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Analysis of human brain tissue derived from DBS surgery

Translational Neurodegeneration 2022年第1期11卷 625-640页

作者： Salla M.Kangas Jaakko Teppo Maija J.Lahtinen Anu Suoranta Bishwa ghimire Pirkko Mattila Johanna Uusimaa Markku Varjosalo Jani Katisko Reetta Hinttala PEDEGO Research Unit University of OuluOuluFinland Medical Research Center Oulu University HospitalUniversity of OuluOuluFinland Biocenter Oulu University of OuluOuluFinland Institute of Biotechnology HiLIFE Helsinki Institute of Life ScienceUniversity of HelsinkiHelsinkiFinland Drug Research Program Faculty of PharmacyUniversity of HelsinkiHelsinkiFin-land Neurosurgery Research Unit of Clinical NeuroscienceOulu University HospitalUniversity of OuluOuluFinland Oulu Research Group of Advanced Surgical Technologies and Physics(ORGASTP) Research Unit of Clinical NeuroscienceOulu University HospitalUniversity of OuluOuluFinland Institute for Molecular Medicine Finland(FIMM) HiLIFE Helsinki Institute of Life ScienceUniversity of HelsinkiHelsinkiFinland Clinic for Children and Adolescents Division of Pediatric NeurologyOulu University HospitalOuluFinland

Background:Transcriptomic and proteomic profiling of human brain tissue is hindered by the availability of fresh samples from living *** samples usually represent the advanced disease stage of the ***-thermore,the postmortem interval can affect the transcriptomic and proteomic ***,fresh brain tissue samples from living patients represent a valuable resource of metabolically intact *** of deep brain stimulation(DBS)electrodes into the human brain is a neurosurgical treatment for,e.g.,movement ***,we describe an improved approach to collecting brain tissues from surgical instruments used in implantation of DBS device for transcriptomics and proteomics ***:Samples were extracted from guide tubes and recording electrodes used in routine DBS implantation procedure to treat patients with Parkinson’s disease,genetic dystonia and *** sequencing was performed in tissues extracted from the recording microelectrodes and liquid chromatography-mass spectrometry(LC-MS)per-formed in tissues from guide *** assess the performance of the current approach,the obtained datasets were compared with previously published datasets representing brain ***:Altogether,32,034 RNA transcripts representing the unique Ensembl gene identifiers were detected from eight samples representing both hemispheres of four *** using LC-MS,we identified 734 unique proteins from 31 samples collected from 14 *** datasets are available in the BioStudies database(accession number S-BSST667).Our results indicate that surgical instruments used in DBS installation retain brain material sufficient for protein and gene expression *** with previously published datasets obtained with similar approach proved the robustness and reproducibility of the ***:The instruments used during routine DBS surgery are a useful source for obtaining fresh brain tis-sues from living patien

关键词： Deep brain stimulation Movement disorders Brain Proteomics Transcriptomics RNA sequencing LC-MS Personalized medicine

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Physico-Chemical Parameters of High-Altitude Rivers in the Sagarmatha (Everest) National Park, Nepal

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Journal of Water Resource and Protection 2013年第8期5卷 761-767页

作者： Narayan Prasad ghimire Pramod Kumar Jha Gianumberto Caravello Central Department of Botany Tribhuvan University Kathmandu Nepal Department of Environment Health and Hygiene Padova University Padova Italy

The aim of this research was to analyse physical and chemical characteristics of high altitude rivers of the Sagarmatha National Park, Khumbu region. The study was conducted for three years from 2008 to 2010 in the elevation 1900 m to 5300 m of the park. The study develops a database for monitoring high land rivers of Nepal. The river water quality in general still stands good in terms of standards for drinking water (WHO, Nepal standard) but degradation process has started. Certain changes in water quality parameters in water bodies on the major tourist treks have been recorded, mainly due to anthropogenic activities, particularly tourists and waste disposal. Total nitrogen in water samples is lower than the WHO standard but an increase in the nitrate nitrogen has been recorded comparison between 2008, 2009 and 2010 as well as when compared with earlier reports. Similarly total phosphorous value was also found increased annually as well as earlier reports. It is urgent need to check further degradation of river water quality. The outcomes of this research work would be a useful tool to manage the river water ecosystem in Sagarmatha National Park and Buffer Zone.

关键词： Physico-Chemical Characteristics High Altitude Water Quality

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Water Quality of High-Altitude Lakes in the Sagarmatha (Everest) National Park, Nepal

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Journal of Environmental Protection 2013年第7期4卷 22-28页

The aim of this research was to analyze physical and chemical characteristics of high altitude lakes (Gokyo lake series, Imja lake, Pyramid lake) of the Sagarmatha National Park, Khumbu region located above 4500 m altitude. The lake water was studied for three years (2008, 2009 and 2010) to compare the annual changes in the parameters. The findings created a database for present status of high land lakes of Nepal, which can be used for the management of lakes as well as to study the impact of tourism on water quality. The lake water quality in general still stands good in terms of standards for drinking water (WHO, Nepal standard) but degradation process has started. Total nitrogen in water samples was lower than the WHO standard but an increase in the nitrate nitrogen has been recorded. Similarly, total phosphorrous quality was also found increased.

关键词： Physico-Chemical Characteristics Water Quality Tourism High Altitudinal Lake

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Charcoal Production as a Means of Forest Management, Biodiversity Conservation and Livelihood Support in Nepal

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Journal of Agricultural Science and Technology(B) 2017年第3期7卷 187-193页

作者： Menaka Panta Neupane Kishor Prasad Bhatta Suman ghimire International Union for Conservation of Nature Nepal Country Office P.O. Box No. 3923 Kupondole Lalitpur Nepal

Invasive alien species （IAS） are considered as an overlooked forest resources in Nepal, despite its rapid expansion is considered as one of the main drivers of Nepal＇s forest degradation and deforestation. In this study, stratified systematic sampling, with nested circular plots of 500 m2, was performed in Sindhupalchowk to find out whether the removal of IAS contributes for an increase in plant diversity, Interaction with more than 310 entrepreneurs was carded to investigate the economic benefits in terms of income and employment of converting IAS into charcoal through pyrolysis in ＂bio-energy kilns＂. The study showed a higher Shannon-Weiner plant diversity index at regeneration level in IAS removed area （2.43） than that in control （1.95）. Similarly, the number of seedlings and saplings was significantly higher （P 〈 0.05） in the treatment block than the number of trees in the control one. Also, the pyrolysis of 7,500 million tons （MT） of IAS in bio-energy kilns produced 1,500 MT of charcoal powder which generated a total additional income of Nepali Rupees （NRs.） 18,900,000 to 1,050 poor and disadvantaged people in ! 6 districts of Terai and Midhills. In spite of that, some policy hurdles, such as charcoal transportation, were observed at the operational level. It is suggested that the plant diversity could be increased through the removal of IAS, and considerable economic benefits could be achieved if charcoal is substantially produced and utilized.

关键词： Invasive alien species forest resources livelihood plant diversity charcoal.

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Magnetic and Electronic Structure Calculations of Rare-Earth Nitrides

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材料科学与工程（中英文A版） 2011年第1X期1卷 53-57页

作者： Sandeep M.P. ghimire Ram Kumar Thapa Department of Physics Mizoram University Tanhril 796009 Aizawl Mizoram India Condensed Matter Physics Research Center New Horizon Institute Butwal RupendehL Nepal Faculty of Science Nepal Academy of Science and Technology Khumaltar G.P.O. 3323 Kathmandu Nepal

A broad range of applications in spintronics and spin-filtering devices are found in rare earth nitrides due to its half-metallic behaviour and high magnetic moments. We intend to study the electronic and magnetic properties of REN in the frame work of density functional theory (DFT) by using the full-potential linearized augmented plane wave (FP-LAPW) method. It was found from the computed density of states (DOS) and the band structures that the total DOS of EuN is contributed mainly by the 4f-state electrons of the Eu atom. In the case of SmN and EuN, we fill the majority spin f states and create an exchange field that is felt by the other electrons in the material whose effect is more pronounced and leads to a significant-splitting of the nitrogen p bands.

关键词：稀土氮化物电子结构计算密度全势线性缀加平面波自旋电子学磁性密度泛函理论过滤装置

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Polarization Flipping of Even-Order Harmonics in Monolayer Transition-Metal Dichalcogenides

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Ultrafast Science 2021年第1期1卷 39-47页

作者： Yuki Kobayashi Christian Heide Hamed Koochaki Kelardeh Amalya Johnson Fang Liu Tony F.Heinz David A.Reis Shambhu ghimire Stanford PULSE Institute SLAC National Accelerator LaboratoryMenlo ParkCA 94025USA Department of Applied Physics Stanford UniversityStanfordCA 94305USA Max Planck Institute for the Physics of Complex Systems Nöthnitzer Str.3801187 DresdenGermany Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA Department of Chemistry Stanford UniversityStanfordCA 94305USA Department of Photon Science Stanford UniversityStanfordCA 94305USA

We present a systematic study of the crystal-orientation dependence of high-harmonic generation in monolayer transition-metal dichalcogenides,WS2 and MoSe2,subjected to intense linearly polarized midinfrared laser *** measured spectra consist of both odd-and even-order harmonics,with a high-energy cutoff extending beyond the 15th order for a laser-field strength around~1 V/*** WS2,we find that the polarization direction of the odd-order harmonics smoothly follows that of the laser field irrespective of the crystal orientation,whereas the direction of the even-order harmonics is fixed by the crystal mirror ***,the polarization of the even-order harmonics shows a flip in the course of crystal rotation when the laser field lies between two of the crystal mirror *** numerically solving the semiconductor Bloch equations for a gapped-graphene model,we qualitatively reproduce these experimental features and find the polarization flipping to be associated with a significant contribution from interband *** contrast,high-harmonic signals from MoSe2 exhibit deviations from the laser-field following of oddorder harmonics and crystal-mirror-plane following of even-order *** attribute these differences to the competing roles of the intraband and interband contributions,including the deflection of the electron-hole trajectories by nonparabolic crystal bands.

关键词： polarization harmonics mirror

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COST EFFECTIVENESS OF PUBLIC AND METROPOLITIANDOTS CENTRE IN KATHMNDU METROPOLITAN

COST EFFECTIVENESS OF PUBLIC AND METROPOLITIANDOTS CENTRE IN...

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第二届国际防痨和肺部疾病联合会亚太区学术大会暨2009年中国防痨协会学术会议

作者： Sitaram ghimire Kraipornsak Pirom Kamol-Ratanakul National Tuberculosis Centre BhaktapurNepal Chulalongkorn University Faculty of icsBangkook10330Thailand

Background:Tuberculosis(TB) is still a major cause of death *** is one of the major public health problems in *** 45 percent of the total populations are infected with TB,out of which 60 percents are adult and 70 percent of cases in the most economically productive age *** DOTS strategy being success in TB control,it is still a big challenges in urban area.

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散发性脊髓血管母细胞瘤MRI特征分析(附6例报道)

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武汉大学学报（医学版） 2012年第5期33卷 738-741页

作者：朱凌吴光耀苏佳佳 Prasanna ghimire 武汉大学中南医院MRI室湖北武汉430071

目的:分析散发性脊髓血管母细胞瘤MRI特征。方法:回顾性分析6例经病理证实散发性脊髓血管母细胞瘤MRI表现,结合文献比较与Von Hippel-Lindau(VHL)病相关脊髓血管母细胞瘤MRI表现差异。结果:6例散发性脊髓血管母细胞瘤均为髓内单发病灶,... 详细信息

目的:分析散发性脊髓血管母细胞瘤MRI特征。方法:回顾性分析6例经病理证实散发性脊髓血管母细胞瘤MRI表现,结合文献比较与Von Hippel-Lindau(VHL)病相关脊髓血管母细胞瘤MRI表现差异。结果:6例散发性脊髓血管母细胞瘤均为髓内单发病灶,其中3例位于胸髓,2例位于颈髓,1例同时累及延颈髓;病灶长径1.7-7.3cm。5例病灶为实性,1例为囊实性,肿瘤均位于脊髓背侧,边界清楚,肿瘤实性部分表现为以等或稍长T1、长T2信号为主的混杂信号,强化明显,囊实性病灶囊壁亦明显强化,1例胸髓病例邻近软脊膜线样强化的"尾征";合并流空血管影、脊髓空洞各4例,1例囊实性肿瘤并囊内出血,矢状位T2加权图像见液-液平面。结论:散发性脊髓血管母细胞瘤MRI表现具有特征性,与VHL病相关脊髓血管母细胞瘤病灶常多发、体积较小,预后较差且易复发相区别。

关键词：血管母细胞瘤脊髓肿瘤 VonHippel-Lindau病磁共振成像

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黄土高原绿肥填闲种植的水分与产量效应:Meta分析

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中国生态农业学报（中英文） 2021年第11期29卷 1879-1892页

作者：张少宏王俊 RAJAN ghimire 邢文超胡映明张南南西北大学城市与环境学院西安710127 陕西省地表系统与环境承载力重点实验室西安710127 中国科学院教育部水土保持与生态环境研究中心杨凌712100 New Mexico State University Agricultural Science Center at ClovisNM 88101USA

绿肥填闲种植是黄土高原旱作农业区一项历史悠久的种植方式,但受降水资源限制,绿肥种植可能会增加土壤水分消耗,进而影响后茬粮食作物的产量。本研究基于46篇黄土高原绿肥相关文献数据,采用整合分析(Metaanalysis)方法探究绿肥种植对休... 详细信息

绿肥填闲种植是黄土高原旱作农业区一项历史悠久的种植方式,但受降水资源限制,绿肥种植可能会增加土壤水分消耗,进而影响后茬粮食作物的产量。本研究基于46篇黄土高原绿肥相关文献数据,采用整合分析(Metaanalysis)方法探究绿肥种植对休闲期降水储存效率(PSE)、粮食作物播种时土壤储水量(SWSP)、粮食作物产量、蒸散量(ET)和水分利用效率(WUE)的影响。结果表明,与裸地休闲相比,绿肥种植系统PSE、SWSP和ET分别降低28.28%、4.93%和2.51%(P<0.05),而后茬粮食作物产量和WUE平均提高2.37%和8.97%(P<0.05)。绿肥填闲种植的水分和产量效应随绿肥翻压至后茬粮食作物播种间隔时间、绿肥生物量以及气候条件而发生变化。PSE、SWSP和后茬粮食作物产量随豆科绿肥翻压至后茬粮食作物播种间隔时间的延长均呈先增加后减少变化,指标的效应量(response ratio,RR)均在间隔时间约13 d时达最大。后茬粮食作物产量和WUE的RR与豆科绿肥生物量之间存在二项式相关,并分别在绿肥生物量为2200 kg·hm^(-2)和3100 kg·hm^(-2)左右时达最大。总体来看,黄土高原地区种植绿肥虽然降低了土壤水分,但对后茬粮食作物产量形成和水分利用具有显著的促进作用,提前13 d左右进行绿肥翻压、控制豆科绿肥生物量在2200~3100 kg·hm^(-2)能够有效减缓对土壤水分的负面影响。

关键词：绿肥土壤水分产量水分利用效率整合分析

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Optimization of M/M/s/N Queueing Model with Reneging in a Fuzzy Environment

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American Journal of Operations Research 2021年第3期11卷 121-140页

作者： Ananda Prasad Panta Ram Prasad ghimire Dinesh Panthi Shankar Raj Pant Department of Mathematics Tri-Chandra Campus Tribhuvan University Kathmandu Nepal Department of Mathematics Kathmandu University Kavre Nepal Department of Mathematics Valmeeki Campus Nepal Sanskrit University Kathmandu Nepal Central Department of Mathematics Tribhuvan University Kirtipur Nepal

This paper deals with the study of multi-server queueing model in a fuzzy environment with imposition of reneging of customers. Entry of the customers in the system is assumed to be Poisson process and exponential service time distribution under first-come-first-served basis. Specific of this investigation is to derive the various fuzzy performance measures such as fuzzy queue length, fuzzy waiting time in queue, fuzzy response time and fuzzy optimal number of servers in explicit form for the finite capacity multi-server queueing system by using recursive method. For the validity of the model we have obtained the numerical illustrations in tabular form which shows that fuzzy-queue can be more realistic than crisp queue.

关键词： Fuzzy Environment Poisson Optimal Reneging

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