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Investigate Evaluation of Oxidative Stress and Lipid Profile in STZ-Induced Rats Treated with Antioxidant Vitamin

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Pharmacology & Pharmacy 2014年第3期5卷 272-279页

作者： Abdella Emam Abdella Baragob Waleed Hassan AlMalki Hassan Elsiddig Hassan Farag Alla asim ibrahim Salwa Khojali Muhammed Samia Abdella Department of Pharmaceuticalchemistry Faculty of Pharmacy Umm Al Qura University Makkah Saudi Arabia Department of Pharmacology and Toxicology Faculty of Pharmacy Umm Al Qura University Makkah Saudi Arabia Department of Public Health Health Sciences College at Al-lieth Umm Al Qura University Makkah Saudi Arabia Department of Histopathology and Cytology College of Medical La-boratory Science Sudan University of Science and Technology Khartoum Sudan Veterinary Research Institute Department of Biochemistry Khartoum Sudan Veterinary Research Institute Department of Pharmacology Khartoum Sudan

The objective of this study was designed to investigate, evaluate the effect of vitamin E on streptozotocin (STZ)-induced diabetic rats by showing significant changes in blood glucose, water, food intake, lipid profile, serum urea and ceratinine level, and antioxidant enzyme parameters activity. Streptozotocin (STZ)-induced toxicity was studied in male Waster rats;each divided into four groups: G1, GII, GIII, and GIV. Control rats GI, rats treated with vitamin E (GII), STZ-induced diabetic rats (GIII), and STZ-induced diabetic rats treated with vitamin E (G1V). Moreover, vitamin E reduced (p < 0.05) blood glucose and urea, thus, our study improved the lipid profile (reduced the serum levels of amount of total cholesterol, LDL, VLDL, cholesterol and triacyglycerols, and increased HDL cholesterol) and increased total amount protein in STZ-induced diabetic rats (GIV). Vitamin prevented modification in the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSX-Px) and in the concentration of the lipid hydroperoxide. Finally the study suggested that vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats.

关键词： Investigate Lipid Profile STZ Oxidative Stress Vitamin E

The impact of alpha-fetoprotein (AFP), child-turcotte-pugh (CTP) score and disease staging on the survival of hepatocellular carcinoma (HCC) patients: a retrospective cohort from single oncology center

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Oncology research 2025年第1期33卷 149-160页

作者： Nasser Mulla Yousef Katib asim M Almughamsi Duaa S Alkhayat Mohamed Mosaad Samir T Alfotih Rawan Alaofi Department of Internal Medicine Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Radiology Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Surgery Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Endemic and Infectious Diseases Suez Canal University Ismailia 41522 Egypt. King Salman bin Abdulaziz Medical City Madinah 42311 Saudi Arabia. Prince Mohammed Bin Abdulaziz Hospital Madinah 41511 Saudi Arabia.

Background:Hepatocellular carcinoma (HCC) is the most common cause of cancer-related death in Saudi Arabia. Our study aimed to investigate the patterns of HCC and the effect of TNM staging, Alfa-fetoprotein (AFP), and Child-Turcotte Pugh (CTP) on patients' overall survival (OS).Methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to 2020. All patients had to fulfill one of the following criteria: (a) a liver lesion reported as definitive HCC on dynamic imaging and/or (b) a biopsy-confirmed diagnosis.Results:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:1. All patients were stratified into two groups: viral HCC (n = 22, 51%) and non-viral HCC (n = 21, 49%). Among viral-HCC patients, 55% were due to HBV and 45% due to HCV. Cirrhosis was diagnosed in 79% of cases. Age and sex did not significantly statistically differ in OS among viral and non-viral HCC patients (-value > 0.05). About 65% of patients had tumor size >5 cm during the diagnosis, with a significant statistical difference in OS (-value = 0.027). AFP was >400 ng/ml in 45% of the patients. There was a statistically significant difference in the OS in terms of AFP levels (-value = 0.021). A statistically significant difference was also observed between the CTP score and OS (-value = 0.02). CTP class B had the longest survival. BSC was the most common treatment provided to HCC patients followed by sorafenib therapy. There was a significant statistical difference in OS among viral and non-viral HCC patients (-value = 0.008).Conclusions:The most common predictors for OS were the underlying cause of HCC, AFP, and tumor size. Being having non-viral etiology, a tumor size >5 cm, an AFP > 400 ng/mL, and a CTP score class C were all negatively associated with OS.

关键词： Alpha-fetoprotein (AFP) Child-turcotte-pugh Hepatocellular carcinoma Pattern Progression free survival

Scalability of biomass-derived graphene derivative materials as viable anode electrode for a commercialized microbial fuel cell: A systematic review

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Chinese Journal of Chemical Engineering 2023年第3期55卷 277-292页

作者： Mustapha Omenesa Idris Claudia Guerrero-Barajas Hyun-Chul Kim asim Ali Yaqoob Mohamad Nasir Mohamad ibrahim School of Chemical Sciences Universiti Sains Malaysia11800 PenangMalaysia Department of Pure and Industrial Chemistry Kogi State UniversityP.M.B 1008 AnyigbaKogi StateNigeria Laboratorio de Biotecnologia Ambiental Departamento de BioprocesosUnidad Profesional Interdisciplinaria de BiotecnologiaInstituto Politecnico NacionalAv.Acueducto s/nCol.Barrio La Laguna Ticoman07340 Mexico CityMexico Research Institute for Advanced Industrial Technology College of Science and TechnologyKorea UniversitySejong 30019Republic of Korea

Microbial fuel cell(MFC) is an advanced bioelectrochemical technique that can utilize biomass materials in the process of simultaneously generating electricity and biodegrading or bio transforming toxic pollutants from wastewater. The overall performance of the system is largely dependent on the efficiency of the anode electrode to enhance electron transportation. Furthermore, the anode electrode has a significant impact on the overall cost of MFC setup. Hence, the need to explore research focused towards developing cost-effective material as anode in MFC. This material must also have favourable properties for electron transportation. Graphene oxide(GO) derivatives and its modification with nanomaterials have been identified as a viable anode material. Herein, we discussed an economically effective strategy for the synthesis of graphene derivatives from waste biomass materials and its subsequent fabrication into anode electrode for MFC applications. This review article offers a promising approach towards replacing commercial graphene materials with biomass-derived graphene derivatives in a view to achieve a sustainable and commercialized MFC.

关键词： Microbial fuel cell Biomass Anode fabrication Catalyst Design Cost-effective performance

Preparation of LDPE-Acetylated/Butyrylated Starch Blend Blow Films and Characterization

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Chinese Journal of Polymer Science 2014年第3期32卷 268-279页

作者： Sangeeta Garg asim Kumar Jana Department of Chemical Engineering National Institute of TechnologyJalandhar Department of Biotechnology National Institute of TechnologyJalandhar

Development of modified plastics has been studied through the LDPE-acylated starch blend films to examine the effect of different acyl groups and degrees of substitution （DS） on properties of films. Corn starch was modified with acetyl and hutyryl groups and films were prepared by blending acylated starch with low density polyethylene （LDPE）. Systematic studies were done to observe the effect of acyl groups, DS and starch concentration on the properties and biodegradability of the blend films. It was observed that blend films containing 5% acetylated and butyrylated starches of high DS （2.5, 1.7） maintained 75% and 83% of tensile strength of LDPE films. Thermal analysis results indicated that acetylated and butyrylated starch blend films decomposed at 370℃ and 389℃ which were higher than the decomposition temperature of native starch film （349℃）. Scanning electron micrographs of blend films containing high DS acylated starch showed well dispersed starch particles due to improvement in dispersion between starch and LDPE. Water absorption capacity of high DS acetylated and butyrylated starch blend films （4.18% and 3.76%, respectively） was lower than that of native starch films （5%）. This study has an advantage because of blown films prepared can be integrated with the present manufacturing systems without any other requirement.

关键词： Acylated starch LDPE-starch blend films Mechanical properties Water absorption capacity Biodegradability.

Generation of a long-term daily gridded precipitation dataset for the rTjSj-Upper Indus Basin(UIB)through temporal Reconstruction,Correction I sag&Informed Regionalization-“ReCIR”

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International Soil and Water Conservation Research 2021年第3期9卷 445-460页

作者： asim Jahangir Khan Manfred Koch Department of Geohydraulics and Engineering Hydrology University of Kassel34125KasselGermany

This study attempted to generate a long-term(1961-2010)daily gridded precipitation dataset for the Upper Indus Basin(UIB)with orographic adjustments so as to generate realistic precipitation estimates,enabling hydrological and water resource investigations that can close the water balance,that is difficult,if not impossible to achieve with the currently available precipitation data products for the *** procedure includes temporal reconstruction of precipitation series at points where data were not recorded prior to the mid-nineties,followed by a regionalization of the precipitation series to a smaller scale across the basin(0.125°x 0.125°),while introducing adjustments for the orographic effect and changes in glacier *** reconstruction process involves interpolation of the precipitation at virtual locations of the current(1995-)dense observational network,followed by corrections for frequency and intensity and adjustments for temporal trends at these virtual *** data generated in this way were further validated for temporal and spatial representativeness through evaluation of SWAT-modelled streamflow responses against observed flows across the *** results show that the calibrated SWAT-simulated daily discharge at the basin outlet as well as at different sub-basin outlets,when forcing the model with the reconstructed precipitation of years 1973—1996,is almost identical to that when forcing it with the reference precipitation data(1997-2008).Finally,the spatial distribution pattern of the reconstructed(1961—1996)and reference(1997—2008)precipitation were also found consistent across the UIB,reflecting well the large-scale atmospheric-circulation pattern in the region.

关键词： Precipitation Temporal reconstruction Orographic correction factor(OCF) Soil and water assessment tool(SWAT) Glacier/water mass balance Upper indus basin(UIB)

Sampling Designs for Validating Digital Soil Maps: A Review

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Pedosphere 2018年第1期28卷 1-15页

作者： asim BISWAS Yakun ZHANG School of Environmental Sciences University of Guelph Department of Natural Resource Sciences McGill University University of Wisconsin-Madison Department of Soil Science FD Hole Soils Lab

Sampling design(SD) plays a crucial role in providing reliable input for digital soil mapping(DSM) and increasing its *** design, with a predetermined sample size and consideration of budget and spatial variability, is a selection procedure for identifying a set of sample locations spread over a geographical space or with a good feature space coverage. A good feature space coverage ensures accurate estimation of regression parameters, while spatial coverage contributes to effective spatial ***, we review several statistical and geometric SDs that mainly optimize the sampling pattern in a geographical space and illustrate the strengths and weaknesses of these SDs by considering spatial coverage, simplicity, accuracy, and efficiency. Furthermore, Latin hypercube sampling, which obtains a full representation of multivariate distribution in geographical space, is described in detail for its development, improvement, and application. In addition, we discuss the fuzzy k-means sampling, response surface sampling, and Kennard-Stone sampling, which optimize sampling patterns in a feature space. We then discuss some practical applications that are mainly addressed by the conditioned Latin hypercube sampling with the flexibility and feasibility of adding multiple optimization criteria. We also discuss different methods of validation, an important stage of DSM, and conclude that an independent dataset selected from the probability sampling is superior for its free model assumptions. For future work, we recommend: 1) exploring SDs with both good spatial coverage and feature space coverage; 2) uncovering the real impacts of an SD on the integral DSM procedure;and 3) testing the feasibility and contribution of SDs in three-dimensional(3 D) DSM with variability for multiple layers.

关键词： calibration geographical space Latin hypercube sampling model-based design spatial coverage three-dimensional(3D) digital soil mapping

Binding energy of the donor impurities in GaAs-Ga_(1-x)Al_xAs quantum well wires with Morse potential in the presence of electric and magnetic fields

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Chinese Physics B 2016年第10期25卷 39-44页

作者： Esra Aciksoz Orhan Bayrak asim Soylu Department of Physics Akdeniz University Department of Physics Nigde University

The behavior of a donor in the GaAs–GaAlAs quantum well wire represented by the Morse potential is examined within the framework of the effective-mass approximation. The donor binding energies are numerically calculated for with and without the electric and magnetic fields in order to show their influence on the binding energies. Moreover, how the donor binding energies change for the constant potential parameters(De, re, and a) as well as with the different values of the electric and magnetic field strengths is determined. It is found that the donor binding energy is highly dependent on the external electric and magnetic fields as well as parameters of the Morse potential.

关键词： Morse potential electric field magnetic field the donor atom quantum well wire

An optimized framework for degree distribution in LT codes based on power law

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Journal of Central South University 2013年第10期20卷 2693-2699页

作者： asim Muhammad Choi GoangSeog Department of Information and Communication Engineering Chosun University

LT codes are practical realization of digital fountain codes, which provides the concept of rateless coding. In this scheme, encoded symbols are generated infinitely from k information symbols. Decoder uses only(1+α)k number of encoded symbols to recover the original information. The degree distribution function in the LT codes helps to generate a random graph also referred as tanner graph. The artifact of tanner graph is responsible for computational complexity and overhead in the LT codes. Intuitively, a well designed degree distribution can be used for an efficient implementation of LT codes. The degree distribution function is studied as a function of power law, and LT codes are classified into two different categories: SFLT and RLT codes. Also, two different degree distributions are proposed and analyzed for SFLT codes which guarantee optimal performance in terms of computational complexity and overhead.

关键词： fountain codes degree distribution overhead computational complexity power law

Mainstreaming Early Warning Systems in Development and Planning Processes: Multilevel Implementation of Sendai Framework in Indus and Sahel

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International Journal of Disaster Risk Science 2015年第2期6卷 189-199页

作者： asim Zia Courtney Hammond Wagner Department of Community Development and Applied Economics University of Vermont Department of Computer Science University of Vermont Rubenstein School of the Environment and Natural Resources University of Vermont

The third UN World Congress on Disaster Risk Reduction, held in Sendai, Japan in March 2015, agreed on a new framework to guide disaster risk reduction policy and practice for the next 15 years. The Sendai Framework for Disaster Risk Reduction 2015–2030(SFDRR) leaves important implementation issues unspecified and potentially creates both problems and opportunities for complex,multilevel governance systems in coping with hazards and disastrous events. Early warning systems(EWS), if built into the mainstream of planning for development and disaster relief and recovery, could present a significant opportunity to realize many SFDRR goals. We explore the complexities of using hydrometeorological EWS to prepare for drought and flood disasters in the densely populated communities of Pakistan’s Indus River Basin in contrast to the African Sahel’s less densely settled grasslands. Multilevel governance systems are often dominated by a topdown, technocentric, centralized management bias and have great difficulty responding to the needs of peripheral and vulnerable populations. People-centered, bottom-up approaches that incorporate disaggregated communities with local knowledge into a balanced, multilevel disaster risk management and governance structure have adramatically better chance of realizing the SFDRR goals for disaster risk reduction.

关键词： Early warning systems Infrastructure development Land-use planning Policy implementation Risk governance Sendai Framework Science-policy interface