检索结果-南通市图书馆

Thymoquinone as a potential therapeutic for Alzheimer’s disease in transgenic Drosophila melanogaster model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2021年第5期45卷 1251-1262页

作者： narayanan NAMPOOTHIRI V.P. VIGNESH SUNDARARAJAN PALLAVI DAN G.DEVANAND VENKATASUBBU SAHABUDEEN SHEIK MOHIDEEN Department of Biotechnology School of BioengineeringSRM Institute of Science and TechnologyKattankulathur603203India Department of Physics and Nanotechnology School of BioengineeringSRM Institute of Science and TechnologyKattankulathur603203India

Alzheimer’s disease(AD)is one of the most common forms of *** dysfunction and memory loss are the two main clinical symptoms of *** melanogaster models of AD,which are based on overexpression of human amyloidβ(Aβ)or human tau(hTau)protein,have been used to study the mechanism underlying AD and to screen potential therapeutic *** that are currently available for AD provide only symptomatic *** unmet medical needs exists to slow,stop,or reverse the progression of ***(TQ)is an active ingredient isolated from Nigella sativa(NS)and possesses various pharmacological activities,and it is also a potential neuropharmacological *** current study was performed to investigate the effect of dietary administration of TQ at concentrations of 12.5μM and 25μM for 15 and 30 days on biochemical and behavioral parameters,gene,and protein expression of hTau,using Drosophila models of *** Drosophila models exhibiting pan-neuronal and eye-specific expression of hTau were generated using the GAL4/UAS *** with TQ at both concentrations resulted in a significant increase in behavioral activity,a significant reduction in the amount of reactive oxygen species(ROS),and restoration of depleted superoxide dismutase(SOD)and acetylcholine esterase(AChE)activities.A significant decrease in gene and protein expression of hTau was also observed at the molecular level for both concentrations of ***,TQ has the potential to be investigated as a potential therapeutic phytochemical for the treatment of AD in future studies.

关键词： hTau GAL4/UAS system Nigella sativa

A Survey of Techniques for Brain Anomaly Detection and Segmentation Using Machine Learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Communications, Network and System Sciences 2023年第7期16卷 151-167页

作者： Kamala narayanan Shahram Latifi Department of Electrical and Computer Engineering University of Nevada Las Vegas Las Vegas Nevada USA

In this research report, various Machine Learning (ML) models are discussed for the purpose of detecting brain anomalies like tumors. In the first step, we review previous work that uses Deep Learning (DL) to classify and detect brain tumors. Next, we present a detailed analysis of the ML methods in tabular form to address the brain tumor morphology, accessible datasets, segmentation, extraction, and classification using DL, and ML models. Finally, we summarize all relevant material for tumor detection, including the merits, limitations and future directions. In this study, it is found that employing DL-based and hybrid-based metaheuristic approaches proves to be more effective in accurately segmenting brain tumors, compared to the conventional methods. However, the brain tumor segmentation using ML models suffers from drawbacks due to limited labelled data, variability in tumor appearance, computational memory requirements, transparency in models, and difficulty in integration into clinical workflows. By pursuing techniques such as Data Augmentation, Pre-training, Active-learning, Multimodal fusion, Hardware acceleration, and Clinical integration, researchers and developers can overcome the bottlenecks and enhance the accuracy, efficiency, and clinical utility of ML-based brain tumor segmentation models.

关键词： Department of Electrical and Computer Engineering University of Nevada Las Vegas Las Vegas Nevada USA

Shock Induced Chemical Reactions of Intermetallic Mixture of Nickel and Aluminum and Associated Transition States

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science and Chemical Engineering 2021年第4期9卷 60-67页

作者： Vindhya narayanan Sathya Hanagud Georgia Institute of Technology Atlanta GA USA

In this paper, numerical simulation of shock-induced chemical reactions of intermetallic mixtures is discussed. Specifically, the paper focuses on intermetallic mixture of nickel and aluminum. To initiate the chemical reactions, the thermal input or the shockwave should supply the energy to take the reactants, mixture of nickel and aluminum, to the transition state. Thus, for any numerical simulation or analysis of the shock or thermally induced chemical reaction in a continuum scale or a meso scale, it is necessary to identify the transition state. The transition state for the intermetallic mixture of nickel and the aluminum is identified in this paper and a result of the numerical simulation of the shock-induced chemical reaction, in a continuum scale is presented. The numerical solutions clearly show the chemical reactions, release of heat energy, increase of the temperature and the formation of products, following the transition state and the resulting shock-induced chemical reaction of a binary intermetallic energetic mixture of nickel and aluminum. The studies also show that the collapse of porosity is a mechanism that takes the reactants to the transition state, in shock-induced chemical reactions of binary intermetallic mixtures.

关键词： Transition State Shock Induced Chemical Reaction Void Collapse NIckel-Aluminum Energetic Mixture

Transition States for Shock Induced Chemical Reactions in Binary Energetic Materials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science and Chemical Engineering 2020年第7期8卷 27-35页

作者： Vindhya narayanan Sathya Hanagud Georgia Institute of Technology Atlanta GA USA

In this paper, numerical simulation of shock induced chemical reactions of a thermite mixture of binary energetic material, aluminum and iron oxide, are discussed. To initiate the chemical reactions, the impact or the shockwave should supply the energy to take the reactants, aluminum and iron oxide, to the transition state. Thus, for any numerical simulation of the shock or impact induced chemical reaction in a continuum or mesoscale, it is necessary to identify the transition state. The transition state for the thermite mixture, of aluminum and iron oxide, is identified in this paper and a result from a numerical simulation of the shock induced chemical reaction, in a continuum scale is presented.

关键词： Numerical Simulation Chemical Reaction

Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline Proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor Julian C.Schmidt Michael A.Schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton Jaime Mateus Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

Simulated Annealing Algorithm to Minimize Makespanin Single Machine Scheduling Problem withUniform Parallel Machines

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intelligent Information Management 2011年第1期3卷 22-31页

作者： Panneerselvam Senthilkumar Sockalingam narayanan 不详

This paper presents a simulated annealing algorithm to minimize makespan of single machine scheduling problem with uniform parallel machines. The single machine scheduling problem with uniform parallel machines consists of n jobs, each with single operation, which are to be scheduled on m parallel machines with different speeds. Since, this scheduling problem is a combinatorial problem;usage of a heuristic is inevitable to obtain the solution in polynomial time. In this paper, simulated annealing algorithm is presented. In the first phase, a seed generation algorithm is given. Then, it is followed by three variations of the simulated annealing algorithms and their comparison using ANOVA in terms of their solutions on makespan.

关键词： Uniform Parallel Machines Measure of Performance Heuristic Simulated Annealing Algorithm ANOVA

Transoral endoscopic excision of a giant parapharyngeal space tumour:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Laparoscopic, Endoscopic and Robotic Surgery 2021年第2期4卷 53-56页

作者： Yazid Bin Pol Ong Liew Yew Toong Sakina Binti Gauth Prepageran narayanan Department of Otolaryngology University of Malaya Medical CentreKuala Lumpur 59100Malaysia

Most of the parapharyngeal space tumours are *** primary treatment is complete resection of the *** to its location in the deep neck space,a pre-styloid tumour can be resected via the transoral ***,the surgical field is limited by the small oral *** the use of rigid endoscopes,removing benign tumours through transoral approach in the parapharyngeal space is possible as they provide a broad and enlarged view of the confined ***,we report a case of a 64-year-old male with a giant pre-styloid parapharyngeal space tumour,who successfully underwent transoral endoscopic ***,the patient had short hospital stay of total 3 *** chewing and swallowing were not affected,and he resumed oral feeding prior to discharge.

关键词： Parapharyngeal space Salivary gland tumour Transoral endoscopic surgery

Ce-SAD Phasing of Glucose Isomerase and Thermolysin Using Cu <i>Kα</i>Radiation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Crystal Structure Theory and Applications 2013年第3期2卷 93-99页

作者： Sibi narayanan Devadasan Velmurugan Centre of Advanced Study in Crystallography and Biophysics University of Madras Maraimalai (Guindy) Campus Chennai India

Current structural genomics projects aim to solve a large number of selected protein structures as fast as possible. High degree of automation and standardization is required at every step of the whole process to speed up protein structure determination. Phase problem is a bottleneck in macromolecular structure determination and also in model building which is a time-consuming task. The simplest approach to phasing macromolecular crystal structures is the use of a SAD signal. SAD data can be collected using the in-house copper (1.54 A) wavelength source. Data collected using copper wavelength with the incorporation of anomalously scattering heavy metal atoms may serve as a powerful tool for structural biologists to solve novel protein structures as well where synchrotron beam line is not available. A short soak of protein crystals in heavy metal solution or by incorporating heavy atoms into the protein drop while crystallizing the protein (co-crystallization) leads to incorporation of these heavy metal ions into the ordered solvent shell around the protein surface. The present work aims to determine whether cerium ion can be successfully incorporated into the protein crystal through quick-soaking method while maintaining the isomorphism. The study also aims in understanding whether this metal ion can be used for phasing purpose. The intensity data are collected and analyzed for anomalous signal, substructure solution and the binding sites.

关键词： Anomalous Scattering SAD phasing Ce Glucose Isomerase Thermolysin

Lab Source Anomalous Scattering Using Cr Kα Radiation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Crystal Structure Theory and Applications 2013年第2期2卷 57-64页

作者： Sibi narayanan Devadasan Velmurugan Centre of Advanced Study in Crystallography and Biophysics University of Madras Maraimalai (Guindy) Campus Chennai India

High-throughput crystallography requires a method by which the structures of proteins can be determined quickly and easily. Experimental phasing is an essential technique in determining the three-dimensional protein structures using single-crystal X-ray diffraction. In macromolecular crystallography, the phases are derived either by Molecular Replacement (MR) method using the atomic coordinates of a structurally similar protein or by locating the positions of heavy atoms that are intrinsic to the protein or that have been added (MIR, MIRAS, SIR, SIRAS, MAD and SAD). Availability of in-house lab data collection sources (Cu Kα and Cr Kα radiation), cryo-crystallography and improved software for heavy atom location and density modification have increased the ability to solve protein structures using SAD. SAD phasing using intrinsic anomalous scatterers like sulfur, chlorine, calcium, manganese and zinc, which are already present in the protein becomes increasingly attractive owing to the advanced phasing methods. An analysis of successful SAD phasing on three proteins, lysozyme, glucose isomerase and thermolysin based on the signal of weak anomalous scatterers such as sulfur atom and chloride ion have been carried out. This analysis also proves that even the anomalous signal provided or present naturally in a macromolecule is good enough to solve crystal structures successfully using lab source chromium-generated X-ray radiation.

关键词： Anomalous Scattering SAD Phasing Lysozyme Glucose Isomerase Thermolysin