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Advancements in medical treatment for pancreatic neuroendocrine tumors:A beacon of hope

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World Journal of Gastroenterology 2024年第12期30卷 1670-1675页

作者： Somdatta giri Jayaprakash Sahoo Department of Endocrinology and Metabolism Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherry605006India

This editorial highlights the remarkable advancements in medical treatment strategies for pancreatic neuroendocrine tumors(pan-NETs),emphasizing tailored approaches for specific *** surgery and somatostatin analogs(SSAs)play pivotal roles in managing tumors,while palliative options such as molecular targeted therapy,peptide receptor radionuclide therapy,and chemotherapy are reserved for SSA-refractory ***,insul-inomas,glucagonomas,carcinoid tumors and VIPomas necessitate distinct thera-peutic *** the genetic basis of pan-NETs and exploring immunotherapies could lead to promising avenues for future *** review underscores the evolving landscape of pan-NET treatment,offering renewed hope and improved outcomes for patients facing this complex disease.

关键词： Pancreatic neuroendocrine tumor Medical management Somatostatin analog Immunotherapy Everolimus

Tuning the crystallinity of titanium nitride on copper-embedded carbon nanofiber interlayers for accelerated electrochemical kinetics in lithium-sulfur batteries

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Carbon Energy 2024年第6期6卷 40-55页

作者： Yinyu Xiang Liqiang Lu Feng Yan Debarun Sengupta Petra Rudolf Ajay giri Prakash Kottapalli Yutao Pei Advanced Production Engineering Engineering and Technology Institute GroningenUniversity of GroningenGroningenThe Netherlands Zernike Institute for Advanced Materials University of GroningenGroningenThe Netherlands

The development of lithium-sulfur(Li-S)batteries is hindered by the disadvantages of shuttling of polysulfides and the sluggish redox kinetics of the conversion of sulfur species during discharge and ***,the crystallinities of a titanium nitride(TiN)film on copper-embedded carbon nanofibers(Cu-CNFs)are regulated and the nanofibers are used as interlayers to resolve the aforementioned crucial issues.A low-crystalline TiN-coated Cu-CNF(L-TiN-Cu-CNF)interlayer is compared with its highly crystalline counterpart(H-TiN-Cu-CNFs).It is demonstrated that the L-TiN coating not only strengthens the chemical adsorption toward polysulfides but also greatly accelerates the electrochemical conversion of *** to robust carbon frameworks and enhanced kinetics,impressive highrate performance at 2 C(913 mAh g^(-1)based on sulfur)as well as remarkable cyclic stability up to 300 cycles(626 mAh g^(-1))with capacity retention of 46.5%is realized for L-TiN-Cu-CNF interlayer-configured Li-S *** under high loading(3.8 mg cm^(-2))of sulfur and relatively lean electrolyte(10μL electrolyte per milligram sulfur)conditions,the Li-S battery equipped with L-TiN-Cu-CNF interlayers delivers a high capacity of 1144 mAh g^(-1)with cathodic capacity of 4.25 mAh cm^(-2)at 0.1 C,providing a potential pathway toward the design of multifunctional interlayers for highly efficient Li-S batteries.

关键词： crystallinity electrochemical kinetics interlayer lithium-sulfur batteries titanium nitride

Cracking the silent gallstone code:Wait or operate?

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World Journal of Clinical Cases 2024年第16期12卷 2692-2697页

作者： Aakansha giri Goswami Somprakas Basu Department of General Surgery All India Institute of Medical SciencesRishikesh 249203UttarakhandIndia

The widespread availability of abdominal ultrasound has revealed the common occurrence of asymptomatic *** the treatment for symptomatic gallstones is clear,the benefits of minimally invasive laparoscopic cholecystectomy have sparked debate about the best approach to managing silent *** potential for asymptomatic gallstones to become symptomatic or lead to complications complicates the decision-making process regarding surgical intervention,as it's uncertain when or which patients might develop ***,risk stratification appears to play a critical role in guiding decisions about silent ***,there is no definitive evidence to direct management,and a consensus-based on high-quality evidence is yet to be established.

关键词： Asymptomatic gallstones Silent gallstones Cholecystectomy Gallbladder cancer Risk stratification

Probabilistic Analysis of Slope Using Finite Element Approach and Limit Equilibrium Approach around Amalpata Landslide of West Central, Nepal

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International Journal of Geosciences 2024年第5期15卷 416-432页

作者： Mahendra Acharya Khomendra Bhandari Sandesh Dhakal Aasish giri Prabin Kafle Central Department of Geology Tribhuvan University Kathmandu Nepal Department of Geology Tri-Chandra Multiple Campus Tribhuvan University Kathmandu Nepal Sri Revana Siddeshwara Institute of Technology Visvesvaraya Technological University Bengaluru India

The stability study of the ongoing and recurring Amalpata landslide in Baglung in Nepal’s Gandaki Province is presented in this research. The impacted slope is around 200 meters high, with two terraces that have different slope inclinations. The lower bench, located above the basement, consistently fails and sets others up for failure. The fluctuating water level of the slope, which travels down the slope masses, exacerbates the slide problem. The majority of these rocks are Amalpata landslide area experiences several structural disruptions. The area’s stability must be evaluated in order to prevent and control more harm from occurring to the nearby agricultural land and people living along the slope. The slopes’ failures increase the damages of house existing in nearby area and the erosion of the slope. Two modeling techniques the finite element approach and the limit equilibrium method were used to simulate the slope. The findings show that, in every case, the terrace above the basement is where the majority of the stress is concentrated, with a safety factor of near unity. Using probabilistic slope stability analysis, the failure probability was predicted to be between 98.90% and 100%.

关键词： Finite Element Approach Limit Equilibrium Method Slope Factor of Safety

Prevalence and outcome of sarcopenia in non-alcoholic fatty liver disease

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World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 44-54页

作者： Suprabhat giri Prajna Anirvan Sumaswi Angadi Ankita Singh Anurag Lavekar Department of Gastroenterology and Hepatology Kalinga Institute of Medical SciencesBhubaneswar 751024OdishaIndia Department of Gastroenterology Kalinga Gastroenterology FoundationCuttack753001OdishaIndia Department of Gastroenterology Nizam’s Institute of Medical SciencesHyderabad 500082TelanganaIndia Department of Gastroenterology Seth GS Medical College and KEM HospitalMumbai 400012MaharashtraIndia Department of Gastroenterology Sagar HospitalBengaluru 560041KarnatakaIndia

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)includes a spectrum of conditions,progressing from mild steatosis to advanced ***,characterized by decreased muscle strength and mass,shares common pathophysiological traits with *** association exists between sarcopenia and increased NAFLD ***,data on the prevalence of sarcopenia in NAFLD and its impact on the outcomes of NAFLD remain *** To analyze the prevalence and outcomes of sarcopenia in patients with *** We conducted a comprehensive search for relevant studies in MEDLINE,Embase,and Scopus from their inception to June *** included studies that focused on patients with NAFLD,reported the prevalence of sarcopenia as the primary outcome,and examined secondary outcomes,such as liver fibrosis and other adverse *** also used the Newcastle-Ottawa scale for quality *** Of the 29 studies included,the prevalence of sarcopenia in NAFLD varied widely(1.6%to 63.0%),with 20 studies reporting a prevalence of more than 10.0%.Substantial heterogeneity was noted in the measurement modalities for *** was associated with a higher risk of advanced fibrosis(odd ratio:1.97,95%confidence interval:1.44-2.70).Increased odds were consistently observed in fibrosis assessment through biopsy,NAFLD fibrosis score/body mass index,aspartate aminotransferase to alanine aminotransferase ratio,diabetes(BARD)score,and transient elastography,whereas the fibrosis-4 score showed no such *** in NAFLD was associated with a higher risk of steatohepatitis,insulin resistance,cardiovascular risks,and *** This systematic review highlights the critical need for standardized diagnostic criteria and measurement methods for sarcopenia in NAFLD *** variability in study designs and assessment methods for sarcopenia and liver fibrosis may account for the inconsistent *** review demonstrates the multidimension

关键词： Non-alcoholic fatty liver disease Sarcopenia Hepatic fibrosis Low muscle mass Hand grip strength Bioelectric impedance analysis Dual X-ray absorptiometry

Fixed-time Distributed Voltage and Reactive Power Compensation of Islanded Microgrids Using Sliding-mode and Multi-agent Consensus Design

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Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 232-240页

作者： Mohamed Ghazzali Mohamed Haloua Fouad giri Electrical Engineering Department Mohammadia School of EngineersUniversity Mohammed VRabatMorocco Caen Automation Laboratory(LAC) Caen Normandie University(UNICAEN)CaenFrance

This paper investigates a fixed-time distributed voltage and reactive power compensation of islanded microgrids using sliding-mode and multi-agent consensus design.A distributed sliding-mode control protocol is proposed to ensure voltage regulation and reference tracking before the desired preset fixed-time despite the unknown *** reactive power sharings among distributed generators are *** secondary controller is synthesized without the knowledge of any parameter of the *** is implemented using a sparse one-way communication network modeled as a directed graph.A comparative simulation study is conducted to highlight the performance of the proposed control strategy in comparison with finite-time and asymptotic control systems with load power variations.

关键词： Secondary controller microgrids reactive power control voltage control

Optimal batch shipment policy for an imperfect production system under price-,advertisementand green-sensitive demand

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Journal of Management Analytics 2022年第1期9卷 86-119页

作者： Bibhas C.giri Anamika Dash Department of Mathematics Jadavpur UniversityKolkataIndia

In this paper,we consider an imperfect production-inventory system which consists of a single manufacturer and a single *** manufacturer delivers the order quantity to the retailer in some unequal-sized *** separate the defective items,the retailer performs an error-free screening process after receiving each delivery from the *** in retailer’s inventory is allowed and completely *** customer demand is influenced by the retail price,advertisement frequency and greening level of the *** centralized model and the decentralized model based on a Stackelberg gaming approach are developed to determine optimal pricing,advertising and inventory decisions.A cost-sharing contract between the manufacturer and the retailer is implemented,which enhances the environmental performance,advertisement frequency and profitability of the supply chain *** proposed model is illustrated with a numerical *** analysis for some key parameters is carried out and several managerial insights are also highlighted.

关键词： Imperfect production unequal batch shipment price- advertisementand green-sensitive demand cost-sharing contract

Filtered High Gain Observer for an Electric Vehicle’s Electro-hydraulic Brake: Design and Optimization Using Multivariable Newton-based Extremum Seeking

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Chinese Journal of Electrical Engineering 2023年第4期9卷 73-87页

作者： Jamal El-bakkouri Hamid Ouadi Fouad giri Mohamed Khafallah ENSEM Hassan II University of CasablancaCasablanca BP 8118Morocco ENSAM Rabat Mohammed V UniversityRabat BP 6207Morocco Department of Electrical Engineering University of Caen NormandyCaen 14032France

Designing high-gain observers(HGOs)for the state estimation of an electric vehicle’s electrohydraulic brake(EHB)system is *** type of observer is applicable to model nonlinearities and constant feature ***,they are very sensitive to measurement noise,which is unavoidable in *** first novelty of this study is that it compensates for the measurement noise using a filtered high-gain observer(FHGO)to ensure EHB state *** proposed FHGO provides an estimate of the master cylinder pressure,motor current,and rotor speed from measurements of the rotor *** second novelty is the design of an extremum-seeking(ES)optimization loop to adjust the FHGO gains *** performance of the developed FHGO with ES-based online gain optimization was highlighted in the presence of model uncertainties and output measurement noise using a Matlab/Simulink *** superiority of the FHGO(even with a fixed gain)over a standard high gain observer(SHGO)was also demonstrated.

关键词： Electrohydraulic brake filtered HGO measurement noise optimization extremum-seeking Lyapunov theory

Adaptive neural network observer for proton-exchange membrane fuel cell system

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Clean Energy 2023年第5期7卷 1078-1090页

作者： Abdelaziz El Aoumari Hamid Ouadi Jamal El-Bakkouri Fouad giri ERERA National School of Arts and CraftsMohammed V UniversityRabatMorocco LESE Lab ENSEMHassan II UniversityCasablancaMorocco Normandie University UNICAENENSICAENLAC14000 CaenFrance

This paper develops an adaptive neural network(NN)observer for proton-exchange membrane fuel cells(PEMFCs).Indeed,information on the oxygen excess ratio(OER)value is crucial to ensure optimal management of the durability and reliability of the *** OER indicator is computed from the mass of oxygen and nitrogen inside the PEMFC ***,the measurement process of both these masses is difficult and *** solve this problem,the design of a PEMFC state observer is ***,the behaviour of the fuel cell system is highly non-linear and its modelling is *** to this constraint,a multilayer perceptron neural network(MLPNN)-based observer is proposed in this paper to estimate the oxygen and nitrogen *** notable advantage of the suggested MLPNN observer is that it does not require a database to train the ***,the weights of the NN are updated in real time using the output *** addition,the observer parameters,namely the learning rate and the damping factor,are online adapted using the optimization tools of extremum ***,the proposed observer stability analysis is performed using the Lyapunov *** observer performances are validated by simulation under MATLAB®/Simulink®.The supremacy of the proposed adaptive MLPNN observer is highlighted by comparison with a fixed-parameter MLPNN observer and a classical high-gain observer(HGO).The mean rela-tive error value of the excess oxygen rate is considered the performance index,which is equal to 1.01%for an adaptive MLPNN and 3.95%and 9.95%for a fixed MLPNN and HGO,***,a robustness test of the proposed observer with respect to measurement noise is performed.

关键词： fuel cell system(PEMFC) multilayer perceptron neural network(MLPNN)observer optimization extremum seeking(ES) oxygen excess ratio(OER)