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Open Journa. of Ga.troenterology 2016年第3期6卷 75-82页

作者： ashraf a. hammam a.a. a. Jouda.Mona.E. Ha.hem Interna. Medicine Depa.tment Zagazig University Zagazig Egypt Tropica. Medicine Depa.tment Zagazig University Zagazig Egypt Clinica. Pa.hology Depa.tment Zagazig University Zagazig Egypt

Ba.kground a.d a.m: The levels of thyroid hormones a.d their binding proteins a.e a.tered in pa.ient with cirrhosis. We a.m to study the cha.ges in triiodothyronine level in HCV rela.ed cirrhosis a.d its correla.ion to the severity of liver decompensa.ion. Pa.ients a.d Methods: This study included seventy two pa.ients with HCV rela.ed cirrhosis in three groups Group I: 24 pa.ients with Child a.cla.s Group II: 24 pa.ients with Child B a.d C cla.ses without hepa.ic encepha.opa.hy Group III: 24 pa.ients with Child B a.d C cla.ses with hepa.ic encepha.opa.hy. Results: T3 level wa. significa.tly lower in group III tha. group I a.d II (0.74 ng/ml vs 1 a.d 1.3 ng/ml in group II a.d I in succession). The correla.ion between Child’s score a.d T3 level wa. highly significa.t (r = -0.64, P a.d its level is correla.ed to the severity of decompensa.ion.

关键词： Free T4 TSH Clinica. Euthyroid Cirrhosis HCV

Eva.ua.ion of soil loss severity a.d ecologica. restora.ion a.proa.h for susta.na.le a.riculture in the Hindu Kush, Ka.a.ora. a.d Hima.a.a.region

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Journa. of Mounta.n Science 2024年第5期21卷 1509-1521页

作者： a.sha. ashraf Imra. a.Ma. Clima.e Energy and Water Research InstituteNational Agricultural Research Centre(NARC)Islamabad 44000Pakistan

Soil erosion ha. resulted in remova. of the topsoils conta.ning fine soil pa.ticles a.d pla.t nutrients, ca.sing decrea.e in soil fertility in the Hindu Kush, Ka.a.ora. a.d Hima.a.a.HKH) region. The existing production of cerea. crop gra.ns ha. been reduced to one third of the potentia. crop gra.ns production owing to la.d degra.a.ion a.d poor fa.ming pra.tices. It is necessa.y to a.sess risk of soil loss a.d identify a.propria.e controlling mea.ures to a.dress issues of low a.riculture productivity a.d wa.er insecurity in the region. In the present study, severity of soil loss wa. predicted using Revised Universa. Loss Equa.ion(RUSLE) a.d ecologica. mea.ures were identified for susta.na.le mounta.n a.riculture in the HKH region of Upper Indus Ba.in, Pa.ista.. Overa.l 62.6% a.ea.wa. found to ha.e very low risk of soil loss, i.e., a.yr), 15.8% a.ea.low risk, i.e., 5-25 t/(ha.yr) a.d 7.5% a.ea.modera.e risk, i.e., 25-50 t/(ha.yr) in the region. The risk wa. high, i.e., 50-100 t/(ha.yr) a.d very high, i.e., >100 t/(ha.yr) in a.out 6.8% a.d 7.4% a.ea. respectively. The mea. ra.e of soil loss wa. a.out 41.9 t/(ha.yr) in the Hindu Kush, 31.1 t/(ha.yr) in the Hima.a.a., 18.8 t/(ha.yr) in the Ka.a.ora. a.d overa.l 29.7 t/(ha.yr) in the three HKH ra.ges. a. such no considera.le mea.ures ha.e been a.opted by the communities for restora.ion of the degra.ed a.ea. except ra.sing fruit/fa.m trees a.d supporting limited socia. forestry for their livelihoods. The slopes clea.ed for cultiva.ion a.d susceptible to erosion ma. be sta.ilized through sowing/pla.ting of multi-purpose pla.t species a.d forma.ion of proper bench terra.es. The conserva.ion of forest ecosystem a.d pa.tures a. higher eleva.ions would help in reducing overla.d wa.er flow, risk of fla.h flood ha.a.d a.d minimizing sediment loa.s in the downstrea.. It is essentia. to a.opt site-specific resource conserva.ion techniques a.d restore possible ecosystem hea.th for susta.na.le a.riculture a.d economic developm

关键词： Clima.e cha.ge Erodibility Indus ba.in La.d degra.a.ion Slope sta.iliza.ion

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Wa.e propa.a.ion of a.functiona.ly gra.ed pla.e via.integra. va.ia.les with a.hyperbolic a.csine function

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Ea.thqua.e Engineering a.d Engineering Vibra.ion 2024年第3期23卷 547-561页

作者： Mokhta. Ella.i Mokhta. Boua.za.ashraf M.Zenkour Sma.t structures La.ora.ory University of Ain TemouchentAin Temouchent 46000Algeria Depa.tment of Civil Engineering University Tahri Mohamed of BecharBechar 08000Algeria Depa.tment of Ma.hema.ics Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia La.ora.ory of Ma.eria.s a.d Hydrology(LMH) University of Sidi Bel AbbesSidi Bel Abbes 22000Algeria Depa.tment of Ma.hema.ics Faculty of ScienceKafrelsheikh UniversityKafrelsheikh 33516Egypt

Severa. studies on functiona.ly gra.ed ma.eria.s(FGMs)ha.e been done by resea.chers,but few studies ha.e dea.t with the impa.t of the modifica.ion of the properties of ma.eria.s with rega.d to the functiona. propa.a.ion of the wa.es in *** work a.ms to explore the effects of cha.ging compositiona. cha.a.teristics a.d the volume fra.tion of the constituent of pla.e ma.eria.s rega.ding the wa.e propa.a.ion response of thick pla.es of *** model is ba.ed on a.higher-order theory a.d a.new displa.ement field with four unknowns tha. introduce indetermina.e integra. va.ia.les with a.hyperbolic a.csine *** FGM pla.e is a.sumed to consist of a.mixture of meta. a.d cera.ic,a.d its properties cha.ge depending on the power functions of the thickness of the pla.e,such a. linea.,qua.ra.ic,cubic,a.d inverse *** utilizing Ha.ilton’s principle,genera. formula. of the wa.e propa.a.ion were obta.ned to esta.lish wa.e modes a.d pha.e velocity curves of the wa.e propa.a.ion in a.functiona.ly gra.ed pla.e,including the effects of cha.ging compositiona. cha.a.teristics of ma.eria.s.

关键词： FGM pla.e effects of ma.eria. properties wa.e propa.a.ion indetermina.e integra. va.ia.les inverse sinus hyperbolic function

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MicroRNa.630:a.potentia. gua.dia. a.a.nst infla.ma.ion in dia.etic kidney disea.e

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World Journa. of Dia.etes 2024年第9期15卷 1837-1841页

作者： ashraf a. Ma.houn Depa.tment of Genetics a.d Bioinforma.ics Dasman Diabetes InstituteDasman 15400Kuwait

In this editoria.,we comment on the a.ticle by Wu et a. published“MicroRNa.630 a.levia.es infla.ma.ory rea.tions in ra.s with dia.etic kidney disea.e by ta.geting toll-like receptor 4”.Dia.etic kidney disea.e(DKD)sta.ds a. a.significa.t complica.ion occurring from dia.etes mellitus,which contributes substa.tia.ly to the morbidity a.d morta.ity ra.es *** tubula. epithelia. cell da.a.e,often a.compa.ied by infla.ma.ory responses a.d mesenchyma. tra.sdifferentia.ion,pla.s a.pivota. role in the progression of *** extensive resea.ch,the intrica.e molecula. mecha.isms underlying these processes rema.n to be *** et a. rema.ka.le work identifies microRNa.630(miR-630)a. a. emerging potentia. regula.or of cell migra.ion,a.optosis,a.d a.topha.y,prompting investiga.ion into its a.socia.ion with DKD *** study endea.ors to elucida.e the impa.t of miR-630 on TEC injury a.d the infla.ma.ory response in DKD *** role of miR-630 in huma. DKD will be of interest for future studies.

关键词： Dia.etic kidney disea.e MicroRNA MicroRNa.630 Toll-like receptor 4 Infla.ma.ion

Glucokina.e regula.ory protein rs780094 polymorphism is a.socia.ed with type 2 dia.etes mellitus, dyslipidemia. non-a.coholic fa.ty liver disea.e, a.d nephropa.hy

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World Journa. of Dia.etes 2024年第5期15卷 814-817页

作者： ashraf a. Ma.houn Depa.tment of Genetics a.d Bioinforma.ics Dasman Diabetes InstituteDasman 15400Kuwait

In this editoria.,we comment on the a.ticle by Liu et a. published in the recent issue of the World Journa. of Dia.etes(Rela.ionship between GCKR gene rs780094 polymorphism a.d type 2 dia.etes with a.buminuria..Type 2 dia.etes mellitus(T2DM)is a.chronic disorder cha.a.terized by dysregula.ed glucose *** persistent eleva.ed blood glucose level in T2DM significa.tly increa.es the risk of developing severe complica.ions,including ca.diova.cula. disea.e,re-tinopa.hy,neuropa.hy,a.d nephropa.hy.T2DM a.ises from a.complex interpla. between genetic,epigenetic,a.d environmenta. *** genomic studies ha.e identified numerous genetic va.ia.ions a.socia.ed with a. increa.ed risk of ***,va.ia.ions within the glucokina.e regula.ory protein(GCKR)gene ha.e been linked to heightened susceptibility to T2DM a.d its a.socia.ed *** clinica. tria. by Liu et a. further elucida.es the role of the GCKR rs780094 polymorphism in T2DM a.d nephropa.hy *** findings demonstra.e tha. individua.s ca.rying the CT or TT genotype a. the GCKR rs780094 locus a.e a. a.higher risk of developing T2DM with a.buminuria.compa.ed to those with the CC *** findings highlight the importa.ce of genetic testing a.d risk a.sessment in T2DM to develop effective preventive stra.egies a.d persona.ized trea.ment pla.s.

关键词： Glucokina.e regula.ory protein rs780094 Type 2 dia.etes mellitus Dyslipidemia Non-a.coholic fa.ty liver disea.e Nephropa.hy

Teneligliptin:a.potentia. thera.eutic a.proa.h for dia.etic ca.diomyopa.hy

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World Journa. of Dia.etes 2024年第8期15卷 1654-1658页

作者： ashraf a. Ma.houn Depa.tment of Genetics a.d Bioinforma.ics Dasman Diabetes InstituteDasman 15400Kuwait

In this editoria.,we comment on the a.ticle by Zha.g et *** mellitus is a.chronic disorder a.socia.ed with severa. complica.ions like ca.diomyopa.hy,neuropa.hy,a.d *** preva.ence is increa.ing *** dia.etes medica.ions a.e prescribed ba.ed on individua. pa.ients’***,the exa.t mecha.isms by which ma.y of these drugs exert their protective effects rema.n *** et a. elucida.es molecula. mecha.isms undela.ing ca.dioprotective effect of the dipeptidyl peptida.e-IV inhibitor,***,teneligliptin a.levia.es the a.tiva.ion of NOD-like receptor protein 3 infla.ma.ome,a.multiprotein complex tha. pla.s a.pivota. role in regula.ing the inna.e immune system a.d infla.ma.ory *** of NOD-like receptor protein 3 infla.ma.ome a.tivity reduces the expression of cytokines,oxygen ra.ica.s a.d *** findings highlight teneligliptin a. a. a.ti-dia.etic ca.dioprotective rea.ent.

关键词： Teneligliptin Dia.etes mellitus NOD-like receptor protein 3 infla.ma.ome Infla.ma.ion Ca.diomyopa.hy

Tra.elling wa.e solutions of nonlinea. conforma.le a.a.ytica. a.proa.hes

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a.plied Ma.hema.ics(a.Journa. of Chinese Universities) 2024年第3期39卷 502-518页

作者： Hira.Ta.iq Hira.ashraf Ha.i Reza.a.eh Ulviye Demirbilek Depa.tment of Ma.hema.ics Government College Women UniversitySialkotPakistan Fa.ulty of Engineering Technology Amol University of Special Modern TechnologiesAmolIran Fa.ulty of a.ts a.d Sciences Department of MathematicsMersin UniversityMersinTurkey

The presented study dea.s with the investiga.ion of nonlinea. Bogoya.lenskii equa.ions with conforma.le time-deriva.ive which ha. grea. importa.ce in pla.ma.physics a.d non-inspectora. sca.tering *** wa.e solutions of this nonlinea. conforma.le model a.e constructed by utilizing two powerful a.a.ytica. a.proa.hes,na.ely,the modified a.xilia.y equa.ion method a.d the Sa.da. sub-equa.ion *** novel soliton solutions a.e extra.ted using these ***,3D surfa.e gra.hs,contour plots a.d pa.a.etric gra.hs a.e dra.n to show dyna.ica. beha.ior of some obta.ned solutions with the a.d of symbolic softwa.e such a. *** constructed solutions will help to understa.d the dyna.ica. fra.ework of nonlinea. Bogoya.lenskii equa.ions in the rela.ed physica. phenomena.

关键词： nonlinea. pa.tia. differentia. equa.ions modified a.xilia.y equa.ion method Sa.da. sub-equa.ion method soliton solutions

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Modifying effects a.d mecha.isms of superfine sta.nless wires on microstructures a.d mecha.ica. properties of ultra.high performa.ce sea.a.er sea.sa.d concrete

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Science China.Technologica. Sciences 2024年第10期67卷 3205-3220页

作者： YU Feng DONG SuFen a.HOUR ashraf DING SiQi Ha. Ba.Guo School of Infra.tructure Engineering Dalian University of Technology Fa.ulty of Engineering & Informa.ics University of Bradford Depa.tment of Civil a.d Environmenta. Engineering The Hong Kong Polytechnic University

Ultra.high-performa.ce sea.a.er sea.sa.d concrete（UHPSSC） presents a.prospective solution to a.dress the na.ura. resource shorta.e in ma.ine infra.tructure construction. To elimina.e the corrosion risk of steel fibers a.d broa.en the a.plica.ility of UHPSSC, this study investiga.es the mecha.ica. properties a.d free chloride ion content a. well a. microstructures of UHPSSC reinforced with superfine sta.nless wires（SSWs） under na.ura. curing. The results indica.e tha. 1.5% SSWs ca. rema.ka.ly improve the flexura. strength a.d toughness of UHPSSC by 127% a.d 1724%, respectively, a.d mitiga.e the long-term strength degra.a.ion of UHPSSC. The strong interfa.ia. bond between SSW a.d UHPSSC improves the compa.tness of UHPSSC, thus reducing the growth spa.e for Ca.OH）2crysta.s a.d swelling hydra.ion products genera.ed by sulfa.e a.d ma.nesium ions. This ca. be supported by the observed reduction in the Ca.Si ra.io of C–S–H gels, CH crysta. orienta.ion index, a.d ***, through mecha.isms such a. pull-out, rupture, overla.ping network, a.d interna. a.chor interfa.e, SSWs effectively prevent microcra.k growth a.d propa.a.ion, tra.sforming single long-connected microcra.ks into multiple-emission microcra.ks centered on SSW. a.ditiona.ly, the free chloride ion content of the composites a. 28 a.d 180 d meets the a.I 318-19 sta.da.d requirements for concrete exposed to sea.a.er. This complia.ce is a.tributed to the chloride immobiliza.ion fa.ilita.ed by Friedel's sa.t a.d C–S–H gels within the interfa.es a.ound SSWs a.d sea.sa.d. Consequently, SSWs-reinforced UHPSSC exhibits considera.le potentia. for a.plica.ions in susta.na.le ma.ine infra.tructures, dema.ding long-term mecha.ica. properties a.d high dura.ility.

关键词： ultra.high performa.ce sea.a.er sea.sa.d concrete superfine sta.nless wire mecha.ica. properties chloride ion content microstructure

Optimiza.ion a.gorithms of PERT/CPM Network Dia.ra.s in Linea. Diopha.tine Fuzzy Environment

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 1095-1118页

作者： Ma.i Pa.ima.a.Ka.thikeya. Pra.a.h ashraf a.-Qura. Muha.ma. Ria. Sa.id Ja.a.i Depa.tment of Ma.hema.ics Bannari Amman Institute of TechnologySathyamangalamTamil Nadu638401India Ba.ic Sciences Depa.tment Preparatory Year DeanshipKing Faisal UniversityAl-Ahsa31982Saudi Arabia Depa.tment of Ma.hema.ics University of the PunjabLahorePakistan College of Vestsja.lla.d South Herrestraede 11Slagelse4200Denmark

The idea.of linea. Diopha.tine fuzzy set(LDFS)theory with its control pa.a.eters is a.strong model for ma.hine lea.ning a.d optimiza.ion under *** a.tivity times in the critica. pa.h method(CPM)representa.ion procedures a.proa.h a.e initia.ly sta.ic,but in the Project Eva.ua.ion a.d Review Technique(PERT)a.proa.h,they a.e *** study proposes a.novel wa. of project review a.d a.sessment methodology for a.project network in a.linea. Diopha.tine fuzzy(LDF)*** LDF expected ta.k time,LDF va.ia.ce,LDF critica. pa.h,a.d LDF tota. expected time for determining the project network a.e a.l computed using LDF numbers a. the time of ea.h a.tivity in the project *** prima.y premise of the LDF-PERT a.proa.h is to a.dress a.biguities in project network a.tivity timesmore simply tha. other a.proa.hes such a. conventiona. PERT,Fuzzy PERT,a.d so *** LDF-PERT is a. efficient a.proa.h to a.a.yzing symmetries in fuzzy control systems to seek a. optima. *** a.so present a.new a.proa.h for loca.ing LDF-CPM in a.project network with uncerta.n a.d erroneous a.tivity *** the a.a.la.le resources a.d a.tivity times a.e imprecise a.d unpredicta.le,this stra.egy ca. help decision-ma.ers ma.e better judgments in a.project.a.compa.ison a.a.ysis of the proposed technique with the existing techniques ha. a.so been *** suggested techniques a.e demonstra.ed with two suita.le numerica. exa.ples.

关键词： Linea. Diopha.tine fuzzy gra.hs project ma.a.ement PERT CPM linea. Diopha.tine fuzzy numbers score function a.cura.y function

Rising tide: The globa. surge of type 2 dia.etes in children a.d a.olescents dema.ds a.tion now

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World Journa. of Dia.etes 2024年第5期15卷 797-809页

作者： Joseph M Pa.pa.ha. Cornelius Ja.es Ferna.dez a.bika.P ashraf Depa.tment of Endocrinology a.d Meta.olism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Fa.ulty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Fa.ulty of Biology Medicine&HealthThe University of ManchesterManchester M139PLUnited Kingdom Depa.tment of Endocrinology&Meta.olism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Division of Pedia.ric Endocrinology a.d Dia.etes Department of PediatricsUniversity of Alabama at BirminghamBirminghamAL 35233United States

Childhood-onset obesity ha. emerged a. a.ma.or public hea.thca.e cha.lenge a.ross the globe,fueled by a. obesogenic environment a.d influenced by both genetic a.d epigenetic *** ha. led to a. exponentia. rise in the incidence of type 2 dia.etes mellitus in children a.d *** looming wa.e of dia.etes-rela.ed complica.ions in ea.ly a.ulthood is a.ticipa.ed to stra.n the hea.thca.e budgets in most *** there is a.collective globa. effort to curb the deva.ta.ion ca.sed by the situa.ion,the impa.t is poised to be pro-found.a.multifa.eted resea.ch effort,governmenta. legisla.ion,a.d effective socia. a.tion a.e crucia. in a.ta.ning this *** a.ticle delves into the current epidemiologica. la.dsca.e,explores evidence concerning potentia. risks a.d consequences,delves into the pa.hobiology of childhood obesity,a.d discusses the la.est evidence-ba.ed ma.a.ement stra.egies for dia.esity.

关键词： Childhood obesity Dia.esity Type 2 dia.etes mellitus a.olescence Ca.diova.cula. disea.e Pha.ma.othera.y