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Target-site mediated insecticide resistance in major mosquito(Diptera:Culicidae)vectors:A systematic review

Asian Pacific Journal of Tropical Medicine 2024年第11期17卷 481-490,I0001-I0028页

作者： Subhajit Das Abhirup saha Prapti Das Debayan Raha Dhiraj saha Insect Biochemistry and Molecular Biology Laboratory Department of ZoologyUniversity of North BengalRaja RammohunpurP.O.NBUDarjeelingWest Bengal734013India

The use of insecticides remain the most effective vector control approach for mosquito borne diseases like malaria,dengue fever,chikungunya,and Zika virus disease;however,their increasing resistance has complicated the *** in kdr,ace-1/ace-2,rdl,and nAChR,are involved in target-site mediated resistance and prevent the binding of pyrethroids and dichlorodiph enyltrichloroethane,organophosphorus pesticide,carbamates and cyclodienes,***,we review the current knowledge on target-site mediated insecticidal resistance mechanisms in major mosquito vectors and the techniques used to identify these *** results showed that kdr mutations are frequently reported in mosquito species,indicating the overuse of pyrethroid in mosquito *** on ace mutations is very limited,primarily detected in Anopheles and Culex,with extremely low detection rate in Aedes,despite the wide application of organophosphates in their ***,reports of rdl mutations and changes in nAChR are rare,which provides an opportunity to exploit these target sites,particularly in the event of disease *** various detection methods such as RFLP,TaqMan,Multiplex PCR and FRET,allele-specific PCR is mostly employed,especially in detecting kdr ***,allele-specific PCR cannot detect novel *** a result,there is an urgent need to develop a scalable,cost-effective tool that can be widely applied especially as these mutations are genetic markers for early detection of insecticide *** monitoring methods remain critical to manage insecticide resistance and effective control of mosquito-borne diseases.

关键词： Mosquito Culex Anopheles Aedes Insecticide resistance kdr Acetylcholinesterase GABAA receptor

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Applicability of unique scarf joint configuration in friction stir welding of AA6061-T6:Analysis of torque,force,microstructure and mechanical properties

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Defence Technology（防务技术） 2022年第4期18卷 567-582页

作者： Durjyodhan Sethi Uttam Acharya Shashank Shekhar Barnik saha Roy Department of Mechanical Engineering National Institute of Technology AgartalaBarjalaJiraniaWest TripuraPin-799046India Department of Materials Science and Engineering Indian Institute of Technology KanpurKanpur208016India

The present research introduces a unique concept of scarf joint technique in friction stir welding(FSW) of aluminum alloy AA 6061-T6 plates and an investigation on weld quality.A new joint configuration with two distinct scarf angles(75°and 60°) was considered in this *** various aspects of welding were compared with contemporary simple square butt(SSB) joint *** was carried out at a constant tool rotation speed(TRS),tool traverse speed(TTS) and tool tilt angle of 1100 rpm,2 mm/s and2°,*** results are analyzed in terms of force and torque distribution,microstructure,macrostructure,and mechanical property perspective for different joint *** study reveals the minimum amount of force and torque at 60°scarf angle joint configuration compared to that of square butt joint *** study shows that all the joints were defect-free,and a prominent onion ring was present in the lower portion of the weld nugget(WN).Fine equiaxed grains with a minimum average grain size diameter of 6.82 μm were obtained in the WN of scarf joint configuration(SJC).The maximum ultimate tensile strength(UTS) and maximum average NZ hardness of 267 MPa and83.82 HV0.1were obtained in SJC3 at a scarf angle of 60°.It has been observed from the investigation that the joint efficiency increases from 72.5%(SSB) to 86%(SJC3) at a 60° scarf *** unique characteristic may lay an impetus on probable joint strength enhancement technique without increasing the production cost.

关键词： Friction stir welding Joint configuration Al alloys Force and torque Microstructure Mechanical property

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Painlevé analysis,auto-Bäcklund transformation and new exact solutions of(2+1)and(3+1)-dimensional extended Sakovich equation with time dependent variable coefficients in ocean physics

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Journal of Ocean Engineering and Science 2023年第3期8卷 246-262页

作者： Shailendra Singh S.saha Ray National Institute of Technology Department of MathematicsRourkela 769008India

This article considers time-dependent variable coefficients(2+1)and(3+1)-dimensional extended Sakovich ***éanalysis and auto-Bäcklund transformation methods are used to examine both the considered ***éanalysis is appeared to test the integrability while an auto-Bäcklund transformation method is being presented to derive new analytic soliton solution families for both the considered *** new family of exact analytical solutions are being obtained success-fully for each of the considered *** soliton solutions in the form of rational and exponential functions are being *** results are also expressed graphically to illustrate the potential and physical behaviour of both *** the considered equations have applications in ocean wave theory as they depict new solitary wave soliton solutions by 3D and 2D graphs.

关键词： (2+1)-dimensional extended Sakovich equation (3+1)-dimensional extended Sakovich equation Auto-Bäcklund transformation Painlevéanalysis Solitary wave solution

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New Exact Solutions for the Wick-Type Stochastic Kudryashov–Sinelshchikov Equation

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Communications in Theoretical Physics 2017年第2期67卷 197-206页

作者： S.saha Ray S.Singh Department of Mathematics National Institute Technology Rourkela Orissa-769008 India

In this article, exact solutions of Wick-type stochastic Kudryashov–Sinelshchikov equation have been obtained by using improved Sub-equation method. We have used Hermite transform for transforming the Wick-type stochastic Kudryashov–Sinelshchikov equation to deterministic partial differential equation. Also we have applied inverse Hermite transform for obtaining a set of stochastic solutions in the white noise space.

关键词： Kudryashov–Sinelshchikov Wick-product White noise space improved Sub-equation method Hermite transform inverse Hermite transform

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New Exact Solutions of Fractional Zakharov–Kuznetsov and Modified Zakharov–Kuznetsov Equations Using Fractional Sub-Equation Method

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Communications in Theoretical Physics 2015年第1期63卷 25-30页

作者： S.saha Ray S.Sahoo Department of Mathematics National Institute of Technology Rourkela Orissa- 769008 India

In the present paper, we construct the analytical exact solutions of some nonlinear evolution equations in mathematical physics; namely the space-time fractional Zakharov–Kuznetsov(ZK) and modified Zakharov–Kuznetsov(m ZK) equations by using fractional sub-equation method. As a result, new types of exact analytical solutions are obtained. The obtained results are shown graphically. Here the fractional derivative is described in the Jumarie's modified Riemann–Liouville sense.

关键词： fractional sub-equation method space-time fractional Zakharov-Kuznetsov (ZK) equation space-time fractional modified Zakharov-Kuznetsov (mZK) equation modified Riemann-Liouvillederivative Mittag-leffler function

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A Stack-based Ensemble Framework for Detecting Cancer MicroRNA Biomarkers

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Genomics, Proteomics & Bioinformatics 2017年第6期15卷 381-388页

作者： Sriparna saha Sayantan Mitra Ravi Kant Yadav Department of Computer Science and Engineering Indian Institute of TechnologyPatna 801103India

MicroRNA （miRNA） plays vital roles in biological processes like RNA splicing and regulation of gene expression. Studies have revealed that there might be possible links between onco- genesis and expression profiles of some miRNAs, due to their differential expression between normal and tumor tissues. However, the automatic classification of miRNAs into different cate- gories by considering the similarity of their expression values has rarely been addressed. This article proposes a solution framework for solving some real-life classification problems related to cancer, miRNA, and mRNA expression datasets. In the first stage, a mulfiobjective optimization based framework, non-dominated sorting genetic algorithm II, is proposed to automatically determine the appropriate classifier type, along with its suitable parameter and feature combinations, pertinent for classifying a given dataset. In the second page, a stack-based ensemble technique is employed to get a single combinatorial solution from the set of solutions obtained in tke first stage. The performance of the proposed two-stage approach is evaluated on several cancer and RNA expression pro- file datasets. Compared to several state-of-the-art approaches for classifying different datasets, our method shows supremacy in the accuracy of classification.

关键词： Sequential minimal optimizer Non-dominated sorting genetic algorithm Multiobjective optimization MicroRNA

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Cascade controller based modeling of a four area thermal:gas AGC system with dependency of wind turbine generator and PEVs under restructured environment

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Protection and Control of Modern Power Systems 2022年第1期7卷 696-713页

作者： Debdeep saha Lalit Chandra Saikia Asadur Rahman Department of Electrical Engineering Indian Institute of Engineering Science and Technology ShibpurShibpurWest BengalIndia Department of Electrical Engineering National Institute of Technology SilcharSilcharAssamIndia Department of Electrical Engineering National Institute of Technology SrinagarSrinagarIndia

This paper investigates automatic generation control(AGC)of a realistic hybrid four-control area system with a dis-tinct arrangement of thermal units,gas units and additional power generation.A proportional-integral-double deriva-tive cascaded with proportional-integral(PIDD-PI)controller is employed as secondary controller in each control area for robust restructured AGC considering bilateral transactions and contract *** Harris Hawks algorithm is used to determine the optimal controller gains and system parameters under several *** vehicle(EV)aggregators are employed in each area to participate fully along with thermal and gas units to compensate for the unscheduled system demand in the local area.A comparison of non-cascaded controllers such as PI-PD,PD-PID and the proposed PIDD-PI proves the superiority of the *** effect of the decline in inertia is closely examined because of the sudden outage of a generating unit while at the same time considering the change in area frequency response characteristics and area control *** fleets make significant contributions to improving the system dynamics dur-ing system inertia *** use of EVs in the presence of a wind energy-supported grid can provide a stable efficacy to the power *** simulations with higher load demands,stochastic communication delays in presence of the WTG plant,and violations in system loadings and changes in gas turbine time constants in the absence of WTG demonstrate the robustness of the proposed control approach.

关键词： Automatic generation control Cascade controller Electric vehicle Harris Hawks algorithm Wind turbine generator

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Higher-order approximate solutions of fractional stochastic point kinetics equations in nuclear reactor dynamics

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Nuclear Science and Techniques 2019年第3期30卷 114-126页

作者： S.Singh S.saha Ray Department of Mathematics National Institute of Technology Rourkela

Stochastic point kinetics equations(SPKEs) are a system of Ito? stochastic differential equations whose solution has been obtained by higher-order *** this study, a fractional model of SPKEs has been analyzed. The efficiency of the proposed higher-order approximation scheme has been discussed in the results section. The solutions of SPKEs in the presence of Newtonian temperature feedback have also been provided to further discuss the physical behavior of the fractional model.

关键词： Fractional stochastic point reactor kinetics equations Fractional calculus Higher-order approximation Caputo derivative Neutron population

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A NOVEL TECHNIQUE FOR MULTIPLE FAULTS AND THEIR LOCATIONS DETECTION AND START ELECTRODE SELECTION IN MICROFLUIDIC DIGITAL BIOCHIP

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Journal of Innovative Optical Health Sciences 2013年第4期6卷 19-26页

作者： MUKTA MAJUMDER NILANJANA DAS SUJAN KUMAR saha Department of Computer Science and Engineering Birla Institute of Technology Mesra RanchiJharkhandIndia Maynaguri CCC WBSEDCLJalpaiguri West BengalIndia

A device,that is used for biomedical operation or safety-critical applications like point-of-care health asssment,massive parallel DNA analysis,automated drug discovery,air-quality monitoring and food-safety testing,must have the attributes like relia bility,dependability and *** the biochips are used for these purposes;therefore,these devices must be fault free all the *** before usi ng these chips,they must be well *** are proposing a novel technique that can detect mutiple fults,locate the fault positions within the biochip,as well as calculate the traversal time if the biochip is fault *** proposed technique also highlights a new idea how to select the appropriate base node or pseudo source(start electrode).The main idea of the proposed technique is to form multiple loops with the neighboring electrode arrays and then test each loop by traversing test droplet to check whether there is any *** a fault is detected then the propoed technique also locates it by backtracking the test *** case,no fault is detected,the biochip is fault free then the proposed technique also calculates the time to traverse the *** result suggests that the proposed technique is eficient and shows significant improvement to ca lculate fault-free biochip traversal time over existing method.

关键词： Biochip lab-on-chip medical microsystems biochemical droplet biomedical operation

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A three-pronged analysis confirms the association of the serotoninergic system with attention deficit hyperactivity disorder

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World Journal of Pediatrics 2022年第12期18卷 825-834页

作者： Mahasweta Chatterjee Sharmistha saha Swagata Sinha Kanchan Mukhopadhyay Manovikas Biomedical Research and Diagnostic Centre Manovikas Kendra482 MadudahPlot I-24Sector JEM BypassKolkataWest Bengal700107India

Background The serotonin transporter(SERT),encoded by the solute carrier family 6 number 4(SLC6A4)gene,controls serotonin(5-HT)availability and is essential for the regulation of behavioral *** SLC6A4 genetic variants,5-HTTLPR and STin2,were widely investigated in patients with various neurobehavioral disorders,including attention deficit hyperactivity disorder(ADHD).Methods We analyzed the association of the 5-HTTLPR(L/S)and STin2(10/12)variants,plasma 5-HT,and 5-hydroxyindole acetic acid(5-HIAA),as well as SERT messenger RNA(mRNA)with ADHD in the eastern Indian *** families with ADHD probands(n=274)and ethnically matched controls(n=367)were recruited following the Diagnostic and Statistical Manual of Mental *** traits,executive function,and intelligence quotient(IQ)of the probands were assessed using the Conner's Parent Rating Scale–Revised,Parental Account of Children’s Symptoms(PACS),Barkley Deficit in Executive Functioning—Child and Adolescent Scale,and Wechsler Intelligence Scale for Children-III,*** obtaining informed written consent,peripheral blood was collected to analyze genetic variants,plasma 5-HT,5-HIAA,and SERT mRNA *** ADHD probands showed a higher frequency of the 5-HTTLPR“L”allele and“L/L”genotype(P<0.05),lower 5-HIAA level,and higher SERT mRNA *** for behavioral problems and hyperactivity were higher in the presence of the“S”allele and“S/S”genotype,while executive deficit was higher in the presence of the“L”*** score was lower in the presence of the STin2“12”allele and L-12 *** Data obtained indicate a significant association of the serotoninergic system with ADHD,warranting further in-depth investigation.

关键词： Attention deficit hyperactivity disorder 5-Hydroxyindole acetic acid 5-Serotonin 5-HTT-linked polymorphic region SERT mRNA

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