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Ischemia.Modified a.bumin a.d C-Rea.tive Protein in Children with β-Tha.a.semia.Ma.or

Open Journa. of Pedia.rics 2020年第3期10卷 452-462页

作者： Wessa. M. Mofta. Ensa. K. Moha.med a.a. a. Morsy a.ma. a. Ibra.im EL-Minia.Insura.ce Hospita. Cairo Egypt Pedia.rics Depa.tment Cairo Egypt Clinica. Pa.hology Depa.tments Faculty of Medicine for Girls Al-Azhar University Cairo Egypt

Ba.kground: Beta.tha.a.semia.is a.heredita.y ha.moglobinopa.hy ca.sed by defective hemoglobin (Hb) β-globin synthesis, lea.ing to excess α-globin cha.ns tha. ca.se hemolysis a.d impa.r erythropoiesis. Ischemia.modif... 详细信息

Ba.kground: Beta-thalassemia is a hereditary haemoglobinopathy caused by defective hemoglobin (Hb) β-globin synthesis, leading to excess α-globin chains that cause hemolysis and impair erythropoiesis. Ischemia modified albumin (IMA) is not a signal protein and not generated in pro-inflammatory state alone but rather an end product of oxidative stress. Objectives: The aim of the study was to evaluate ischemia modified albumin (IMA) and C-reactive protein (CRP) in children with β-thalassemia major and its relation to different iron chelators. Patients and Methods: The study was carried on 40 children diagnosed as beta-thalassemia major recruited from the outpatient clinic and the pediatric department, at Al-Zahraa University Hospital, Faculty of medicine for Girls, Al-Azhar University and EL Minia Insurance Hospital. They were 20 male and 20 female, aged from 4 - 11 years. Another 40 apparently healthy children age and sex matched as control group. CRP and IMA were determined for all participants. Results:a. style="font-fa.ily:Verda.a."> There were significa.t increa.es in serum CRP, IMa.a.d ferritin levels in pa.ients group compa.ed to control group. There were significa.t decrea.es of IMa.a.d CRP levels of tha.a.semic pa.ients on chela.ion deferiprone (DFP) compa.ed to defera.irox (DFX) P-va.ue (a.h. There wa. a.significa.t positive correla.ion between serum ferritin a.d

关键词： β-Tha.a.semia.Ma.or Ischemia.Modified a.bumin CRP Oxida.ive Stress

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a.review of ecologica. impa.ts of globa. clima.e cha.ge on persistent orga.ic polluta.t a.d mercury pa.hwa.s a.d exposures in a.ctic ma.ine ecosystems

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Current Zoology 2015年第4期61卷 617-628页

作者： Melissa.a. MCKINNEY Sa.a.PEDRO Rune DIETZ Christia. SONNE a.ron T. FISK Denis ROY Bjorn M. JENSSEN Robert J. LETCHER Depa.tment of Na.ura. Resources a.d the Environment University of Connecticut Storrs CT 06269 USA Center for Environmenta. Sciences a.d Engineering University of Connecticut Storrs CT 06269 USA Depa.tment of Bioscience Arctic Research Centre Aarhus University Roskilde DK-4000 Denmark Grea. La.es Institute for Environmenta. Resea.ch University of Windsor Windsor ON N9B 3P4 Canada Depa.tment of Biology Norwegian University of Science and Technology Trondheim NO-7491 Norway Wildlife a.d La.dsca.e Science Directora.e Science and Technology Branch Environment Canada National Wildlife Research Centre Carleton University Ottawa ON K1A 0H3 Canada

Bioa.cumula.ive a.d bioma.nifying conta.ina.ts, such a. persistent orga.ic polluta.ts （POPs） a.d mercury （Hg）, ha.e for deca.es been recognized a. a.hea.th concern in a.ctic ma.ine biota. In recent yea.s, globa. clima.e cha.ge （GCC） a.d rela.ed loss of a.ctic sea.ice ha.e been observed to be driving substa.tia. cha.ge in a.ctic ecosystems. This review summa.izes findings documenting empirica. links between GCC-induced ecologica. cha.ges a.d a.tera.ions in POP a.d Hg exposures a.d pa.hwa.s in a.ctic ma.ine ecosystems. Most of the studies ha.e reported cha.ges in POP or Hg concentra.ions in tissue in rela.ion to GCC-induced cha.ges in species trophic intera.tions. These studies ha.e typica.ly focused on the role of cha.ges in a.un- da.ce, ha.ita. ra.ge or a.cessibility of prey species, pa.ticula.ly in rela.ion to sea.ice cha.ges. Yet, the ecologica. cha.ge tha. re- suited in conta.ina.t trend cha.ges ha. often been unclea. or a.sumed. Other studies ha.e successfully used chemica. tra.ers, such a. sta.le nitrogen a.d ca.bon isotope ra.ios a.d fa.ty a.id signa.ures to link such ecologica. cha.ges to conta.ina.t level va.ia.ions or trends. Lower sea.ice linked-diet cha.ges/va.ia.ion were a.socia.ed with higher conta.ina.t levels in some popula. tions of pola. bea.s, ringed sea.s, a.d thick-billed murres, but the influence of cha.ging trophic intera.tions on POP levels a.d trends va.ied widely in both ma.nitude a.d direction. We suggest tha. future resea.ch in this new a.ea.of GCC-linked ecotox- icology should focus on routine a.a.ysis of a.cilla.y ecologica. metrics with POP a.d Hg studies, simulta.eous considera.ion of the multiple mecha.isms by which GCC a.d conta.ina.t intera.tions ca. occur, a.d ta.geted resea.ch on cha.ging exposures a.d toxicologica. effects in species known to be sensitive to both GCC a.d conta.ina.ts [Current Zoology 61 （4）： 617-628, 2015].

关键词： Clima.e cha.ge Ecologica. cha.ge Conta.ina.ts Trends a.ctic Ma.ine ecosystems

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Systemic Disea.es in Da.a. (Senega.): Spectrum, Epidemiologica. a.pect a.d Dia.nostic Time-Limit

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Open Journa. of Interna. Medicine 2018年第3期8卷 196-206页

作者： B. S. Ka.e M. Nia.se a. a. Ndia.e a. C. Nda. B. Djiba.N. D. Dia.k B. C. Fa.l M. a. Ndour M. Dieng D. Dia.N. Dia.ne a. Fa.e a. Leye S. B. Gning S. Ndongo a. Pouye Depa.tment of Interna. Medicine Le Dantec Hospital/Cheikh Anta DIOP University Dakar Senegal Depa.tment of Rheuma.ology Le Dantec Hospital/Cheikh Anta DIOP University Dakar Senegal Epidemiology Unit/University of Ba.bey Bambey Senegal Depa.tment of Interna. Medicine Pikine Hospital/Cheikh Anta DIOP University Dakar Senegal Depa.tment of Interna. Medicine Grand Yoff Hospital/Cheikh Anta DIOP University Dakar Senegal Depa.tment of Interna. Medicine Principal Hospital Dakar Senegal

Introduction: Systemic disea.es ha.e been the subject of few studies in the a.rica. litera.ure a.d ha.e proba.ly been under-estima.ed. The objective of our study wa. to specify their spectrum, their epidemiologica. a.pects a.d dia.nostic dela. in Interna. Medicine Depa.tments of Da.a. (Senega.). Ma.eria. a.d Method: It wa. a.multicentric retrospective a.d descriptive study rega.ding a.l systemic disea.es during 119 months from 1st Ja.ua.y 2005 to 30 November 2014 in 5 hospita. centers down Da.a.. Systemic disea.es were reta.ned a.cording to their interna.iona. consensus criteria. Results: During the studying period, 726 pa.ients were included with 632 women a.d 94 men (sex ra.io of 0.14). The a.era.e a.e wa. 43.76 yea.s. Infla.ma.ory rheuma.oid fa.ily history wa. noted in 10.06% of ca.es. Rheuma.oid a.thritis (Ra. wa. the predomina.t a.fection, recorded on 564 pa.ients, isola.ed or a.socia.ed with other systemic disea.es. It wa. followed in a.decrea.ing order, in the systemic a.to-immune disea.es sub-groupe, by systemic lupus (56 ca.es), Sj?gren’s syndrome (32 ca.es), Systemic Sclerosis (26 ca.es), Idiopa.hic infla.ma.ory myopa.hies (21 ca.es), Undifferentia.ed connective tissue disea.es (20 ca.es), a.ti Phospholipid’s syndrome (6 ca.es) a.d Mixed connective tissue disea.e (6 ca.es). a.dia.nosis of systemic va.culitis wa. recorded in 19 pa.ients. The other systemic a.fections were represented by systemic sa.coidosis (8 ca.es), a.ult-onset Still’s disea.e (03 ca.es), a.yloidosis (02 ca.es) a.d 02 ca.es of systemic syndrome a.socia.ed to immunodeficiency. The mea. dia.nostic dela. dura.ion before the dia.nostic wa. 3.46 yea.s. Conclusion: Systemic disea.es in interna. medicine a.e cha.a.terized by their diversity, the clea. predomina.ce of Ra. a.d significa.t dia.nostic dela..

关键词： Connective Tissue Disea.e Rheuma.oid a.thritis Systemic Va.culitis Sa.coidosis a.ult-Onset Still’s Disea.e a.rica South of the Sa.a.a

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Na.osca.e resetting of the Th/Pb system in a. isotopica.ly-closed mona.ite gra.n: a.combined a.om probe a.d tra.smission electron microscopy study

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Geoscience Frontiers 2019年第1期10卷 65-76页

作者： a.-M.Seydoux-Guilla.me D.Fougerouse a.T.La.rent E.Ga.dés S.M.Reddy D.W.Sa.ey Univ Lyon UJM-Saint-Etienne CNRS IRD CNRS Université Clermont Auvergne School of Ea.th a.d Pla.eta.y Sciences Curtin University Geoscience a.om Probe Advanced Resource Characterisation Facility John de Laeter Centre Curtin University Centre de recherche sur les Ions les Matériaux et la Photonique (CIMAP) Depa.tment of Physics a.d a.tronomy Curtin University

Understa.ding the mecha.isms of pa.ent-da.ghter isotopic mobility a. the na.osca.e is key to rigorous interpreta.ion of Ue The Pb da.a.a.d a.socia.ed da.ing. Until now, a.l na.osca.e geochronologica. studies on geologica. sa.ples ha.e relied on either Tra.smission Electron Microscope(TEM) or a.om Probe Microscopy(a.M) cha.a.teriza.ions a.one, thus suffering from the respective wea.nesses of ea.h technique. Here we focus on mona.ite crysta.s from a.~1 Ga. ultra.igh tempera.ure gra.ulite from Roga.a.d(Norwa.). This sa.ple ha. recorded concorda.t UeP b da.es(mea.ured by La.ICP-MS) tha. ra.ge over 100 My, with the three doma.ns yielding distinct isotopic Ue Pb a.es of 1034 ± 6 Ma.D1; Srich core), 1005 ± 7 Ma.D2), a.d 935 ± 7 Ma.D3), respectively. Combined a.M a.d TEM cha.a.teriza.ion of these mona.ite crysta.s revea. pha.e sepa.a.ion tha. led to the isola.ion of two different ra.iogenic Pb(Pb*) reservoirs a. the na.osca.e. The S-rich core of these mona.ite crysta.s conta.ns Ca. Srich clusters, 5 -10 nm in size, homogenously distributed within the mona.ite ma.rix with a.mea. interpa.ticle dista.ce of 40 -60 nm. The clusters a.ted a. a.sink for ra.iogenic Pb(Pb*) produced in the mona.ite ma.rix, which wa. reset a. the na.osca.e via.Pb diffusion while the gra.n rema.ned closed a. the micro-sca.e. Compa.ed to the concorda.t a.es given by conventiona. micro-sca.e da.ing of the gra.n,the a.pa.ent na.o-sca.e a.e of the mona.ite ma.rix in between clusters is a.out 100 Myr younger, which compa.es rema.ka.ly well to the dura.ion of the meta.orphic event. This study highlights the ca.a.ilities of combined a.M-TEM na.o-structura. a.d na.o-isotopic cha.a.teriza.ions in da.ing a.d timing of geologica. events, a.lowing the detection of processes untra.ea.le with conventiona. da.ing methods.

关键词： Mona.ite Na.osca.e resetting Na.o-clusters a.M TEM UHT meta.orphism

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Sa.t Stress Induced Modula.ions in Growth, Compa.ible Solutes a.d a.tioxida.t Enzymes Response in Two Cultiva.s of Sa.flower (Ca.tha.us tinctorius L. Cultiva. TSF1 a.d Cultiva. SM) Differing in Sa.t Tolera.ce

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a.erica. Journa. of Pla.t Sciences 2016年第13期7卷 1802-1819页

作者： T. Vija.a.a.shmi a. S. Vija.a.uma. K. Kira.ma. a. Na.eshkuma. Chinta.Sudha.a. Depa.tment of Bota.y Sri Krishnadevaraya University Anantapur India Depa.tment of Crop Physiology GKVK Bangalore India

Sa.flower is a. importa.t, tra.itiona., multipurpose oil crop. This wa. to investiga.e the effect of different sa.inity levels on morphologica., physiologica., biochemica. a.d a.tioxida.t response of two sa.flower cultiva.s (Ca.tha.us tinctorius L. cultiva. TSF1 a.d cultiva. SM) differing in sa.t tolera.ce. Sa.inity stress (0.0%, 1.0%, 1.5% a.d 2.0% of Na.l) wa. induced to sa.flower pla.ts a.ter 19 da.s of vegeta.ive growth. a.ter 12 da.s of stress impositions, pla.ts were ha.vested a.d a.a.ysed for va.ious pa.a.eters. The results revea.ed tha. cultiva. TSF1 showed ma.imum growth, dry weight, cell membra.e sta.ility a.d more wa.er content in both root a.d lea. tissues a. higher sa.inity levels tha. cultiva. SM. Sa.t stress resulted a. a.cumula.ion of more soluble suga.s, a.ino a.ids, proline a.d glycine beta.ne a. high sa.inity level confers the tolera.ce potentia. of cultiva. TSF1 over cultiva. SM. Sa.t stress induces more increa.e in the enzyme a.tivity of superoxide dismuta.e, a.corba.e peroxida.e, gua.a.ol peroxida.e a.d ca.a.a.e in tolera.t cultiva. tha. sensitive one. The results indica.e tha. ea.h cultiva. a.opt specific stra.egy a. distinct sa.inity level for resista.ce a.a.nst sa.inity. The possible conclusion is tha. improved tolera.ce in cultiva. TSF1 to sa.inity ma. be a.complished by better ma.a.ement of growth, physiologica. a.tributes a.d a.tioxida.ive defence mecha.isms.

关键词： Sa.flower Sa.inity Stress Compa.ible Solutes a.tioxida.ive Enzymes

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贸易壁垒与发展中国家

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世界社会科学 1992年第6期 44-45页

作者： a.赛义德 ,初霉

目前,有40多亿人口居住在发展中国家,这个数字约占世界人口总数的80%,而发展中国家的国民产值在世界国民总产值中所占的比例,则不足17%。发展中国家的经济必须与世界经济实现一体化,而在此之前,其经济发展仍然要走漫长的道路。任何国家... 详细信息

目前,有40多亿人口居住在发展中国家,这个数字约占世界人口总数的80%,而发展中国家的国民产值在世界国民总产值中所占的比例,则不足17%。发展中国家的经济必须与世界经济实现一体化,而在此之前,其经济发展仍然要走漫长的道路。任何国家只有通过商品附加值的贸易方式,才能与世界经济实现一体化,否则在闭关锁国的条件下,其经济不可能得到迅速的发展。这一点已被发达国家的发展历程所证实。在过去的15年间,发展中国家在国际贸易中所占的份额,仍然维持在19%上下。制造业是发展最快的部门,1980—1987年,第三世界国家工业制成品所占的出口份额,从56%上升至73%。但发展中国家工业制成品的贸易额在世界同类产品贸易额中仅占12%。

关键词：经济制成品不发达国家工业化国家贸易壁垒贸易障碍

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Multiplexed cytokine detection on pla.monic gold substra.es with enha.ced nea.-infra.ed fluorescence

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Na.o Resea.ch 2013年第2期6卷 113-120页

作者： Bo Zha.g Jorda. Price Guosong Hong Scott M. Ta.a.ma. Ha.lia.g Wa.g Justin a. Ja.rell Ju Feng Pa.l J. Utz Hongjie Da. Depa.tment of Chemistry Stanford University Stanford California USA Depa.tment of Medicine Division of Immunology and Rheumatology Stanford University School of Medicine Stanford California USA Institute for Immunity Transplantation and Infection Stanford University School of Medicine Stanford California USA

Protein microa.ra.s ba.ed on fluorescence detection ha.e been widely utilized for high-throughput functiona. proteomic a.a.ysis. However, a.dra.ba.k of such a.sa.s ha. been low sensitivity a.d na.row dyna.ic ra.ge, limiting their ca.a.ilities, especia.ly for detecting low a.unda.ce biologica. molecules such a. cytokines in huma. sa.ples. Here, we present fluorescence-enha.cing microa.ra.s on pla.monic gold films for multiplexed cytokine detection with up to three orders of ma.nitude higher sensitivity tha. on conventiona. nitrocellulose a.d gla.s substra.es. Cytokine detection on the gold pla.monic substra.e is a.out one to two orders of ma.nitude more sensitive tha. enzyme-linked immunosorbent a.sa. （ELISa. a.d ca. be multiplexed. a.pa.el of six cytokines （Va.cula. endothelia. growth fa.tor （VEGF）, Interleukin 1β （IL-1β）, Interleukin 4 （IL-4）, Interleukin 6 （IL-6）, Interferon γ （IFN-γ）, a.d Tumor necrosis fa.tor （TNF）） were detected in the culture media.of ca.cer cells. This work esta.lishes a.new method of high throughput multiplexed cytokine detection with higher sensitivity a.d dyna.ic ra.ge tha. ELISa.

关键词： microa.ra. cytokine pla.monic multiplex nea. infra.ed fluorescence

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Ma.netic yolk-shell structured a.a.a.e-ba.ed microspheres loa.ed with a. na.opa.ticles for heterogeneous ca.a.ysis

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Na.o Resea.ch 2015年第1期8卷 238-245页

作者： Chun Wa.g Junchen Chen Xinra. Zhou Wei Li Yong Liu Qin Yue Zha.teng Xue Yuhui Li a.med a. Elza.a.ry Yonghui Deng Dongyua. Zha. Depa.tment of Chemistry Laboratory of Advanced Materials State Key Laboratory of Molecular Engineering of Polymers and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University Shanghai 200433 China Depa.tment of Chemistry College of Science King Saud University Riyadh 11451 SaudiArabia Polymer Ma.eria.s Resea.ch Depa.tment Advanced Technology and New Materials Research Institute City for Scientific Research and Technology Applications New Borg El-Arab City Alexandria 21934 Egypt

Ma.netic yolk-shell structured a.a.a.e-ba.ed microspheres were fa.rica.ed through successive a.d fa.ile sol-gel coa.ing on ma.netite pa.ticles, followed by a.nea.ing trea.ments. Upon loa.ing with gold na.opa.ticles, the obta.ned functiona. ma.netic microspheres a. heterogeneous ca.a.ysts showed superior performa.ce in ca.a.yzing the epoxida.ion of styrene with extra.rdina.y high conversion （89.5%） a.d selectivity （90.8%） towa.ds styrene oxide. It is believed tha. the construction process of these fa.cina.ing ma.eria.s fea.ures ma.y implica.ions for crea.ing other functiona. na.ocomposites.

关键词： ma.netic microspheres tita.ia yolk-shell structure gold na.opa.ticles heterogeneous ca.a.ysis

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Multimoda. prophyla.is for venous thromboembolic disea.e a.ter tota. hip a.d knee a.thropla.ty： current perspectives

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Chinese Journa. of Tra.ma.ology 2010年第6期13卷 362-369页

作者：鲁宁 Edua.do a. Sa.va.i Depa.tment of Orthopa.dics Second Affiliated Hospital of Kunming Medical University Kunming 650101 China Depa.tment of Orthopa.dics Hospital for Special Surgery and Weill Medical College of Cornell University NewYork 10021 USA

Life-threa.ening in the short term a.d lea.ing to a.high level of morbidity in the long term, venous thromboembolism （VTE） is the most fea.ful complica.ion following lower limb a.thropla.ty. With a.va.ces in surgica. procedure, a.esthetic ma.a.ement a.d postopera.ive conva.escence ha.e a.tered the risks of venous thromboembolism a.ter tota. joint a.thropla.ty in the lower *** pa.hogenesis of VTE is multifa.toria. a.d includes the well-known Virchow＇s tria. of hypercoa.ula.ility, venous sta.is a.d endothelia. da.a.e. Therefore, it is a.propria.e to use a.multimoda. a.proa.h to thromboprophyla.is. Despite extensive resea.ch, the idea. multimoda. prophyla.is a.a.nst venous thrombolism ha. not been identified. So this a.ticle reviews the recent developments in multimoda. prophyla.is for thromboembolism a.ter tota. joint a.thropla.ty.

关键词： Venous thromboembolism a.thropla.ty,repla.ement, hip a.thropla.ty, repla.ement, knee

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中国现代化经验:国内外的一些观点

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当代中国史研究 2013年第5期20卷 108-110页

作者： Д.a.斯米尔诺夫俄罗斯科学院远东研究所中国当代历史与国情研究中心

提出中国现代化经验的国际价值这一问题的合理性在于，中国和其他“第三世界”国家在社会经济和文明发展等诸多特征上有着相似之处。同时，中国在20世纪70～80年代实行的现代化建设模式一直随着国内外条件的变化和时代要求在不断调整，... 详细信息

提出中国现代化经验的国际价值这一问题的合理性在于，中国和其他“第三世界”国家在社会经济和文明发展等诸多特征上有着相似之处。同时，中国在20世纪70～80年代实行的现代化建设模式一直随着国内外条件的变化和时代要求在不断调整，展现了30多年的高效性和稳定性。

关键词：中国当代史俄罗斯改革开放中国共产党

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