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Geochemical studies of hybrid granite from Madugulapalli area, Eastern Dharwar Craton, Southern India: Implications for crustal mixing

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Acta Geochimica 2023年第1期42卷 9-23页

作者： Nagamma J Ratnakar J Ajay kumar A ashok Ch State Mines and Geology Department 508001 NalgondaIndia Department of Geology Osmania University500007 HyderabadIndia CSIR-National Geophysical Research Institute 500007 UppalHyderabadIndia

Magma produced by melting of continental crust and mantle at the Archean-Proterozoic boundary are compositionally variable and chemical compositions provide evidence for the mixing of two sources. Understanding the composition of hybrid magma is essential for determining the comparative infl uence of crust and mantle sources during orogenesis. The hybrid granites are less documented in Indian cratons, especially less in Dharwar Craton. Here we present petrographic and whole-rock geochemical data of Madgulapalli granitic rocks situated in the NE part of the Eastern Dharwar Craton(EDC), to elucidate their petrogenesis and role in crust formation. The Madugulapalli granites(MPG) are composed chiefl y of plagioclase, quartz, and alkali feldspar with associated biotite showing alteration and inter-granular textures. Geochemically, they are metaluminous to peraluminous in nature with calc-alkaline hybrid granite. The hybrid granites exhibit both negative and positive europium anomalies;the lower Rb/Sr, Rb, Sr, and higher Sr/Y,(Dy/Yb)N ratios suggest that the interaction of older rocks with residual garnet source melted at high pressures. We hypothesize that hybrid granites are formed by interaction(e.g., metasomatism, mingling, or mixing) between parental magmas and pre-existing rocks with the infl uence of sanukitoid melts(heat source) in a subduction environment. The genesis of the hybrid granites demonstrates the mixing coupled with diff erentiation in the petrogeny’s residue system in a syn-collision setting followed by continental crust stability in EDC during the Neoarchean period.

关键词： Madugulapalli granite Hybrid granite Crustal mixing Subduction

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Luminescence Dating and Bracketing Time of the Youngest Toba Tuff Deposits in the Quaternary Sediments of Purna Alluvial Basin,Central India

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Journal of Earth Science 2022年第4期33卷 1007-1016页

作者： Singh Ajab K.Srivastava ashok Chauhan Naveen Department of Geology Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Department of Geology SGB Amravati UniversityAmravati 444602India Physical Research Laboratory Ahmedabad 380009India

Light gray to yellowish brown youngest Toba tuff(YTT)ash,preserved in the Quaternary sediments of India,have been used as a tool to know depositional and bracketing time period of the same in the sediments through applications of luminescence dating to interpret age connotation of various geological ***-and post-tephra sediments of YTT ash beds from Hudki and Sukali areas of Purna alluvial basin,Central India have been optically dated to interpret the depositional age and bracketing time of the tephra within sedimentary *** sediments are yellowish brown,thinly bedded,laminated,silty clay and host laterally extend discontinued beds of 0.15–0.20 m *** ash is light gray,fine grained and powdery in nature,massive to structureless and lacks any sign of retransportation and redeposition,hence,considered as primary in *** four sediment samples,one each from pre-and post-tephra lithounits of both the localities have been dated through optically stimulated luminescence technique(OSL)equipped with single aliquot regenerative(SAR)procedure on the feldspar *** shows pre-and post-tephra ages of 57±5 and 70±4 ka respectively for Hudki and 66±5 and 67±4 ka for Sukali *** depositional ages suggest that the ash was bracketed within sediments thousands years after YTT *** is correlatable with the previously reported depositional and absolute ages for the YTT ash from the localities of Ghoghara and Khuntheli,Son Valley;Tejpur,Madhumati River Basin and Jwalapuram,Jurreru *** ages also provide an idea about the period of existence of biological communities represented by the remains of faunal and vegetational activities before and during settlement of the YTT ash in the basin area.

关键词： youngest Toba tuff Tephra optically stimulated luminescence Quaternary sediments depositional age

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Bioresorbable magnesium-based alloys containing strontium doped nanohydroxyapatite promotes bone healing in critical sized bone defect in rat femur shaft

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Journal of Magnesium and Alloys 2023年第1期11卷 270-286页

作者： Shazia Shaikh Irfan Qayoom R.Sarvesha ashok Kumar Department of Biological Sciences and Bioengineering Indian Institute of Technology KanpurKanpur 208016India Centre for Environmental Science and Engineering Indian Institute of Technology KanpurKanpur 208016India Department of Materials Science and Engineering Indian Institute of Technology KanpurKanpur 208016India Center for Nanosciences Indian Institute of Technology KanpurKanpur 208016India The Mehta Family Centre for Engineering in Medicine Indian Institute of Technology KanpurKanpur 208016India

Magnesium-based biomaterials have been in extensive research for orthopedic applications for decades due to their optimal mechanical features and osteopromotive nature;nevertheless,rapid degradation restricts their clinical *** this study,pristine magnesium was purified(P-Mg)using a melt self-purification approach and reinforced using indigenously synthesized nanohydroxyapatite(HAP,0.6 wt.%)and strontium substituted nanohydroxyapatite(SrHAP,0.6 wt.%)using a low-cost stir assisted squeeze casting method to control their degradation *** electron back-scattered diffraction(EBSD)and X-ray diffraction(XRD)examinations,all casted materials were carefully evaluated for microstructure and phase *** characteristics,in vitro degradation,and in vitro biocompatibility with murine pre-osteoblasts were also tested on the fabricated *** in vivo examination of bone formation,osteointegration,and degradation rate,the magnesium-based alloys were fabricated as small cylindrical pins with a diameter of 2.7 mm and a height of 2 *** pins were implanted in a critical-sized defect in a rat femur shaft(2.7 mm diameter and 2 mm depth)for 8 weeks and evaluated by microCT and histological evaluation for bone growth and *** compared to P-Mg and P-MgHAP,micro-CT and histological analyses revealed that the P-MgSrHAP group had the highest bone formation towards the periphery of the implant and hence maximum *** the removed pins from the bone defect were analyzed using GIXRD,they displayed hydroxyapatite peaks that were consistent with *** P-Mg,P-MgHAP,and P-MgSrHAP 8 weeks after implantation,in vivo degradation rates derived from micro-CT were around 0.6 mm/year,0.5 mm/year,and 0.1 mm/year,***,P-MgSrHAP possesses the requisite degradation rate as well as sufficient mechanical and biological properties,indicating that it has the potential to be used in the development/fabrication of bi

关键词： Magnesium purification Reinforcement Degradation rate Nanocement Bone regeneration

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Interplay between genome organization and epigenomic alterations of pericentromeric DNA in cancer

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Journal of Genetics and Genomics 2021年第3期48卷 184-197页

作者： Subhadip Kundu M.D.Ray ashok Sharma Laboratory of Chromatin and Cancer Epigenetics Department of BiochemistryAll India Institute of Medical SciencesAnsari NagarNew Delhi 110029India Department of Surgical Oncology IRCHAll India Institute of Medical SciencesAnsari NagarNew Delhi 110029India

In eukaryotic genome biology,the genomic organization inside the three-dimensional(3D)nucleus is highly complex,and whether this organization governs gene expression is poorly *** lamina(NL)is a filamentous meshwork of proteins present at the lining of inner nuclear membrane that serves as an anchoring platform for genome *** chromatin domains termed as lamina-associated domains(LADs),play a major role in silencing genes at the nuclear *** interaction of the NL and genome is dynamic and ***,many genes change their positions during developmental processes or under disease conditions such as cancer,to activate certain sorts of genes and/or silence *** heterochromatin(PCH)is mostly in the silenced region within the genome,which localizes at the nuclear *** show that several genes located at the PCH are aberrantly expressed in *** interesting question is that despite being localized in the pericentromeric region,how these genes still manage to overcome pericentromeric *** epigenetic mechanisms control the expression of the pericentromeric region,recent studies about genome organization and genome-nuclear lamina interaction have shed light on a new aspect of pericentromeric gene regulation through a complex and coordinated interplay between epigenomic remodeling and genomic organization in Cancer.

关键词： LADs Pericentromere Heterochromatin Gene regulation Epigenetics Cancer Genome organization

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Automotive Visible-Light Communication: Alternative Devices and Systems

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清华大学学报:自然科学版(英文版) 2023年第4期28卷 719-728页

作者： Lin Cheng Yue Wu Chenren Xu Khadija Ashraf Ashwin ashok Department of Engineering Trinity CollegeHartfordCT 06106USA Department of Computer Science Yale UniversityNew HavenCT 06520USA Department of Computer Science and Technology Peking UniversityBeijing 100084China Department of Computer Science Georgia State UniversityAtlantaGA 30302USA

Continuous advancements in visible-light communication(VLC)technology have paved the way for future high-capacity communication links that can simultaneously provide data transmission and *** is being accepted as a potential complementary technology in 5G networks,and standardization efforts through IEEE 802.15.7 are on their ***,vehicular networking applications have become increasingly complex with tight power and performance ***,devices and systems that can meet diverse vehicular networking applications are in great *** this article,we discuss three alternatives for vehicular networking applications in(1)LED–photodiode-based active VLC,(2)VLC with a multicamera array receiver,and(3)passive VLC based on decoding information from optical *** also present our recent experimental and modeling work using our camera-based and passive VLC prototype implementations.

关键词： visible-light communications automobile camera communications

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Lycopene and male infertility

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Asian Journal of Andrology 2014年第3期16卷 420-425页

作者： Damayanthi Durairajanayagam ashok Agarwal Chloe Ong Pallavi Prashast Center for Reproductive Medicine Glickman Urological and Kidney Institute Cleveland Clinic Cleveland Ohio USA Faculty of Medicine MARA University of Technology Sungai Buloh Selangor Malaysia.

Excessive amounts of reactive oxygen species （ROS） cause a state of oxidative stress, which result in sperm membrane lipid peroxidation, DNA damage and apoptosis, leading to decreased sperm viability and motility. Elevated levels of ROS are a major cause of idiopathic male factor infertility, which is an increasingly common problem today. Lycopene, the most potent singlet oxygen quencher of all carotenoids, is a possible treatment option for male infertility because of its antioxidant properties. By reacting with and neutralizing free radicals, lycopene could reduce the incidence of oxidative stress and thus, lessen the damage that would otherwise be inflicted on spermatozoa. It is postulated that lycopene may have other beneficial effects via nonoxidative mechanisms in the testis, such as gap junction communication, modulation of gene expression, regulation of the cell cycle and immunoenhancement. Various lycopene supplementation studies conducted on both humans and animals have shown promising results in alleviating male infertility--lipid peroxidation and DNA damage were decreased, while sperm count and viability, and general immunity were increased. Improvement of these parameters indicates a reduction in oxidative stress, and thus the spermatozoa is less vulnerable to oxidative damage, which increases the chances of a normal sperm fertilizing the egg. Human trials have reported improvement in sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene daily for 3-12 months. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility.

关键词： antioxidants lycopene male infertility oxidative stress reactive oxygen species sperm parameters

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Proteomic analysis of seminal plasma from bilateral varicocele patients indicates an oxidative state and increased inflammatory response

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Asian Journal of Andrology 2019年第6期21卷 544-550页

作者： Manesh Kumar Panner Selvam ashok Agarwal Saradha Baskaran American Center for Reproductive Medicine Cleveland ClinicClevelandOH 44195USA.

Seminal plasma is a rich source of proteins and serves as an ideal sample for proteomic analysis of male *** varicoceleassociated in fertility,the contributory role of semi nal plasma proteins specific to un ilateral and bilateral varicocele is not ***,there is a lack of specific protein biomarker to differentiate bilateral from unilateral *** main objective is to identify the differentially regulated molecular and cellular pathways in bilateral varicocele?Furthermore,we intend to identify seminal plasma biomarkers to differentiate bilateral and unilateral varicocele patients in comparison with fertile healthy *** proteomic an alysis of seminal plasma protei ns has identified the function ality of d iff ere ntially expressed proteins(DEPs)in varicocele *** analysis has revealed response to reactive oxygen species and oxidative stress,and tissue homeostasis as top process pathways that are affected in bilateral varicocele patients compared to fertile healthy *** comparison with unilateral varicocele patients,inflammatory response pathways were dysregulated,especially interleukin 6(IL-6)signaling and Janus kinasesignal transducer and activator of transcription(Jak?STAT)pathways,in bilateral varicocele patients,owing to the involvement of underexpressed *** DEPs associated with oxidative stress(peroxiredoxin 2;PRDX2),DNA fragmentation(fatty acid synthase;FASN),and inflammatory resp onse(fibr on ectin 1;FN1)validated by western blot analysis revealed differential expressi on of these proteins in unilateral and bilateral varicocele *** expression of DEPs and its association with key processes show that the seminal plasma homeostasis is compromised in bilateral varicocele patients?Furthermore,we propose PRDX2,FASN,and FN1 as potential noninvasive seminal plasma markers for the differentiation of unilateral and bilateral varicocele patients.

关键词： biomarkers male in fertility proteomics semi nal plasma varicocele

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Varicocele and male infertility： current concepts and Future perspectives

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Asian Journal of Andrology 2016年第2期18卷 161-162,J0002页

作者： ashok Agarwal Sandro C Esteves American Center for Reproductive Medicine Cleveland Clinic 10681 Carnegie Avenue X-11Cleveland OH 44195 USA ANDROFERT Centerfor Male Reproduction Av. Dr. Heitor Penteado 1464Camp nas SP 13075-460 Braz.

This Special Issue of Asian Journal of Andrology is fully dedicated to the thematic area of Varicocele, which has been one of the most controversial issues in the field of Urology, Andrology, and Reproductive Medicine. Recognized as a dinical entity for over a century, varicocele from Latin： varix （dilated vein） and from Greek： kele （tumor） still elicits heated debate among scientists and clinicians on an arguable negative effect on male fertility and gonadal function and has fueled thousands of scholarly articles since its first report in the 18^th century.

关键词： Varicocele male infertility

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Critical evaluation of two models of flow cytometers for the assessment of sperm DNA fragmentation:an appeal for performance verification

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Asian Journal of Andrology 2019年第5期21卷 438-444页

作者： Rakesh Sharma Sajal Gupta Ralf Henkel ashok Agarwal American Center for Reproductive Medicine Cleveland ClinicClevelandOH 44195USA Department of Medical Bioscience University of the Western CapeBellville 7535South Africa

Lack of standardized,reproducible protocols and referencO values is among the challenges faced when using new or upgraded versions of instruments in reproductive laboratories and flow *** deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assay combined with flow cytometry routinely used for diagnostic measurement of sperm DNA fragmentation(SDF)is a unique *** change in the setting of the standard instrument,including upgrades of hardware or software,can lead to different results and may affect clinicians'decision for ***,we compared TUNEL results of SDF obtained from a standard(C6)flow cytometer with a newer version of the same instrument(C6 Plus)and examined the cutoff,sensitivity,and specificity without calibration(adjustment)and after *** sperm preparation and matched acquisition settings were used to examine the performance of two flow *** strength of agreement of the results between the two observers was also *** adjustment of the settings,overall concordance became high and the two cytometers showed 100%positive and negative predictive value with 100%area under the *** overall correlation coefficient observed between C6 and C6 Plus was highly significant(P99%.The in terobserver agreeme nt on C6 flow cytometer for the two observers was 0.801±0.062 and 0.746±0.044 for C6 *** demonstrated a strong agreement between the samples tested on the two flow cytometers after calibration and established the robustness of both instruments.

关键词： DNA fragmentation flow cytometer oxidative stress sperm TUNEL assay

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Novel Lyapunov-based rapid and ripple-free MPPT using a robust model reference adaptive controller for solar PV system

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Protection and Control of Modern Power Systems 2023年第1期8卷 205-229页

作者： Saibal Manna ashok Kumar Akella Deepak Kumar Singh Department of Electrical Engineering National Institute of Technology JamshedpurJharkhand 831014India

The technological,economic,and environmental benefits of photovoltaic(PV)systems have led to their wide-spread adoption in recent years as a source of electricity ***,precisely identifying a PV system’s maximum power point(MPP)under normal and shaded weather conditions is crucial to conserving the maximum generated *** of the biggest concerns with a PV system is the existence of partial shading,which produces multiple peaks in the P–V characteristic *** these circumstances,classical maximum power point tracking(MPPT)approaches are prone to getting stuck on local peaks and failing to follow the global maximum power point(GMPP).To overcome such obstacles,a new Lyapunov-based Robust Model Reference Adaptive Controller(LRMRAC)is designed and implemented to reach GMPP rapidly and *** proposed controller also achieves MPP accurately under slow,abrupt and rapid changes in radiation,temperature and load *** and OPAL-RT real-time simulators in various scenarios are performed to verify the superiority of the proposed approach over the other state-of-the-art methods,i.e.,ANFIS,INC,VSPO,and P&*** and GMPP are accomplished in less than 3.8 ms and 10 ms,*** on the results presented,the LRMRAC controller appears to be a promising technique for MPPT in a PV system.

关键词： Photovoltaic(PV) MPPT Partial shading Lyapunov-based robust model reference adaptive control(LRMRAC) Lyapunov stability

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