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Journal of Sensor Technology 2012年第4期2卷 196-205页

作者： asit kar Michael George Laboratory for Materials and Surface Science Department of Chemistry University of Alabama in Huntsville Huntsville AL 35899 USA

The use of multi-segmented Position Sensitive Photodiodes (PSD) to measure microcantilever deflections have been found to produce nonlinear signal output, especially when the dynamic range is large. The reflected beam of the microcantilever may undergo intensity and shape modifications prior to reaching the PSD. In a multi-microcantilever sensor system the variation in the size of the individual spots plays an additional role contributing to the nonlinearities of detector output. Irrespective of the range of operation the merits of intensity normalization have been discussed. We show that the output is proportional to the width of the spot along the split line of the detector. This enables the determination of the shape of a spot. We show that the microcantilever vibrational spectrum can be obtained just using a single segment photodetector instead of using multiple segmented PSDs. These concepts will greatly facilitate interpretation of sensor data acquired from either single or multi-microcantilever experimental platforms.

关键词： Photodetectors Microcantilever Sensors Signal Artifacts Laser Spot Shape AFM

Liposomal dual delivery systems in visceral leishmaniasis enhance the synergistic effects of combination therapy:A promise for the future

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 47-60页

作者： Raghunath Hazra Amrita kar Santanu kar Mahapatra Department of Paramedical and Allied Health Sciences Biodiversity and Environmental Studies Research CentreMidnapore City CollegeKuturiyaBhadutalaPaschim Medinipur-721129West BengalIndia

Visceral leishmaniasis(VL)is a neglected tropical disease,and this review has summarized the current treatment scenario and its *** also highlights alternative approaches used by research groups in India and around the world to develop cutting-edge and potent anti-leishmanial *** though numerous medications could be utilized to treat VL,the limitations of current treatments including their toxicity,cost,route of administration,and duration of doses,have contributed to the emergence of *** therapy might be a better option due to its shorter duration,easier route of administration,and ability to extend the lifespan of individual ***,there is a risk of not delivering both the drugs to the target site together,which can be overcome by the liposomal entrapment of those drugs and at a time knock an opportunity to reduce the dosage of amphotericin B if the combination drug provides a synergistic effect with ***,this review presents a novel strategy to fight against VL by introducing dual drug-loaded liposomes.

关键词： Visceral leishmaniasis Liposomal anti-leishmanial drug Dual drug liposome

Removal of Dye Using Lignin-Based Biochar/Poly(ester amide urethane)Nanocomposites from Contaminated Wastewater

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Journal of Renewable Materials 2024年第9期12卷 1507-1540页

作者： Annesha kar Niranjan karak Advanced Polymer and Nanomaterial Laboratory(APNL) Department of Chemical SciencesTezpur UniversityNapaamTezpur784028India Research and Development RymbalRTCSahibabad Industrial Area Site 4SahibabadGhaziabad201010India

The pursuit of incorporating eco-friendly reinforcing agents in polymer composites has accentuated the exploration of various natural biomass-derived *** burgeoning environmental crisis spurred by the discharge of synthetic dyes into wastewater has catalyzed the search for effective and sustainable treatment *** the various sorbent materials explored,biochar,being renewable,has gained prominence due to its excellent adsorption properties and environmental *** has also emerged as a focal point for its potential to replace other conventional reinforcing agents,viz.,fumed silica,aluminum oxide,treated clays,*** study introduces a novel class of polymer nanocomposites comprising of lignin-based biochar particles and poly(ester amide urethane)matrix via a feasible *** structural evaluation of these nanocomposites was accomplished using Fourier-transform infrared spectroscopy,X-ray photoelectron spectroscopy,and powder X-ray *** polymer nanocomposites exhibited superior mechanical properties with an increment in tensile strength factor by 45%in comparison to its pristine matrix,along with an excellent toughness value of 90.22 MJm^(−3)at a low loading amount of only 1 wt%.The composites showed excellent improvement in thermal properties with a sharp rise in the glass transition temperature(Tg)value from−28.15℃to 84℃,while also championing sustainability through inherent biodegradability *** their structural prowess,these polymer nanocomposites demonstrated excellent potential as adsorbents,displaying efficient removal of malachite green and tartrazine dyes from aqueous systems with a removal efficiency of 87.25%and 73.98%,*** kinetics study revealed the pseudo second order model to be the precision tool to assess the dye removal *** this,the Langmuir adsorption isotherm provided a framework to assess the sorption features of the polymer ***,these ren

关键词： Reinforcing agents biochar polymer nanocomposites poly(ester amide urethane) dye removal adsorption kinetics pseudo second order model langmuir isotherm

Measurement of Temperature Induced Unfolding of DNA Hairpins by Microcantilever Sensors

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Open Journal of Applied Biosensor 2013年第3期2卷 78-82页

作者： Joseph D. Ng Jeffrey J. Dowell asit K. kar karolyn Hansen Thomas Thundat Michael A. George Department of Biology University of Dayton Dayton USA Department of Chemical and Materials Engineering University of Alberta Edmonton Canada Department of Chemistry University of Alabama Huntsville USA Laboratory for Structural Biology and the Department of Biological Science University of Alabama Huntsville USA

The technical feasibility of monitoring DNA melting and cooling transitions using a microcantilever substrate has been demonstrated and these results were compared with those measured in solution by circular dichroism. DNA hairpins have been immobilized on the surface of gold-coated microcantilever surfaces and their DNA melting and cooling transitions were monitored by nanomechanical deflections. The hairpins comprised of a 16 base-pair GACA repeat motif stem duplex with a 29 nucleotide variable region. Microcantilever deflection profiles, measured by the microcantilever response as a function of temperature, were unique to different hairpins indicative of the molecules’ general stability and denaturation characteristics. The major melting and cooling transition temperatures for all three immobilized oligonucleotides were between 41。C - 52。C. The composition and flexibility of the DNA stem loops were shown to influence the thermal transitions.

关键词： Hairpin DNA Microcantilever Thermal Melting Unfolding

Recent advances in understanding neurotoxicity,behavior and neurodegeneration in siluriformes

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Aquaculture and Fisheries 2024年第3期9卷 404-410页

作者： Sonika kar Balasubramanian Senthilkumaran Department of Animal Biology School of Life SciencesUniversity of HyderabadP.O.Central UniversityHyderabadTelangana500046India

Occurrence of neurotoxic chemicals in the aquatic environment is on the rise posing a potential threat to aquatic biota including *** teleosts,zebrafish has become a popular model organism for toxicological studies and testing ***,over the decade,siluriformes(catfish)are also finding ever increasing application being robust as well as their adaptability to adverse ecological conditions,surgical interventions,and tolerant models for toxicity studies and *** information can infer potential effects occurring to other species exposed to neurotoxins in their aquatic environment and predicting potential risks of a chemical for the aquatic *** aim of this review is to compare and interpret recent results published concerning neuro-behavioral and morphological disturbances caused by toxicants/pollutants providing a holistic view of potential neurotoxic outcomes in ***,this review summarizes various effects of toxicants/pollutants in terms of neurotoxicity and neurodegeneration associated with behavioral phenotypes.

关键词： Neurotoxicity Behavior Neurodegeneration Siluriformes Bioaccumulation

Extraction of intersecting palm-vein and palmprint features for cancellable identity verification

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 69-86页

作者： Jaekwon Lee Beom-Seok Oh kar-Ann Toh School of Electrical and Electronic Engineering Yonsei UniversitySeoulRepublic of Korea Department of Applied Artificial Intelligence Seoul National University of Science and TechnologySeoulRepublic of Korea

A novel method based on the cross-modality intersecting features of the palm-vein and the palmprint is proposed for identity *** on the unique geometrical relationship between the two biometric modalities,the cross-modality intersecting points provides a stable set of features for identity *** facilitate flexibility in template changes,a template transformation is *** maintaining non-invertibility,the template transformation allows transformation sizes beyond that offered by the con-ventional *** experiments using three public palm databases are conducted to verify the effectiveness the proposed system for identity recognition.

关键词： biometrics hand vein recognition hand-based biometrics multi-biometrics palmprint recognition

A review of MXene-derived quantum dots:Synthesis,characterization,properties,and applications

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Particuology 2024年第8期91卷 50-71页

作者： Chunhe Zhou kar Ban Tan Wenjuan Han Li Wang Ming Lu The Joint Laboratory of MXene Materials Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of EducationJilin Normal UniversityChangchunJilin 130103China Department of Chemistry Faculty of ScienceUniversiti Putra MalaysiaSerdangSelangor 43400Malaysia

Cutting MXene to a minimum size and forming the derived two-dimensional MXene quantum dots(MQDs),which possess a unique intrinsic layered geometry structure,restricts exciton due to their novel spatial *** gives rise to a broad spectrum of fascinating properties,rendering them for various ***,the correlation between composition,structure,and processing control of MQDs is investigated systematically,giving further insight into the intrinsic and extrinsic *** review also provides an opportunity to explore new compositions,modify the properties,and tailor MQDs into the guided architectural design before any prospective applications.

关键词： MXene Quantum dots Characterization Properties Applications

Transcultural adaptation of Odia version of health-related kidney disease and quality of life-36 instrument

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Journal of Integrative Nursing 2024年第1期6卷 41-48页

作者： Rashmimala PRADHAN Pravati TRIPATHY Debaprasad kar Department of Medical Surgical Nursing SUM Nursing CollegeSiksha‘O'Anusandhan(Deemed to be University)BhubaneswarOdishaIndia SUM Nursing College Siksha‘O'Anusandhan(Deemed to be University)BhubaneswarOdishaIndia Department of Nephrology IMS and SUM HospitalBhubaneswarOdishaIndia

Objective:The study objective was to translate,validate,and test the reliability of the original kidney disease and quality of life-36(KDQOL-36^(TM))instruments in *** and Methods:A cross-sectional design with a purposive sampling technique was *** to RAND Corporation guidelines,initially,the items of the KDQOL-36^(TM)questionnaires were translated into Odia by two independent,bilingual,professional translators,and then back-translated to English,followed by tryout and field *** experts validated the KDQOL-36^(TM)instrument review committee for review related to kidney health *** tool was implemented among 180 patients undergoing“maintenance”*** following tests evaluated reliability and validity:test-retest reliability with Cronbach’s alpha correlation(stability),(reliability)internal consistency,and contents validity ***:The Cronbach’s alpha value and intraclass correlation coefficient(ICC)score of all five domains,namely“physical component summary,mental component summary(MCS),the burden of kidney disease,symptoms and problems of kidney disease,and effects of kidney disease”of both KDQOL-36^(TM)English and Odia(KDQOL-36-E^(TM)and KDQOL-36-O^(TM))version,recommended excellent homogeneity.A high positive correlation(r=0.998)was found between the Odia version of KDQOL-36^(TM)and the English version KDQOL-36^(TM)*** ICC score ranges from 0.889 to 0.997 at a 95%confidence interval for test-retest reliability,and Cronbach’s alpha was ***:This study explores the Odia version of KDQOL-36^(TM)psychometric properties,depicted at an acceptable level of internal *** KDQOL-36-O^(TM)instrument is a valid and reliable tool for assessing the kidney disease-related quality of life in Odia-speaking hemodialysis patients.

关键词： Hemodialysis patients kidney disease and quality of life‑36 reliability transcultural validation

Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease

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Genes & Diseases 2024年第1期11卷 67-71页

作者： Souvik kar Andrea Perrelli Kiran Kumar Bali Raffaella Mastrocola Arpita kar Bushra Khan Luis Gand Arnab Nayak Christian Hartmann Wolfram SKunz Amir Samii Helmut Bertalanffy Saverio Francesco Retta International Neuroscience Institute Rudolf-PichlmayrStrasse 4Hannover 30625Germany Department of Clinical and Biological Sciences University of TorinoOrbassano(TO)10043Italy CCM Italia Research Network National Coordination Center at the Department of Clinical and Biological SciencesUniversity of TorinoOrbassano(TO)10043Italy Department of Experimental Pain Research Mannheim Center for Translational Neuroscience(MCTN)Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Department of Kidney Liver and Metabolic DiseasesChildren’s HospitalHannover Medical SchoolHannover 30625Germany Ricarda-Huch-Street-10B Hannover 30880Germany Institute of Molecular and Cell Physiology Hannover Medical SchoolHannover 30625Germany Department of Neuropathology Institute of PathologyHannover Medical SchoolHannover 30625Germany Institute of Experimental Epileptology and Cognition Research and Department of Epileptology University Hospital BonnVenusberg-Campus 1Bonn 53127Germany epartment of Pharmacology and Physiology University of Rochester Medical CenterRochesterNY 14642USA

cerebrovascular disease of genetic origin characterized by abnormally dilated capillaries and a wide spectrum of symptoms,including headaches,seizures,neurological deficits,and intracerebral *** unpredictable clinical course and the current lack of therapies make the identification of prognostic and predictive biomarkers an imperative research challenge.1 Herein,we provide evidence that galectin-3(Gal-3),a major tissue and circulating biomarker of oxidative stress and inflammation,is significantly up-regulated both in CCM patients and ***,wholetranscriptome sequencing,qRT-PCR,and Western blotting studies demonstrated a significant up-regulation of Gal-3 expression levels both in surgical CCM specimens and in blood samples of CCM patients.

关键词： inflammation cerebral dilated

Improved reservoir characterization by means of supervised machine learning and model-based seismic impedance inversion in the Penobscot field,Scotian Basin

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Energy Geoscience 2024年第2期5卷 183-201页

作者： Satya Narayan Soumyashree Debasis Sahoo Soumitra kar Sanjit Kumar Pal Subhra Kangsabanik Oil and Natural Gas Corporation(ONGC)Limited DehradunIndia Department of Applied Geophysics IIT(ISM)DhanbadIndia

The present research work attempted to delineate and characterize the reservoir facies from the Dawson Canyon Formation in the Penobscot field,Scotian *** integrated study of instantaneous frequency,P-impedance,volume of clay and neutron-porosity attributes,and structural framework was done to unravel the Late Cretaceous depositional system and reservoir facies distribution patterns within the study *** strikes were found in the EW and NEE-SWW directions indicating the dominant course of tectonic activities during the Late Cretaceous period in the region.P-impedance was estimated using model-based seismic *** properties such as the neutron porosity(NPHI)and volume of clay(VCL)were estimated using the multilayer perceptron neural network with high ***,a combination of low instantaneous frequency(15-30 Hz),moderate to high impedance(7000-9500 gm/cc*m/s),low neutron porosity(27%-40%)and low volume of clay(40%-60%),suggests fair-to-good sandstone development in the Dawson Canyon *** calibration with the welllog data,it is found that further lowering in these attribute responses signifies the clean sandstone facies possibly containing *** present study suggests that the shale lithofacies dominates the Late Cretaceous deposition(Dawson Canyon Formation)in the Penobscot field,Scotian *** faults and overlying shale facies provide structural and stratigraphic seals and act as a suitable hydrocarbon entrapment mechanism in the Dawson Canyon Formation's *** present research advocates the integrated analysis of multi-attributes estimated using different methods to minimize the risk involved in hydrocarbon exploration.

关键词： Reservoir characterization Model-based inversion Multilayer perceptron(MLP) Impedance Petrophysical properties Scotian Basin