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Journal of Biomaterials and Nanobiotechnology 2011年第4期2卷 414-425页

作者： Umesh kumar Parida ashok kumar nayak Birendra kumar Binhani P. L. nayak KIIT School of Biotechnology KIIT University Bhubaneswar India. P. L. nayak Research Foundation Neelachal Bhavan Bidyadharpur Cuttack India P. L. nayak Research Foundation Neelachal Bhavan Cuttack India P. L. nayak Research Foundation Neelachal Bhavan Cuttack India

In the present research program, polymer nanocomposites have been used as the drug carrier for delivery systems of anticancer drug. Chitosan (Cs) and Polyvinyl Alcohol (PVA) with different ratios were blended with different wt% of Cloisite 30B solution by solvent casting method. Glutaraldehyde with different wt% was added to the blended solution as a crosslinking agent. Cloisite 30B was incorporated in the formulation as a matrix material component which also plays the role of a co-emulsifier in the nanocomposite preparation. Curcumin with different concentrations were loaded with CS-PVA/ C 30B nanocomposites for studying the in-vitro drug delivery systems. Morphology and structure characterization of nanocomposites were investigated by fourier transmission infra red spectroscopy (FTIR), scanning electron microscope (SEM), tensile strength and water uptake capacity. The drug release was studied by changing time, pH and drug concentrations. The kinetics of the drug release was studied in order to ascertain the type of release mechanism. Based on the diffusion as well as the kinetics, the mechanism of the drug release from the composite matrix has been reported.

关键词： Chitosan PVA C 30B Glutaraldehyde Curcumin Drug Delivery

A review on edge analytics:Issues,challenges,opportunities,promises,future directions,and applications

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Digital Communications and Networks 2024年第3期10卷 783-804页

作者： Sabuzima nayak Ripon Patgiri Lilapati Waikhom Arif Ahmed National Institute of Technology Silchar India Ericsson Sweden

Edge technology aims to bring cloud resources(specifically,the computation,storage,and network)to the closed proximity of the edge devices,i.e.,smart devices where the data are produced and *** computing and application in edge devices lead to emerging of two new concepts in edge technology:edge computing and edge *** analytics uses some techniques or algorithms to analyse the data generated by the edge *** the emerging of edge analytics,the edge devices have become a complete ***,edge analytics is unable to provide full support to the analytic *** edge devices cannot execute advanced and sophisticated analytic algorithms following various constraints such as limited power supply,small memory size,limited resources,*** article aims to provide a detailed discussion on edge *** key contributions of the paper are as follows-a clear explanation to distinguish between the three concepts of edge technology:edge devices,edge computing,and edge analytics,along with their *** addition,the article discusses the implementation of edge analytics to solve many problems and applications in various areas such as retail,agriculture,industry,and ***,the research papers of the state-of-the-art edge analytics are rigorously reviewed in this article to explore the existing issues,emerging challenges,research opportunities and their directions,and applications.

关键词： Edge analytics Edge computing Edge devices Big data Sensor Artificial intelligence Machine learning Smart technology Healthcare

Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease

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Genes & Diseases 2024年第1期11卷 67-71页

作者： Souvik Kar Andrea Perrelli Kiran kumar Bali Raffaella Mastrocola Arpita Kar Bushra Khan Luis Gand Arnab nayak Christian Hartmann Wolfram SKunz Amir Samii Helmut Bertalanffy Saverio Francesco Retta International Neuroscience Institute Rudolf-PichlmayrStrasse 4Hannover 30625Germany Department of Clinical and Biological Sciences University of TorinoOrbassano(TO)10043Italy CCM Italia Research Network National Coordination Center at the Department of Clinical and Biological SciencesUniversity of TorinoOrbassano(TO)10043Italy Department of Experimental Pain Research Mannheim Center for Translational Neuroscience(MCTN)Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Department of Kidney Liver and Metabolic DiseasesChildren’s HospitalHannover Medical SchoolHannover 30625Germany Ricarda-Huch-Street-10B Hannover 30880Germany Institute of Molecular and Cell Physiology Hannover Medical SchoolHannover 30625Germany Department of Neuropathology Institute of PathologyHannover Medical SchoolHannover 30625Germany Institute of Experimental Epileptology and Cognition Research and Department of Epileptology University Hospital BonnVenusberg-Campus 1Bonn 53127Germany epartment of Pharmacology and Physiology University of Rochester Medical CenterRochesterNY 14642USA

cerebrovascular disease of genetic origin characterized by abnormally dilated capillaries and a wide spectrum of symptoms,including headaches,seizures,neurological deficits,and intracerebral *** unpredictable clinical course and the current lack of therapies make the identification of prognostic and predictive biomarkers an imperative research challenge.1 Herein,we provide evidence that galectin-3(Gal-3),a major tissue and circulating biomarker of oxidative stress and inflammation,is significantly up-regulated both in CCM patients and ***,wholetranscriptome sequencing,qRT-PCR,and Western blotting studies demonstrated a significant up-regulation of Gal-3 expression levels both in surgical CCM specimens and in blood samples of CCM patients.

关键词： inflammation cerebral dilated

Biological,pathological,and multifaceted therapeutic functions of exosomes to target cancer

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Oncology Research 2024年第1期32卷 73-94页

作者： VIGNESH BALAJI E DIVYA RAMESH MANISHA CHUNGAN SHAJU AKSHARA kumar SAMYAK PANDEY RAKSHA nayak V.ALKA SRISHTI MUNJAL AMIR SALIMI K.SREEDHARA RANGANATH PAI SHANKAR M.BAKKANNAVAR Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Forensic Medicine and Toxicology Kasturba Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India School of Health and Community Services Durham CollegeOshawaOntarioL1G2G5Canada Department of Pharmaceutical Regulatory Affairs and Management Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Clinical Psychology Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Speech and Hearing Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India

Exosomes,small tiny vesicle contains a large number of intracellular particles that employ to cause various diseases and prevent several pathological events as well in the human *** is considered a“double-edged sword”,and depending on its biological source,the action of exosomes varies under physiological ***,the isolation and characterization of the exosomes should be performed accurately and the methodology also will vary depending on the exosome ***,the uptake of exosomes from the recipients’cells is a vital and initial step for all the physiological *** are different mechanisms present in the exosomes’cellular uptake to deliver their cargo to acceptor *** the exosomal uptake takes place,it releases the intracellular particles that leads to activate the physiological *** though exosomes have lavish functions,there are some challenges associated with every step of their preparation to bring potential therapeutic ***,overcoming the pitfalls would give a desired quantity of exosomes with high purity.

关键词： Exosomes Physiology Cancer Therapeutics Challenges

Optimization of Wire-EDM Parameters for Ti-6Al-4V Using Taguchi-MRSN Optimization Approach

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Journal of Harbin Institute of Technology(New series) 2024年

作者： Ipsita nayak Jaydev Rana Department of Mechanical Engineering， Veer Surendra Sai University of Technology

Ti-6Al-4V is a lightweight， extremely strong material with high resistance to corrosion and is widely used in aerospace industries， medical implants and many more. Contour cutting in such material with sharp corner radius， narrow kerf width， and maintaining high dimensional accuracy and surface integrity is a challenge for the modern manufacturing industry. Wire electrical discharge machining （WEDM） is a feasible process to meet the above challenges. However， proper control of process parameters is highly necessary for quality cutting of such material. In order to meet the above challenges， the present work focuses on the optimum selection of different process parameters such as pulse-on time (TON)， pulse-off time (TOFF)， spark gap voltage （SV） and wire feed rate （WF） using Taguchi-based multi response signal to noise ratio （MRSN） technique. This is a very simple multi response optimization technique to simultaneously optimize vital responses like thickness of white layer formed on the machined surfaces， average crack density， surface roughness and dimensional accuracy， without the assistance of any software. Moreover， simple regression models are developed to determine the above responses for any combination of process parameters. Industry personnel will find this study useful in utilizing this expensive non-conventional machining method in a techno-economic manner.

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Characterization of early maturing elite genotypes based on MTSI and MGIDI indexes:an illustration in upland cotton(Gossypium hirsutum L.)

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Journal of Cotton Research 2024年第3期7卷 253-265页

作者： D S RAJ Supritha PATIL Rajesh S. PATIL Bhuvaneshwara R. nayak Spurthi N. PAWAR Kasu N. Department of Genetics and Plant Breeding College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Agricultural Research Station Dharwad 580005India Department of Biotechnology College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Department of Crop Physiology College of AgricultureUniversity of Agricultural SciencesDharwad 580005India

Background Globally,the cultivation of cotton is constrained by its tendency for extended periods of *** maturity plays a potential role in rainfed-based multiple cropping system especially in the current era of climate *** the current study,a set of 20 diverse Gossypium hirsutum genotypes were evaluated in two crop seasons with three planting densities and assessed for 11 morphological traits related to early *** study aimed to identify genotype(s)that mature rapidly and accomplish well under diverse environmental conditions based on the two robust multivariate techniques called multi-trait stability index(MTSI)and multi-trait genotype-ideotype distance index(MGIDI).Results MTSI analysis revealed that out of the 20 genotypes,three genotypes,viz.,NNDC-30,A-2,and S-32 accomplished well in terms of early maturity traits in two ***,three genotypes were selected using MGIDI method for each planting densities with a selection intensity of 15%.The strengths and weaknesses of the genotypes selected based on MGIDI method highlighted that the breeders could focus on developing early-maturing genotypes with specific traits such as days to first flower and boll *** selected genotypes exhibited positive genetic gains for traits related to earliness and a successful harvest during the first and second ***,there were negative gains for traits related to flowering and boll *** The study identified three genotypes exhibiting early maturity and accomplished well under different planting *** multivariate methods(MTSI and MGIDI)serve as novel approaches for selecting desired genotypes in plant breeding programs,especially across various growing *** methods offer exclusive benefits and can easily construe and minimize multicollinearity issues.

关键词： Cotton MTSI MGIDI Genotype environment interaction Early maturity Multi-trait Multi-environment

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Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy?

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Stroke & Vascular Neurology 2024年第3期9卷 279-288,I0247页

作者： Adam Ingleton Marko Raseta Rui-En Chung Kevin Jun Hui Kow Jake Weddell Sanjeev nayak Changez Jadun Zafar Hashim Noman Qayyum Phillip Ferdinand Indira Natarajan Christine Roffe Neurosciences University Hospitals of North Midlands NHS TrustStoke-on TrentUK Statistics and Mathematical Modelling Department of Molecular GeneticsErasmus Medical CenterRotterdamZuid-HollandThe Netherlands Radiology University Hospitals of North Midlands NHS TrustStoke-on TrentUK School of Medicine Keele UniversityKeeleUK Interventional Radiology University Hospitals of North Midlands NHS TrustStoke-on TrentUK Stroke Research Keele UniversityKeeleUK

Background Intraoperative antiplatelet therapy is recommended for emergent stenting during mechanical thrombectomy(MT).Most patients undergoing MT are also given *** agents are contraindicated within 24 hours of *** evaluated outcomes and complications of patients stented with and without intravenous aspirin during *** All patients who underwent emergent extracranial stenting during MT at the Royal Stoke University Hospital,UK between 2010 and 2020,were *** were thrombolysed before MT,unless *** 500 mg intravenously was given intraoperatively at the discretion of the *** intracranial haemorrhage(sICH)and the National Institutes for Health Stroke Scale score(NIHSS)were recorded at 7 days,and mortality and functional recovery(modified Rankin Scale:mRS≤2)at 90 *** Out of 565 patients treated by MT 102 patients(median age 67 IQR 57–72 years,baseline median NIHSS 18 IQR 13–23,76(75%)thrombolysed)had a stent *** these 49(48%)were given aspirin and 53(52%)were *** treated with aspirin had greater NIHSS improvement(median 8 IQR 1–16 vs median 3 IQR-9–8 points,p=0.003),but there were no significant differences in sICH(2/49(4%)vs 9/53(17%)),mRS≤2(25/49(51%)vs 19/53(36%))and mortality(10/49(20%)vs 12/53(23%))with and without *** improvement(median 12 IQR 4–18 vs median 7 IQR-7–10,p=0.01)was greater,and mortality was lower(4/33(12%)vs 6/15(40%),p=0.05)when aspirin was combined with thrombolysis,than for aspirin alone,with no increase in *** Our findings based on registry data derived from routine clinical care suggest that intraprocedural intravenous aspirin in patients undergoing emergent stenting during MT does not increase sICH and is associated with good clinical outcomes,even when combined with intravenous thrombolysis.

关键词： patients aspirin intravenous

Differential Power Based Selective Phase Tripping for Fault-resilient Microgrid

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 459-470页

作者： Bhatraj Anudeep Paresh kumar nayak the Department of Electrical Engineering Indian Institute of Technology(ISM)DhanbadDhanbadIndia

Modern fault-resilient microgrids(MGs)require the operation of healthy phases during unbalanced short-circuits to improve the system *** study proposes a differential power based selective phase tripping scheme for MGs consisting of synchronous and inverter-interfaced distributed generators(DGs).First,the differential power is computed using the line-end superimposed voltage and current ***,to make the scheme threshold-free,a power coefficient index is derived and used for identifying faulted phases in an *** protection scheme is tested on a standard MG operating in either grid-connected or islanding mode,which is simulated using PSCAD/*** efficacy of the scheme is also assessed on the OPAL-RT manufactured real-time digital simulation(RTDS)***,the performance of the proposed protection scheme is compared with a few existing *** results show that the selective tripping of faulted phases in MGs can be achieved quickly and securely using the proposed scheme.

关键词： Distributed generator differential power fault detection microgrid protection selective phase tripping.

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Thermal Characteristics of Air-Water Spray Impingement Cooling of Hot Metallic Surface under Controlled Parametric Conditions

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Journal of Thermal Science 2016年第3期25卷 266-272页

作者： Santosh kumar nayak Purna Chandra Mishra School of Mechanical Engineering KIIT University

Experimental results on the thermal characteristics of air-water spray impingement cooling of hot metallic surface are presented and discussed in this *** controlling input parameters investigated were the combined air and water pressures,plate thickness,water flow rate,nozzle height from the target surface and initial temperature of the hot *** effects of these input parameters on the important thermal characteristics such as heat transfer rate,heat transfer coefficient and wetting front movement were measured and *** flat plate samples of mild steel with dimension 120 mm in length,120 mm breadth and thickness of 4 mm,6 mm,and 8mm respectively were *** air assisted water spray was found to be an effective cooling media and method to achieve very high heat transfer rate from the *** heat transfer rate and heat transfer coefficients were obtained for the lesser i.e,4 mm thick *** in the nozzle height reduced the heat transfer efficiency of spray *** an inlet water pressure of 4 bar and air pressure of 3 bar,maximum cooling rates670℃/s and average cooling rate of 305.23℃/s were achieved for a temperature of 850℃ of the steel plate.

关键词： air-water spray transient temperature cooling rate plate thickness

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State-of-the-art on the protection of FACTS compensated high-voltage transmission lines:a review

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High Voltage 2018年第1期3卷 21-30页

作者： Sauvik Biswas Paresh kumar nayak Department of Electrical Engineering Indian Institute of Technology(ISM)Dhanbad 826004India

In recent years,the inclusion of flexible AC transmission systems(FACTS)-based compensating devices such as a thyristor-controlled series capacitor(TCSC)and a unified power flow controller(UPFC)has been increased in high-voltage power transmission systems due to numerous technical and economical ***,the operation of such FACTS devices introduces harmonics and non-linearity in power system and causes fast changes in line *** a result,the most widely used fixed impedance setting based distance relaying scheme finds limitation in protecting such compensated *** research has been carried out in recent years to develop new algorithms and methods to address the *** paper presents a comprehensive review of recent developments in the protection of TCSC/UPFC compensated high-voltage transmission *** relative merits and demerits of each of the available methods are also presented for *** to detail review,the impact of TCSC/UPFC on distance protection is evaluated by using data generated through EMTDC/PSCAD on a 400 kV two-bus test power *** study can be useful to both academic researchers and practicing engineers to gain insight on the protection of FACTS compensated transmission lines and for further development of newer algorithms.

关键词： impedance harmonics protection