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Validation and application of Vierordt’’s spectrophotometric method for simultaneous estimation of tamoxifen/coenzyme Q10 in their binary mixture and pharmaceutical dosage forms

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Asian Journal of Pharmaceutical Sciences 2016年第2期11卷 318-325页

作者： Eman S. el-Leithy Rania S. abdel-Rashid Department of Pharmaceutics Faculty of Pharmacy Helwan University

For the sake of improving patient compliance and sustainability of chemotherapy healthcare system, both TC and CoQ10 were formulated as solid lipid nanoparticles (SLNs). The study was focused on establishing and validating a simple and reproducible spectrophotometric method for simultaneous determination of TC and CoQ10 in their binary mixture or pharmaceutical dosage forms. A new method based on simultaneous estimation of drug mixture without prior separation was developed. Validation parameters were checked with International Conference on Harmonization (ICH) guidelines. The accuracy and reproducibility of proposed method was statistically compared to HPLC. The TC and CoQ10 were quantified at absorptivity wavelengths of 236 nm and 275 nm, respectively. Calibration curves obeyed Beer’s law in range of 2–14 μg/ml with a correlation coefficient (R^2) of 0.999 in both methanol and simplified simulated intestinal fluid (SSIF). The %means recovery of TC and Co Q10 in pure state or binary mixture at various concentration levels were all around 100%.The low values of SD and %RSD (<2%) confirm high precision and accuracy of the proposed method. Formulated SLNs showed different %means recovery in range 81–92% for TC and 32–59% for CoQ10. The data obtained by applying simultaneous Vierordt’s equations showed no statistical significance in comparison to HPLC. Vierordt’s method was successfully applied as a simple, accurate, precise, and economical analysis method for estimating TC and CoQ10 concentrations in pure state, binary mixture and pharmaceutical dosage forms.

关键词： Tamoxifen citrate Coenzyme Q10 Binary mixture Solid lipid nanoparticles Validation

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Synergistic renoprotective effect of a compiled branched-chain amino acids and Cymbopogon schoenanthus extract against experimentally induced oxido-nitrosative renal insult

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Asian Pacific Journal of Tropical Medicine 2018年第5期11卷 342-349页

作者： Omar abdel-Hamed Ahmed-Farid Bosy Azmy Abd el-Motelp Enaam abdel-Mohsen Essa Mohamad Warda Physiology Department National Organization for Drug Control and Research Zoology Department-Faculty of Women for Arts Science and EducationAin Shams University Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary Medicine Cairo University

Objective: To better investigate the protective role of branched-chain amino acids(BCAAs)and Cymbopogon schoenanthus(CS) extract against the potassium dichromate(PDC)-induced oxido-nitrosative nephrotoxic insult in the experimental rat model. Methods: Thirty male rats were randomly divided into five equal groups: The 1 st group served as control; the 2^(nd)was injected with a single dose of PDC(15 mg/kg b.w i.p.);the 3^(rd), 4^(th), and 5^(th) groups were respectively treated with BCAAs, CS, and their combination for 15 d prior to induction of renal insult via PDC single dose(15 mg/kg b.w s.c.). The experimental period was terminated in all groups 2 d after induction of renal insult. The harvested kdney samples were divided for biochemical assays and histological examination. Results: The PDC-induced nephrotoxic effect caused a depletion of renal oxidative scavengers glutathione, superoxide dismutase with consequent lipo-oxidative cellular membrane deterioration manifested by a rise in malonaldehyde, oxidized glutathione, myeloperoxidase and the concomitant increase in inflammatory response elements tumor necrosis factor α, nitric oxide, and interleukin 1 β.Moreover, the comet assay and increased 8-hydroxy-2-deoxyguanosine proved an accelerated apoptotic DNA fragmentation. These local renal changes were met with global altered blood biochemistry. The BCAAs and CS or their compiled administration showed an ameliorative effect against PDC-induced nephrotoxic in a synergistic pattern. Conclusions: Both BCAAs and CS or their combined administration afford potential competitors against renal insult induced by polyvalent anion pollutants in experimentally studied animals model. As a route for novel drug discovery, further investigation should be attempted to optimize their augmenting reno-protecting potential.

关键词： Branched chain amino acids Cymbopogon schoenanthus Nephrotoxicity Comet assay Rats

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Flavonoid chemical composition and antidiabetic potential of Brachychiton acerifolius leaves extract

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Asian Pacific Journal of Tropical Biomedicine 2017年第5期7卷 389-396页

作者： Aisha Hussein Abou Zeid Mohamed Ali Farag Manal abdel Aziz Hamed Zeinab abdel Aziz Kandil Radwa Hassan el-Akad Hanaa Mohamed el-Rafie Pharmacognosy Department National Research Centre Pharmacognosy Department College of PharmacyCairo University Therapeutic Chemistry Department National Research Centre

Objective:To evaluate Brachychiton acerifolius leaf extracts as antidiabetic potential agent and to identify the main active constituents using bioactivity guided ***:In vitro antioxidant activity was evaluated for *** different extracts using DPPH assay and vitamin C as *** activity was then determined using STZ-induced rats treated daily with ethyl acetate and 70% ethanol leaf extracts for4 weeks at a dose of 200 g/kg body weight against gliclazide reference *** glucose,a-amylase,lipid profile,liver function enzymes and oxidative stress markers were assessed along with histopathological study for liver and pancreatic *** and structural elucidation of active compounds were made using Diaion and Sephadex followed by spectral ***:The results indicated that ethyl acetate and ethanol leaf extracts exhibited the strongest antioxidant activity compared to that of vitamin C(IC500.05,0.03 and 12 mg/m L,respectively).Both extracts showed potent anti-hyperglycemic activity evidenced by a significant decrease in serum glucose levels by 82.5% and 80.9% and a-amylase by45.2% and 53.6%,as compared with gliclazide 68% and 59.4%,*** of ethanol extract resulted in the isolation of 9 flavonoids including apigenin-7-O-arhamnosyl(1/2)-b-D-glucuronide,apigenin-7-O-b-D-glucuronide,apigenin-7-O-b-Dglucoside and ***:This study highlights the potential use of *** leaf extract enriched in flavones for the treatment of diabetes that would warrant further clinical trials investigation.

关键词： STZ-induced diabetes Diaion fractionation Flavonoid glucuronides Brachychiton acerifolius

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Clinicopathological features and surgical outcome of patients with fibrolamellar hepatocellular carcinoma(experience with 22 patients over a 15-year period)

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World Journal of Gastrointestinal Surgery 2017年第2期9卷 61-67页

作者： Mohamed abdel Wahab Ehab el Hanafy Ayman el Nakeeb Mahmoud abdelwahab Ali Gastroenterology Surgical Center Mansoura UniversityMansoura 35516Egypt

AIM To evaluate the clinicopathological features and the surgical outcomes of patients with fibrolamellar hepato-cellular carcinoma(FL-HCC)over a 15-year period. METHODS This is a retrospective study including 22 patients with a pathologic diagnosis of FL-HCC who underwent hepatectomy over a 15-year period. Tumor characteristics,survival and recurrence were evaluated. RESULTS There were 11 male and 11 female with a median age of 29 years(range from 21 to 58 years). Two(9%)patients had hepatitis C viral infection and only 2(9%)patients had alpha-fetoprotein level > 200 ng/m L. The median size of the tumors was 12 cm(range from 5-20 cm). Vascular invasion was detected in 5(23%)patients. Four(18%)patients had lymph node metastases. The median follow up period was 42 mo and the 5-year survival was 65%. Five(23%)patients had a recurrent disease,4 of them had a second surgery with 36 mo median time interval. Vascular invasion is the only significant negative prognostic factor CONCLUSION FL-HCC has a favorable prognosis than common HCC and should be suspected in young patients with non cirrhotic liver. Aggressive surgical resection should be done for all patients. Repeated hepatectomy should be considered for these patients as it has a relatively indolent course.

关键词： Fibrolamellar hepatocellular carcinoma Common hepatocellular carcinoma Recurrence after resection fibrolamellar hepatocellular carcinoma Pathology of fibrolamellar hepatocellular carcinoma Survivalefter resection fibrolamellar hepatocellular carcinoma

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Effects of Moringa oleifera aqueous extract on the growth performance,blood characteristics,and histological features of gills and livers in Nile tilapia

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Aquaculture and Fisheries 2024年第1期9卷 85-92页

作者： Mahamoud A.Emam Ramy M.Shourbela Waleed N.el-Hawarry Seham Y.Abo-Kora Fatma abdel-Monem Gad ashraf M.Abd el-latif Mahmoud A.O.Dawood Histology Department Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Department of Animal Husbandry and Animal Wealth Development Faculty of Veterinary MedicineAlexandria UniversityAlexandria22758Egypt Pharmacology Department Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Clinical Pathology Department Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Department of Aquatic Animal Diseases and Management Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Animal Production Department Faculty of AgricultureKafrelsheikh UniversityKafr El-Sheikh33511Egypt The Center for Applied Research on the Environment and Sustainability The American University in CairoCairo11835Egypt

Moringa oleifera is well known as a highly nutritious plant and a water purifier in fish *** fish has many impressive qualities making them very suitable for ***,this study aimed to evaluate the effect of supplementation of Moringa oleifera aqueous extract(MOAE)at varying concentrations(0,100,200,and 400 mg/kg diet for 90 days)on growth performance,hematological,and some biochemical parameters of Nile ***,histological changes and immunohistochemical expression of caspase 3 in gills and livers were *** enhancements(Pells,hemoglobin,packed cell volume,white blood cells,and total serum protein were observed in fish fed 200 mg MOAE/kg diet compared with other ***,a significant reduction(Pells indicating severe apoptotic ***,a dietary MOAE at 200 mg/kg diet is recommended to improve the growth performance,hematological parameters,liver and kidney functions in Nile ***,caution must be considered when using MOAE at a concentration over 200 mg/kg diet.

关键词： Growth performance Liver Gills Moringa oleifera Nile tilapia

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Role of Ultrasonographic Measurement of Fetal Kidney Length in Determination of Gestational Age during Third Trimester of Pregnancy

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Open Journal of Obstetrics and Gynecology 2021年第3期11卷 221-232页

作者： Mahmoud Mohamed Ghaleb Afnan Ibrahim abdel fatah Shokri Mohammed Salah el Sayed el Sokkary Maged Mahmoud Ali el Shourbagy Department of Obstetrics and Gynecology Faculty of Medicine Ain Shams University Cairo Egypt

Background: In routine ultrasonography, the ultrasonologist measures the bi-parietal diameter (BPD), head circumference (HC), abdominal circumference (AC) and femur length (FL) in estimating the gestational age (GA) and estimated date of delivery. However, as the pregnancy advances these parameters become increasingly unreliable in prediction of GA. Estimation of GA in late second and third trimester accurately still a problem till now. Fetal kidney has been shown a steady growth of 1.7 mm fortnightly (every 2 weeks) along pregnancy and is unaffected by growth abnormalities. Many studies have reported that fetal kidney length (FKL) correlates with the gestational age in late trimester very strong. The study aimed to assess the accuracy of the gestational age estimated by mean fetal kidney length compared to multiple growth parameters like BPD, HC, AC & FL in addition to the actual gestational age derived from the reliable last menstrual period. Methods: Cross sectional hospital based study, was conducted at ultrasound unit;department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University from the period of July 2018 to December 2018. A total number of 115 Pregnant women at their third trimester by reliable LMP attended antenatal care clinic at Ai

关键词： Kidney Length Gestational Age Growth Parameters

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A geometric phase for superconducting qubits under the decoherence effect

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Chinese Physics B 2013年第10期22卷 88-93页

作者： S.abdel-Khalek K.Berrada Mohamed A.el-Sayed M.Abel-Aty Mathematics Department Faculty of ScienceSohag University82524 SohagEgypt Mathematics Department Faculty of ScienceTaif UniversityTaifSaudi Arabia Al Imam Mohammad Ibn Saud Islamic University (IMSIU) College of ScienceDepartment of PhysicsRiyadhSaudi Arabia The Abdus Salam International Centre for Theoretical Physics Strada Costiera 11Miramare-TriesteItaly Laboratoire de Physique The'orique Faculte' des SciencesUniversite' Mohammed V-AgdalAvenue Ibn BattoutaBote Postale 1014Agdal RabatMorocco Informatics Department Faculty of ScienceTaif UniversityTaifSaudi Arabia

We propose a relaxation rate or dissipative cavity-based parameters that can be used as indicators of the stationary limit of a mixed state geometric phase. We perform our considerations for the system of a superconducting qubit in an open transmission line or interacting with a dissipative cavity. This system is very useful for performing an effective quantum computation by exhibiting the long collapse time of the geometric phase. It is shown that the geometric phase in the stationary limit does not depend on interaction time if the decay time exceeds an upper bound.

关键词： superconducting-qubit meometric phase mixed state decoherence

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Non-ischemic priapism in dog: Case report

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Asian pacific Journal of Reproduction 2018年第1期7卷 47-48页

作者： el-Sherry TM abdel-Ghani MA Department of Theriogenology Faculty of Veterinary MedicineAssiut UniversityAssiutEgypt Laboratory of Theriogenology Department of Clinical SciencesDivision of Veterinary MedicineFaculty of Veterinary MedicineHokkaido UniversitySapporoJapan

Bulldog with unilateral cryptorchidism was admitted to our clinic suffering from a persistent erection for 2 d. The animal was left for the first time for breeding without observation. Penis was hyperaemic, oedematous with area of mucous membrane necrosis and swollen bulbus glandis. Doppler ultrasound was optimized to allow adequate recognition of blood flow sensitive for slow flow on the head, shaft of the penis and bulbus glandis. Penis showed unsymmetrical blood flow that started in the left side of the bulbus glandis, and continue to the shaft until the gland penis;whereas, the other half of the penis showed no blood flow. Using Doppler ultrasonography was useful for diagnosis of the blood flow pattern that was beneficial to give the appropriate treatment.

关键词： Dog Priapism Doppler

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LINEAR SEARCH FOR A BROWNIAN TARGET MOTION

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Acta Mathematica Scientia 2003年第3期23卷 321-327页

作者： A.B.el-Rayes abdel-MoneimA.Mohamed Hamdy M.Abou Gabal Military Technical College CairoEgyptMilitary Technical CollegeCairoEgyptDepartment of MathematicsFaculty of ScienceTanta UniversityTantaEgypt

A target is assumed to move according to a Brownian motion on the real line. The searcher starts from the origin and moves in the two directions from the starting point. The object is to detect the target. The purpose of this paper is to find the conditions under which the expected value of the first meeting time of the searcher and the target is finite, and to show the existence of a search plan which made this expected value minimum.

关键词： Brownian process expected value linear search optimal search plan

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Outcomes of pancreaticoduodenectomy in elderly patients

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Hepatobiliary & Pancreatic Diseases International 2016年第4期15卷 419-427页

作者： Ayman el Nakeeb Ehab Atef Ehab el Hanafy Ali Salem Waleed Askar Helmy Ezzat Ahmed Shehta Mohamed abdel Wahab Gastroenterology Surgical Center Mansoura University

BACKGROUND： Although the mortality and morbidity of pancreaticoduodenectomy（PD） have improved significantly over the past years, the concerns for elderly patients undergoing PD are still present. Furthermore, the frequency of PD is increasing because of the increasing proportion of elderly patients and the increasing incidence of periampullary tumors. This study aimed to analyze the outcomes of PD in elderly ***： We studied all patients who had undergone PD in our center between January 1995 and February 2015. The patients were divided into three groups based on age： group I（patients aged 〈60 years）, group II（those aged 60 to 69 years） and group III（those aged ≥70 years）. The primary outcome was the rate of total postoperative complications. Secondary endpoint included total operative time, hospital mortality, length of postoperative hospital stay, delayed gastric emptying, re-exploration, and survival ***： A total of 828 patients who had undergone PD for resection of periampullary tumor were included in this study. There were 579（69.9%） patients in group I, 201（24.3%） in group II, and 48（5.8%） in group III. The overall incidence of complications was higher in elderly patients（25.9% in group I, 36.8% in group II, and 37.5% in group III; P=0.006）. There were more patients complicated with delayed gastric emptying in group II compared with the other two groups. There was no significant difference in the incidence of postoperative pancreatic fistula, biliary leakage, pancreatitis, pulmonary complications and hospital ***： PD can be performed safely in selected elderly patients. Advanced age alone should not be a contraindication for PD. The outcome of elderly patients who have undergone PD is similar to that of younger patients, and the increased rate of complications is due to the presence of associated comorbidities.

关键词： pancreaticoduodenectomy elderly pancreatic fistula delayed gastric emptying

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