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Diagnosis of Helicobacter pylori : What should be the gold standard?

World Journal of Gastroenterology 2014年第36期20卷 12847-12859页

作者： Saurabh kumar Patel Chandra Bhan Pratap ashok kumar jain Anil kumar Gulati Gopal Nath Department of Microbiology Institut of Medical Sciences Banaras Hindu University Varanasi U221005 India Department of Gastroenterology Institute of Medical Sciences Banaras Hindu University Varanasi UP221005 India Department of Microbiology Institutof Medical Sciences Banaras Hindu University Varanasi U221005 India

Since the discovery of Helicobacter pylori (H. pylori) in 1983, numerous detection methods for the presence of the bacterium have been developed. Each one of them has been associated with advantages and disadvantages. Noninvasive tests such as serology, 13C urea breath test (UBT) and stool antigen tests are usually preferred by the clinicians. Serology has its own limitation especially in endemic areas while 13C UBT is technically very demanding. The stool antigen detection method, although specific, is usually associated with poor sensitivity. The 13C UBT is believed to be specific, but with present revelation of the fact that stomach is colonized by many other urease producing bacteria makes it questionable. Histology, culture, rapid urease test and polymerase chain reaction (PCR) are the tests which are carried out on antral biopsies collected by invasive means. Histology has been proposed to be very sensitive and specific but the question is how by simply looking the morphology of the bacteria in the microscope, one can claim that the curved bacterium is exclusively H. pylori. Rapid urease test (RUT), the doctor’s test, is also challenged because the presence of other urease producing bacteria in the stomach cannot be denied. Moreover, RUT has been reported with poor sensitivity specially, when density of the bacterium is low. Isolation of H. pylori is essential to investigate its growth requirements, antibiotic susceptibility testing, studying virulence factor to develop vaccine and many more explorations. It has also got several disadvantages i.e., special condition for transporting, media, incubation and few days waiting for the colonies to appear, apart from the speed essentially needed to process the specimens. Till date, majority of the microbiological laboratories in the world are not equipped and trained to isolate such fastidious bacterium. The option left is PCR methods to detect H. pylori’s DNA in gastr

关键词： Helicobacter pylori review Invasive tests Non-invasive tests Gold standard Polymerase chain reaction detection Nested polymerase chain reaction

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Pseudomonas fluorescens-like bacteria from the stomach:A microbiological and molecular study

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World Journal of Gastroenterology 2013年第7期19卷 1056-1067页

作者： Saurabh kumar Patel Chandra Bhan Pratap Ajay kumar Verma ashok kumar jain Vinod kumar Dixit Gopal Nath Department of Microbiology Institute of Medical SciencesBanaras Hindu UniversityVaranasi UP 221005India Department of Gastroenterology Institute of Medical SciencesBanaras Hindu UniversityVaranasi UP 221005India

AIM:To characterize oxidase-and urease-producing bacterial isolates,grown aerobically,that originated from antral biopsies of patients suffering from acid peptic ***:A total of 258 antral biopsy specimens were subjected to isolation of bacteria followed by tests for oxidase and urease production,acid tolerance and aerobic *** selected isolates were further characterized by molecular techniques *** for 16S rRNA using universal eubacterial and HSP60 gene specific *** amplicons were subjected to restriction analysis and partial sequencing.A phylogenetic tree was generated using unweighted pair group method with arithmetic mean(UPGMA) from evolutionary distance computed with bootstrap test of *** of acidity tolerance of bacteria isolated from antrum was performed using hydrochloric acid from 10-7 mol/L to 10-1 mol/***:Of the 258 antral biopsy specimens collected from patients,179(69.4%) were positive for urease production by rapid urease test and 31%(80/258) yielded typical Helicobacter pylori(***) after 5-7 d of incubation under a microaerophilic environment.A total of 240(93%) antral biopsies yielded homogeneous semi-translucent and small colonies after overnight *** partial 16S rRNA sequences revealed that the isolates had 99% similarity with Pseudomonas species.A phylogenetic tree on the basis of 16S rRNA sequences denoted that JQ927226 and JQ927227 were likely to be related to Pseudomonas fluorescens(***).On the basis ofHSP60 sequences applied to the UPGMA phylogenetic tree,it was observed that isolated strains in an aerobic environment were likely to be ***,and HSP60 sequences had more discriminatory potential rather than 16S rRNA ***,this bacterium was acid tolerant for hours at low ***,a total of 250(96.9%) genomic DNA samples of 258 biopsy specimens and DNA from 240 bacterial isolates were positive for the 613 bp amplicons by targetin

关键词： Antral biopsy Helicobacter pylori Pseudomonas fluorescens HSP60 Nested polymerase chain reaction Acid-tolerant bacteria

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准幻核中的近似广义辛弱数守恒（英文）

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原子核物理评论 2017年第1期34卷 73-81页

作者： ashok kumar jain Bhoomika Maheshwari 印度鲁尔基理工学院物理系

对称性在了解诸如原子核的转动、自旋和宇称、及同位旋等核结构性质中都起着重要的作用,并且使复杂的原子核结构问题得以简化。辛弱数就是由于原子核的对相互作用中的对称性所导出的众所周知的好量子数。通过对丰中子和缺中子核素及核... 详细信息

对称性在了解诸如原子核的转动、自旋和宇称、及同位旋等核结构性质中都起着重要的作用,并且使复杂的原子核结构问题得以简化。辛弱数就是由于原子核的对相互作用中的对称性所导出的众所周知的好量子数。通过对丰中子和缺中子核素及核素的高自旋态的衰变数据分析来揭示辛弱数的近似守恒性质。研究结果表明,在准幻核的高自旋同质异能素链中,无论所涉及的价空间的核子轨道有何不同,广义辛弱数总是近似的好量子数。

关键词：广义辛弱数同质异能素准幻核

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Image smog restoration using oblique gradient profile prior and energy minimization

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Frontiers of Computer Science 2021年第6期15卷 147-153页

作者： ashok kumar Arpit jain College of Computing Science and Information Technogy TeerthankerMahaveer UniversityMoradabad 244001India

Removing the smog from digital images is a challenging pre-processing tool in various imaging ***,many smog removal(i.e.,desmogging)models are proposed so far to remove the effect of smog from *** desmogging models are based upon a physical model,it means it requires efficient estimation of transmission map and atmospheric veil from a single smoggy ***,many prior based restoration models are proposed in the literature to estimate the transmission map and an atmospheric ***,these models utilized computationally extensive minimization of an energy ***,the existing restoration models suffer from various issues such as distortion of texture,edges,and ***,in this paper,a convolutional neural network(CNN)is used to estimate the physical attributes of smoggy *** gradient channel prior(OGCP)is utilized to restore the smoggy ***,a dataset of smoggy and sunny images are ***,we have trained CNN to estimate the smog gradient from smoggy ***,based upon the computed smog gradient,OGCP is utilized to restore the still smoggy *** analyses reveal that the proposed CNN-OGCP based desmogging model outperforms the existing desmogging models in terms of various performance metrics.

关键词： convolutional neural networks desmogging smog oblique gradient channel prior

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Investigation of structural, morphological and electrochemical properties of mesoporous La2CuCoO6 rods fabricated by facile hydrothermal route

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International Journal of Minerals,Metallurgy and Materials 2020年第7期27卷 987-995页

作者： Jashandeep Singh ashok kumar Department of Physics National Institute of Technology KurukhsetraHaryana 136119India Department of Applied Sciences National Institute of Technical Teachers Training and ResearchChandigarh 160019India

This work introduces the facile hydrothermal synthesis of double perovskite La2CuCoO6.X-ray diffraction pattern confirmed the formation of a monoclinic phase with P121/c1 *** electron microscopy results revealed that the self-assembled porous rods were composed of nanocrystallite *** estimated specific surface area of these mesoporous rods with an average pore diameter of 6 nm was^41 m^2·g^–*** presence of ions with oxidation states of La^3+,Cu^2+,and Co^2+/Co^3+on the surface of the mesoporous La2CuCoO6 rods was confirmed by X-ray photoelectron spectroscopic *** cyclicvoltammetry and chronopotentiometry,the electrode fabricated from the mesoporous La2CuCoO6 rods were found to exhibit pseudocapacitive behavior with a specific capacitance of 259.4 F·g^–1 at a current density of 0.5 A·g^–***^89%retention in specific capacitance was achieved after 1000 charge/discharge cycles at a constant current density of4 A·g^–1.

关键词： rare earth double perovskites oxide materials hydrothermal electrochemical

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Translocator protein and neurodegeneration: insights from Alzheimer’s disease

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Neural Regeneration Research 2025年第4期20卷 1090-1091页

作者： Arpit kumar Pradhan Rainer Rupprecht Gerhard Rammes Klinik für Anaesthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany Graduate School of Systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany Department of Psychiatry and Psychotherapy University RegensburgRegensburgGermany

The 18 kDa translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce *** main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.

关键词： cholesterol organs

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Historical temporal variation in precipitation over Western Himalayan Region：1857-2006

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Journal of Mountain Science 2016年第4期13卷 672-681页

作者： naresh kumar ashok kumar jaswal India Meteorological Department Lodi Road New Delhi 110003 India India Meteorological Department Pune 411005 India

This study has examined the temporal variation in monthly, seasonal & annual precipitation over the Western Himalayan Region(WHR) and the influence of global teleconnections, like the North Atlantic Oscillation(NAO) and Southern Oscillation(SO) Indices on seasonal & annual precipitation. The Mann–Kendall non-parametric test is applied for trend detection and the Pettitt–Mann–Whitney test is used to detect possible shift. Maximum entropy spectral analysis is applied to find the periodicity in annual & seasonal precipitation. The study shows a non-significant decreasing trend in annual precipitation over WHR for the period 1857-2006. However, in seasonal precipitation, a significant decreasing trend is observed in monsoon and a significant increasing trend in post-monsoon season during the same period. The significant decrease in monsoon precipitation may be due to weakening of its teleconnection with NAO as well as SO Indices mainly during last three decades. It is observed that the probable change of year in annual & monsoon precipitation over WHR is 1979. The study also shows significant periodicities of 2.3-2.9 years and of 3.9-4.7 years in annual & seasonal precipitation over WHR.

关键词： Monsoon Precipitation Western Himalayan region Temporal Variation

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Analysis of frequency shifting in seismic signals using Gabor-Wigner transform

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Earthquake Engineering and Engineering Vibration 2015年第4期14卷 715-724页

作者： Roshan kumar P.Sumathi ashok kumar Deaprtment of Earthquake Engineering IIT Roorkee Deaprtment of Electrical Engineering IIT Roorkee

A hybrid time-frequency method known as Gabor-Wigner transform (GWT) is introduced in this paper for examining the time-frequency patterns of earthquake damaged buildings. GWT is developed by combining the Gabor transform (GT) and Wigner-Ville distribution (WVD). GT and WVD have been used separately on synthetic and recorded earthquake data to identify frequency shifting due to earthquake damages, but GT is prone to windowing effect and WVD involves ambiguity function. Hence to obtain better clarity and to remove the cross terms (frequency interference), GT and WVD are judiciously combined and the resultant GWT used to identify frequency shifting. Synthetic seismic response of an instrumented building and real-time earthquake data recorded on the building were investigated using GWT. It is found that GWT offers good accuracy for even slow variations in frequency, good time-frequency resolution, and localized response. Presented results confirm the efficacy of GWT when compared with GT and WVD used separately. Simulation results were quantified by the Renyi entropy measures and GWT shown to be an adequate technique in identifying localized response for structural damage detection.

关键词： time-frequency distribution seismic signals cross-term interference Gabor transform Wigner- Ville distribution Gabor-Wigner transform

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A Comprehensive Survey on Federated Learning Applications in Computational Mental Healthcare

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 49-90页

作者： Vajratiya Vajrobol Geetika jain Saxena Amit Pundir Sanjeev Singh Akshat Gaurav Savi Bansal Razaz Waheeb Attar Mosiur Rahman Brij B.Gupta Institute of Informatics and Communication University of DelhiDelhi110021India Maharaja Agrasen College University of DelhiDelhi110096India Computer Engineering Ronin InstituteMontclairNJ 07043USA Department of Research and Innovation Insights2TechinfoJaipur302001India University Centre for Research and Development(UCRD) Chandigarh UniversityChandigarh140413India Management Department College of Business AdministrationPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia CCRI&Department of Computer Science and Information Engineering Asia UniversityTaichung413Taiwan Symbiosis Centre for Information Technology(SCIT) Symbiosis International UniversityPune411057India Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India

Mental health is a significant issue worldwide,and the utilization of technology to assist mental health has seen a growing *** aims to alleviate the workload on healthcare professionals and aid *** applications have been developed to support the challenges in intelligent healthcare ***,because mental health data is sensitive,privacy concerns have *** learning has gotten some *** research reviews the studies on federated learning and mental health related to solving the issue of intelligent healthcare *** explores various dimensions of federated learning in mental health,such as datasets(their types and sources),applications categorized based on mental health symptoms,federated mental health frameworks,federated machine learning,federated deep learning,and the benefits of federated learning in mental health *** research conducts surveys to evaluate the current state of mental health applications,mainly focusing on the role of Federated Learning(FL)and related privacy and data security *** survey provides valuable insights into how these applications are emerging and evolving,specifically emphasizing FL’s impact.

关键词： Depression emotional recognition intelligent healthcare systems mental health federated learning stress detection sleep behaviour

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Effect of processing parameters on the electromagnetic radiation emission during plastic deformation and crack propagation in copper-zinc alloys

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第11期7卷 1800-1809页

作者： kumar Rajeev MISRA ashok Department of Mechanical Engineering Birla Institute of Technology Mesra 835215 Ranchi India

This paper presents some investigations on the effect of processing parameters on the emission of electromagnetic radiation （EMR） during plastic deformation and crack propagation in copper-zinc alloys. Timing of the EMR emissions, maximum stress during crack instability, stress-intensity factor, elastic strain energy release rate, maximum EMR amplitude, RMS value of EMR amplitude, EMR frequency and electromagnetic energy release rate were analysed for the effect of rolling directions at different percentage of zinc content in Cu-Zn alloy specimens. The same parameters were also analysed for 68-32 Cu-Zn alloy specimens at different annealing temperatures and at different angles 0, to the rolling direction. EMR emissions are observed to be highly anisotropic in nature. At θ=45° to 60°, marked changes in mechanical and electromagnetic parameters were observed. Specimens annealed at 500℃, just above the recrystallization temperature, and at 700℃, when grain-size growth is rapid, EMR responses have been found to have well-defined patterns.

关键词： Radiation Plastic deformation Rolling direction Annealing Fracture

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