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Cancer Biology & Medicine 2014年第4期11卷 264-269页

作者： Dmitriy Sergeevich Kobyakov ashot merudzhanovich avdalyan Aleksandr Fedorovich Lazarev Elena Leonidovna Lushnikova Lev Moiseevich Nepomnyashchikh Budget Institution Kogalym City Hospital Laboratory of Molecular Diagnostics of Altai Branch of Russian N.N.Blokhin Cancer Research Center Federal State Budget Institution Research Institute of Regional Pathology and Pathomorphology of Siberian Branch of Russian Academy of Medical Sciences

Objective： To evaluate the relation between argyrophilic nucleolar organizer region （AgNOR）-associated proteins and clinicopathological parameters and survival in non-small-cell lung cancer （NSCLC）. Methods： A total of 207 surgical specimens diagnosed as NSCLC were included in this study. Double-staining procedures were performed using antigen Ki-67 （clone MIB-1） and silver nitrate by immunohistochemical and AgNOR-staining methods. Results： The AgNOR area in MIB-l-positive cells of NSCLC is related to clinicopathological parameters under the TNM （tumor, node, and metastasis） system. The survival of patients with small AgNOR area in MIB-1-positive cells is better than that of patients with large AgNOR area. Molecular, biological （AgNOR area in MIB-l-positive cells）, and clinicopathological （greatest tumor dimension, metastases to regional lymph nodes, histology, and differentiation） parameters are independent prognostic factors of ***： The AgNOR area in MIB- 1-positive cells is related to clinicopathological parameters and survival in NSCLC.

关键词： Argyrophilic nucleolar organizer region (AgNOR) MIB-1 survival non-small cell lung cancer (NSCLC)

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The Future of Tax Administration

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Belt and Road Initiative Tax Journal 2024年第1期 15-19页

作者： ashot Muradyan State Revenue Committee the Republic of Armenia

This article analyzes the historical progression of tax administration in the utilization of computer technology since the mid-20th *** digitalization of tax administration is divided into three main stages which are elaborated *** most precise analysis is performed for today's practice with using of machine learning and artificial intelligence(ML&AI),and the key areas for ML&AI implementation in tax administration are *** examples and results of applying ML&AI tools in Armenian Tax Administration are also *** for future activities in the area of digitalization are also *** article also tries to predict in which direction progress will go,what will be the most important change in Tax Officer *** Cooperation.

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On Characterization of Poised Nodes for a Space of Bivariate Functions

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Advances in Linear Algebra & Matrix Theory 2016年第4期6卷 89-103页

作者： Hayk avdalyan Hakop Hakopian Department of Informatics and Applied Mathematics Yerevan State University Yerevan Armenia

There are several examples of spaces of univariate functions for which we have a characterization of all sets of knots which are poised for the interpolation problem. For the standard spaces of univariate polynomials, or spline functions the mentioned results are well-known. In contrast with this, there are no such results in the bivariate case. As an exception, one may consider only the Pascal classic theorem, in the interpolation theory interpretation. In this paper, we consider a space of bivariate piecewise linear functions, for which we can readily find out whether the given node set is poised or not. The main tool we use for this purpose is the reduction by a basic subproblem, introduced in this paper.

关键词： Bivariate Interpolation Problem Poisedness Fundamental Function Bivariate Piecewise Linear Function Reductions by Basic Subproblems

Could the Cuticle of Beetles Serve Also for Their Radiative Thermoregulation?

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Optics and Photonics Journal 2013年第7期3卷 17-22页

作者： Karen Allahverdyan Tigran Galstian ashot Gevorgyan Rafik Hakobyan Center for Optics Photonics and Laser Department of Physics Engineering Physics and Optics Laval University Québec City Canada Department of Physics Yerevan State University Yerevan Armenia

Based on the recent observation of the asymmetry of light energy flow through a material system that is similar to an iridescent beetle’s cuticle, we discuss the key roles of chiral molecular organization (responsible for the iridescent color of beetles) and of asymmetric boundary conditions (defined by the position of their cuticle) in the evolution of such photonic biological structures. Question is raised about the possible role of such energy flow asymmetry in the radiative thermoregulation of those beetles.

关键词： Light Propagation in Tissues Photonic Band-Gap Materials Optical Properties

Zinc oxide nanocomposites with antitumor activity

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Natural Science 2010年第12期2卷 1341-1348页

作者： Emma Arakelova ashot Khachatryan Karapet Avjyan Zoya Farmazyan Alvard Mirzoyan Lilia Savchenko Sedrak Ghazaryan Flora Arsenyan 不详

Zinc oxide nanocomposites in the form of coatings and composite films with antitumor activity were obtained by deposition of ZnO nanofilms on surfaces of ethyl ether Sali- cylidene DL-tyrosine (S1) and ethyl ether Sali- cylidene DL-tyrosine Cu (II) chelate (S2) by magnetron sputtering of Zn target. Ethyl ether salicylidene DL-tyrosine, Cu (II) chelate of ethyl ether salicylidene DL-tyrosine reveal some anticancer properties. Their zinc oxide nano- composites were obtained in the form of coat- ings (S1 + ZnO, S2 + ZnO) and composite films presenting a mixture of polyvinyl alcohol (PVA) with S1, S2 (S1 + PVA + ZnO, S2 + PVA + ZnO), for the purpose of increasing anticancer activity. Considerable increase in antitumor activity re- veal ZnO nanocomposites with salicylidene amino acid chelates (as distinct from their ethers) in the form of S2 + ZnO (47%) and S2 + PVA + ZnO (48%) in comparison with S2 (20%). Structural, spectral properties of the salicylidene amino acids and their ZnO nanocomposites were studied.

关键词： Zinc Oxide Nanofilm Magnetron Sputtering Nanocomposites Antitumor Activity

Purine and Pyrimidine-Linked Enzymes and Genes are Strongly Responsible for the Development of Tumors, Particularly Glioblastoma Multiforme

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Computational Molecular Bioscience 2020年第3期10卷 73-80页

作者： Kristine Edgar Danielyan Tatul ashot Yeghiazaryan Samvel Grigoriy Chailyan Levon Ruben Harutyunyan Ruben Levon Harutyunyan Gurgen Sergei Petrosyan H. Buniatian Institute of Biochemistry National Academy of Science of Armenia Yerevan Armenia National Center of Oncology named after V. A. Fanarjian Yerevan Armenia Institute for Informatics and Automation Problems of the National Academy of Science of Armenia Yerevan Armenia

We were aiming to delineate, by the utility of the biological data results, in our investigations the link between the purine and pyrimidine metabolism and development of the glioblastoma. We analyzed the sets of the genes, belonging to the purine and pyrimidine metabolism by the utility of GSEA software as well as MSIgnDB application of the GSEA. The GEO database, GEOR2 tools were serving for the visualization of the genes expression profiles of the disease. The Cancer Proteome Atlas as well as the tools of the data sets were also used to collect and analyze the results. We concluded and came to the following consequential results. 1) Neurogenesis and Glioblastoma are sharing some common genes. 2) Purine and pyrimidine metabolism-linked enzymes and genes are responsible for the upregulation of DNA and mRNA synthesis in the settings of the tumor development. 3) EGFR expression responsible genes, mRNA as well as protein is upregulated during the development of the glioblastoma. 4) GMPS genes are more strongly upregulated in the settings of the glioblastoma than ADSL. 5) PRPS1 is strongly synthetized in neurospheres in contrast to the mature tissue during glioblastoma development.

关键词： Data Bases Purine Pyrimidine Metabolism Glioblastoma PRPS1

米哈伊尔·瓦西里耶维奇·罗蒙诺索夫——“我国的第一所大学”

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科学与社会 1986年第4期 56-65页

作者： ashot T.Grigoryan,何永晋国际科学史研究院

从一个没有文化的渔民之子成长为自己祖国第一所大学的创办人——这是俄国科学家和文豪米哈伊尔·瓦西里耶维奇·罗蒙诺索夫的事迹。他是睿智的理论家和学者,同时又是“文艺复兴式人物”,其知识之广博简直了无边际。他是科学发展史上的... 详细信息

从一个没有文化的渔民之子成长为自己祖国第一所大学的创办人——这是俄国科学家和文豪米哈伊尔·瓦西里耶维奇·罗蒙诺索夫的事迹。他是睿智的理论家和学者,同时又是“文艺复兴式人物”,其知识之广博简直了无边际。他是科学发展史上的一位伟人。为纪念他275周年诞辰,本期发表一位科学史大家讲述罗蒙诺索夫的光辉生平和工作的文章。

关键词：罗蒙诺索夫俄国莫斯科大学米哈伊尔瓦西维奇里耶

INFLUENCE OF DISCHARGE AND STORAGE ON THE IMPEDANCE OF LITHIUM/THIONYL CHLORIDE CELLS

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INFLUENCE OF DISCHARGE AND STORAGE ON THE IMPEDANCE OF LITHI...

The 5th International Meeting on Lithium Batteries

作者： M.B.avdalyan V.S.Bagotzky L.S.Kanevsky V.E.Kazarinov E.A.Nizhnikovsky A.N.Frumkin Institute of Electrochemistry Academy of Sciences of the USSR

＜正＞The change during storage and discharge in the impedance characteristics of lithium/thionyl chloride cells in the range of high and medium frequencies has been *** were made on button cells with rated capacity o...

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深断裂带超大型矿床矿化的某些特性

地质科学译丛 1997年第1期14卷 62-63页

作者： ashot Karapetian 陈金银 IGS of NAS of Repubic of Armenia and EBERHART & STOUN Inc.U.S.A

在小高加索山脉中,可以区分出许多具有一系列侵入、喷出、变质及矿化等特征的长期持续活动的深断裂带。深断裂带中矿床本身是长期地质、岩浆、变质作用等综合活动作用的结果。

关键词：热液矿床大型矿床矿化断裂带矿床成矿

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Investigating molecular/physiological mechanisms of plant heavy metal accumulation using Thlaspi caerulescens as a model plant system

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Investigating molecular/physiological mechanisms of plant he...