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C-MEMS-derived glassy carbon electrochemical biosensors for rapid detection of SARS-CoV-2 spike protein

Microsystems & Nanoengineering 2023年第6期9卷 247-260页

作者： Naresh mandal Raja Mitra Bidhan Pramanick School of Electrical Sciences Indian Institute of Technology Goa403401 PondaGoaIndia School of Chemical and Materials Sciences Indian Institute of Technology Goa403401 PondaGoaIndia Centre of Excellence in Particulates Colloids and Interfaces Indian Institute of Technology Goa403401 PondaGoaIndia school of Interdisciplinary Life Sciences Indian Institute of Technology Goa403401 PondaGoaIndia

According to a World Health Organization(WHO)report,the world has experienced more than 766 million cases of positive SARS-CoV-2 infection and more than 6.9 million deaths due to COVID through May *** WHO declared a pandemic due to the rapid spread of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus,and the fight against this pandemic is not over *** reasons for virus spread include the lack of detection kits,appropriate detection techniques,delay in detection,asymptomatic cases and failure in mass *** the last 3 years,several researchers and medical companies have introduced successful test kits to detect the infection of symptomatic patients in real time,which was necessary to monitor the ***,it is also important to have information on asymptomatic cases,which can be obtained by antibody testing for the SARS-CoV-2 *** this work,we developed a simple,advantageous immobilization procedure for rapidly detecting the SARS-CoV-2 spike ***-MEMS-derived glassy carbon(GC)is used as the sensor electrode,and the detection is based on covalently linking the SARS-CoV-2 antibody to the GC *** was used as a cross-linker between the antibody and glassy carbon electrode(GCE).The binding was investigated using Fourier transform infrared spectroscopy(FTIR)characterization and cyclic voltammetric(CV)*** impedance spectroscopy(EIS)was utilized to measure the change in total impedance before and after incubation of the SARS-CoV-2 antibody with various concentrations of SARS-CoV-2 spike *** developed sensor can sense 1 fg/ml to 1µg/ml SARS-CoV-2 spike *** detection is label-free,and the chances of false positives are *** calculated LOD was~31 copies of viral RNA/*** coefficient of variation(CV)number is calculated from EIS data at 100 Hz,which is found to be 0.398%.The developed sensor may be used for mass screening because it is cost-effective.

关键词： glassy impedance linking

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Study of Tachyon Warm Intermediate and Logamediate Inflationary Universe from Loop Quantum Cosmological Perspective

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Communications in Theoretical Physics 2016年第8期65卷 256-262页

作者： Jyotirmay Das mandal Ujjal Debnath Department of Mathematics Indian Institute of Engineering Science and Technology

We have studied the tachyon intermediate and logamediate warm inflation in loop quantum cosmological background by taking the dissipative co-efficient Γ = Γ_0(where Γ_0 is a constant) in "intermediate" inflation and Γ = V(φ),(where V(φ) is the potential of tachyonic field) in "logamediate" inflation. We have assumed slow-roll condition to construct scalar field φ, potential V, N-folds, etc. Various slow-roll parameters have also been *** have analyzed the stability of this model through graphical representations.

关键词： tachyonic field loop quantum cosmological warm inflation

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Powder mixed electrochemical discharge process for micro machining of C103 niobium alloy

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Defence Technology（防务技术） 2023年第8期26卷 84-101页

作者： Niladri mandal Nitesh Kumar Alok Kumar Das Defence Research&Development Laboratory(DRDL)-DRDO HyderabadIndia Department of Mechanical Engineering Indian Institute of Technology(ISM)DhanbadIndia

This work demonstrates the viability of the powder-mixed micro-electrochemical discharge machining(PMECDM) process to fabricate micro-holes on C103 niobium-based alloy for high temperature *** processes are involved simultaneously *** erosion,chemical etching,and abrasive grinding for removal of material while the classical electrochemical discharge machining process involves double actions *** erosion,and chemical *** powder-mixed electrolyte process resulted in rapid material removal along with a better surface finish as compared to the classical microelectrochemical discharge machining(MECDM).Further,the results are optimized through a multiobjective optimization approach and study of the surface topography of the hole wall surface obtained at optimized *** the selected range of experimental parameters,PMECDM shows a higher material removal rate(MRR) and lower surface roughness(R_(a))(MRR:2.8 mg/min and R_(a) of 0.61 μm) as compared to the MECDM process(MRR:2.01 mg/min and corresponding Raof 1.11 μm).A detailed analysis of the results is presented in this paper.

关键词： Micro-electrochemical discharge machining C103 niobium alloy Surface integrity Material removal rate Hybrid powder mixed ECDM

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Optimal Linear Phase Finite Impulse Response Band Pass Filter Design Using Craziness Based Particle Swarm Optimization Algorithm

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Journal of Shanghai Jiaotong university(Science) 2011年第6期16卷 696-703页

作者： SANGEETA mandal SAKTI Prasad Ghoshal RAJIB Kar DURBADAL mandal Department of Electrical Engineering Department of Electronics and Communication Engineering National Institute of Technology

An efficient method is proposed for the design of finite impulse response(FIR) filter with arbitrary pass band edge,stop band edge frequencies and transition *** proposed FIR band stop filter is designed using craziness based particle swarm optimization(CRPSO) *** the filter specifications to be realized,the CRPSO algorithm generates a set of optimal filter coefficients and tries to meet the ideal frequency response *** this paper,for the given problem,the realizations of the optimal FIR band pass filters of different orders have been *** simulation results have been compared with those obtained by the well accepted evolutionary algorithms,such as Parks and McClellan algorithm(PMA),genetic algorithm(GA) and classical particle swarm optimization(PSO).Several numerical design examples justify that the proposed optimal filter design approach using CRPSO outperforms PMA and PSO,not only in the accuracy of the designed filter but also in the convergence speed and solution quality.

关键词： finite impulse response(FIR) filter particle swarm optimization(PSO) craziness based particle swarm optimization(CRPSO) Parks and McClellan algorithm(PMA) genetic algorithm(GA) optimization

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Physicochemical and elemental studies of Hydrocotyle javanica Thunb. for standardization as herbal drug

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Asian Pacific Journal of Tropical Biomedicine 2017年第11期7卷 979-986页

作者： Manab mandal Debabrata Misra Narendra Nath Ghosh Vivekananda mandal Plant and Microbial Physiology and Biochemistry Laboratory Department of BotanyUniversity of Gour BangaMalda 732 103West BengalIndia Department of Chemistry University of Gour BangaMalda 732 103West BengalIndia

Objective: To explore the leaves of Hydrocotyle javanica Thunb. as a source of safe and effective antibacterial herbal ***: The standardization was validated by stepwise physicochemical studies,element analysis, determination of ash values, fluorescence analysis, assessment of moisture content, extractive values in different solvent systems and extraction *** metal contents, mineral and element contents were analysed by atomic absorption spectrophotometry, inductively coupled plasma-mass spectrometer and CHNS/O analyser, ***: The methanol extract of the folklore medicinal plant having antibacterial efficacy contained flavonoids and phenolic OH groups. The ICP multi standard indicated the presence of three major compounds with molecular mass of 161 190 and 221 Da. Heavy metals viz. lead, mercury and copper content were 4.38 ppm, < 0.05 ppm and 24.70 ppm,respectively. Minerals content of calcium, phosphorus, potassium and iron were 1 190.94 mg/100 g, 375.57 mg/100 g, 2 820 mg/100 g and 340.20 mg/100 g of plant sample, respectively. Elements like carbon, hydrogen, nitrogen and sulphur contents were38.18%, 5.67%, 2.23% and 0.51%, respectively. Heavy metal profile of the tested plant was within the permissible limits of the regulatory ***: Hence the present physicochemical and elements studies reveals that the plant Hydrocotyle javanica Thunb. could be a potent source of herbal preparation as well as a safe and novel synthetic antibacterial drug.

关键词： Hydrocotyle javanica Thunb Herbal drug Physico-chemical analysis Mineral and elemental compositions Heavy metals contents Biomedical significance

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Investigation on the Trap Signature in Organic Semiconductor Turmeric Film Through Current-Voltage Analysis

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Transactions of Tianjin University 2020年第4期26卷 265-272页

作者： Kushal Chakraborty Aloke Kumar Das Ratan mandal Dulal Krishna mandal Department of Physics Jadavpur UniversityKolkata 700032India School of Energy Studies Jadavpur UniversityKolkata 700032India Department of Mechanical Engineering Jadavpur UniversityKolkata 700032India

The analytical description of the trap signature in the charge conduction process of turmeric dye-based organic semiconductor has been presented in this *** analytical explanation of the built-in potential Ⅴx-Ⅴ graph that emphasizes the presence of trapping states has been *** analysis of current-voltage(Ⅰ-Ⅴ)characteristics has also been conducted to verify the trap signature of the carrier in the *** non-monotonous decrement of the G(Ⅴ)-Ⅴ plot verifies the trap *** values of trap energy(Et)and trap factor(θ)have been derived from the logarithmic Ⅰ-Ⅴ *** the analysis of the semilogarithmic Ⅰ-Ⅴ plot,the barrier height(ϕbi)of the device has also been *** overallⅠ-Ⅴcurve has been taken into account to examine the Richardson-Schottky and Poole-Frenkel effects on the trap-assisted charge conduction *** the results of the experiment,the Schottky effect has been observed to be effective,which leads to a bulk-limited charge conduction process.

关键词： Organic semiconductor Trap energy Trap factor Turmeric Schottky effect

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Enhancing chloramphenicol and trimethoprim in vitro activity by Ocimum sanctum Linn.(Lamiaceae) leaf extract against Salmonella enterica serovar Typhi

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Asian Pacific Journal of Tropical Medicine 2012年第3期5卷 220-224页

作者： Shyamapada mandal Manisha Deb mandal Nishith Kumar Pal Department of Microbiology Bacteriology and Serology UnitCalcutta School of Tropical MedicineC.R.AvenueKolkata-700073India Department of Physiology and Biophysics KPC Medical College and HospitalJadavpurKolkata-700032India

Objective:To evaluate the antibacterial activity of Ocimum sanctum(***) leaf extract, alone,and in combination with chloramphenicol(C) and trimethoprim(Tm) against Salmonella enterica serovar Typhi(***).Methods:The antibacterial activity of ethanolic extract of tulsi, ***,leaf(TLE:500μg) for 23 *** isolates was determined following agar diffusion. The C(30μg) and Tm(5μg) activity alone and in combination with TLE(250μg) was determined by disk *** zone diameter of inhibition(ZDI) for the agents was recorded, and growth inhibitory indices(Glls) were ***:The *** isolates(n=23),which were resistant to both C(ZDI 6 mm) and Tm(ZDI 6 mm),had TLE(500μg) ZDIs 16-24 *** ZDIs of C and Tm were increased up to 15-21 mm and 17-23 mm,respectively,when TLE(250μg) was added to the C and Tm *** Glls ranged 0.789-1.235 and 0.894-1.352,due to combined activity against *** isolates,of C and TLE and Tm and ***:The data suggest that TLE,in combination with C and Tm,had synergistic activity for *** isolates, and hence *** is potential in combating *** drug resistance,as well promising in the development of non-antibiotic drug for *** infection.

关键词： Antibacterial activity Ocimum sanctum Chloramphenicol Trimethoprim Growth inhibitory index Synergy Salmonella enterica serovar Typhi

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Comparison of Different Approaches of Finding the Positive Definite Metric in Pseudo-Hermitian Theories

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Communications in Theoretical Physics 2013年第5期59卷 533-539页

作者： Ananya Ghatak Bhabani Prasad mandal Department of Physics Banaras Hindu University

To develop a unitary quantum theory with probabilistic description for pseudo-Hermitian systems one needs to consider the theories in a different Hilbert space endowed with a positive definite metric operator. There are different approaches to find such metric operators. We compare the different approaches of calculating positive definite metric operators in pseudo-Hermitian theories with the help of several explicit examples in non-relativistic as well as in relativistic situations. Exceptional points and spontaneous symmetry breaking are also discussed in these models.

关键词： pseudo-Hermitian quantum theory positive definite metric operator relativistic non-Hermitian system P T symmetry quantum mechanics modified Hilbert space

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Coriander(Coriandrum sativum L.) essential oil: chemistry and biological activity

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Asian Pacific Journal of Tropical Biomedicine 2015年第6期5卷 421-428页

作者： Shyamapada mandal Manisha mandal Laboratory of Microbiology and Experimental Medicine Department of ZoologyUniversity of Gour Banga Department of Physiology MGM Medical College and LSK Hospital

Coriandrum sativum L.(C. sativum) is one of the most useful essential oil bearing spices as well as medicinal plants, belonging to the family Umbelliferae/Apiaceae. The leaves and seeds of the plant are widely used in folk medicine in addition to its use as a seasoning in food preparation. The C. sativum essential oil and extracts possess promising antibacterial, antifungal and anti-oxidative activities as various chemical components in dif erent parts of the plant, which thus play a great role in maintaining the shelf-life of foods by preventing their spoilage. This edible plant is non-toxic to humans, and the C. sativum essential oil is thus used in dif erent ways, viz., in foods(like l avoring and preservatives) and in pharmaceutical products(therapeutic action) as well as in perfumes(fragancias and lotions). The current updates on the usefulness of the plant C. sativum are due to scientii c research published in dif erent web-based journals.

关键词： Coriandrum sativum essential oil Coriander chemistry Antibacterial activity Antifungal activity Antioxidant activity Food spoila

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Amplified fluorescence of Mg^2+ selective red-light emitting carbon dot in water and direct evaluation of creatine kinase activity

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Nano Research 2020年第10期13卷 2770-2776页

作者： Saptarshi mandal Jagannath Pal Ranga Subramanian Prolay Das Department of Chemistry Indian Institute of Technology PatnaPatna 801103India

Carbon quantum dot/carbon dot(CD)exhibiting sustained photoluminescence at longer wavelengths in aqueous solution is difficult to prepare,but has enormous potential in biomedical *** the first time,we report the magnesium(II)selective fluorescence enhancement of a red-light emitting anthrarufin and boric acid-derived CD in aqueous solution for direct evaluation of creatine kinase(CK)enzyme *** CD displayed visually detectable,intense red fluorescence only in the presence of magnesium ion(Mg^2+)at physiological pH value when irradiated with an ultraviolet(UV)***,a significant increase in steady-state fluorescence intensity and fluorescence lifetime was documented.A time-dependent density functional theory(TD-DFT)analysis displayed a bathochromic shift in UV–visible(vis)absorption,and increased oscillator strength of transition resulting from the selective chelation of Mg^2+withβ-hydroxy keto functionality on the surface of the *** CD–Mg^2+assembly was subsequently used to conceptualize the detection of CK directly through the exploration of the differential binding affinity of Mg2+with adenosine triphosphate(ATP),adenosine diphophate(ADP),and CD that is otherwise not possible with commercially available kits as of ***,the report delineated here usher grandeur potential of CD for biological explorations related to Mg2+or ATP sensing and monitoring of Mg^2+-dependent enzymatic activity through a clear understanding of the chemistry.

关键词： carbon dot(CD) Mg^2+indicator fluorescence amplification creatine kinase(CK) adenosine triphosphate(ATP)

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