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Ayurvedic concept of Shatkriyakala:a traditional knowledge of cancer pathogenesis and therapy

Journal of Integrative Medicine 2017年第2期15卷 88-94页

作者： ashutosh chauhan Deepak Kumar Semwal Satyendra Prasad Mishra Ruchi Badoni Semwal Department of Biotechnology Faculty of Biomedical Sciences Uttarakhand Ayurved University Harrawala Dehradun 248001 India Department of Phytochemistry Faculty of Biomedical Sciences Uttarakhand Ayurved University Harrawala Dehradun 248001 India Uttarakhand Ayurved University Harrawala Dehradun 248001 India Department of Pharmaceutical Sciences Tshwane University of Technology Pretoria 0001 South Africa

The term Kriyakala refers to the recognition of the stage of a disease＇s progress, which helps to determine appropriate measure to correct the imbalance in Doshas （biological factors）. It is a compound expression, comprised of Kriya and Kala, where Kriya means the choice to treatment （medicine, food and daily-routine） used to improve the disturbance in Doshas, and Kala refers to the stage of progress of a disease. Sushruta, an ancient Indian surgeon, has described the concept of Kriyakala in Vamaprashnadhyaya, an ancient Vedic Sanskrit text, which seeks to explain the incidence of Vamas in terms of Doshic disturbances. Vama, in modern parlance, may be described as an inflammatory process that may lead ulceration and chronic inflammation, promoting all stages of carcinogenesis. Abnormal interactions between Prakriti （genotype） and environmental factors vitiate the Doshas and impair immunity, which can lead to aberrant cell growth and cancer. Moreover, the interaction between vitiated Doshas and weak Dhatus （body tissues） manifests as cancers of a specific organ. Shatkriyakala （six stages of progress of a disease）, on the other hand, provides a framework to assess the cancer and its pathogenesis in different stages. According to Ayurvedic concepts, all cancer therapies treat the affected tissues indirectly by eliminating vitiated Doshas, rejuvenating Dhatus and restoring immunity in cancer patients. The present review describes the six stages of Shatkriyakala in detail, with an emphasis on research areas to validate the concept of Shatkriyakala. This traditional knowledge can be utilized with modern technologies to detect predisposition for cancer or diagnose cancer in its early stages.

关键词： medicine, Ayurvedic Shatkriyakala tumors, malignant

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Status of Indian medicinal plants in the International Union for Conservation of Nature and the future of Ayurvedic drugs: Shouldn’t think about Ayurvedic fundamentals?

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Journal of Integrative Medicine 2019年第4期17卷 238-243页

作者： Deepak Kumar Semwal ashutosh chauhan An kit Kumar Sonali Aswal Ruchi Badoni Semwal Abhimanyu Kumar Department of Phytochemistry Faculty of Biomedical Sciences Uttarakhand Ayurved University Harrawala Dehradun 248001 India Department of Biotechnology Faculty of Biomedical Sciences Uttarakhand Ayurved University Harrawala Dehradun 248001 India Research and Development Centre Faculty of Biomedical Sciences Uttarakhand Ayurved University Harrawala Dehradun 248001 India Department of Chemistry Pt. Lalit Mohan Sharma Government Postgraduate College Rishikesh Uttarakhand 249201 India Uttarakhand Ayurved University Harrawala Dehradun 248001 India

The present market for herbal drugs is estimated about ?40 billion, which is expected to increase by 16% in next 3-4 years. The current production of many Ayurvedic herbs is less than their market demand, which incentivizes adulteration in the Ayurvedic drug supply chain. The present work aims to highlight the most used Ayurvedic plants that have been listed in the International Union for Conservation of Nature's "red list" of endangered or vulnerable plants. The future of Ayurvedic medicines from these listed plants is uncertain, as the collection of herbs from their natural habitat is prohibited and their cultivation does not meet market demands. Many of these plants, such as Taxus baccata and T. wallichiana, are endangered and are only grown in their natural habitats;their cultivation in other areas is impractical. This is the present state, and will worsen as demand continues to grow, with increasing populations and increasing adoption of this system of medicine. It is possible that in coming years most of the Ayurvedic drugs will be adulterated, and will cause only side effects rather than the therapeutic effects. The Ayurvedic fundamentals are under-explored areas where the Ayurvedic practitioners and research scientists can work together. The scientific work on the basic principles will unravel many unknown or little-known facts of this ancient science. Hence, the present review emphasizes the conservation of Ayurvedic herbs, minimization of the use of medicinal plants and the promotion of the research based on Ayurvedic fundamentals.

关键词： Ayurvedic fundamentals Ayurvedic herbs Endangered plants Polyherbal formulations Prakriti

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Ethnomedicinal Investigation of Medicinal Plants of Chakrata Region(Uttarakhand)Used in the Traditional Medicine for Diabetes by Jaunsari Tribe

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Natural Products and Bioprospecting 2019年第3期9卷 175-200页

作者： Ankit Kumar Sonali Aswal ashutosh chauhan Ruchi Badoni Semwal Abhimanyu Kumar Deepak Kumar Semwal Research and Development Centre Faculty of Biomedical SciencesUttarakhand Ayurved UniversityHarrawalaDehradun 248001India Department of Biotechnology Faculty of Biomedical SciencesUttarakhand Ayurved UniversityHarrawalaDehradun 248001India Department of Chemistry Pt.Lalit Mohan Sharma Government Postgraduate CollegeRishikeshUttarakhand 249201India Uttarakhand Ayurved University HarrawalaDehradun 248001India Department of Phytochemistry Faculty of Biomedical SciencesUttarakhand Ayurved UniversityHarrawalaDehradun 248001India

The Himalayan region is the treasure house of natural wealth,particularly of medicinal and aromatic *** plants are used by the Indian traditional healers for the past many centuries to treat various ailments such as skin disorders,asthma,diabetes,snake bite,fever,pain,eye diseases,diarrhoea,indigestion,jaundice,burn,wound,liver disorder,CNS disorders and urinary tract *** indigenous traditional knowledge of medicinal plants and therapies of various local communities has been lost due to changes in traditional culture and the introduction of modern ***,it is essential to explore the traditional knowledge of the indigenous medicinal plants mainly in such areas where there is a severe threat to natural vegetation owing to human *** present study aimed to explore the medicinal plants of Chakrata region(Jaunsar-Bawar Hills),Uttarakhand,India used in the folk medicine for the management of diabetes by Jaunsari *** a comprehensive feld survey,the information about the medicinal plants have been mainly collected from the traditional healers and other elderly people belong to the tribal *** the information about the medicinal plants of the study area was documented in a feld *** tools have been used to collect the samples for identifcation purpose and the authentication of the plants was done with the help of *** literature on these plants was also searched from online(PubMed and Scopus)as well as from some textbooks and Ayurvedic classical *** present survey-based work described a total of 54 plants belonging to 47 genera and 30 families used in the traditional medicine for the management of diabetes in Chakrata *** information gathered from the local community revealed that the plants are efective in diabetes and one can use most of them without consulting a practitioner or traditional *** literature revealed that most of the surveyed plants are already used in the pr

关键词： Ayurveda Diabetes Herbal formulations Traditional healers Folk medicine

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An experimental study on optimizing parameters for sand consolidation with organic-inorganic silicate solutions

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Petroleum 2024年第3期10卷 483-493页

作者： Saurabh Mishra Geetanjali chauhan Keka Ojha Department of Energy Science and Technology Centre for Advanced StudiesLucknowIndia Department of Petroleum Engineering and Earth Sciences Indian Institute of Petroleum and EnergyVisakhapatnamIndia Department of Petroleum Engineering Indian Institute of Technology(ISM)DhanbadIndia

Sand production along with the oil/gas detrimentally affects the oil production rate,downhole&subsurface *** equipment and various chemicals like epoxy resin,furan resin,phenolic resin,*** used in the industry to reduce or eliminate this *** the present study,a blend of organic and inorganic silicates are used to consolidate loose sand in the presence and absence of crude oil using a core flooding *** effects of chemical concentration,pH,curing temperature and time,and the presence of residual oil on the consolidation treatment results such as compressive strength and permeability retention,were investigated and ***-IR and FE-SEM characterization techniques were employed to investigate the interaction between the chemical molecules and the sand *** current binding agent exhibited a viscosity of less than 6 cP at room temperature,which facilitates efficient pumping of binding agent into the desired formation through the well *** developed mixture demonstrated consolidation properties across all pH ***,during the experimental investigation,the curing time and temperature was carefully optimized at 12 h and 423.15K,respectively to achieve the highest compressive strength of 2021 psi while achieving the permeability retention of 64%.The current chemical system exhibited improved consolidation capacity and can be effectively utilized for sand consolidation treatment in high-temperature formations.

关键词： Chemical sand consolidation Rheology Compressive strength Permeability retention Silicate system Curing

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Design of computer vision assisted machine learning based controller for the Stewart platform to track spatial objects

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Frontiers of Structural and Civil Engineering 2024年第8期18卷 1195-1208页

作者： Dev Kunwar Singh chauhan Pandu R.VUNDAVILLI Indian Institute of Technology Bhubaneswar Bhubaneswar 752050India

The present work aims to develop an object tracking controller for the Stewart platform using a computer vision-assisted machine learning-based *** research is divided into two *** first module focuses on the design of a motion controller for the Physik Instrumente(PI)-based Stewart *** contrast,the second module deals with the development of a machine-learning-based spatial object tracking algorithm by collecting information from the Zed 2 stereo vision ***,simple feed-forward neural networks(NN)are used to predict the orientation of the top table of the *** training,the x,y,and z coordinates of the three-dimensional(3D)object,extracted from images,are used as the input to the *** contrast,the orientation information of the platform(that is,rotation about the x,y,and z-axes)is considered as the output from the *** orientation information obtained from the network is fed to the inverse kinematics-based motion controller(module 1)to move the platform while tracking the *** training,the optimised NN is used to track the continuously moving 3D *** experimental results show that the developed NN-based controller has successfully tracked the moving spatial object with reasonably good accuracy.

关键词： Stewart platform feed-forward neural networks motion controller inverse kinematics stereo vision

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Impacts of hydropower-induced flow alterations on composition and diversity of riparian vegetation in the Western Himalayas: A case study in Uttarakhand, India

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Journal of Mountain Science 2024年第4期21卷 1272-1286页

作者： Dharmveer KAINTURA Sabyasachi DASGUPTA Dhanpal Singh chauhan Hemvati Nandan Bahuguna Garhwal University Srinagar Garhwal 246174India Tripura University SuryamaninagarAgartala 799022India

The increasing demand for water and energy resources has led to widespread dam construction,particularly in ecologically sensitive regions like the Himalayan *** study focuses on the Uttarakhand state in the Western Himalayas,where hydroelectric projects(HEPs)have significantly altered river flow *** research investigates the impact of flow alterations on the composition and structure of riparian vegetation in the Garhwal Himalayas,specifically analysing four rivers regulated by hydroelectric *** the paired-reach comparison method,control(undisturbed),diverted(downstream of barrage/dam),and altered flow conditions(downstream of water outlet)were *** research reveals diverse and unique riparian ecosystems,with 89 genera and 113 taxa identified,showcasing the dominance of families like Asteraceae and *** study unveils the structural importance of key species such as Berberis asiatica and Artemisia *** density,diversity,and richness of shrub and herb species vary significantly across flow ***,altered flow conditions demonstrate resilience in vegetation structure,while diverted conditions exhibit decreased species richness and *** study emphasizes the importance of nuanced environmental flow management for mitigating adverse effects on riparian biodiversity in the fragile Himalayan *** findings contribute to the global discourse on dam impacts and riparian ecology,shedding light on the complexities of this dynamic relationship in a vulnerable ecosystem.

关键词： Dam construction Water stress Western Himalayas Disturbed flow regimes Riparian ecosystem

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Modulatory role of plant-derived metabolites on host-microbiota interactions:personalized therapeutics outlook

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BIOCELL 2024年第8期48卷 1127-1143页

作者： POOJA YADAV NAR SINGH chauhan Department of Biochemistry Maharshi Dayanand University RohtakRohtakHaryanaIndia

A diverse array of microbes in and on the human body constitute the *** micro-residents continuously interact with the human host through the language of metabolites to dictate the host’s physiology in health and *** biotic and abiotic component ensuring a balanced host-microbiota interaction are potential microbiome therapeutic agents to overcome human *** metabolites are continually being used to treat various *** metabolites target the host’s metabolic machinery and host-gut microbiota interactions to overcome human *** the paramount therapeutic significance of the factors affecting host-microbiota interactions,a comprehensive overview of the modulatory role of plant-derived metabolites in host-microbiota interactions is *** current review puts an effort into comprehending the role of medicinal plants in gut microbiota modulation to mitigate various human *** would develop a holistic understanding of hostmicrobiota interactions and the role of effectors in health and diseases.

关键词： Microbiome therapeutics Human gut microbiota Host-microbiota interactions Personalized therapeutics Plant metabolites Human health and diseases

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Fractal analysis of major faults and fractal dimension of lineaments in the Indo-Gangetic Plain on a regional scale

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Earthquake Science 2024年第2期37卷 107-121页

作者： Vipin chauhan Jagabandhu Dixit Disaster Management Laboratory Shiv Nadar UniversityDelhi NCRGautam Buddha NagarUttar Pradesh 201314India

The Indo-Gangetic Plain(IGP)is one of the most seismically vulnerable areas due to its proximity to the *** information system(GIS)-based seismic characterization of the IGP was performed based on the degree of deformation and fractal *** zone between the Main Boundary Thrust(MBT)and the Main Central Thrust(MCT)in the Himalayan Mountain Range(HMR)experienced large variations in earthquake magnitude,which were identified by Number-Size(NS)fractal *** central IGP zone experienced only moderate to low mainshock *** analysis of earthquake epicenters reveals a large scattering of earthquake epicenters in the HMR and central IGP ***,the fault fractal analysis identifies the HMR,central IGP,and south-western IGP zones as having more ***,the seismicity of the study region is strong in the central IGP,south-western IGP,and HMR zones,moderate in the western and southern IGP,and low in the northern,eastern,and south-eastern IGP zones.

关键词： geospatial analysis fractal modeling seismicity pattern fractal dimension

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Mineralogy and geochemistry of trachytic rocks from the Lichi Volcanics, Eastern Himalaya: insights into the Kerguelen mantle plume activity in the Eastern Himalayan Region

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Acta Geochimica 2024年第1期43卷 180-197页

作者： Pallabi Basumatary Deepshikha Borah Hiredya chauhan Tribujjal Prakash Bibhuti Gogoi Department of Geology Cotton UniversityGuwahatiAssam 781001India Wadia Institute of Himalayan Geology DehradunUttarakhand 248001India

The Lichi volcanics are a suite of mafic-intermediate-felsic rocks and are considered coeval with the Abor volcanics(~132 Ma) of the Siang window in the Eastern Himalaya. Here, we present the first report of trachytic rocks from the Lichi volcanics, which are exposed in the Ranga valley, along the Kimin-Yazali road section in the Eastern Himalayan Region, Northeast India. The trachytes occur in close association with sandstones of the Gondwana Group of rocks and are characterised based on field, petrographical, and geochemical *** fine-grained trachytes are composed of alkali feldspar, biotite, plagioclase, sodic-amphibole, apatite, illmenite, and titanite. The REE profiles of the evolved trachytic rocks(higher SiO_(2)content) display fractionated trends. The fractionation of accessory mineral phases, like apatite and titanite, was possibly responsible for the strongly fractionated REE patterns of the evolved *** trachytic rocks demonstrate high apatite saturation temperatures of 988 ± 14 ℃(1σ, n = 8). The Aluminium Saturation Index(< 1.1) and binary discrimination diagrams of these peralkaline trachytes define their affinity with A-type granitoids. Elemental ratios like Y/Nb, Nb/U,and Ce/Pb signify that the Lichi trachytes are differentiated products of mantle-derived ocean island basalts. Trace elemental discrimination diagrams Th/Yb versus Nb/Yb, Y versus Nb, and Y + Nb versus Rb reflect a within-plate tectonic regime for the trachytes. From the results presented in this work, we infer that the development of rifting events during the breakup of eastern Gondwana due to the onset of Kerguelen plume activity further led to underplating of basic magma in lower crustal levels. These parental basaltic magmas underwent fractionation processes forming differentiated trachyandesites and *** into consideration the similarities recorded between the Lichi volcanics and Abor volcanics, this study supports the idea that Kerguelen plume ac

关键词： Peralkaline trachytes Trachyandesites A-type granitoids Apatite saturation temperature Abor volcanics Eastern Gondwana

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Assessing foundation behaviour under complex loading near tunnels

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Journal of Mountain Science 2024年第10期21卷 3503-3520页

作者： Piyush KUMAR Vinay Bhushan chauhan Aayush KUMAR Civil Engineering Department Madan Mohan Malaviya University of TechnologyGorakhpur 273010India

The stability of strip footings subjected to eccentrically inclined loads is critical for reliable foundation *** study investigates the effect of a circular unlined tunnel in a rock mass on the ultimate bearing capacity(UBC)of a foundation with width B under inclined and eccentric *** finite element limit analysis was employed to evaluate the reduction in UBC of the footing resting above a *** examined critical parameters include normalized load eccentricity(e/B),load inclination(β),and horizontal and vertical distances of the tunnel from the foundation(P/B and Q/B,respectively),along with rock mass *** results reveal that for e/B≥0.25 and≤60°,the reduction coefficient,Rc≥0.90,suggesting that the presence of a tunnel has a minimal impact on the load-bearing capacity of the footing,with failure primarily governed by load eccentricity and ***,potential failure mechanisms are explored,showing that at lower e/B,higherβ,and lower Q/B,the tunnel significantly affects footing's failure ***,at higher e/B and lowerβ,failure is due to rotational effects of footing,regardless of the tunnel's *** predict the Rc more accurately,due to the time-consuming nature of direct calculations,both MLR and ANN models were *** MLR model provided a baseline for comparison,while the ANN model,with a coefficient of determination(R2)of 0.98,demonstrated superior accuracy compared to the R2=0.96 of *** both approaches ensured robust and efficient predictions of *** Rc does not directly provide the reduced UBC of footing due to presence of tunnel,the study introduced bearing capacity factor(Nc)to enable direct calculation of the reduced UBC of *** findings offer theoretical guidelines for preliminary design and provide practitioners with an effective tool for evaluating UBC reduction in complex loading scenarios involving tunnels.

关键词： Unlined tunnel Shallow foundation FELA Rock Mass ANN MLR

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