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Novel immune modulatory vaccines targeting TGFβ

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Cellular & Molecular Immunology 2023年第5期20卷 551-553页

作者： Mads Hald andersen National Center for Cancer Immune Therapy(CCIT-DK) Department of OncologyCopenhagen University Hospital HerlevHerlevDenmark Department of Immunology and Microbiology University of CopenhagenCopenhagenDenmark

Immune modulatory vaccines (IMVs) are novel therapies designed to activate anti-regulatory T cells (anti-Tregs) [1]. Anti-Tregs recognize HLA-restricted antigens on the surface of regulatory immune cells derived from tumor microenvironment antigens (TMAs) [2], such as IDO [3], PD-L1 [4], and TGFβ [5, 6]. Having established that specific T cells recognize target cells in a TGFβ-dependent manner, we reported that such TGFβ-specific T cells are associated with clinical benefit and improved survival after combined treatment with radiotherapy (RT) and immune checkpoint inhibitors (ICIs) in patients with pancreatic cancer (PC) [7]. Additionally, we found that a TGFβ-based IMV impacted tumor growth in murine models of PC via immune modulation of the tumor microenvironment (TME) [8]. These data suggest that combining a TGFβ-based IMV with RT/ICI therapy will be beneficial for patients with PC.

关键词： TGFβ vaccines immune

Dehydration Melting and Proterozoic Granite Petrogenesis in a Collisional Orogen——A Case from the Svecofennian of Southern Finland

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Journal of Earth Science 2021年第6期32卷 1289-1299页

作者： Tom andersen O.Tapani Rämö Department of Geosciences University of OsloN-0316OsloNorway Department of Geosciences and Geography Geology and Geophysics Research ProgramUniversity of Helsinki00014HelsinkiFinland

Dehydration melting of metasupracrustal rocks at mid-to deep-crustal levels can generate water undersaturated granitic *** this study,we evaluate the potential of~1.89–1.88 Ga metasupracrustal rocks of the Precambrian of southern Finland as source rocks for the 1.86–1.79 Ga late-orogenic leucogranites in the region,using the Rhyolite-MELTS *** close in composition to leucogranite is produced over a range of realistic pressures(5 to 8 kbar)and temperatures(800 to 850℃),at 20%–30%of partial melting,allowing separation of melt from unmelted *** solid residue is a dry,enderbitic to charnoenderbitic ganulite depleted in incompatible components,and will only yield further melt above 1000–1050℃,when rapidly increasing fractions of increasingly calcic(granodioritic to tonalitic)melts are *** solid residue after melt extraction is incapable of producing syenogranitic magmas similar to the Mid-Proterozoic,A-type rapakivi granites on further *** granitic fraction of the syenogranitic rapakivi complexes must thus have been formed by a different chain of processes,involving mantle-derived mafic melts and melts from crustal rock types not conditioned by the preceding late-orogenic Svecofennian anatexis.

关键词： leucogranite rapakivi granite anatexis restite depleted granulite Finland

Has the risk of colorectal cancer in inflammatory bowel disease decreased?

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World Journal of Gastroenterology 2013年第43期19卷 7561-7568页

作者： Nynne Nyboe andersen Tine Jess Department of Epidemiology Research Statens Serum InstitutDK-2300 CopenhagenDenmark

The association between inflammatory bowel disease(IBD)and colorectal cancer(CRC)has been acknowledged for almost a century and is assumedly promoted by a chronic inflammation-driven carcinogenic process in the intestine in combination with a genetic *** magnitude of the risk of CRC in IBD remains a continuing subject of *** early,high risk estimates for CRC in IBD were most likely overestimated due to selected patient populations originating from tertiary referral centers with a disproportional high percentage of patients with severe *** population-based studies calculating risk estimates from a broad spectrum of IBD patients have found the risk to be significantly *** present,there is evidence that IBD patients with longstanding and extensive disease with uncontrolled inflammation are those at increased ***,other recognized risk factors include early age at onset,family history of CRC,and concomitant primary sclerosing cholangitis.A significant amount of effort is put into identifying potential preventive factors of CRC in IBD,including surveillance programs and chemopreventive agents but the individual effect of these remains ***,recent studies have reported a decline in risk of CRC over *** programs and the new treatment strategies,particular biological treatment might be part of the reason for the observed decline in risk of CRC in IBD over time but future studies will have investigate this assumption.

关键词： Inflammatory bowel disease Colorectal cancer Risk Ulcerative colitis Crohn’s disease

Risk of infections associated with biological treatment in inflammatory bowel disease

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World Journal of Gastroenterology 2014年第43期20卷 16014-16019页

作者： Nynne Nyboe andersen Tine Jess Department of Epidemiology Research Statens Serum InstitutDK-2300 CopenhagenDenmark

Tumor necrosis factor-α (TNF-α) inhibitors are biological agents introduced in the late 1990s for the treatment of different immune-mediated diseases as inflammatory bowel disease, rheumatoid arthritis and psoriasis. The most commonly used TNF-α antagonists are infliximab, adalimumab, and certolizumab pegol, and though highly effective in lowering inflammation, the efficacy must be weighed against the potential for adverse events. The treatment-induced immunosuppression is suspected to increase the risk of infections, including the risk of reactivation of latent tuberculosis, as the TNF-α cytokine plays an important role in the immune function. In this topic highlight a short overview of the infection risk associated with TNF-α inhibiter therapy is outlined with a focus on the overall risk of serious infections, mycobacterial infection and latent viral infections.

关键词： Inflammatory bowel disease Biological treatment Tumor necrosis factor-α inhibitors Risk Infections Ulcerative colitis Crohn’ s disease

Challenges facing the USA in matching Germany on advanced manufacturing for green growth

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International Journal of Innovation Studies 2024年第1期8卷 13-24页

作者： Mikael Skou andersen Aarhus University Dept.of Environmental ScienceKatrinebjergvej 89G8200Aarhus N.Denmark

This study explores the relative strength of public policies promoting advanced manufacturing by comparing the government programs and capacities of two world leaders in science and technology:the USA and *** on insights from’varieties-of-capitalism’literature and using process tracing methodology,this study identifies significant differences in today’s pursuit of advanced *** German model of Rhine capitalism has strength due to its long tradition of diversified quality work,built on a long-term commitment to government-industry collaboration,with significant indirect public support provided by vocational training and research *** American model of Manchester capitalism has been challenged by the loss of millions of low-skilled manufacturing jobs due to outsourcing and competition from *** study finds that the“Manufacturing USA”policy initiative of the Obama era,although directly inspired by Germany’s Fraunhofer institutes,is hampered by the contextual and institutional circumstances *** biobased carbon fibers offering the potential of a novel,low-cost material,pursued with research and development(R&D)efforts in both countries,it provides a measure for evaluating policy outcomes,and the study confirms Germany’s technological *** addition,the study’s process-tracing methodology reveals that significant legacies from German knowledge creation in the past have spilled over to American science and technology,and may continue to do so,lured by government *** studies on advanced manufacturing should test the robustness of these findings.

关键词： Research policy Industry 4.0 Bioeconomy Low-carbon innovation Varieties of capitalism Process tracing

Poul Erik andersen's radiological work on osteochondrodysplasias and interventional radiology

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World Journal of Radiology 2011年第8期3卷 210-214页

作者： Poul Erik andersen Department of Radiology Cardiovascular SectionOdense University Hospital

Poul Erik andersen is a Professor and Interventional Radiologist at the University of Southern Denmark,Odense and Odense University Hospital,*** innovative and expertise is primarily in vascular interventions where he has introduced and developed many procedures at Odense University *** significant experience and extensive scientific work has led to many posts in the Danish Society of Interventional Radiology,the European Society of Radiology and the Cardiovascular and Interventional Radiological Society of Europe,where he is a fellow and has passed the European Board of Interventional Radiology-The European qualification in Interventional Radiology.

关键词： Biography Clinical competence Education Interventional Radiology

Total Variation Based Parameter-Free Model for Impulse Noise Removal

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Numerical Mathematics(Theory,Methods and Applications) 2017年第1期10卷 186-204页

作者： Federica Sciacchitano Yiqiu Dong Martin S.andersen Department of Applied Mathematics and Computer Science Technical University of Denmark2800 Kgs.LyngbyDenmark

We propose a new two-phase method for reconstruction of blurred im-ages corrupted by impulse *** the first phase,we use a noise detector to iden-tify the pixels that are contaminated by noise,and then,in the second phase,we reconstruct the noisy pixels by solving an equality constrained total variation mini-mization problem that preserves the exact values of the noise-free *** images that are only corrupted by impulse noise(i.e.,not blurred)we apply the semismooth Newton’s method to a reduced problem,and if the images are also blurred,we solve the equality constrained reconstruction problem using a first-order primal-dual *** proposed model improves the computational efficiency(in the denoising case)and has the advantage of being regularization *** numerical results suggest that the method is competitive in terms of its restoration capabilities with respect to the other two-phase methods.

关键词： Image deblurring image denoising impulse noise noise detector primal-dual first-order algorithm semismooth Newton method total variation regularization

Hard-thermal-loop QED thermodynamics

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Chinese Physics C 2010年第9期34卷 1527-1529页

作者：苏楠 Jens O.andersen Michael Strickland Frankfurt Institute for Advanced Studies Department of Physics Norwegian University of Science and Technology Department of Physics Gettysburg College

The weak-coupling expansion for thermodynamic quantities in thermal field theories is poorly convergent unless the coupling constant is *** discuss the calculation of the free energy for a hot gas of electrons and photons to three-loop order using hard-thermal-loop perturbation theory （HTLpt）.We show that the hard-thermal-loop perturbation reorganization improves the convergence of the successive approximations to the QED free energy at large coupling,e ～ *** reorganization is gauge invariant by construction,and due to the cancellations among various contributions,we obtain a completely analytic result for the resummed thermodynamic potential at three loops.

关键词： resummation hard-thermal-loop thermal field theory QED free Energy

Single cell profiling reveals window for immunotherapy in liver cancers

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Hepatobiliary Surgery and Nutrition 2018年第1期7卷 48-51页

作者： Jesper B.andersen Biotech Research&Innovation Centre(BRIC) Department of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark

Primary liver cancer has the second highest mortality rate with more than 700,000 *** carcinoma(HCC),the most prevalent tumor type in the liver,arises predominantly from hepatocytes and is often related to known etiologies such as chronic hepatitis B or C virus,obesity,diabetes mellitus,metabolic liver diseases and life style factors(for example,alcohol).

关键词： liver mortality Primary