检索结果-南通市图书馆

Antioxidant treatment for oligoasthenoteratozoospermia and varicocele:a DBPC trial to evaluate the impact of age and body mass index

引用

Asian Journal of Andrology 2024年第3期26卷 239-244页

作者： Gian Maria Busetto Bernarde F Rodrigues Ashraf Virmani Andrea Checchia Antonella Ninivaggi Anna Ricapito Giovanni Barbieri Piero Fischetti Ugo G Falagario Pasquale Annese Nicola d’Altilia Vito Mancini Matteo Ferro Felice Crocetto Angelo Porreca Carlo Bettocchi Luigi Cormio ashok agarwal Giuseppe Carrieri University of Foggia Foggia 71122Italy Department of Urology and Renal Transplantation Policlinico of FoggiaFoggia 71122Italy Department of Urology Human Reproduction SectionFederal University of Sao PauloSao Paulo 05403-000Brazil Alfasigma Healthscience Utrecht 3528 BGThe Netherlands Urology Unit “G.Tatarella”HospitalCerignola 71042Italy Urology Unit European Institute of Oncology(IEO)IRCCSMilan 20142Italy University of Naples Federico II Naples80126Italy Department of Oncological Urology Veneto Institute of Oncology(IOV)IRCCSPadua 35039Italy Urology Unit “L.Bonomo”HospitalAndria 70031Italy Global Andrology Forum Moreland HillsOH 44022USA

Oxidative stress is one of the main mechanisms responsible for male *** conditions such as varicocele,obesity,advanced age,and lifestyle can lead to an increase in reactive oxygen species,causing an oxidative imbalance in the *** are sensitive to reactive oxygen species and require energy to carry out their main function of fertilizingthe *** reactive oxygen species can affect sperm metabolism,leading to immobility,impaired acrosome reaction,and celldeath,thereby impairing reproductive *** double-blind randomized study evaluated the effect of supplementation withL-carnitine,acetyl-L-carnitine,vitamins,and other nutrients on semen quality in 104 infertile patients with or without varicocele,while also investigating the impact of factors such as obesity and advanced age on *** concentration significantlyincreased in the supplemented group compared to the placebo group(P=0.0186).Total sperm count also significantly increasedin the supplemented group(P=0.0117),as did sperm motility(P=0.0120).The treatment had a positive effect on patients upto 35 years of age in terms of sperm concentration(P=0.0352),while a body mass index(BMI)above 25 kg m^(−2) had a negativeeffect on sperm concentration(P=0.0110).Results were not showing a net benefit in stratifying patients in accordance withtheir BMI since sperm quality increase was not affected by this *** conclusion,antioxidant supplementation may bebeneficial for infertile patients and has a more positive effect on younger patients with a normal weight.

关键词： aging antioxidants body mass index oligoasthenoteratozoospermia varicocele

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Are men talking their reproductive health away？

引用

Asian Journal of Andrology 2015年第3期17卷 433-434页

作者： ashok agarwal Damayanthi Durairajanayagam Center for Reproductive Medicine Cleveland Clinic Cleveland Ohio USA MARA University of Technology Sungai Buloh Malaysia

The advent of mobile phones has revolutionized communication trends across the globe. As the popularity of mobile phone usage continues to escalate, there is now growing concern about the effects of radiofrequency electromagnetic waves （RF-EMW） exposure on biological tissues, such as the brain and testes. Researchers have sought to link the much debated decline in human sperm quality in the last decade, with increased exposure to RF-EMW, particularlythrough mobile phone usage. In a recent systematic review and meta-analysis on the effect of mobile phone RF-EMW radiation on sperm quality, Adams et al.1 demonstrated an association between mobile phone exposure and reduced sperm motility and viability, with inconsistent effects on sperm concentration.1 Results from 10 pooled experimental （in vitro） and observational （in vivo） human studies （n = 1492） led these researchers to suggest that exposure to RF-EMW radiation from carrying a mobile phone in the trouser pocket negatively impacts sperm quality.

关键词： RADIATION PHONES IMPACT

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The new 6^(th) edition of the WHO Laboratory Manualfor the Examination and Processing of HumanSemen: is it a step toward better standard operatingprocedure?

引用

Asian Journal of Andrology 2022年第2期24卷 123-124页

作者： Eric Chung Mohamed Arafa Florence Boitrelle Hussein Kandil Ralf Henkel Ramadan Saleh Rupin Shah Paraskevi Vogiatzi Armand Zini ashok agarwal AndroUrology Centre BrisbaneQLD 4000Australia University of Queensland Princess Alexandra HospitalBrisbaneQLD 4000Australia American Center for Reproductive Medicine Cleveland ClinicClevelandOH 44195USA Department of Andrology Cairo UniversityCairo 12613Egypt Department of Urology Hamad Medical CorporationDoha 122104Qatar Reproductive Biology Fertility PreservationAndrologyCECOSPoissy HospitalPoissyParis 78300France Saclay University UVSQINRAEBREEDJouy-en-Josas 78350France Fakih IVF Fertility Center Abu Dhabi 51133UAE Department of Metabolism Digestion and ReproductionImperial College LondonLondon SW72AZUK Department of Medical Biosciences University of the Western CapeBellville 7530South Africa LogixX Pharma ThealeBerkshire GU154DUUK Department of Dermatology Venereology and AndrologyFaculty of MedicineSohag UniversitySohag 82518Egypt Department of Urology Lilavati Hospital and Research CentreMumbaiMaharashtra 400001India Andromed Health and Reproduction Fertility Diagnostics LaboratoryMaroussiAthens 10431Greece Department of Surgery McGill UniversityMontrealQC H3A 0G4Canada

Semen analysis(SA)remains the cornerstone of male infertility evaluation and should ideally be performed by an accredited andrology laboratory or in vitro fertilization(IVF)clinics based on the standards defined by the World Health Organization(WHO)for the Examination and Processing of Human Semen and in accordance with the International Organization for Standardization’s Basic Semen Examination on Specification and Test Methods.

关键词： Basic Human corners

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Afterword to varicocele and male infertility： curreni concepts and future perspectives

引用

Asian Journal of Andrology 2016年第2期18卷 319-322页

作者： Sandro C Esteves ashok agarwal ANDROFERT Center for Male Reproduction Av.Dr. Heitor Penteado 1464 Campinas SP 13075-460Brazil American Center for Reproductive Medicine Cleveland Clinic 10681 Carnegie Avenue X-11Cleveland OH 44195 USA.

We summarize and comment on the topics discussed by the contributors to this Special Issue of Asian Journal of Andrology. The scope of varicocele covers a wide spectrum, including proteomics and metabolomics, hormonal control, interventional therapy, and assisted reproductive technology （ART）. The selection of topics demonstrates the exciting breadth of this thematic area and the opportunity research holds for both increasing the understanding and improving the reproductive health of males with varicocele.

关键词： @@

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Proteomic analysis of mature and immature ejaculated spermatozoa from fertile men

引用

Asian Journal of Andrology 2016年第5期18卷 735-746页

作者： Zhihong Cui Rakesh Sharma ashok agarwal American Center for Reproductive Medicine Cleveland Clinic Cleveland OH 44195 USA Institute of Toxicology Third Military Medical University Chongqing 400038PR China.

Dysfunctional spermatozoa maturation is the main reason for the decrease in sperm motility and morphology in infertile men. Ejaculated spermatozoa from healthy fertile men were separated into four fractions using three-layer density gradient. Proteins were extracted and bands were digested on a LTQ-Orbitrap Elite hybrid mass spectrometer system. Functional annotations of proteins were obtained using bioinformatics tools and pathway databases. Western blotting was performed to verify the expression levels of the proteins of interest. 1469 proteins were identified in four fractions of spermatozoa. The number of detected proteins decreased according to the maturation level of spermatozoa. During spermatozoa maturation, proteins involved in gamete generation, cell motility, energy metabolism and oxidative phosphorylation processes showed increasing expression levels and those involved in protein biosynthesis, protein transport, protein ubiquitination, and response to oxidative stress processes showed decreasing expression levels. We validated four proteins （HSP 70 1A, clusterin, tektin 2 and tektin 3） by Western blotting. The study shows protein markers that may provide insight into the ejaculated spermatozoa proteins in different stages of sperm maturation that may be altered or modified in infertile men.

关键词： bioinformatics protein validation proteins proteomics spermatozoa maturation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Proteomic analysis of seminal plasma from bilateral varicocele patients indicates an oxidative state and increased inflammatory response

引用

Asian Journal of Andrology 2019年第6期21卷 544-550页

作者： Manesh Kumar Panner Selvam ashok agarwal Saradha Baskaran American Center for Reproductive Medicine Cleveland ClinicClevelandOH 44195USA.

Seminal plasma is a rich source of proteins and serves as an ideal sample for proteomic analysis of male *** varicoceleassociated in fertility,the contributory role of semi nal plasma proteins specific to un ilateral and bilateral varicocele is not ***,there is a lack of specific protein biomarker to differentiate bilateral from unilateral *** main objective is to identify the differentially regulated molecular and cellular pathways in bilateral varicocele?Furthermore,we intend to identify seminal plasma biomarkers to differentiate bilateral and unilateral varicocele patients in comparison with fertile healthy *** proteomic an alysis of seminal plasma protei ns has identified the function ality of d iff ere ntially expressed proteins(DEPs)in varicocele *** analysis has revealed response to reactive oxygen species and oxidative stress,and tissue homeostasis as top process pathways that are affected in bilateral varicocele patients compared to fertile healthy *** comparison with unilateral varicocele patients,inflammatory response pathways were dysregulated,especially interleukin 6(IL-6)signaling and Janus kinasesignal transducer and activator of transcription(Jak?STAT)pathways,in bilateral varicocele patients,owing to the involvement of underexpressed *** DEPs associated with oxidative stress(peroxiredoxin 2;PRDX2),DNA fragmentation(fatty acid synthase;FASN),and inflammatory resp onse(fibr on ectin 1;FN1)validated by western blot analysis revealed differential expressi on of these proteins in unilateral and bilateral varicocele *** expression of DEPs and its association with key processes show that the seminal plasma homeostasis is compromised in bilateral varicocele patients?Furthermore,we propose PRDX2,FASN,and FN1 as potential noninvasive seminal plasma markers for the differentiation of unilateral and bilateral varicocele patients.

关键词： biomarkers male in fertility proteomics semi nal plasma varicocele

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Varicocele and male infertility： current concepts and Future perspectives

引用

Asian Journal of Andrology 2016年第2期18卷 161-162,J0002页

作者： ashok agarwal Sandro C Esteves American Center for Reproductive Medicine Cleveland Clinic 10681 Carnegie Avenue X-11Cleveland OH 44195 USA ANDROFERT Centerfor Male Reproduction Av. Dr. Heitor Penteado 1464Camp nas SP 13075-460 Braz.

This Special Issue of Asian Journal of Andrology is fully dedicated to the thematic area of Varicocele, which has been one of the most controversial issues in the field of Urology, Andrology, and Reproductive Medicine. Recognized as a dinical entity for over a century, varicocele from Latin： varix （dilated vein） and from Greek： kele （tumor） still elicits heated debate among scientists and clinicians on an arguable negative effect on male fertility and gonadal function and has fueled thousands of scholarly articles since its first report in the 18^th century.

关键词： Varicocele male infertility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Long-term effectiveness of luteinizing hormone-releasing hormone agonist or antiandrogen monotherapy in elderly men with localizect prostate cancer （T1-2）： a retrospective study

引用

Asian Journal of Andrology 2007年第2期9卷 253-258页

作者： Rupesh Raina Geetu Pahalajani ashok agarwal Craig Zippe Department of Medicine and Pediatrics Metrohealth Medical Center （Case School of Medicine） Cleveland Ohio 44109 USA Glickman Urological Institute Cleveland Clinic Foundation at Mary Mount Cleveland Clinic Foundation Ohio 44125 USA

Aim： To evaluate the long-term effectiveness, side effects and compliance rates of two types of drugs （luteinizing hormone-releasing hormone [LHRH] agonist and antiandrogen） that were used individually to treat patients with localized prostate cancer （T1-2） at our institution. Methods： Ninety-seven patients who were diagnosed in the period from April 1997 to January 2000 as having clinically localized prostate cancer （T1-2） received either LHRH agonist （leuprolide acetate 7.5 mg/month） monotherapy （group 1, n = 62） or antiandrogen monotherapy （group 2, n = 35; 18 received bicalutamide 50 mg q.d., 13 received nilutamide 150 mg t.i.d, and 4 received flutamide 250 mg t.i.d.）. The mean age in both groups was 76 years. Results： The mean follow-up time was （50.8 ±8.5） months in group 1 and （43.1 ± 2.2） months in group 2. Prostate-specific antigen （PSA） levels rose in only 1 of the 62 patients （1.6%） in group 1, and in 20 of the 35 patients （57.1%） in group 2. In group 2, 10 of the 20 patients （50 %） with increasing PSA levels were treated with LHRH salvage therapy, and eight （80%） responded. Hot flashes （54.8%） and lethargy （41.9%） were the most common side effects in group 1. In contrast, nipple-tenderness （40%） and light-dark adaptation （17.1%） were more often seen in group 2. Only 1 of the 62 patients （1.6%） in group 1 switched to another medication because of adverse side effects; whereas 8 of the 35 patients （22.9%） in group 2 did so. Conclusion： Unlike antiandrogen monotherapy, LHRH agonist monotherapy provided long-term durable control of localized prostate cancer （T1-2）. It can also be an effective treatment option for patients whose disease failed to respond to antiandrogen monotherapy. The limitations of our study are the lack of health outcomes analysis and a small sample size.

关键词： localized prostate cancer antiandrogen prostate-specific antigen luteinizing hormone-releasing hormone agonist androgen ablation monotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel insights into the pathophysiology of varicocele and its association with reactive oxygen species and sperm DNA fragmentation

引用

Asian Journal of Andrology 2016年第2期18卷 186-193,J0003页

作者： Chak-Lam Cho Sandro C Esteves ashok agarwal Division of Urology Department of Surgery Kwong Wah Hospital 25 Waterloo Road Yau Ma Tei Hong Kong ANDROFERT Center for Male Reproduction Av. Dr. Heitor Penteado 1464 campinas SP 13075-460 Brazil American Center for Reproductive Medicine 10681 Carnegie Avenue X-11 Cleveland OH 44195 USA.

Varicocele has been associated with reduced male reproductive potential. With the advances in biomolecular techniques, it has been possible to better understand the mechanisms involved in testicular damage provoked by varicocele. Current evidence suggests the central role of reactive oxygen species （ROS） and the resultant oxidative stress （OS） in the pathogenesis of varicocele-associated male subfertility although the mechanisms have not yet been fully described and it is likely to be multifactorial. Excessive ROS is associated with sperm DNA fragmentation, which may mediate the clinical manifestation of poor sperm function and fertilization outcome related to varicocele. Testing of ROS/OS and DNA fragmentation has the potential to provide additional diagnostic and prognostic information compared to conventional semen analysis and may guide therapeutic management strategies in individual patient.

关键词： antioxidants infertility male reproduction oxidative stress sperm DNA damage sperm DNA fragmentation varicocele varicocelectomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Proteomic analysis reveals dysregulated cell sign aling in ejaculated spermatozoa from in fertile men

引用

Asian Journal of Andrology 2019年第2期21卷 121-130页

作者： Luna Samanta Rakesh Sharma Zhihong Cui ashok agarwal American Center for Reproductive Medicine Cleveland ClinicClevelandOH 44195USA Department of Zoology School of Life SciencesRavenshaw UniversityCuttackOdisha 753003India Institute of Toxicology The Third Military Medical UniversityChongqing 400038China

Dysfunctional sperm maturation is the primary reason for the poor sperm motility and morphology in infertile *** from infertile men were fractioned on three-layer density gradient(80%,60%,and 40%).Fraction 1(Fl)refers to the least mature stage having the lowest den sity,whereas the fraction 4(F4)in eludes the most dense and morphologically mature motile *** 2(F2)and fraction 3(F3)represent the intermediate *** were extracted and separated by dimensional *** were digested with trypsin and analyzed on a LTQ-Orbitrap Elite hybrid mass spectrometer *** annotations of proteins were obtained using bioinformatics tools and pathway databases.A total of 1585 proteins were detected in the four fractions of spermatozoa.A dysregulated protein turnover and protein folding may lead to accumulation of defective proteins or proteins that otherwise would have been eliminated during the process of maturation,resulting in the impairment of sperm fun *** nt chaper one expressi on may be a major con tributing factor to the defective sperm *** n receptor was predicted as a transcription regulator in one of the networks and the affected pathways were chaperone-mediated stress response,proteosomal pathway,and sperm *** down regulation of key pathways and protei ns which compromises the fertilizi ng potential of spermatozoa may provide in sight into the mecha nisms that lead to male infertility.

关键词： androgen receptor chaperone immature sperm infertile men proteasome spermatozoa

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：