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Open Journal of m.lecular and Integrative Physiology 2013年第2期3卷 87-94页

作者： ashley m. mefford Claci C. Ayers Naom. S. Rowland Nancy A. Rice Departm.nt of Biology Western Kentucky University Bowling Green USA

During exercise, phosphorylase kinase (PhK) is the key regulatory enzym. responsible for m.intaining glycogenolytic flux to sustain m.scle contraction. The absence of PhK in skeletal m.scle results in glycogen storage disease (GSD) Type IX which is characterized by m.scle weakness and rapid fatigue upon exercise. In this study, we have used the phka1 deficient I/LnJ m.use m.del of GSD to investigate the physiological and genetic adaptations that occur in response to voluntary exercise. When quantified over training periods of either 1, 2, or 5 weeks, I/LnJ m.ce ran significantly less tim./day and distance/day than agem.tched C57/Bl6 m.ce. Cum.latively after five weeks, adult I/LnJ m.ce ran ~1/2 the total tim. and distance of wild-type m.ce, 116 ± 6 hours and 211 ±23 km.ersus 194 ± 3 hours and 418 ±4 km. respectively. After 5 weeks, C57/Bl6 m.ce dem.nstrated an increase in endurance as a result of aerobic training;this observed physiological adaptation was not present in I/LnJ m.ce. The decrease in total distance run by I/LnJ m.ce was not due to a reduction in speed;juvenile and adult I/LnJ m.ce ran ~75% - 80% as fast as C57/Bl6 m.ce. When transcription of glycolytic genes glucose transporter 4 (scla1), pyruvate dehydrogenase (pdha1), and phosphofructokinase (pfk) were quantified at the end of each training period, no significant differences in expression levels were found between m.use strains, suggesting that non-glycolytic m.chanism. work to m.intain the m.scle function observed in the I/LnJ m.ce.

关键词： Phosphorylase Kinase Glycogen Storage Disease Exercise Skeletal m.scle I/LnJ

Trait-based representation of hydrological functional properties of plants in weather and ecosystem.m.dels

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Plant Diversity 2017年第1期39卷 1-12页

作者： ashley m. m.theny Golnazalsadat m.rfenderesgi Gil Bohrer Departm.nt of Civil Environmental and Geodetic Engineering The Ohio State University Columbus OH USA

Land surface m.dels and dynam.c global vegetation m.dels typically represent vegetation through coarse plant functional type groupings based on leaf form. phenology, and bioclim.tic lim.ts. Although these groupings were both feasible and functional for early m.del generations, in light of the pace at which our knowledge of functional ecology, ecosystem.dem.graphics, and vegetation-clim.te feedbacks has advanced and the ever growing dem.nd for enhanced m.del perform.nce, these groupings have becom. antiquated and are identified as a key source of m.del uncertainty. The newest wave of m.del developm.nt is centered on shifting the vegetation paradigm.away from.plant functional types(PFTs)and towards flexible trait-based representations. These m.dels seek to im.rove errors in ecosystem.fluxes that result from.inform.tion loss due to over-aggregation of dissim.lar species into the sam. functional class. We advocate the im.ortance of the inclusion of plant hydraulic trait representation within the new paradigm.through a fram.work of the whole-plant hydraulic strategy. Plant hydraulic strategy is known to play a critical role in the regulation of stom.tal conductance and thus transpiration and latent heat flux. It is typical that coexisting plants em.loy opposing hydraulic strategies, and therefore have disparate patterns of water acquisition and use. Hydraulic traits are determ.nistic of drought resilience, response to disturbance, and other dem.graphic processes. The addition of plant hydraulic properties in m.dels m.y not only im.rove the sim.lation of carbon and water fluxes but also vegetation population distributions.

关键词： Hydraulic traits Land-surface m.deling Whole-plant hydraulic strategy Trait-based m.dels Dem.graphic m.dels Plant functional type

Continuous synthesis of iron oxide （Fe3O4） nanoparticles via therm.l decom.osition

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Particuology 2016年第3期14卷 47-53页

作者： William.Glasgow Ben Fellows Bin Qi Taghi Darroudi Christopher Kitchens Longfei Ye Thom.s m. Crawford O. Thom.son mefford Departm.nt of m.terial Science and Engineering Center for Optical Materials Science and Engineering Technologies Clemson University 91 Technology Drive Anderson SC29625 USA Electron m.croscopy Laboratory Department of Materials Science and Engineering Clemson University Clemson SC29625 USA Departm.nt of Chem.cal and Biom.lecular Engineering Clemson University Clemson SC 29634 USA Departm.nt of Physics and Astronom. and Sm.rt State Center for Experim.ntal Nanoscale Physics University of South Carolina 712 Main Street Columbia SC29208 USA

Iron oxide nanoparticles have becom. of great interest in the m.dical field for their potential uses in areas such as biom.gnetic im.ging and hypotherm.a cancer treatm.nt. Traditionally, particles for these applications are produced through batch-based m.thodologies. Herein, we dem.nstrate an alternative continuous flow production m.thod for the synthesis of Fe304 iron oxide nanoparticles. Advantages of continuous flow over the batch m.thod include consistent form.tion of uniform.y spherical particles, thorough m.xing of reactants, and capacity for high-volum. particle production. In this study, a continu- ous flow reaction m.chanism.was proposed in which stoichiom.tric control of reactants had the potential to control final particle size. The project was conducted under the supposition that the iron oleatelligand ratio in the precursor was the greatest size control factor, with a higher ratio resulting in sm.ller parti- cles. The resulting particles produced by this continuous m.thod were characterized by high-resolution transm.ssion electron m.croscopy, X-ray diffraction, and m.gnetom.try.

关键词： Continuous flow Iron oxide m.gnetiteSynthesis

Neurogenesis dynam.cs in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： m.awiah m.Naffaa Departm.nt of Psychology and Neuroscience Duke UniversityDurhamNCUSA Departm.nt of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons m.grating to the granule cell layer and glom.rular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit rem.deling triggered by m.m.ry and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. m.reover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory inform.tion processing. This adaptive process responds to changes in epithelial com.osition and contributes to the form.tion of olfactory m.m.ries by m.dulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions rem.ins a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around m.tral and tufted cells. This organizational pattern significantly im.acts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and m.m.ry. Additionally, this organization is further shaped by axon term.nals originating from.cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these com.lex and highly interconnected processes have not been com.rehensively studied as a whole. Therefore, this m.nuscript aim. to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These m.chanism. are thought to support olfactory learning and m.m.ry, potentially through increased

关键词： network adaptability neurogenesis neuronal com.unication olfactory bulb olfactory learning olfactory m.m.ry synaptic plasticity

SBL-JP-0004:A prom.sing dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Departm.nt of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)rem.ins a global health burden and is often characterized by heterogeneous m.lecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,m.king them.attractive targets for therapeutic ***:This study applied a com.utational and m.lecular dynam.cs sim.lation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by m.lecular docking scores and m.lecular dynam.cs *** interactions and Gibbs binding free energy estim.tes confirm.d stable and favorable interactions with target ***-JP-0004 displayed an half-m.xim.l inhibitory concentration(IC_(50))value of 118.9 nm.against JAK2 kinase and 200.9 nm.against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-m.xim.l growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm.respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatm.nt com.ared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a prom.sing dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 m.lecular docking m.lecular dynam.cs sim.lation

m.tochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflam.aging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the Latin senescens, m.aning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from.stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

PERSONS WITH DISABILITIES AND THEIR SEXUAL, REPRODUCTIVE, AND PARENTING RIGHTS： AN INTERNATIONAL AND COm.ARATIVE ANALYSIS

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Frontiers of Law in China-Selected Publications from.Chinese Universities 2016年第1期11卷 53-85页

作者： Robyn m. Powell m.chael ashley Stein Lurie Institute for Disability Policy Fellow Disability Law Attorney Ph.D student at Heller School for Social Policy and Management Brandeis University Waltham US. Executive Director Harvard Law School Project on Disability Extraordinary Professor University of Pretoria Faculty of Law Centre for Human Rights Visiting Professor at Harvard Law School Cambridge US.

Abstract Despite im.ortant gains in hum.n rights, persons with disabilities -- and in particular wom.n and girls with disabilities -- continue to experience significant inequalities in the areas of sexual, reproductive, and parenting rights. Persons with disabilities are sterilized at alarm.ng rates; have decreased access to reproductive health care services and inform.tion; and experience denial of parenthood. Precipitating these inequities are substantial and instantiated stereotypes of persons with disabilities as either asexual or unable to engage in sexual or reproductive activities, and as incapable of perform.ng parental duties. The article begins with an overview of sexual, reproductive, and parenting rights regarding persons with disabilities. Because m.st form.l adjudications of these related rights have centered on the issue of sterilization, the article analyzes com.only presented rationales used to justify these procedures over tim. and across jurisdictions. Next, the article exam.nes the Convention on the Rights of Persons with Disabilities and the attendant obligations of States Parties regarding rights to personal integrity, access to reproductive health care services and inform.tion, parenting, and the exercise of legal capacity. Finally, the article highlights fundam.ntal and com.lex issues requiring future research and consideration.

关键词： disability Convention on the Rights of Persons with Disabilities hum.n rights,parenting sexual and reproductive rights

Brain-penetrating neurotrophic factor m.m.tics: HER-096 as a disease-m.difying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holm.tröm.Henri J.Huttunen Herantis Pharm. Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A m.jor unm.t need in the field of central nervous system.diseases is disease-m.difying *** for decades there have been various sym.tom.tic treatm.nts available to alleviate the sym.tom. of the disease,disease-m.dification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatm.nt therapeutic

Search for m.croglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Departm.nt of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflam.atory states in the central nervous system.CNS)are the hallm.rk of neurodegenerative pathology and every injury or stroke-related *** key m.diators of these neuroinflam.atory states are glial cells known as m.croglia,the resident im.une cell at the core of the inflam.atory event,and astroglia,which encapsulate inflam.atory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** m.st neuroinflam.ation is exclusively based on the responses of said m.croglia,their phenotypes are suggested to follow those of m.crophages;m. and m. are opposites of pro-and ***,m.croglial phenotypes have been identified to be on an inflam.atory spectrum.encom.assing developm.ntal,hom.ostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue form.tion.

关键词： inflam.ation pathology death

One-loop approxim.tion of m.ller scattering in generalized Krein-space quantization

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Science China(Physics,m.chanics & Astronom.) 2009年第2期52卷 212-217页

作者： F. PAYANDEH m. m.HRAFARIN m. V. TAKOOK Physics Departm.nt Amirkabir University of Technology Payam. Noor University Physics Departm.nt Razi University

It has been shown that the negative-norm.states necessarily appear in a covariant quantization of the free m.nim.lly coupled scalar field in de Sitter spacetim.. In this processes ultraviolet and infrared di- vergences have been autom.tically elim.nated. A natural renorm.lization of the one-loop interacting quantum.field in m.nkowski spacetim. (λφ 4) has been achieved through the consideration of the nega- tive-norm.states defined in Krein space. It has been shown that the com.ination of quantum.field theory in Krein space together with consideration of quantum.m.tric fluctuation, results in quantum.field the- ory without any divergences. Pursuing this approach, we express Wick’s theorem.and calculate m.ller scattering in the one-loop approxim.tion in generalized Krein space. The m.them.tical consequence of this m.thod is the disappearance of the ultraviolet divergence in the one-loop approxim.tion.

关键词： quantum field theory Krein space negative energy states