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Compartmentalized Metabolic Engineering for Artemisinin Biosynthesis and Effective Malaria Treatment by Oral Delivery of Plant Cells

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Molecular Plant 2016年第11期9卷 1464-1477页

作者： Karan Malhotra Mayavan Subramaniyan Khushboo Rawat Md. Kalamuddin M. Irfan Qureshi Pawan Malhotra asif mohmmed Katrina Cornish Henry Daniell Shashi Kumar1 Metabolic Engineering Group Malaria Research Group International Centre for Genetic Engineering and Biotechnology Aruna Asaf Ali Marg New Delhi 110067 India Department of Biotechnology Jamia Millia Islamia New Delhi 110025 India Department of Horticulture and Crop Science The Ohio State University Wooster OH 44691 USA Department of Biochemistry School of Dental Medicine University of Pennsylvania Philadelphia PA 19104 USA

Artemisinin is highly effective against drug-resistant malarial parasites, which affects nearly half of the global population and kills 〉500 000 people each year. The primary cost of artemisinin is the very expensive process used to extract and purify the drug from Artemisia annua. Elimination of this apparently unnecessary step will make this potent antimalarial drug affordable to the global population living in endemic regions. Here we reported the oral delivery of a non-protein drug artemisinin biosynthesized （~0.8 mg/g dry weight） at clinically meaningful levels in tobacco by engineering two metabolic pathways targeted to three different cellular compartments （chloroplast, nucleus, and mitochondria）. The doubly transgenic lines showed a three-fold enhancement of isopentenyl pyrophosphate, and targeting AACPR, DBR2, and CYP71AV1 to chloroplasts resulted in higher expression and an efficient photo-oxidation of di- hydroartemisinic acid to artemisinin. Partially purified extracts from the leaves of transgenic tobacco plants inhibited in vitro growth progression of Plasmodium falciparum-infected red blood cells. Oral feeding of whole intact plant cells bioencapsulating the artemisinin reduced the parasitemia levels in challenged mice in comparison with commercial drug. Such novel synergistic approaches should facilitate low-cost production and delivery of artemisinin and other drugs through metabolic engineering of edible plants.

关键词： bioencapsulation oral delivery of plant material dihydroartemisinic acid isopentenyl pyrophosphate,plant transformation drug biosynthesis

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Quintessence anisotropic stellar models in quadratic and Born-Infeld modified teleparallel Rastall gravity

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Chinese Physics B 2024年第3期33卷 179-189页

作者： Allah Ditta 夏铁成 Irfan Mahmood asif Mahmood Department of Mathematics Shanghai University and Newtouch Center for Mathematics of Shanghai UniversityShanghai 200444China Centre for High Energy Physics University of the PunjabLahorePakistan College of Engineering Chemical Engineering DepartmentKing Saud University RiyadhSaudi Arabia

This study aims to discuss anisotropic solutions that are spherically symmetric in the quintessence field,which describe compact stellar objects in the modified Rastall teleparallel theory of *** achieve this goal,the Krori and Barua arrangement for spherically symmetric components of the line element is *** explore the field equations by selecting appropriate off-diagonal tetrad ***-Infeld function of torsion f(T)=β√λT+1-1 and power law form h(T)=δTn are *** Born-Infeld gravity was the first modified teleparallel gravity to discuss *** use the linear equation of state pr=ξρto separate the quintessence *** obtaining the field equations,we investigate different physical parameters that demonstrate the stability and physical acceptability of the stellar *** use observational data,such as the mass and radius of the compact star candidates PSRJ 1416-2230,Cen X-3,&4U 1820-30,to ensure the physical plausibility of our findings.

关键词： anisotropic spheres quintessence field modified Rastall teleparallel gravity equation of state(EoS) f(T)gravity

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Phonon Thermal Transport at Interfaces of a Graphene/Vertically Aligned Carbon Nanotubes/Hexagonal Boron Nitride Sandwiched Heterostructure

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Chinese Physics Letters 2024年第1期41卷 57-62页

作者：李檬璘 Muhammad asif Shakoori 王瑞鹏李海鹏 School of Materials Science and Physics China University of Mining and TechnologyXuzhou 221116China

Molecular dynamics simulation is used to calculate the interfacial thermal resistance of a graphene/carbon nanotubes/hexagonal boron nitride(Gr/CNTs/hBN)sandwiched heterostructure,in which vertically aligned carbon nanotube(VACNT)arrays are covalently bonded to graphene and hexagonal boron nitride *** find that the interfacial thermal resistance(ITR)of the Gr/VACNT/hBN sandwiched heterostructure is one to two orders of magnitude smaller than the ITR of a Gr/hBN van der Waals heterostructure with the same plane *** is observed that covalent bonding effectively enhances the phonon coupling between Gr and hBN layers,resulting in an increase in the overlap factor of phonon density of states between Gr and hBN,thus reducing the ITR of Gr and *** addition,the chirality,size(diameter and length),and packing density of sandwich-layer VACNTs have an important influence on the ITR of the *** the same CNT diameter and length,the ITR of the sandwiched heterostructure with armchair-shaped VACNTs is higher than that of the sandwiched heterostructure with zigzag-shaped VACNTs due to the different chemical bonding of chiral CNTs with Gr and *** the armchair-shaped CNT diameter increases or the length decreases,the ITR of the sandwiched heterostructure tends to ***,the increase in the VACNT packing density also leads to a continuous decrease in the ITR of the sandwiched heterostructure,attributed to the extremely high intrinsic thermal conductivity of CNTs and the increase of out-of-plane heat transfer *** work may be helpful for understanding the mechanism for ITR in multilayer vertical heterostructures,and provides theoretical guidance for a new strategy to regulate the interlayer thermal resistance of heterostructures by optimizing the design of sandwich layer thermal interface materials.

关键词： sandwich shaped packing

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Caching Strategies in NDN Based Wireless Ad Hoc Network:A Survey

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Computers, Materials & Continua 2024年第7期80卷 61-103页

作者： Ahmed Khalid Rana asif Rehman Byung-Seo Kim Department of Computer Science FAST School of ComputingNational University of Computer and Emerging SciencesLahore54000Pakistan Department of Software and Communications Engineering Hongik UniversitySejong City30016Republic of Korea

Wireless Ad Hoc Networks consist of devices that are wirelessly *** Ad Hoc Networks(MANETs),Internet of Things(IoT),and Vehicular Ad Hoc Networks(VANETs)are the main domains of wireless ad hoc *** is used in wireless ad hoc *** is based on Transmission Control Protocol(TCP)/Internet Protocol(IP)network where clients and servers interact with each other with the help of IP in a pre-defined *** fetches data from a fixed *** redundancy,mobility,and location dependency are the main issues of the IP network *** these factors result in poor performance of wireless ad hoc *** main disadvantage of IP is that,it does not provide in-network ***,there is a need to move towards a new network that overcomes these *** Data Network(NDN)is a network that overcomes these *** is a project of Information-centric Network(ICN).NDN provides in-network caching which helps in fast response to user *** NDN in wireless ad hoc network provides many benefits such as caching,mobility,scalability,security,and *** considering the certainty,in this survey paper,we present a comprehensive survey on Caching Strategies in NDN-based Wireless *** cachingmechanism-based results are also *** the last,we also shed light on the challenges and future directions of this promising field to provide a clear understanding of what caching-related problems exist in NDN-based wireless ad hoc networks.

关键词： Content centric network Internet of Things mobile ad hoc network named data network vehicular ad hoc network

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Synthesis and Thermal Characterization of Solar Salt-Based Phase Change Composites with Graphene Nanoplatelets

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Journal of Thermal Science 2024年第2期33卷 491-500页

作者： Pethurajan VIGNESHWARAN Saboor SHAIK Sivan SURESH Müslüm ARICI asif AFZAL Department of Thermal and Energy Engineering School of Mechanical Engineering(SMEC)Vellore Institute of TechnologyVelloreTamil NaduIndia Nanotechnology Research Laboratory Department of Mechanical EngineeringNational Institute of TechnologyTiruchirappalliTamil NaduIndia Mechanical Engineering Department Engineering FacultyKocaeli UniversityUmuttepe CampusKocaeli41001Turkey Department of Mechanical Engineering P.A.College of Engineering(affiliated to Visvesvaraya Technological UniversityBelagavi)Mangaluru574153India

Thermal energy storage(TES) systems use solar energy despite its irregular availability and day-night temperature *** work reports the thermal characterizations of solar salt-based phase change composites in the presence of graphene nanoplatelets(GNP).Solar salt(60:40 of NaNO_(3):KNO_(3)) possessing phase transition temperature and melting enthalpy of 221.01℃ and 134.58 kJ/kg is proposed as a phase change material(PCM) for high-temperature solar-based energy storage *** conductivity must be improved to make them suitable for widespread applications and to close the gap between the system needs where they are *** is added at weight concentrations of 0.1%,0.3%,and 0.5% with solar salt using the ball milling method to boost its thermal *** studies indicated the formation of a uniform surface of GNP on solar *** spectrum peaks identified the physical interaction between salt and *** characterization of the composites,such as thermal conductivity,DSC and TGA was carried out for the samples earlier and later 300 thermal cycles.0.5% of GNP has improved the thermal conductivity of salt by 129.67% and after thermal cycling,the enhancement reduced to 125.21% indicating that thermal cycling has a minor impact on thermal *** change temperature decreased by around 2.32% in the presence of0.5% GNP and the latent heat reduced by 4.34% after thermal *** thermograms depicted the composites initiated the weight loss at around 550℃ after which it was *** thermal cycling,the weight loss initiated at ~40℃ lower compared to pure salt,which was found to be a minor *** characterization of solar salt and GNP-based solar salt composites revealed that the composites can be used for enhanced heat transfer in high-temperature solar-based heat transfer and energy storage applications.

关键词： thermal energy storage high temperature solar salt graphene nanoplatelets thermal characterization

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A Comprehensive Systematic Review: Advancements in Skin Cancer Classification and Segmentation Using the ISIC Dataset

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2131-2164页

作者： Madiha Hameed Aneela Zameer Muhammad asif Zahoor Raja Department of Computer Sciences Pakistan Institute of Engineering and Applied SciencesNilore50700Islamabad Future Technology Research Center National Yunlin University of Science and TechnologyDouliou64002TaiwanChina Directorate of IT Services University of GujratGujrat50700Pakistan

The International Skin Imaging Collaboration(ISIC)datasets are pivotal resources for researchers in machine learning for medical image analysis,especially in skin cancer *** datasets contain tens of thousands of dermoscopic photographs,each accompanied by gold-standard lesion diagnosis *** challenges associated with ISIC datasets have spurred significant advancements,with research papers reporting metrics surpassing those of human *** cancers are categorized into melanoma and non-melanoma types,with melanoma posing a greater threat due to its rapid potential for metastasis if left *** paper aims to address challenges in skin cancer detection via visual inspection and manual examination of skin lesion images,processes historically known for their *** notable advancements in machine learning and deep learning models,persistent challenges remain,largely due to the intricate nature of skin lesion *** review research on convolutional neural networks(CNNs)in skin cancer classification and segmentation,identifying issues like data duplication and augmentation *** explore the efficacy of Vision Transformers(ViTs)in overcoming these challenges within ISIC dataset *** leverage their capabilities to capture both global and local relationships within images,reducing data duplication and enhancing model ***,ViTs alleviate augmentation issues by effectively leveraging original *** a thorough examination of ViT-based methodologies,we illustrate their pivotal role in enhancing ISIC image classification and *** study offers valuable insights for researchers and practitioners looking to utilize ViTs for improved analysis of dermatological ***,this paper emphasizes the crucial role of mathematical and computational modeling processes in advancing skin cancer detection methodologies,highlighting their significance in improving algorithmic

关键词： Medical image skin cancer classification skin cancer segmentation international skin imaging collaboration convolutional neural network deep learning

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Impact of natural resource mining on sustainable economic development:The role of education and green innovation in China

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Geoscience Frontiers 2024年第3期15卷 346-357页

作者： Xing Li Lina Ma asif M.Ruman Najaf Iqbal Wadim Strielkowski School of Media&Linguistics Anhui University of Finance&EconomicsBengbuAnhuiChina Graduate School of Management&Information Technology Hannan UniversityJapan School of Accounting Wuhan Textile UniversityWuhanHubeiChina Business School University of OuluOuluFinland School of Finance Anhui University of Finance and EconomicsBengbu 233030AnhuiChina Africa-Asia Centre for Sustainability Business SchoolUniversity of AberdeenScotlandUK Department of Trade and Finance Faculty of Economics and ManagementCzech University of Life Sciences PragueKamycká129Prague 616500 PragueCzech Republic Centre for Energy Studies Cambridge Institute for Advanced StudiesKing str.23CB11AH CambridgeUK

As the extraction and usage of natural resources continue to be a double-edged sword-supporting economic growth but deteriorating the environment-we study the impact of natural resource mining on sustainable economic development in the largest(PPP)*** use province-level data from 2001 to 2020 and employ econometric panel techniques,such as fixed effects,two-stage least squares,and a battery of robustness *** further explore the potential effects of education and green innovation in mitigating/exacerbating the role of natural resources in the Chinese provincial *** results show that:(1)Natural resource mining hurts sustainable development,verifying the“resource curse”effect.(2)Green innovation and education restrain the negative impact of resource mining on sustainable development,turning the curse into a blessing.(3)A regional heterogeneity is observed in the impact of resource mining on sustainable development,showing more significant effects in the Western and low-urbanized regions.(4)Green innovation and education can assuage the curse effect of natural resources into gospel *** implications and recommendations are proposed in light of the findings to promote sustainable economic development in China.

关键词： Natural resource mining Sustainable economic growth Education Green innovation Resource curse China

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An asymmetrical multilevel inverter with minimum voltage stress and fewer components for photovoltaic renewable-energy system

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Clean Energy 2024年第1期8卷 1-22页

作者： Rabail Memon Mukhtiar Ahmed Mahar Abdul Sattar Larik Syed asif Ali shah Department of Electrical Engineering Mehran University of Engineering and TechnologyJamshoroPakistan

The enhanced power quality provided by multilevel inverters(MLIs)has made them more appropriate for medium-and high-power applications,including photovoltaic ***,a prevalent limitation involves the necessity for numerous switches and increased voltage stress across these switches,consequently increasing the overall system *** address these challenges,a new 17-level asymmetrical MLI with fewer components and low voltage stress is proposed for the photovoltaic *** innovative MLI configuration has four direct current(DC)sources and 10 *** on the trinary sequence,the proposed topology uses photovoltaics with boost converters and fuzzy logic controllers as its DC *** equations are used to calculate cru-cial parameters for this proposed design,including total standing voltage per unit(TSVPU),cost function per level(CF/L),component count per level(CC/L)and voltage stress across the *** comparison is conducted by considering switches,DC sources,TSVPU,CF/L,gate driver circuits and CC/L with other existing MLI *** analysis is carried out under various conditions,encompassing different levels of irradiance,variable loads and modulation *** reduce the total harmonic distortion of the suggested topology,the phase opposition disposition approach has been *** suggested framework is simulated in MATLAB®/Simulink®.The results indicate that the proposed topology achieves a well-distributed stress profile across the switches and has CC/L of 1.23,TSVPU of 5 and CF/L of 4.58 and 5.76 with weight coefficients of 0.5 and 1.5,*** values are not-ably superior to those of existing MLI *** results demonstrate that the proposed topology maintains a consistent output at varying irradiance levels with FLCs and exhibits robust performance under variable loads and diverse modulation ***,the total harmonic distortion achieved with phase opposition disposi

关键词： asymmetrical multilevel inverter photovoltaic system renewable energy component count per level cost function per level total standing voltage per unit phase opposition disposition technique

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Core-shell design of UiO66-Fe_(3)O_(4) configured with EDTA-assisted washing for rapid adsorption and simple recovery of heavy metal pollutants from soil

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Journal of Environmental Sciences 2024年第5期139卷 556-568页

作者： Xi Wang asif Hussain Qingqing Li Mingyu Ma Juan Wu Mingqiang Deng Jie Yang Dengxin Li Department of Environmental Science and Engineering Donghua UniversityShanghai 201620China Department of Environmental Science Federal Urdu University of ArtsScience and Technology75300 KarachiPakistan Shanghai Academy of Environmental Sciences Shanghai 200233China

The coupling of washing with adsorption process can be adopted for the treatment of soils contaminated with heavy metals ***,the complex environment of soil and the competitive behavior of leaching chemicals considerably restrain adsorption capacity of adsorbent material during washing process,which demands a higher resistance of the adsorbents to *** this study,we synthesized strongly magnetic,high specific surface area(573.49 m^(2)/g)UiO66 composites(i.e.,UiO66-Fe_(3)O_(4))using hydrothermal *** UiO66-Fe_(3)O_(4) was applied as an adsorbent during the ethylene diamine tetraacetic acid(EDTA)-assisted washing process of contaminated *** incorporation of UiO66-Fe_(3)O_(4)results in rapid heavy metal removal and recovery from the soil under low concentrations of washing agent(0.001 mol/L)with reduced residual heavy metal mobility of soil after ***,UiO66-Fe_(3)O_(4)can quickly recollect by an external magnet,which offers a simple and inexpensive recovery method for heavy metals from contaminated ***,UiO66-Fe_(3)O_(4)configuration with EDTA-assisted washing process showed opportunities for heavy metals contaminated sites.

关键词： UiO66 composites Metal-EDTA complexes EDTA-assisted washing Heavy metals recovery Soil

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Impact of Proteinuria on Liver Enzyme Levels

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 759-760页

作者： David Yardeni asif Hitawala Lilian Howard Theo Heller Meryl Waldman Department of Gastroenterology and Liver Diseases Soroka University Medical CenterBeer-ShevaIsrael Liver Diseases Branch National Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMDUSA Kidney Diseases Branch National Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMDUSA

Dear Editors,We read with great interest the recently published article“Subnormal Serum Liver Enzyme Levels:A Review of Pathophysiology and Clinical Significance”by Youssef and colleagues.1 While much attention is given to elevations of liver enzymes,the authors highlight clinically important,often unrecognized reasons leading to low liver enzyme *** example,chronic kidney disease was cited as a cause of low serum aspartate aminotransferase(AST)proportional to the progression of the disease,but the cause(s)are not well *** is known about the possible influence of nephrotic syndrome(NS)on liver enzymes.

关键词： Impact Liver Levels

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