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Metagenomics and microbiome of infant:old and recent instincts

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Microenvironment & Microecology Research 2022年第2期4卷 1-10页

作者： Tejswini Sontakke ashwini biradar Prashant Dixit Dinesh Nalage Department of Zoology MGV'sMPH Mahila CollegeMalegaon 423105India Department of Microbiology Dr.B.A.M.UniversitySub Campus OsmanabadOsmanabad 413501India Department of Molecular Biology SRL LimitedMumbai 400062India

The human microbiota is made up of trillions of bacteria that live in the human being,whereas the microbiome is made up of the microbiota's genes and gene *** have long been thought of as pathogens that eventually lead to human *** are increasingly recognized as generally beneficial commensal organisms and hence crucial to proper and healthy human development,thanks to breakthroughs in both cultivation-based approaches and the advent of *** relatively new field of medical study has given more information on illnesses such as inflammatory bowel disease,obesity,metabolic and atopic ***,there is a lot we don't know about the complexities of microbe-microbe and microbe-host *** work targeted at resolving crucial concerns about the early formation of the microbiome,in addition,what determines its dysbiosis,will most likely lead to long-term mitigation of *** this article,review the research on prenatal and newborn microbiome modulations,the role of maternal and environmental variables on forming the newborn microbiome,and future issues and directions in the exciting new field of metagenomic medicine.

关键词： metagenomics microbiome interactions health bacteria organism

Zinc:an essential trace element for human health and beyond

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Food and Health 2023年第3期5卷 12-18页

作者： Rohit Patil Tejswini Sontakke ashwini biradar Dinesh Nalage Department of Botany Government Institute of ScienceAurangabad 431004India Department of Zoology MGV'sMPH Mahila CollegeMalegaon 423105India Department of Microbiology Dr.B.A.M.UniversitySub Campus OsmanabadOsmanabad 413501India Department of Molecular Biology&Microbiology One Step Molecular DiagnosticAurangabad 431003India

Zinc is an essential element that plays a crucial role in the chemistry and biochemistry of living *** serves as a cofactor for numerous enzymes and transcription factors,contributing to DNA synthesis,protein synthesis and cellular ***,zinc acts as a structural component of proteins and participates in cellular signaling *** chemistry of zinc is determined by its electronic configuration,and it readily forms coordination complexes with various *** review explores the diverse functions of zinc in the body,including its involvement in enzyme activity,immunity,neutrophil function,modulation of allergies,its relationship with COVID-19,antioxidant and anti-inflammatory properties,mental health,pregnancy and wound *** has a history of use in traditional medicine systems,and its benefits and applications should be evaluated in the context of current scientific research and medical *** the roles of zinc in these processes highlights its importance as an essential nutrient for overall health and provides insights into potential therapeutic ***,further advancement in understanding the biological function of zinc requires addressing certain *** include overcoming methodological challenges,investigating tissue and cell-type specificity,understanding zinc interactions and redundancy,and employing integrated approaches,advanced imaging techniques,comparative studies,and systems biology approaches to gain a deeper understanding of zinc’s implications in health and disease.

关键词： zinc biochemistry deficiency immune system enzymes

Evaluation of antiplasmodial properties in 15 selected traditional medicinal plants from India

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Journal of Integrative Medicine 2020年第1期18卷 80-85页

作者： Yogesh Subhash biradar Swathi Bodupally Harish Padh Department of Pharmacognosy and Phytochemistry Bharat School of PharmacyMangalpallyIbrahimpatnamHyderabad 501510TelanganaIndia Department of Pharm D Bharat School of PharmacyMangalpallyIbrahimpatnamHyderabad 501510TelanganaIndia Department of Biotechnology B.V.Patel Pharmaceutical Education and Research Development CentreThaltej-Gandhinagar HighwayThaltejAhmedabad 380054GujaratIndia

Objective:The objective of this study was to evaluate the in vitro antiplasmodial properties against malaria parasite in 15 plants mentioned in Indian traditional medicine ***:In vitro antiplasmodial activity of methanolic extracts obtained from Indian traditional medicinal plants was evaluated on Plasmodium falciparum of FCK2 and INDO strains using schizont maturation inhibition assay and parasite lactate dehydrogenase inhibition ***:Methanolic extracts of Adhatoda zeylanica,Embelia ribes,Piper nigrum and Plumbago zeylanica exhibited more than 50%inhibition in both the stains in schizont maturation inhibition *** extracts of seven medicinal plants exhibited antiplasmodial activity at half maximal inhibitory concentration(IC50)<100 mg/m L,and methanolic extracts of five medicinal plants exhibited antiplasmodial activity at IC50<50 mg/m L in *** lactate dehydrogenase(PfLDH)inhibition ***,*** and *** exhibited promising antiplasmodial activity in PfLDH inhibition *** and *** exhibited improved activity against resistant in comparison to sensitive ***:*** and *** were the most promising extracts from this study and deserve further investigation of their antiplasmodial properties.

关键词： Medicinal plants Plasmodium falciparum Schizont maturation inhibition assay Lactate dehydrogenase inhibition assay Cytotoxicity

Improved region growing segmentation for breast cancer detection:progression of optimized fuzzy classifier

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International Journal of Intelligent Computing and Cybernetics 2020年第2期13卷 181-205页

作者： Rajeshwari S.Patil Nagashettappa biradar Department of Electronics and Communication BLDEA’s V P Dr PG Halakatti College of Engineering and TechnologyBijapurIndia Department of Electronics and Communication Bheemanna Khandre Institute of TechnologyBidarIndia

Purpose-Breast cancer is one of the most common malignant tumors in women,which badly have an effect on women’s physical and psychological health and even danger to ***,mammography is considered as a fundamental criterion for medical practitioners to recognize breast ***,due to the intricate formation of mammogram images,it is reasonably hard for practitioners to spot breast cancer ***/methodology/approach-Breast cancer is one of the most common malignant tumors in women,which badly have an effect on women’s physical and psychological health and even danger to ***,mammography is considered as a fundamental criterion for medical practitioners to recognize breast ***,due to the intricate formation of mammogram images,it is reasonably hard for practitioners to spot breast cancer ***-The performance analysis was done for both segmentation and *** the analysis,the accuracy of the proposed IAP-CSA-based fuzzy was 41.9%improved than the fuzzy classifier,2.80%improved than PSO,WOA,and CSA,and 2.32%improved than GWO-based fuzzy ***,the accuracy of the developed IAP-CSA-fuzzy was 9.54%better than NN,35.8%better than SVM,and 41.9%better than the existing fuzzy ***,it is concluded that the implemented breast cancer detection model was efficient in determining the normal,benign and malignant ***/value-This paper adopts the latest Improved Awareness Probability-based Crow Search Algorithm(IAP-CSA)-based Region growing and fuzzy classifier for enhancing the breast cancer detection of mammogram images,and this is the first work that utilizes this method.

关键词： Mammogram Breast cancer detection Optimized region growing Membership optimized-fuzzy classifier Improved crow search algorithm

Common effluent treatment plant(CETP):Reliability analysis and performance evaluation

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Water Science and Engineering 2018年第3期11卷 205-213页

作者： ashwini V.Padalkar Rakesh Kumar CSIR-National Environmental Engineering Research Institute(NEERI) Mumbai 400018India

Common effluent treatment plants(CETPs) have been installed and are in operation at numerous industrial clusters throughout India. They serve to reduce effluent treatment cost, provide better collective treatment, and reduce land cost for small-scale industrial facilities that cannot afford individual treatment plants. Optimum working conditions for treatment of effluent to be at par with discharge standards is a major mandate for any CETP. In this study, the reliability and removal efficiencies(REs) of a CETP in the industrial area of Maharashtra State in India were examined. An established methodology was adopted to determine the effectiveness of the CETP in terms of biochemical oxygen demand(BOD), chemical oxygen demand(COD), total suspended solids(TSS), and oil and grease(O&G) concentrations. The CETP's compliance with respect to design standards and its operation were studied in detail. This paper highlights the results of RE and the coefficient of determination(R2) values obtained from the CETP data, estimates the pollutants removed at the highest and lowest rates over a period of time, and highlights the reasons for problem areas along with remedial measures. It was observed that, except O&G, all the parameters(BOD, COD, and TSS)showed fluctuations in removal efficiencies and their reliabilities. This situation can be improved by releasing effluent containing hydraulic and organic loading to the CETP as per standards and optimizing treatment processes, especially primary clari-flocculators and aeration tanks, both of which are important units of any CETP.

关键词： Aeration tank Clari-flocculator Coefficient of reliability Coefficient of variation Common effluent treatment plant Removal efficiency Reliability analysis

Rare earth(La)and metal ion(Pb)substitution induced structural and multiferroic properties of bismuth ferrite

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Journal of Advanced Ceramics 2015年第4期4卷 292-299页

作者： Poorva SHARMA ashwini KUMAR Dinesh VARSHNEY Materials Science Laboratory School of PhysicsVigyan BhawanDevi Ahilya UniversityKhandwa Road CampusIndore 452001India Department of Physics Southeast UniversityJiangning DistrictNanjing 211189China

In this study,bulk samples of multiferroic with compositional formula,BiFeO3 and Bi_(0.825)A_(0.175)FeO_(3)(A=La,Pb),were synthesized by solid state reaction route.X-ray diffraction(XRD)along with the Rietveld refinement revealed the distorted rhombohedral(R3c)structure for pristine BiFeO3 and Bi0.825La0.175FeO3 and tetragonal(P4/mmm)for Bi_(0.825)Pb_(0.175)FeO_(3)*** support the structural results,bond length between atoms for both of the compounds was calculated.A change in Raman mode position in BiFeO3(BFO)has been observed with La and Pb substitution from Raman scattering measurements and also recommended a structural change with rare earth and metal ion substitution at Bi *** the frequency dependent dielectric constant and dielectric loss plots,a decrease in dielectric values with increase in frequency was observed for both of the *** microelectronic devices,porous ceramics with lower value of dielectric constant are most ***,further studies are also needed to carefully tune the magnetoelectric properties and structural distortion after La/Pb substitution in BFO.

关键词： ceramics X-ray diffraction(XRD) Raman spectroscopy dielectric properties

In situ synthesis of Ag-SiO_2 Janus particles with epoxy functionality for textile applications

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Particuology 2015年第2期13卷 107-112页

作者： Kamlesh Panwar Manjeet Jassal ashwini K.Agrawal SMITA Research Labs Department of Textile TechnologyIndian Institute of Technology

A facile method for the synthesis of silver-silica （Ag-SiO2）Janus particles with functionalities suitable for textile applications is reported. Silica nanoparticles prepared by the StOber method were functionalized with epoxy, amine, and thiol groups, which were confirmed by Fourier transform infrared analysis. The functionalized silica nanoparticles were used to produce Pickering emulsions, and the exposed surface was used for the attachment of silver nanoparticles （AgNPs） via the low-temperature chemical reduction method. The morphology and structure of the Ag-SiO2 Janus particles were characterized by scanning electron microscopy, scanning transmission electron microscopy, high-resolution transmission electron microscopy, energy-dispersive X-ray analysis, and UV-vis spectroscopy. Because of their specific functionalities, these Ag-SiO2 Janus particles are proposed for applications on textile substrates, as they can overcome several drawbacks of direct application of AgNPs on textiles, such as leaching, agglomeration, and instability during storage.

关键词： Ag-SiO2 Janus particles Picketing emulsion Textile applications

Emerging mosquito-borne arboviral infection Zika-An epidemiological review

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Asian Pacific Journal of Tropical Biomedicine 2020年第5期10卷 193-200页

作者： ashwini Malla Balamurugan Shanmugaraj Sathishkumar Ramalingam Plant Genetic Engineering Laboratory Department of BiotechnologyBharathiar UniversityCoimbatoreTamil NaduIndia

The unprecedented resurgence and geographical expansion of arboviral infections such as dengue, chikungunya, yellow fever, and Zika have a significant impact on human health and pose a serious threat to public health globally in recent years. Zika virus is a Flavivirus and is transmitted to humans through an infected mosquito bite. The Zika virus has been identified in many countries in Africa, Asia, and Pacific islands and sporadic human cases have been reported since 1947. The non-specific clinical symptoms of Zika fever are often misdiagnosed with other arboviral infections, especially dengue and chikungunya. Till now, there is no vaccine or specific antiviral treatment for Zika infection. The recent emergence of Zika is alarming and highlights the need for arboviral research to develop an effective treatment. Here in this review, we discussed the epidemiology of Zika, which has re-emerged in the recent decade and caused international concern.

关键词： Arboviruses Epidemiology Mosquito Zika

Atmospheric pressure plasma-assisted green synthesis of amphiphilic SiO2 Janus particles

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Particuology 2017年第4期15卷 50-54页

作者： Kamlesh Panwar Manjeet Jassal ashwini K. Agrawal SMITA Research Lab Department of Textile Technology Indian Institute of Technology Delhi Hauz Khas New Delhi 11 O016 India

A facile green approach for the synthesis of amphiphilic SiO2 Janus particles using low temperature atmospheric pressure plasma is reported in this study. Monodispersed SiO2 particles were masked by embedding half of their surface inside a polystyrene film. The exposed surfaces of the SiO2 particles were readily modified using He/CF3 CFH2 low-temperature atmospheric pressure plasma to obtain amphiphilic Janus particles. Their amphiphilic nature was confirmed using fluorescent microscopy by tagging their hydrophilic part with a fluorescent dye. The present method can be used to generate amphiphilic Janus particles with a variety of functionalities, which may find applications as surfactants and surface modifying agents.

关键词： Hydrophilic Hydrophobic SiO2 FITC Atmospheric pressure plasma