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Fuel loading pattern optimization of a pressurized water reactor by varying internal weights-based particle swarm optimization

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Nuclear Science and Techniques 2018年第3期29卷 61-70页

作者： Aneela Zameer Sikander M.Mirza asifullah khan Furqan Mir Department of Computer and Information Sciences Pakistan Institute of Engineering and Applied Sciences (PIEAS) Department of Physics and Applied Mathematics Pakistan Institute of Engineering and Applied Sciences (PIEAS) Department of Nuclear Engineering Pakistan Institute of Engineering and Applied Sciences (PIEAS)

Fuel reload pattern optimization is essential for attaining maximum fuel burnup for minimization of generation cost while minimizing power peaking factor(PPF).The aim of this work is to carry out detailed assessment of particle swarm optimization(PSO) in the context of fuel reload pattern search. With astronomically large number of possible loading patterns, the main constraints are limiting local power peaking factor, fixed number of assemblies,fixed fuel enrichment, and burnable poison rods. In this work, initial loading pattern of fixed batches of fuel assemblies is optimized by using particle swarm optimization technique employing novel feature of varying inertial weights with the objective function to obtain both flat power profile and cycle k_(eff)>1. For neutronics calculation, PSU-LEOPARD-generated assembly depletiondependent group-constant-based ADD files are used. The assembly data description file generated by PSU-LEOPARD is used as input cross-section library to MCRAC code, which computes normalized power profile of all fuel assemblies of PWR nuclear reactor core. The standard PSO with varying inertial weights is then employed to avoid trapping in local minima. A series of experiments havebeen conducted to obtain near-optimal converged fuelloading pattern of 300 MWe PWR Chashma reactor. The optimized loading pattern is found in good agreement with results found in literature. Hybrid scheme of PSO with simulated annealing has also been implemented and resulted in faster convergence.

关键词： PWR Loading pattern optimization PSO PPF In-core fuel management

Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders

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National Science Review 2019年第6期6卷 1201-1222页

作者： Lian Deng Chao Zhang Kai Yuan Yang Gao Yuwen Pan Xueling Ge Yaoxi He Yuan Yuan Yan Lu Xiaoxi Zhang Hao Chen Haiyi Lou Xiaoji Wang Dongsheng Lu Jiaojiao Liu Lei Tian Qidi Feng asifullah khan Yajun Yang Zi-Bing Jin Jian Yang Fan Lu Jia Qu Longli Kang Bing Su Shuhua Xu Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational BiologyShanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of Sciences School of Life Science and Technology Shanghai Tech University State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences State Key Laboratory of Genetic Engineering and Ministry of Education (MOE) Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University The Eye Hospital School of Ophthalmology &Optometry Wenzhou Medical University China National Center for International Research in Regenerative Medicine and Neurogenetics Institute for Molecular Bioscience Queensland Brain Institute The University of Queensland Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region School of Medicine Xizang Minzu University Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Collaborative Innovation Center of Genetics and Development Human Phenome Institute Fudan University

Human genetic adaptation to high altitudes(>2500 m) has been extensively studied over the last few years,but few functional adaptive genetic variants have been identified, largely owing to the lack of deep-genome sequencing data available to previous studies. Here, we build a list of putative adaptive variants, including 63 missense, 7 loss-of-function, 1,298 evolutionarily conserved variants and 509 expression quantitative traits loci. Notably, the top signal of selection is located in TMEM247, a transmembrane protein-coding *** Tibetan version of TMEM247 harbors one high-frequency(76.3%) missense variant, rs116983452(c.248 C > T; ***83 Val), with the T allele derived from archaic ancestry and carried by >94% of Tibetans but absent or in low frequencies(<3%) in non-Tibetan populations. The rs116983452-T is strongly and positively correlated with altitude and significantly associated with reduced hemoglobin concentration(p = 5.78 × 10), red blood cell count(p = 5.72 × 10) and hematocrit(p = 2.57 × 10). In particular, TMEM247-rs116983452 shows greater effect size and better predicts the phenotypic outcome than any EPAS1 variants in association with adaptive traits in Tibetans. Modeling the interaction between TMEM247-rs116983452 and EPAS1 variants indicates weak but statistically significant epistatic *** results support that multiple variants may jointly deliver the fitness of the Tibetans on the plateau,where a complex model is needed to elucidate the adaptive evolution mechanism.

关键词： Tibetan adaptive genetic variant high-altitude adaptation next-generation sequencing(NGS) archaic ancestry expression quantitative traits loci(eQTL) tissue-specific expression hemoglobin concentration hypoxia

A Synergistic Multi-Attribute Decision-Making Method for Educational Institutions Evaluation Using Similarity Measures of Possibility Pythagorean Fuzzy Hypersoft Sets

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 501-530页

作者： Khuram Ali khan Saba Mubeen Ishfaq Atiqe Ur Rahman Salwa El-Morsy Department of Mathematics University of SargodhaSargodha40100Pakistan Department of Mathematics University of Management and TechnologyLahore54000Pakistan Department of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

Due to the numerous variables to take into account as well as the inherent ambiguity and uncertainty,evaluating educational institutions can be *** concept of a possibility Pythagorean fuzzy hypersoft set(pPyFHSS)is more flexible in this regard than other theoretical fuzzy set-like models,even though some attempts have been made in the literature to address such *** study investigates the elementary notions of pPyFHSS including its set-theoretic operations union,intersection,complement,OR-and *** results related to these operations are also modified for ***,the similarity measures between pPyFHSSs are formulated with the assistance of numerical examples and ***,an intelligent decision-assisted mechanism is developed with the proposal of a robust algorithm based on similarity measures for solving multi-attribute decision-making(MADM)problems.A case study that helps the decision-makers assess the best educational institution is discussed to validate the suggested *** algorithmic results are compared with the most pertinent model to evaluate the adaptability of pPyFHSS,as it generalizes the classical possibility fuzzy set-like theoretical ***,while considering significant evaluating factors,the flexibility of pPyFHSS is observed through structural comparison.

关键词： Hypersoft set Pythagorean fuzzy hypersoft set computational complexity multi-attribute decision-making optimization similarity measures uncertainty

Was Wuhan the early epicenter of the COVID-19 pandemic?——a critique

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National Science Review 2023年第4期10卷 19-21页

作者： Yanan Cao Lingling Chen Hua Chen Yupeng Cun Xiaofeng Dai Hongli Du Feng Gao Fengbiao Guo Yalong Guo Pei Hao Shunmin He Shunping He XiongLei He Zheng Hu Boon-Peng Hoh Xin Jin Qian Jiang Qinghua Jiang asifullah khan Hong-Zhi Kong Jinchen Li Shuai Cheng Li Ying Li Qiang Lin Jianquan Liu Qi Liu Jian Lu Xuemei Lu Shujin Luo Qinghua Nie Zilong Qiu Tieliu Shi Xiaofeng Song Jianzhong Su Sheng-ce Tao Chaolong Wang Chuan-Chao Wang Guo-Dong Wang Jiguang Wang Qi Wu Shaoyuan Wu Shuhua Xu Yu Xue Wenjun Yang Zhaohui Yang Kai Ye Yuan-Nong Ye Li Yu Fangqing Zhao Yiqiang Zhao Weiwei Zhai Dandan Zhang Liye Zhang Houfeng Zheng Qi Zhou Tianqi Zhu Ya-ping Zhang Ruijin Hospital Shanghai Jiao Tong University College of Life Science and Technology Guangxi University Beijing Institute of Genomics Chinese Academy of Sciences Children's Hospital of Chongqing Medical University Wuxi School of Medicine Jiangnan University School of Biology and Biological Engineering South China University of Technology Department of Physics School of ScienceTianjin University School of Pharmaceutical Sciences Wuhan University Institute of Botany Chinese Academy of Sciences Institut Pasteur of Shanghai Chinese Academy of Sciences Institute of Biophysics Chinese Academy of Sciences Institute of Hydrobiology Chinese Academy of Sciences School of Life Sciences Sun Yat-sen University Institute of Synthetic Biology Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Faculty of Medicine and Health Sciences University College Sedaya International School of Medicine South China University of Technology Department of Medical Genetics Capital Institute of Pediatrics School of Life Science and Technology Harbin Institute of Technology Department of Biochemistry Abdul Wali Khan University Xiangya Hospital Central South University Department of Computer Science City University of Hong Kong College of Life Science and Technology Foshan University South China Sea Institute of Oceanology Chinese Academy of Sciences College of Ecology Lanzhou University School of Life Sciences and Technology Tongji University School of Life Sciences Peking University Kunming Institute of Zoology Chinese Academy of Sciences College of Animal Science South China Agricultural University Institute of Neuroscience Chinese Academy of Sciences School of Life Sciences East China Normal University Nanjing University of Aeronautics and Astronautics Wenzhou Institute University of Chinese Academy of Sciences Institute of Systems Biomedicine Shanghai Jiao Tong University Tongji Medical College Huazhong University of Science and Technology School of Life Sciences Xiamen University Division of Life Science and Department of

Recently, Worobey et al.(2022) published a report entitled ‘The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic’ that succinctly summarizes their study [1]. A pre-print version of this study had earlier elicited a series of highprofile media coverages [2,3]. All these reports deliver a social-political message that the Huanan market is the epicenter of COVID-19.

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Exploring Nanoscale Perovskite Materials for Next‑Generation Photodetectors:A Comprehensive Review and Future Directions

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Nano-Micro Letters 2025年第2期17卷 46-108页

作者： Xin Li Sikandar Aftab Maria Mukhtar Fahmid Kabir Muhammad Farooq khan Hosameldin Helmy Hegazy Erdi Akman State Key Laboratory of Pulsed Power Laser Technology National University of Defense TechnologyHefei 230037AnhuiPeople’s Republic of China Anhui Laboratory of Advanced Laser Technology Hefei 230037AnhuiPeople’s Republic of China Nanhu Laser Laboratory Changsha 410015HunanPeople’s Republic of China Department of Semiconductor Systems Engineering and Clean Energy Sejong UniversitySeoul 05006Republic of Korea Department of Artificial Intelligence and Robotics Sejong UniversitySeoul 05006Republic of Korea School of Engineering Science Simon Fraser UniversityBurnabyBC V5A 1S6Canada Department of Electrical Engineering Sejong UniversitySeoul 05006South Korea Department of Physics Faculty of ScienceKing Khalid UniversityP.O.Box 9004AbhaSaudi Arabia Central Labs King Khalid UniversityAlQura’aP.O.Box 96061413 AbhaSaudi Arabia Scientific and Technological Research and Application Center Karamanoglu Mehmetbey University70100 KaramanTurkey

The rapid advancement of nanotechnology has sparked much interest in applying nanoscale perovskite materials for photodetection *** materials are promising candidates for next-generation photodetectors(PDs)due to their unique optoelectronic properties and flexible synthesis *** review explores the approaches used in the development and use of optoelectronic devices made of different nanoscale perovskite architectures,including quantum dots,nanosheets,nanorods,nanowires,and *** a thorough analysis of recent literature,the review also addresses common issues like the mechanisms underlying the degradation of perovskite PDs and offers perspectives on potential solutions to improve stability and scalability that impede widespread *** addition,it highlights that photodetection encompasses the detection of light fields in dimensions other than light intensity and suggests potential avenues for future research to overcome these obstacles and fully realize the potential of nanoscale perovskite materials in state-of-the-art photodetection *** review provides a comprehensive overview of nanoscale perovskite PDs and guides future research efforts towards improved performance and wider applicability,making it a valuable resource for researchers.

关键词： Nanoscale perovskites Photodetectors Nanosheets Nanorods Nanowires Quantum dots Nanocrystals

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Pollution of water resources due to industrialization in arid zone of Rajasthan, India

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Journal of Environmental Sciences 2001年第2期13卷 218-223页

作者： M A khan Central Arid Zone Research Institute Jodhpur-342003 India.

In arid zone of Rajasthan, India, nearly 21,900 hm2 area along Bandi River has been affected by industrial effluent discharge into the river bed. Analysis of groundwater samples collected from these sites revealed that area at the vicinity of the river is most affected. The effluent water in the river is the main source of contamination of ground water. Concentration of sodium and chloride has been higher with proportional increase in TDS and EC value in the area within zone A (river water), zone B (0-100 m), zone C (101-250 m), zone D (251-500 m) and zone E (501-1000 m). There is decreasing trend in ion concentration from zone A to zone E and F, reflecting reduced effect of effluents. The pollution of water resources has resulted in the degradation of other natural resources such as land, soil and vegetation. Nearly 4463 hm2 (20.38%) area has been very severely affected. EC value at places exceeds 20 dS/m. Soil and land have become hard, compact and saline. Cropping intensity has declined. In the area (3633 hm2) affected severely, the EC value of water varies from 10-20 dS/m. Irrigation with such water has created problem of salinity, sodicity in soils. Herbal biomass declined considerably. Double cropping has almost stopped. Almost 8494 hm2 area is affected moderately. EC of ground water varies from 5 to 10 dS/m. Fragile surface crust, declining trend of phosphorous and potassium in the soil, poor density of natural vegetation are significant manifestations. Apart from this, 5305 hm2 area is slightly affected.

关键词： India Pollution of water resources due to industrialization in arid zone of Rajasthan

Accumulation of Pb,Cu,and Zn in native plants growing on contaminated sites and their potential accumulation capacity in Heqing,Yunnan

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Journal of Environmental Sciences 2008年第12期20卷 1469-1474页

作者： Sardar khan Department of Soil Environmental Sciences Research Center for Eco-Environmental Sciences Department of Environmental Sciences University of Peshawar25120 Peshawar

Phytoremediation is one of the cost-effective and environmental friendly technologies used to remove contaminants from contaminated soils,which has been intensively studied during the last ***,few economical and effective remediation methods are available for the remediation of Pb contaminated *** study was conducted to assess the potential of 19 plants growing on contaminated sites in Pb mine *** and associated soil samples were collected and analyzed for total metal concentrati...

关键词： accumulation of Pb Cu and Zn cultivated crops accumulator lead mine remediation

LDH-based nanomaterials for photocatalytic applications:A comprehensive review on the role of bi/trivalent cations, anions,morphology, defect engineering, memory effect, and heterojunction formation

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Journal of Energy Chemistry 2023年第9期84卷 242-276页

作者： Azmat Ali khan Muhammad Tahir Nazish khan Baluchistan University of Information Technology Engineering and Management Sciences(BUITEMS)P.O.Box 87100QuettaPakistan Chemical and Petroleum Engineering Department UAE UniversityP.O.Box 15551Al AinUnited Arab Emirates The University of Agriculture Swat P.O.Box 19040Pakistan

Using sunlight to drive chemical reactions via photocatalysis is paramount for a sustainable *** several photocatalysts,employing layered double hydrides(LDH) for photocatalytic application is most straightforward and desirable owing to their distinctive two-dimensional(2D) lamellar structure and optical *** article reviews the advancements in bimetallic/trimetallic LDHs and various strategies to achieve high efficiency toward an outstanding performing ***,the tuning of LDH components that control the electro nic and structural properties is *** tu ning obtained through the adoption,combination,and incorporation of different cations and anions is also *** progress of modification methods,such as the adoption of different morphologies,delamination,and defect engineering towards enhanced photocatalytic activities,is discussed in the *** band engineering,structural characteristics,and redox tuning are further deliberated to maximize solar energy harvesting for different photocatalytic ***,the progress obtained in forming hierarchical heterostructures through hybridization with other semiconductors or conducting materials is systematically disclosed to get maximum photocatalytic ***,the structural changes during the in-situ synthesis of LDH and the stability of LDH-based photocatalysts are *** review also summarizes the improvements in LDH properties obtained through modification tactics and discusses the prospects for future energy and environmental applications.

关键词： LDH Properties Potential photocatalyst Photocatalytic application Photocatalytic properties Improvement strategies