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Asian Journal of Urology 2024年第1期11卷 26-32页

作者： Awad Elsid Osman Sahar Alharbi Atif ali Ahmed asim ali Elbagir Pathology and Clinical Laboratory Management Department(PCLM) King Fahad Medical CityRiyadhSaudi Arabia Department of Pathology and Laboratory Medicine University of Missouri at Children's Mercy HospitalKansas CityMOUSA

Objective: Genome-wide association studies have demonstrated that single nucleotide polymorphisms (SNPs) are important risk factors for the development of prostate cancer (PCa). Preliminary studies have suggested that the incidence of PCa in Saudi males is low but is probably familial or genetically ***: To identify any possible association of SNP with PCa development in Saudi patients, we investigated a group of SNPs in Saudi PCa patients (n=85) and compared the outcomes to healthy normal controls (n=115) and nodular hyperplasia patients (n=120). DNA was extracted from paraffin-embedded formalin fixed tissue or whole blood from both patients’ groups and healthy control group. A total of thirteen SNPs were genotyped using TaqMan® minor groove binder polymerase chain reaction ***: The rs16901979A, s629242T and rs1447295A alleles were found at significantly higher frequency in PCa patients than controls (p< 0.05). The rs16901979 CA genotype was found at significantly greater frequency in PCa patients than in healthy controls (43% vs. 14%, odds ratio=4.6, p=0.0001) and benign hyperplasia group (43% vs. 25%, odds ratio=2.2, p=0.009).Conclusion: Our study has highlighted the association of rs16901979 SNP with PCa in Saudi males. Such findings have important implications in the PCa diagnosis and in screening unaffected family members of Saudi patients.

关键词： Prostatecancer Saudi Singlenucleotide polymorphism Allele

Scalability of biomass-derived graphene derivative materials as viable anode electrode for a commercialized microbial fuel cell: A systematic review

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Chinese Journal of Chemical Engineering 2023年第3期55卷 277-292页

作者： Mustapha Omenesa Idris Claudia Guerrero-Barajas Hyun-Chul Kim asim ali Yaqoob Mohamad Nasir Mohamad Ibrahim School of Chemical Sciences Universiti Sains Malaysia11800 PenangMalaysia Department of Pure and Industrial Chemistry Kogi State UniversityP.M.B 1008 AnyigbaKogi StateNigeria Laboratorio de Biotecnologia Ambiental Departamento de BioprocesosUnidad Profesional Interdisciplinaria de BiotecnologiaInstituto Politecnico NacionalAv.Acueducto s/nCol.Barrio La Laguna Ticoman07340 Mexico CityMexico Research Institute for Advanced Industrial Technology College of Science and TechnologyKorea UniversitySejong 30019Republic of Korea

Microbial fuel cell(MFC) is an advanced bioelectrochemical technique that can utilize biomass materials in the process of simultaneously generating electricity and biodegrading or bio transforming toxic pollutants from wastewater. The overall performance of the system is largely dependent on the efficiency of the anode electrode to enhance electron transportation. Furthermore, the anode electrode has a significant impact on the overall cost of MFC setup. Hence, the need to explore research focused towards developing cost-effective material as anode in MFC. This material must also have favourable properties for electron transportation. Graphene oxide(GO) derivatives and its modification with nanomaterials have been identified as a viable anode material. Herein, we discussed an economically effective strategy for the synthesis of graphene derivatives from waste biomass materials and its subsequent fabrication into anode electrode for MFC applications. This review article offers a promising approach towards replacing commercial graphene materials with biomass-derived graphene derivatives in a view to achieve a sustainable and commercialized MFC.

关键词： Microbial fuel cell Biomass Anode fabrication Catalyst Design Cost-effective performance

FertilityOnline:A Straightforward Pipeline for Functional Gene Annotation and Disease Mutation Discovery

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Genomics, Proteomics & Bioinformatics 2022年第3期20卷 455-465页

作者： Jianing Gao Huan Zhang Xiaohua Jiang asim ali Daren Zhao Jianqiang Bao Long Jiang Furhan Iqbal Qinghua Shi Yuanwei Zhang The First Affiliated Hospital of USTC Hefei National Laboratory for Physical Sciences at the MicroscaleCAS Key Laboratory of Innate Immunity and Chronic DiseasesSchool of Life SciencesCAS Center for Excellence in Molecular Cell ScienceUniversity of Science and Technology of ChinaCollaborative Innovation Center of Genetics and DevelopmentHefei 230027China

Exploring the genetic basis of human infertility is currently under intensive ***,only a handful of genes have been validated in animal models as disease-causing genes in infertile ***,to better understand the genetic basis of human spermatogenesis and bridge the knowledge gap between humans and other animal species,we construct the FertilityOnline,a database integrating the literature-curated functional genes during spermatogenesis into an existing spermatogenic database,SpermatogenesisOnline *** features,including the functional annotation and genetic variants of human genes,are also incorporated into *** searching this database,users can browse the functional genes involved in spermatogenesis and instantly narrow down the number of candidates of genetic mutations underlying male infertility in a user-friendly web *** application of this database was exampled by the identification of novel causative mutations in synaptonemal complex central element protein 1(SYCE1)and stromal antigen 3(STAG3)in azoospermic *** conclusion,FertilityOnline is not only an integrated resource for spermatogenic genes but also a useful tool facilitating the exploration of the genetic basis of male *** can be freely accessed at http://***/bsc/spermgenes2.0/***.

关键词： FertilityOnline Infertility Database Functional gene Mutation

The hedgehog pathway in breast cancer

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Chinese Journal of Cancer Research 2012年第4期24卷 261-262页

作者： Sheikh asim ali Department of Medical Oncolgy Temple University Hospital

Breast cancer is one of the most common cancers around the world with approximately 1.6 million new cases and 425 thousand deaths from the disease in 2010 （1）. While early detection methods and treatment have continuously evolved and improved over the years, there is still a strong need to further understand the pathways and mechanisms that lead to and drive this malignancy with the ultimate goal being more personalized, less toxic treatment with improved survival and higher cure rates.

关键词： The hedgehog pathway in breast cancer

Genuine entanglement under squeezed generalized amplitude damping channels with memory

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Chinese Physics B 2024年第2期33卷 158-163页

作者： Mazhar ali Department of Electrical Engineering Faculty of EngineeringIslamic University MadinahMadinah 107Saudi Arabia

We study genuine entanglement among three qubits undergoing a noisy process that includes dissipation, squeezing,and decoherence. We obtain a general solution and analyze the asymptotic quantum states. We find that most of these asymptotic states can be genuinely entangled depending upon the parameters of the channel, memory parameter, and the parameters of the initial states. We study Greenberger–Horne–Zeilinger(GHZ) states and W states, mixed with white noise,and determine the conditions for them to be genuinely entangled at infinity. We find that for these mixtures, it is possible to start with a bi-separable state(with a specific mixture of white noise) and end with genuine entangled states. However, the memory parameter μ must be very high. We find that in contrast to the two-qubit case, none of the three-qubit asymptotic states for n → ∞ are genuinely entangled.

关键词： genuine entanglement squeezed thermal baths multipartite states

Heat transfer analysis in particle-laden flows using the immersed boundary method

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Particuology 2024年第7期90卷 394-403页

作者： ali Abbas Zaidi Department of Mechanical Engineering University of Manitoba75A Chancellors CircleWinnipegR3T 5V6Canada

This paper investigates an efficient immersed boundary method(IBM)for multiple-core CPU machines with local grid refinement for the calculation of heat transfer between fluids and finite-sized *** fluid momentum equations are solved by using the fractional step method,while the energy equation is solved by employing the second-order Adams-Bashforth *** efficient load balancing between the CPU cores,the coupling between particles and fluid is obtained by applying the body force in the fluid equations,which depends on the solid volume fraction of particles contained in each grid cell,and then by linearly interpolating the particle temperature and velocity on the fluid grid cell(in place of the delta function commonly used in literature).Several test cases from the literature are studied,and good agreement is observed between the simulation results and the ***,a scaling study on multiple core machines is performed,demonstrating the proposed IBM's capabilities for a significant reduction in processing time.

关键词： Heat transfer Immersed boundary method Particle resolved direct numerical simulations Fluid solid interactions

Simulation of the deformable lateral boundaries in biaxial test using DEM

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Particuology 2024年第5期88卷 161-175页

作者： ali Momeni Barry Clarke Yong Sheng ali Hassanpour WSP 3 Wellington PlaceLeedsLS1 4APUK Hull University HullHU6 7RXUK School of Civil Engineering University of LeedsLeedsLS2 9JTUK School of Computer Science University of HullHullHU6 7RXUK School of Chemical and Process Engineering University of LeedsLeedsLS2 9JTUK

Applying the discrete element method(DEM)in soil mechanics can provide abundant information at the particle-scale and facilitates illustration of the macro-mechanical behaviour of soils based on the inter-particle *** triaxial test is one of the most common laboratory methods to study the macro-mechanical behaviour of particulate materials such as ***,many problems in geotechnical design can be assumed and simplified as a plane strain *** a biaxial test can be conducted to reproduce the macro-mechanical behaviour of soil,where the sample is enclosed by two horizontal rigid platens and a vertical latex membrane,which is a deformable continuous element and allows the enclosed specimen to deform freely while maintaining confining stress during *** paper presents an algorithm to represent physical and mechanical characteristics of latex membrane in the 2D DEM simulation of biaxial test using the PFC^(2D) *** investigate the impact of the lateral boundary conditions on the micro-macro mechanical behaviours of soil samples,two sets of DEM biaxial tests are conducted,*** rigid and deformable lateral boundary *** DEM modeling results indicate that the lateral boundary conditions have a significant effect on the micro-scale fabric properties,thickness and inclination of the shear *** comparison between these two simulations also demonstrates that the lateral boundary conditions play a major role in the peak and post-peak stress-strain behaviours as well as the dilation and critical state behaviours of granular soils.

关键词： Discrete element method Biaxial test Deformable boundaries Shear band Critical state Fabric anisotropy Geometrical stability index

Sensing the heavy water concentration in an H_(2)O-D_(2)O mixture by solid-solid phononic crystals

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Chinese Physics B 2024年第4期33卷 493-498页

作者： Mohammadreza Rahimi ali Bahrami Optoelectronic and Nanophotonics Research Laboratory(ONRL) Faculty of Electrical EngineeringSahand University of TechnologyTabrizIran

A new method based on phononic crystals is presented to detect the concentration of heavy water(D_(2)O)in an H_(2)O-D_(2)O *** have been obtained and analyzed in the concentration range of 0%-10%and 90%-100%D_(2)O.A proposed structure of tungsten scatterers in an aluminum host is *** order to detect the target material,a cavity region is considered as a sound wave resonator in which the target material with different concentrations of D_(2)O is *** changing the concentration of D_(2)O in the H_(2)O-D_(2)O mixture,the resonance frequency undergoes a frequency *** 1%change in D_(2)O concentration in the H_(2)O-D_(2)O mixture causes a frequency change of about 120 *** finite element method is used as the numerical method to calculate and analyze the natural frequencies and transmission spectra of the proposed *** performance evaluation index shows a high Q factor up to 1475758 and a high sensitivity up to 13075,which are acceptable values for sensing *** other figures of merit related to the detection performance also indicate high-quality performance of the designed sensor.

关键词： phononic crystals sensor H_(2)O-D_(2)O mixture cavity

Experimental Study on Heat Storage Properties Comparison of Paraffin/Metal Foams Phase Change Material Composites

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Journal of Thermal Science 2024年第2期33卷 469-478页

作者： Waqar AHMED Abid HUSSAIN Hanzla SHAHID Imran ali Hafiz Muhammad ali Department of Mechanical Engineering University of Engineering and TechnologyTaxila47080Pakistan Department of Mechanical Engineering Institute of Space TechnologyIslamabadPakistan Department of Mechanical Mechatronics and Manufacturing EngineeringUniversity of Engineering and Technology LahoreFaisalabad CampusPunjabPakistan Mechanical Engineering Department King Fahd University of Petroleum and MineralsDhahran31261Saudi Arabia Interdisciplinary Research Center for Renewable Energy and Power Systems(IRC-REPS) King Fahd University of Petroleum and MineralsDhahran31261Saudi Arabia

Heat storage properties of phase change materials(PCMs) are essential characteristics that perform a key role in thermal heat energy storage *** thermal properties of PCMs can be improved by developing metal foam/PCM *** addition of metal foam in PCMs has a significant effect on the thermal characteristics of *** this paper,the heat storage properties of two different metal foam/PCM composites were experimentally *** behavior of paraffin in metal foam(copper and iron-nickel)/paraffin composites concerning pure paraffin at a constant heat flux of 1000 W/m^(2) in three directions simultaneously(x,y,and z) was *** was infiltrated into copper and iron-nickel foams to develop composite materials which resulted in enhancing the thermal conductivity of the paraffin.A comparative analysis is made on the heat storage properties of paraffin in copper and iron-nickel foams/paraffin *** temperature distribution during the phase transition process is experimentally *** comparison indicates that temperature uniformity in copper foam/paraffin composite is better than in iron-nickel foam/paraffin composite and pure paraffin at the same heat *** results show that at heat flux of 1000 W/m^(2),the heat storage time for copper foam/paraffin composite is 20.63% of that of iron-nickel foam/paraffin composite.

关键词： heat storage capacity paraffin/metal foam composite temperature uniformity heat storage rate phase transition process

巴基斯坦巴鲁地区马拉坎含铀花岗岩的地球化学特征及其成因探讨

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巴基斯坦巴鲁地区马拉坎含铀花岗岩的地球化学特征及其成因探讨

作者： asim ali 东华理工大学

学位级别：硕士

二叠纪马拉坎花岗岩位于巴基斯坦北部喜马拉雅造山带巴鲁异常区,是富铀贫钍花岗岩,岩石中晶质铀矿颗粒零星分布在花岗岩中,与石英和萤石关系密切。因此,该岩体被认为是巴基斯坦北部最具矿化潜力的花岗岩。本论文对该岩体开展了详细的野... 详细信息

二叠纪马拉坎花岗岩位于巴基斯坦北部喜马拉雅造山带巴鲁异常区,是富铀贫钍花岗岩,岩石中晶质铀矿颗粒零星分布在花岗岩中,与石英和萤石关系密切。因此,该岩体被认为是巴基斯坦北部最具矿化潜力的花岗岩。本论文对该岩体开展了详细的野外考察,在开展室内岩矿鉴定、岩相学及元素地球化学研究的基础上,取得了以下主要认识:(1)在巴鲁地区存在6个不同尺度的放射性异常带,分布于3000×500m的区域内,马拉坎岩体主要由正长花岗岩、富石英花岗岩和碱长花岗岩组成。(2)主、微量和稀土元素分析表明,花岗岩具有亚碱性及钙碱性特征。马拉坎花岗岩为S型花岗岩。花岗岩LREE相对富集,HREE相对亏损,LREE/HREE比值较大,且Ce和Nd分别呈弱正、负异常。(3)电子探针(EPMA)分析,显示马拉坎岩体中主要的铀矿物为铀石和晶质铀矿。晶质铀矿为主要的富铀和富钍矿物,其HFSE(Nb,Ta&Ti)和HREE(Y&Yb)含量较低。而铀石中的Ti,Nb,Ta,Y,Yb的含量较高。相对于晶质铀矿,铀石中铀和钍含量较低。在花岗伟晶岩中,晶质铀矿常与黑云母、金红石、独居石、锆石、方铅矿、磷钇矿和方解石等共生。而铀石则常与沥青铀矿、方解石、方铅矿和黄铁矿共生。(4)铀矿化与发育在强烈剪切破碎带内的中细粒花岗岩及花岗片麻岩密切相关。含矿裂隙常以单个或一组裂隙产出,并有收缩和发散现象。

关键词：马拉坎花岗岩巴鲁地区铀矿化地球化学特征巴基斯坦