampened in MSCs-elicited cardioprotection associated with dampened apoptosis and inflammation.

关键词： Myocardial infarction MSCs Beclin1 Contraction Apoptosis Autophagy