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The Triple Combination of Meropenem,Avibactam,and a Metallo-β-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different β-Lactamase Producers

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Engineering 2024年第7期38卷 124-132页

作者： Zhuoren Ling Alistair James Macdonald Farley Aditya Lankapalli Yanfang Zhang Shonnette Premchand-Branker Kate Cook Andrei baran Charlotte Gray-Hammerton Claudia Orbegozo Rubio Edgars Suna Jordan Mathias Jürgen Brem Kirsty Sands Maria Nieto-Rosado Maria Mykolaivna Trush Nadira Naznin Rakhi Willames Martins Yuqing Zhou Christopher Joseph Schofield Timothy Walsh Department of Biology&Ineos Oxford Institute for Antimicrobial Research University of OxfordOxford OX13REUK Chemistry Research Laboratory Department of Chemistry and the Ineos Oxford Institute for Antimicrobial ResearchUniversity of OxfordOxford OX13TAUK Latvian Institute of Organic Synthesis Riga LV-1006Latvia Department of Medical Microbiology Division of Infection and ImmunitySchool of MedicineCardiff UniversityCardiff CF144XNUK Enzymology and Applied Biocatalysis Research Center Faculty of Chemistry and Chemical EngineeringBabes-Bolyai UniversityCluj-Napoca 400028Romania

This work explores the potential of a triple combination of meropenem(MEM),a novel metallo-blactamase(MBL)inhibitor(indole-2-carboxylate 58(InC58)),and a serine-b-lactamase(SBL)inhibitor(avibactam(AVI))for broad-spectrum activity against carbapenemase-producing bacteria.A diverse panel comprising MBL-and SBL-producing strains was used for susceptibility testing of the triple combination using the agar dilution *** frequency of resistance(FoR)to MEM combined with InC58 was *** were sequenced and tested for cross resistance,fitness,and the stability of the resistance *** with the double combinations of MEM plus an SBL or MBL inhibitor,the triple combination extended the spectrum of activity to most of the isolates bearing SBLs(oxacillinase-48(OXA-48)and Klebsiella pneumoniae carbapenemase-2(KPC-2))and MBLs(New Delhi metallo-blactamases(NDMs)),although it was not effective against Verona integron-encoded metallo-blactamase(VIM)-carrying Pseudomonas aeruginosa(***)and OXA-23-carrying Acinetobacter baumannii(***).The FoR to MEM plus InC58 ranged from 2.22×10^(-7)to 1.13×10^(-6).The resistance correlated with mutations to ompC and comR,affecting porin C and copper permeability,*** mutants manifested a fitness cost,a decreased level of resistance during passage without antibiotic pressure,and cross resistance to another carbapenem(imipenem)and a b-lactamase inhibitor(taniborbactam).In conclusion,compared with the dual combinations,the triple combination of MEM with InC58 and AVI showed a much wider spectrum of activity against different carbapenemaseproducing bacteria,revealing a new strategy to combat b-lactamase-mediated antimicrobial resistance.

关键词： Carbapenemase Metallo/serine-b-lactamase inhibitor Avibactam Meropenem Antimicrobial resistance

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Mercury emissions and partitioning from Indian coal-fired power plants

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Journal of Environmental Sciences 2021年第2期33卷 28-33页

作者： Hridesh Agarwalla Rabi Narayan Senapati Tarit baran Das Coal Minerals&Heauy Metal Research Group CSIR-Central Institute of Mining and Furl ResearchDhcmbad-82810India

In India coal combustion is the single largest source of emission of mercury which is a widespread persistent global toxicant,travelling across international borders through air and *** a party to the Minamata convention,India aims to monitor and reduce Hg emissions and stricter norms are introduced for mercury emissions from power plants(30μg/Nm 3 for flue gas in stack).This paper presents the results obtained during the experimental studies performed on mercury emissions at four coal-fired and one lignite-fired power plants in *** mercury concentration in the feed coal varied between 0.12-0.27 mg/*** the mercury mass balance,significant proportion of feed coal mercury has been found to be associated with fly ash,whereas bottom ash contained very low mercury.80%-90%of mercury was released to air through stack ***,for circulating fluidised bed boiler burning lignite,about 64.8%of feed mercury was found to get captured in the fly ash and only 32.4%was released to *** mercury emission factor was found to lie in the range of 4.7-15.7 mg/GJ.

关键词： Coal combustion Emission Mercury Flue gas Thermal power plant

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K-P-Burgers equation in negative ion-rich relativistic dusty plasma including the effect of kinematic viscosity

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Chinese Physics B 2016年第10期25卷 215-221页

作者： A N Dev M K Deka J Sarma D Saikia N C adhikary Department of Mathematics Siksha ‘O' Anusandhan University Department of Applied Sciences Institute of Science and Technology Gauhati University Department of Mathematics R G Baruah College Physical Sciences Division Institute of Advanced Study in Science and TechnologyVigyan Path Paschim Boragaon

The stationary solution is obtained for the K–P–Burgers equation that describes the nonlinear propagations of dust ion acoustic waves in a multi-component, collisionless, un-magnetized relativistic dusty plasma consisting of electrons, positive and negative ions in the presence of charged massive dust grains. Here, the Kadomtsev–Petviashvili(K–P) equation, threedimensional(3D) Burgers equation, and K–P–Burgers equations are derived by using the reductive perturbation method including the effects of viscosity of plasma fluid, thermal energy, ion density, and ion temperature on the structure of a dust ion acoustic shock wave(DIASW). The K–P equation predictes the existences of stationary small amplitude solitary wave,whereas the K–P–Burgers equation in the weakly relativistic regime describes the evolution of shock-like structures in such a multi-ion dusty plasma.

关键词： K–P–Burgers equation negative ion relativistic plasma reductive perturbation method

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Analyzing Dominant 13.5 and 27 day Periods of Solar Terrestrial Interaction:A New Insight into Solar Cycle Activities

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Research in Astronomy and Astrophysics 2022年第8期22卷 63-73页

作者： Rissnalin Syiemlieh Manashee adhikary Prasanta K Panigrahi Eeshankur Saikia Department of Applied Sciences Gauhati UniversityAssam 781014India Complex Photonic Systems MESA+Institute for NanotechnologyUniversity of TwenteP.O.Box 2177500 AE EnschedeThe Netherlands Department of Physical Sciences Indian Institute of Science Education and ResearchKolkata 741246India

Our analysis presents an explanation of the Sun–Earth coupling mechanism during declining phase of a solar cycle,and how the dominant 13.5 and 27 day periods play roles in the coupling mechanism which led to intense terrestrial magnetic storms during this declining phase compared to the rising phase of a solar ***,it is observed that while the 27 day period gets strongly modulated in the rising phase,the 13.5 day period modulation is more prominent during the declining *** is suggested that out of the 27 and 13.5 day periods of Sun–Earth interaction,the preferred period of modulation happens to be the one which is more dominant for the less random or quieter system participating in the *** is reported for the first time that the 13.5 day period is more prominent in the Sun–Earth interaction during the declining phase of a solar cycle,as it is the most dominant period of Earth's magnetic system,which happens to be more persistent as a dynamical system and hence quieter or more receptive than the Sun.

关键词： (Sun:)solar wind (Sun:)sunspots (Sun:)solar-terrestrial relation (Sun:)activity methods:data analysis

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Determination of interface states and their time constant for Au/SnO_2 /n-Si (MOS) capacitors using admittance measurements

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Chinese Physics B 2013年第4期22卷 429-433页

作者： H. M. baran A. Tataroglu Department of Physics Faculty of Arts and Sciences Gazi University

The frequency dependence of admittance measurements （capacitance–voltage （C–V ） and conductance–voltage （G/ω–V ）） of Au/SnO2 /n-Si （MOS） capacitors was investigated by taking into account the effects of the interface states （N ss ） and series resistance （Rs ） at room temperature. Admittance measurements were carried out in frequency and bias voltage ranges of 1 kHz–1 MHz and （ 5V）–（＋9V）, respectively. The values of N ss and R s were determined by using a conductance method and estimating from the admittance measurements of the MOS capacitors. At low frequencies, the interface states can follow the AC signal and yield excess capacitance and conductance. In addition, the parallel conductance （G p /ω） versus log（f） curves at various voltages include a peak due to the presence of interface states. It is observed that the N ss and their time constant （τ） range from 1.23 ×10 12 eV-1 ·cm-2 to 1.47 ×10 12 eV-1 ·cm-2 and from 7.29 ×10-5 s to 1.81 ×10-5s, respectively.

关键词： MOS capacitor admittance measurements interface states

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Reactive power control and optimisation of hybrid off shore tidal turbine with system uncertainties

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Journal of Ocean Engineering and Science 2016年第4期1卷 256-267页

作者： asit Mohanty Meera Viswavandya Prakash K Ray Sthitapragyan Mohanty Department of Electrical Engineering College of Engineering and TechnologyBhubaneswar 751003India Associate Professor CET BhubaneswarIndia Department of Electrical Engineering IIITBhubaneswar 751003India Research Scholar CET BhubaneswarIndia

This paper projects an isolated hybrid model of Offshore wind-diesel-tidal turbine and discusses the stability and reactive power management issue of the whole *** hybrid system often loses its stability as it becomes prone to uncertain load and input parameters and therefore the necessity of Reactive power management becomes *** overall stability of the hybrid offshore wind-diesel-tidal turbine is made possible by the management of reactive power in the hybrid system through the application of FACTS *** therefore the dynamic hybrid model of the DFIG and DDPMSG based offshore wind-diesel-tidal turbine is analysed for stability with different input parameters like wind and tidal *** detailed modelling and simulation,a small signal model of the whole hybrid system is designed and reactive power management of the system is achieved by the incorporation of a STATCOM *** improvement of stability and reactive power compensation of the hybrid system,GA and PSO optimised STATCOM controller is used.

关键词： Offshore wind-diesel-tidal hybrid system DFIG DDPMSG Reactive power STATCOM PSO

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Underground mining slurry transportation viability

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International Journal of Coal Science & Technology 2019年第3期6卷 430-437页

作者： Binay Samanta Arun baran Samaddar IIT (ISM) Dhanbad India NIT Ravangla India

Underground mining requires lot of water pumping to surface which increases cost. Because of safety, support, ventilation and environment costs underground mines are closing down gradually all over the world. This innovative paper is based on method studies by computer programming with realistic data. With development of electronic control systems, coal water slurry mix can be remote controlled for transport to surface Separator-bunker. Main consumers need powdered coal/mineral like thermal power stations, for feeding to Fuel Burners of boilers, generating power or in steel plants for feeding into coke ovens to make hard coke for charging into Blast Furnaces for making pig iron. Feed for coal washeries also require crushed coal and output of washed coal as slurry can be sent to coke ovens of steel plants directly. Production from mine faces should be taken through lump-breaker and conveyed to a mixing chamber, near panel sump, from where adequate capacity slurry pump will propel up to pit-top. The projected financial benefit can be several millions of Rupees per year, as compared to road, rail conveyor or winders is shown, by run of a computer program in Java, with realistic cost figures from mines.

关键词： Electronic control Slurry pumping Continuous miner Lump-breaker Panel sump Mixing chamber

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Analyzing capacity of a consumer-grade infrared camera in South Africa for costeffective aerial inspection of building envelopes

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Frontiers of Architectural Research 2020年第3期9卷 697-710页

作者： Naadir Vorajee asit Kumar Mishra Amit Kumar Mishra Electrical Engineering Department University of Cape TownCape Town 7700South Africa Berkeley Education Alliance for Research in Singapore CREATE Tower138602Singapore

Prohibitive equipment cost and certain export regulations are the major obstacles to the widespread adoption of infrared(IR)thermography when evaluating building *** this work,we propose the use of an affordable and easily available camera as a first step of making the technology *** with image post-processing,we hypothesize that a low-cost,low-resolution,and consumer-grade device can provide an economic alternative for the periodic evaluation of building *** a market survey,the Seek Thermal Compact(STC)was chosen for *** STC was able to accurately measure the temperature of surfaces and distinguish small thermal anomalies(3 mm in diameter),and the IR images can be post-processed to reasonably estimate the anomaly *** STC was particularly effective when images were taken within 1.75 m from the *** 1.75 m distance did not pose a challenge in this study,as the goal was to mount the selected IR camera on an unmanned aerial vehicle for the *** small size and weight of the STC were also *** results from the analysis of the capability of the STC and the image post-processing techniques may help form the basis of future investigations aiming at lowering the cost of building thermographic surveys.

关键词： IR thermography Building enve'opes Cost-effective Thermal images Image processing Segmentation algorithms

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Dust Acoustic Shock Waves with Non-Thermal and Vortex-Like Ions in Dusty Plasma

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Plasma Science and Technology 2015年第4期17卷 268-275页

作者： Apul N.DEV Jnanjyoti SARMA Manoj K.DEKA Nirab C.adhikary Department of Science and Humanities College of Science and Technology RUB Bhutan Department of Mathematics R. G. Baruah College Guwahati-781025 Assam India Centre of Plasma Physics Tepesia Sonapur Assam India Physical Science Divison Institute of Advanced Study in Science and Technology Vigyan Path Garchuk Guwahati-781035 Assam India

A rigorous investigation is presented on the propagation characteristics of non-linear dust acoustic（DA）waves in an unmagnetized dusty plasma system containing non-thermal and vortex-like ions and Maxwellian electrons under the effect of a fluctuating charged dust *** three-dimensional（3D）Burgers＇equation and a new form of a lower degree modified 3D Burgers＇equation with their analytical solutions are derived to study the features of shock waves in such *** effect of the population of non-thermal ions,the vortex-like ion parameter as well as the temperature ratios of ions and electrons on the evolution of shock waves in the presence of dust charge fluctuation is *** theoretical investigation might be effectively utilized to unveil the nature of many astrophysical plasma environments（Saturn＇s spokes etc.）where such plasmas are reported to have existed.

关键词： dusty plasma reductive perturbation method 3D Burgers' equation modified 3D Burgers' equation tan-hyperbolic method

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一种生态友好的皮胶原固定方法—麻疯树籽油作为协同鞣剂的作用

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中国皮革 2015年第3期44卷 46-49页

作者： Victor John Sundar Chellappa Muralidharan asit baran Mandal 陈小珂(译) 中央皮革研究所科学和工业研究理事会印度金奈600020 不详

采用麻疯树籽油作为协同鞣剂,与植物鞣剂共同应用于皮革鞣制中,克服了传统植鞣法中的大部分缺点。对鞣制系统的不同工艺参数进行研究。采用柔软测试仪对柔软性的改善效果量化。同时,采用新鲜成熟的真菌,如黑曲霉、黄曲霉和木霉菌作为接... 详细信息

采用麻疯树籽油作为协同鞣剂,与植物鞣剂共同应用于皮革鞣制中,克服了传统植鞣法中的大部分缺点。对鞣制系统的不同工艺参数进行研究。采用柔软测试仪对柔软性的改善效果量化。同时,采用新鲜成熟的真菌,如黑曲霉、黄曲霉和木霉菌作为接种物,考察鞣革的抗菌效果。研究表明,采用麻疯树籽油和植物鞣剂共同鞣制的新型鞣法,是一种利用可再生能源的可行性鞣法。

关键词：铬抗菌性生皮麻疯树籽油皮革鞣制

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