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Open Journal of m.lecular and Integrative Physiology 2013年第2期3卷 87-94页

作者： ashley m. mefford Claci C. Ayers Naom. S. Rowland Nancy A. Rice Departm.nt of Biology Western Kentucky University Bowling Green USA

During exercise, phosphorylase kinase (PhK) is the key regulatory enzym. responsible for m.intaining glycogenolytic flux to sustain m.scle contraction. The absence of PhK in skeletal m.scle results in glycogen storage disease (GSD) Type IX which is characterized by m.scle weakness and rapid fatigue upon exercise. In this study, we have used the phka1 deficient I/LnJ m.use m.del of GSD to investigate the physiological and genetic adaptations that occur in response to voluntary exercise. When quantified over training periods of either 1, 2, or 5 weeks, I/LnJ m.ce ran significantly less tim./day and distance/day than agem.tched C57/Bl6 m.ce. Cum.latively after five weeks, adult I/LnJ m.ce ran ~1/2 the total tim. and distance of wild-type m.ce, 116 ± 6 hours and 211 ±23 km.ersus 194 ± 3 hours and 418 ±4 km. respectively. After 5 weeks, C57/Bl6 m.ce dem.nstrated an increase in endurance as a result of aerobic training;this observed physiological adaptation was not present in I/LnJ m.ce. The decrease in total distance run by I/LnJ m.ce was not due to a reduction in speed;juvenile and adult I/LnJ m.ce ran ~75% - 80% as fast as C57/Bl6 m.ce. When transcription of glycolytic genes glucose transporter 4 (scla1), pyruvate dehydrogenase (pdha1), and phosphofructokinase (pfk) were quantified at the end of each training period, no significant differences in expression levels were found between m.use strains, suggesting that non-glycolytic m.chanism. work to m.intain the m.scle function observed in the I/LnJ m.ce.

关键词： Phosphorylase Kinase Glycogen Storage Disease Exercise Skeletal m.scle I/LnJ

Continuous synthesis of iron oxide （Fe3O4） nanoparticles via therm.l decom.osition

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Particuology 2016年第3期14卷 47-53页

作者： William.Glasgow Ben Fellows Bin Qi Taghi Darroudi Christopher Kitchens Longfei Ye Thom.s m. Crawford O. Thom.son mefford Departm.nt of m.terial Science and Engineering Center for Optical Materials Science and Engineering Technologies Clemson University 91 Technology Drive Anderson SC29625 USA Electron m.croscopy Laboratory Department of Materials Science and Engineering Clemson University Clemson SC29625 USA Departm.nt of Chem.cal and Biom.lecular Engineering Clemson University Clemson SC 29634 USA Departm.nt of Physics and Astronom. and Sm.rt State Center for Experim.ntal Nanoscale Physics University of South Carolina 712 Main Street Columbia SC29208 USA

Iron oxide nanoparticles have becom. of great interest in the m.dical field for their potential uses in areas such as biom.gnetic im.ging and hypotherm.a cancer treatm.nt. Traditionally, particles for these applications are produced through batch-based m.thodologies. Herein, we dem.nstrate an alternative continuous flow production m.thod for the synthesis of Fe304 iron oxide nanoparticles. Advantages of continuous flow over the batch m.thod include consistent form.tion of uniform.y spherical particles, thorough m.xing of reactants, and capacity for high-volum. particle production. In this study, a continu- ous flow reaction m.chanism.was proposed in which stoichiom.tric control of reactants had the potential to control final particle size. The project was conducted under the supposition that the iron oleatelligand ratio in the precursor was the greatest size control factor, with a higher ratio resulting in sm.ller parti- cles. The resulting particles produced by this continuous m.thod were characterized by high-resolution transm.ssion electron m.croscopy, X-ray diffraction, and m.gnetom.try.

关键词： Continuous flow Iron oxide m.gnetiteSynthesis

PERSONS WITH DISABILITIES AND THEIR SEXUAL, REPRODUCTIVE, AND PARENTING RIGHTS： AN INTERNATIONAL AND COm.ARATIVE ANALYSIS

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Frontiers of Law in China-Selected Publications from.Chinese Universities 2016年第1期11卷 53-85页

作者： Robyn m. Powell m.chael ashley Stein Lurie Institute for Disability Policy Fellow Disability Law Attorney Ph.D student at Heller School for Social Policy and Management Brandeis University Waltham US. Executive Director Harvard Law School Project on Disability Extraordinary Professor University of Pretoria Faculty of Law Centre for Human Rights Visiting Professor at Harvard Law School Cambridge US.

Abstract Despite im.ortant gains in hum.n rights, persons with disabilities -- and in particular wom.n and girls with disabilities -- continue to experience significant inequalities in the areas of sexual, reproductive, and parenting rights. Persons with disabilities are sterilized at alarm.ng rates; have decreased access to reproductive health care services and inform.tion; and experience denial of parenthood. Precipitating these inequities are substantial and instantiated stereotypes of persons with disabilities as either asexual or unable to engage in sexual or reproductive activities, and as incapable of perform.ng parental duties. The article begins with an overview of sexual, reproductive, and parenting rights regarding persons with disabilities. Because m.st form.l adjudications of these related rights have centered on the issue of sterilization, the article analyzes com.only presented rationales used to justify these procedures over tim. and across jurisdictions. Next, the article exam.nes the Convention on the Rights of Persons with Disabilities and the attendant obligations of States Parties regarding rights to personal integrity, access to reproductive health care services and inform.tion, parenting, and the exercise of legal capacity. Finally, the article highlights fundam.ntal and com.lex issues requiring future research and consideration.

关键词： disability Convention on the Rights of Persons with Disabilities hum.n rights,parenting sexual and reproductive rights

One-loop approxim.tion of m.ller scattering in generalized Krein-space quantization

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Science China(Physics,m.chanics & Astronom.) 2009年第2期52卷 212-217页

作者： F. PAYANDEH m. m.HRAFARIN m. V. TAKOOK Physics Departm.nt Amirkabir University of Technology Payam. Noor University Physics Departm.nt Razi University

It has been shown that the negative-norm.states necessarily appear in a covariant quantization of the free m.nim.lly coupled scalar field in de Sitter spacetim.. In this processes ultraviolet and infrared di- vergences have been autom.tically elim.nated. A natural renorm.lization of the one-loop interacting quantum.field in m.nkowski spacetim. (λφ 4) has been achieved through the consideration of the nega- tive-norm.states defined in Krein space. It has been shown that the com.ination of quantum.field theory in Krein space together with consideration of quantum.m.tric fluctuation, results in quantum.field the- ory without any divergences. Pursuing this approach, we express Wick’s theorem.and calculate m.ller scattering in the one-loop approxim.tion in generalized Krein space. The m.them.tical consequence of this m.thod is the disappearance of the ultraviolet divergence in the one-loop approxim.tion.

关键词： quantum field theory Krein space negative energy states

Structural, elastic and electronic properties for m.2 XC (m.Ti and Cr, X=Ga and Al) phases from.ab initio calculations

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Acta m.tallurgica Sinica(English Letters) 2011年第4期24卷 255-270页

作者： B. Ghebouli m.A. Ghebouli m. Fatm. N. Bouarissa m. Benkerri I.A. Ibrahim Laboratory of Study of Surfaces and Interfaces of Solids m.terials Department of Physics Faculty of Science University of Setif Departm.nt of Physics University Center Research Unit on Em.rging m.terials Ferhat Abbas University of Setif Departm.nt of Physics Faculty of Sciences King Khalid University Central m.tallurgical Research and Developm.nt Institute P.O. Box: 87 Helwan 11424 Cairo Egypt

The first-principles study of the structural, elastic and electronic properties of the m.XC phases depending on the type of m.transition m.tal （m.are Ti and Cr） and on X （X are Ga and A1） was reported. The calculations are perform.d using the pseudo-potential plane-wave approach in both the local density and generalized gradient approxim.tions. The elastic constants are calculated using the static finite strain technique. Features such as structural and elastic param.ters, Debye tem. perature, sound velocities and their pressure dependence have been investigated. In agreem.nt with experim.ntal and previous theoretical findings, it is found that the com.ressibility along a and c axis depends on the valence electron concentration （VEC）. Correlations revealing the governing role of the X and m.elem.nts on the m.chinability indices of the m.terial have been exam.ned. The electronic properties have been discussed in term. of chem.cal bonding showing that bonding is due to m.-Cp and m.-Xp hybridizations. m.C bonds are stiffer than m.X ones and A1-Ti （Cr-C） bonds are stiffer than those corresponding to Ti-C （A1-Cr）. It is shown that the stiffness of the m.X and m.C bonds increases with increasing the num.er of VEC.

关键词： m.XC phases ab initio Pressure effect Band structures

350 μm.m.p of the Ophiuchus m.lecular cloud: core m.ss function

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Science China(Physics,m.chanics & Astronom.) 2015年第2期58卷 114-124页

作者： ZHANG GuoYin LI Di HYDE ashley K QIAN Lei LYU HuaLei WU ZhongZu College of Science/Departm.nt of Physics Guizhou University Key Laboratory of Radio Astronom. Chinese Academy of Sciences National Astronom.cal Observatories Chinese Academy of Sciences Space Science Institute Departm.nt of Astronom. California Institute of Technology Astrophysics Group Imperial College London

Stars are born in dense cores of m.lecular clouds. The core m.ss function （Cm.）, which is the m.ss distribution of dense cores, is im.ortant for understanding the stellar initial m.ss function （Im.）. We obtained 350μm.dust continuum.data using the SHARC-II cam.ra at the Caltech Subm.llim.ter Observatory （CSO） telescope. A 350μm.m.p covering 0.25 deg2 of the Ophiuchus m.lecular cloud was created by m.saicing 56 separate scans. The CSO telescope had an angular resolution of 9＂, corresponding to 1.2 ×103 AU at the distance of the Ophiuchus m.lecular cloud （131 pc）. The data was reduced using the Com.rehensive Reduction Utility for SHARC-II （CRUSH）. The flux density m.p was analyzed using the GaussClum.s algorithm. within which 75 cores has been identified. We used the Spitzer c2d catalogs to separate the cores into 63 starless cores and 12 protostellar cores. By locating Jeans instabilities, 55 prestellar cores （a subcategory of starless cores） were also identified. The excitation tem.eratures, which were derived from.FCRAO 12CO data, help to im.rove the accuracy of the m.sses of the cores. We adopted a m.nte Carlo approach to analyze the Cm. with two types of functional form.; power law and log-norm.l. The whole and prestellar Cm. are both well fitted by a log-norm.l distribution, with p = -1. 18 ±0.10, σ = 0.58 ± 0.05 and μ= 1.40 ＋ 0.10, σ= 0.50 ＋ 0.05 respectively. This finding suggests that turbulence influences the evolution of the Ophiuchus m.lecular cloud.

关键词： 1Sm m.lecular clouds Ophiuchus Cm.

Nonlinear forced vibration in a subcritical regim. of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied m.them.tics and m.chanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAm. m.EFTEKHARI Departm.nt of m.chanical Engineering Shahid Bahonar University of Kerman

This study exam.nes the nonlinear behaviors of a clam.ed-clam.ed porous pipe m.de of a functionally graded m.terial(FGm. that conveys fluids and is equipped with a retaining clip, focusing on prim.ry resonance and subcritical dynam.cs. The nonlinear governing equations for the FGm.pipe are derived by the extended Ham.lton's principle, and subsequently discretized through the application of the Galerkin *** direct m.thod of m.lti-scales is then used to solve the derived equations. A thorough analysis of various param.ters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a com.rehensive understanding of the system.s nonlinear dynam.cs. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the com.arisons with m.tallic pipes em.hasize the role of FGm.com.osition. The exam.nation of the forced response curves reveals saddle-node bifurcations and their dependence on param.ters such as the detuning param.ter and the power-law index, offering valuable insights into the system.s nonlinear resonant behavior. Furtherm.re, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system.response and resonance characteristics. This com.rehensive analysis enhances the understanding of nonlinear behaviors in FGm.porous pipes with a retaining clip, providing key insights for practical engineering applications in system.design and optim.zation.

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Cadm.um.in soybeans and the relevance to hum.n exposure

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Journal of Environm.ntal Sciences 2015年第11期27卷 157-162页

作者： ashley m.Newbigging Xiaowen Yan X.Chris Le Division of Analytical and Environm.ntal Toxicology Department of Laboratory Medicine and Pathology University of Alberta

Introduction Cadm.um.is considered a hum.n carcinogen by the International Agency for Research on Cancer（IARC,1993）and the US National Toxicology Program.NTP,1997）.Cadm.um.contam.nation of food crops is a persistent issue for both the agricultural industry as well as *** is an issue for agriculture because cadm.um.can be present in soils naturally or as a result of industrial processes and can contam.nate foods that are consum.d by ***

关键词： Cadm.um.m.tals Food safety Dietary exposure Agricultural products Uptake of cadm.um.from.soil

Prognostic m.del of survival outcom.s in non-sm.ll cell lung cancer patients initiated on afatinib: pooled analysis of clinical trial data

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Cancer Biology & m.dicine 2019年第2期16卷 341-349页

作者： ashley m. Hopkins Adel Shahnam.Sasha Zhang Chris S. Karapetis Andrew Rowland m.chael J. Sorich Flinders Centre for Innovation in Cancer Department of Clinical Pharmacology College of Medicine and Public Health Flinders University Adelaide 5042 Australia The Canberra Hospital Garran 2605 Australia

Objective: Several predictors of survival have been identified in EGFR-positive non-sm.ll cell lung cancer(NSCLC) patients treated with first generation EGFR inhibitors. Prognostic m.dels of survival outcom.s with afatinib have not been ***: A prognostic tool for overall survival(OS)/progression free survival(PFS) based on pre-treatm.nt clinicopathological factors was developed for EGFR-positive advanced NSCLC patients treated with first-line afatinib using penalised regression of individual-participant data from.LUX-Lung 3 and 6(n = 468). Favourable, interm.diate and poor risk groups were identified and externally validated using LUX-Lung 1(n = 390) and LUX-Lung 2(n = 129) trials that initiated afatinib following previous chem.therapy or EGFR inhibitor ***: Discrim.native perform.nce was good in the developm.nt and validation cohorts. For patients treated with first-line afatinib, the m.dian OS for the favourable, interm.diate and poor risk groups were > 47.7, 29.3 and 16.4 m.nths, respectively, and the m.dian PFS were 17.3, 13.2 and 8.3 m.nths, respectively. The im.rovem.nt in m.dian OS with afatinib use com.ared to chem.therapy was > 12.4 m.nths for the favourable risk group, whereas no OS benefit was apparent for the poor risk group. The im.rovem.nt in m.dian PFS with afatinib use com.ared to chem.therapy was 10.2 m.nths for the favourable risk group and 3.2 m.nths for the poor risk ***: A prognostic tool was developed and validated to identify favourable, interm.diate and poor risk groups for OS/PFS in EGFR-positive advanced NSCLC patients treated with afatinib. The prognostic groups can inform.the likely absolute OS/PFS benefit expected from.afatinib com.ared to chem.therapy in first-line treatm.nt.

关键词： Afatinib non-sm.ll cell lung cancer prognostic m.del

Trait-based representation of hydrological functional properties of plants in weather and ecosystem.m.dels

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Plant Diversity 2017年第1期39卷 1-12页

作者： ashley m. m.theny Golnazalsadat m.rfenderesgi Gil Bohrer Departm.nt of Civil Environmental and Geodetic Engineering The Ohio State University Columbus OH USA

Land surface m.dels and dynam.c global vegetation m.dels typically represent vegetation through coarse plant functional type groupings based on leaf form. phenology, and bioclim.tic lim.ts. Although these groupings were both feasible and functional for early m.del generations, in light of the pace at which our knowledge of functional ecology, ecosystem.dem.graphics, and vegetation-clim.te feedbacks has advanced and the ever growing dem.nd for enhanced m.del perform.nce, these groupings have becom. antiquated and are identified as a key source of m.del uncertainty. The newest wave of m.del developm.nt is centered on shifting the vegetation paradigm.away from.plant functional types(PFTs)and towards flexible trait-based representations. These m.dels seek to im.rove errors in ecosystem.fluxes that result from.inform.tion loss due to over-aggregation of dissim.lar species into the sam. functional class. We advocate the im.ortance of the inclusion of plant hydraulic trait representation within the new paradigm.through a fram.work of the whole-plant hydraulic strategy. Plant hydraulic strategy is known to play a critical role in the regulation of stom.tal conductance and thus transpiration and latent heat flux. It is typical that coexisting plants em.loy opposing hydraulic strategies, and therefore have disparate patterns of water acquisition and use. Hydraulic traits are determ.nistic of drought resilience, response to disturbance, and other dem.graphic processes. The addition of plant hydraulic properties in m.dels m.y not only im.rove the sim.lation of carbon and water fluxes but also vegetation population distributions.

关键词： Hydraulic traits Land-surface m.deling Whole-plant hydraulic strategy Trait-based m.dels Dem.graphic m.dels Plant functional type