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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang xia Wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi xia George Smith Rui Li Nai-Kui Liu xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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Optimal Sizing of Electricity-hydrogen Integrated Energy System Considering Multi-timescale Operation of Hydrogen Storage System

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Dianwang Jishu/Power System Technology 2025年第1期49卷 12-21页

作者： Li, Zichen xia, Yanghong Sun, Yong Li, Dexin Li, Baoju Wei, Wei College of Electrical Engineering Zhejiang University Zhejiang Province Hangzhou 310027 China Institute of Wenzhou Zhejiang University Zhejiang Province Wenzhou 325006 China State Grid Jilin Electric Power Company Co. Ltd. Jilin Province Jilin 130021 China

Responding to the Carbon Peaking and Carbon Neutrality Goals and the actual demand for local consumption of distributed renewable energy sources, this paper proposes a method to optimize the capacity of an electricity-hydrogen integrated energy system to meet the demand for multiple loads of electricity, heat, and hydrogen to deal with multi-timescale energy mismatches. Firstly, a hybrid energy storage system model containing batteries and cascade hydrogen storage and a multi-timescale operation strategy are proposed. The model fully exploits the short-term and long-term operational characteristics of hydrogen storage to realize its multi-scale utilization. Secondly, to address the challenges in describing the operation characteristics of long-term energy storage devices based on the traditional typical scenario method, a novel scenario reduction method based on the time-series aggregation method is proposed to provide consecutive scenarios comprising both short-time fluctuations and seasonal characteristics. The technique can effectively speed up the solution and ensure its accuracy. After that, a system capacity optimization model is developed based on the typical scenarios to minimize the life cycle cost and consider factors including energy storage’s degradation and the consumption rate of renewable energy. Finally, the effectiveness of the proposed method is verified by cases in Ningbo, Zhejiang, China. The results indicate that the life cycle cost can be reduced by 21.3% with nearly 100% renewable energy consumption compared to the traditional energy management strategy. © 2025 Power System Technology Press. All rights reserved.

关键词： Charge storage

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动态序列情境对面部表情知觉的影响和作用机制

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心理科学进展 2025年第1期33卷 1-10页

作者：方霞潘之禾浙江大学心理与行为科学系杭州310058

现实生活中,面部表情通常随时间推移呈动态变化,个体对任一表情的解读都可能受其所处的动态序列情境的影响。尽管近年来有研究表明同时呈现的情境信息会对目标表情的知觉产生影响,但对于序列变化的表情信息如何影响目标表情知觉却知之... 详细信息

现实生活中,面部表情通常随时间推移呈动态变化,个体对任一表情的解读都可能受其所处的动态序列情境的影响。尽管近年来有研究表明同时呈现的情境信息会对目标表情的知觉产生影响,但对于序列变化的表情信息如何影响目标表情知觉却知之甚少。本研究拟通过行为实验和眼动技术,借助人工合成和真人表演的动态表情,考察序列变化的表情信息(即动态序列情境)对初始表情和最终表情的知觉的影响及其作用机制。研究成果有助于揭示生态化情境下的面部表情加工机制,为基于人工智能的动态表情识别提供参考。

关键词：面部表情情绪知觉动态序列情境

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Palladium installed copper-organic framework for C–C coupling reactions

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Science China Chemistry 2025年

作者： Yu-Mei Wang Mei-xia Tao Kai-Ming Mo Xu Chen Shu-Hua Zhong Elena S Shubina Guo-Hong Ning Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Supramolecular Coordination ChemistryJinan University A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences

The formation of C–C bonds is a crucial aspect of organic synthesis. Synthesists' long-term objective is to identify novel catalysts to optimize reaction systems based on traditional transition metal catalysis. This study explores the synthesis and catalytic potential of palladium-installed covalent metal-organic frameworks(CMOFs) based on copper cyclic trinuclear units(Cu-CTUs). By incorporating palladium ions into the imine-based framework JNM-7 through a straightforward immersion method, we achieved a notable enhancement in catalytic activity for critical C–C coupling reactions, including C–H arylation and Sonogashira cross-coupling. The resulting JNM-7-Pd demonstrated remarkable stability and recyclability, maintaining its efficiency over at least three cycles without any decline in efficiency.

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遵从的自主性建构：基层政府创造性执行的内在逻辑

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求实 2025年第1期 32-45+110页

作者：衡霞吴培豪四川大学公共管理学院

在多层级的国家治理结构体系中，基层政府如何因地制宜地创造性执行上级决策是值得关注的话题。基于对四川省彭州市M街道“小区信义治理”项目执行过程的考察，发现基层政府的创造性执行是在政策冲突情境下，由自主权激励、组织激励和... 详细信息

在多层级的国家治理结构体系中，基层政府如何因地制宜地创造性执行上级决策是值得关注的话题。基于对四川省彭州市M街道“小区信义治理”项目执行过程的考察，发现基层政府的创造性执行是在政策冲突情境下，由自主权激励、组织激励和自然激励复合驱动的，通过再造执行结构和重塑执行能力建构自主性，并运用自主性制造目标群体与上级政府的双重合意性的过程。这一内在逻辑可以归结为“遵从的自主性建构”，主要根植于基层政府作为政府科层体系末端与政社互动前沿的双重角色，蕴含着多重激励的有效性与相容性相统一、基层执行的自主权与自主性相统一、政策结果的权威容纳与目标群体政策遵从相统一等意蕴，其有效缓解了政策执行过程中的多重张力。

关键词：政府治理基层政府政策执行政策遵从创造性执行执行能力自主权激励组织激励

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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期68卷 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Changfa xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

关键词： stomach neoplasms precancerous conditions cancer screening cumulative incidence risk stratification

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A stretchable, ionic conductive, and adhesive patch electrode with ultra-low on-skin impedance for electrophysiological signal recording

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Science China(Information Sciences) 2025年

作者： Yang LI Yuzhe GU Sheng QIAN Yuncong PANG Aoxi YU Shuwen ZHENG Wenjie xia Yuan LIAO Baoguang LIU Shujuan LIU Qiang ZHAO College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts & Telecommunications (NJUPT) State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications (NJUPT)

Flexible electrodes have significant potential in fields such as healthcare and neuroscience, as they enable comprehensive recording and analysis of human electrical signals, providing deeper insights into physiological conditions and the state of internal organs and tissues [1, 2]. However, commercial Ag/AgCl wet electrodes face issues such as dehydration,poor comfort, and insufficient mechanical strength, while other types of electrodes, like dry and semi-dry electrodes,also have their own limitations, including the higher contact impedance. In contrast, ionically conductive electrodes offer potential advantages such as transparency, stability, and low impedance, making them a promising alternative to existing electrically conductive electrodes [3]. Acrylic acid (AA)and 2-acrylamido-2-methylpropanesulfonic acid (AMPS) are commonly used in the synthesis of ionic gels, as they ionize in water to produce a large number of ions, helping to maintain moisture balance and reduce impedance caused by dehydration [4]. However, the presence of freely moving ions in the gel network can interfere with conductivity, highlighting the need to introduce new conductive networks to enhance performance [5].

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang Zhi-Lai Zhan Guang-Lu Chang Yan Gao xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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知识图谱技术在关联贷款审计中的应用研究

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金融科技时代 2025年第1期33卷 55-60页

作者：夏敏广东省农村信用社联合社

文章从客户关联角度,将存在关联的贷款客户视为一个整体,研究关联贷款对银行整体风险的影响。知识图谱技术能够对海量的商业银行贷款客户数据进行分析,且将关联关系可视化,揭示商业银行关联贷款的形成、银行信用风险传导等规律。知识图... 详细信息

文章从客户关联角度,将存在关联的贷款客户视为一个整体,研究关联贷款对银行整体风险的影响。知识图谱技术能够对海量的商业银行贷款客户数据进行分析,且将关联关系可视化,揭示商业银行关联贷款的形成、银行信用风险传导等规律。知识图谱技术适用于开展大数据分析,找到关联贷款形成的数据特征及底层逻辑,对于商业银行防范化解关联贷款风险,具有重要的实践意义。

关键词：知识图谱关联贷款审计

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