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Exercise is mitochondrial medicine for muscle

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Sports Medicine and Health Science 2019年第1期1卷 11-18页

作者： ashley N.Oliveira David A.Hood Muscle Health Research Centre School of Kinesiology and Health ScienceYork UniversityTorontoOntarioCanada

Mitochondria are vital organelles that provide energy for muscle *** these organelles become dysfunctional,they produce less energy as well as excessive levels of reactive oxygen species which can trigger muscle atrophy,weakness and loss of *** this review,molecular evidence is provided to show that exercise serves as a useful therapeutic countermeasure to overcome mitochondrial dysfunction,even when key regulators of organelle biogenesis are *** findings illustrate the complexity and compensatory nature of exercise-induced molecular signaling to transcription,as well as to post-transcriptional events within the mitochondrial synthesis and degradation(***)*** with the first bout of contractile activity,exercise exerts a medicinal effect to improve mitochondrial health and whole muscle function.

关键词： Mitochondria Muscle Exercise Health Aging Metabolism Training

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America Has Spoken

中学生阅读（高中版） 2005年第Z1期 28-31页

作者： bush

美国东部时间2004年11月3日下午3时(北京时间11月4日凌晨4时),令世人关注的美国大选终于落幕。民主党候选人克里承认选举失败,共和党候选人布什成功连任,从而摆脱了其父当年"打赢战争,输掉总统"所留下的阴影,成为美国历史上的第44任、... 详细信息

美国东部时间2004年11月3日下午3时(北京时间11月4日凌晨4时),令世人关注的美国大选终于落幕。民主党候选人克里承认选举失败,共和党候选人布什成功连任,从而摆脱了其父当年"打赢战争,输掉总统"所留下的阴影,成为美国历史上的第44任、第55届总统。当天,美国总统布什偕夫人劳拉在华盛顿的里根中心发表了演讲。同学们,想知道布什获胜后有何感言吗?想知道布什对他的竞争对手克里及其支持者们说了些什么吗?这里我们刊出经过录音整理的演说稿,或许你还可以从中捕捉到布什政府第二任期内美国政策的某种走向。

关键词： America Has Spoken 候选人

Targeted therapy for hepatocellular carcinoma

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1176-1188页

作者： Ao Huang Xin-Rong Yang Wen-Yuan Chung ashley R.Dennison Jian Zhou Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Key Laboratory of Carcinogenesis and Cancer invasion(Fudan University) Ministry of EducationShanghaiChina Shanghai Key Laboratory of Organ Transplantation Zhongshan HospitalFudan UniversityShanghaiChina Department of Hepatobiliary and Pancreatic Surgery University Hospitals of Leicester NHS TrustLeicesterUK institute of Biomedical Sciences Fudan UniversityShanghaiChina State Key Laboratory of Genetic Engineering Fudan UniversityShanghaiChina

The last 3 years have seen the emergence of promising targeted therapies for the treatment of hepatocellular carcinoma(HCC).Sorafenib has been the mainstay of treatment for a decade and newer modalities were ineffective and did not confer any increased therapeutic benefit until the introduction of lenvatinib which was approved based on its non-inferiority to *** subsequent success of regorafenib in HCC patients who progress on sorafenib treatment heralded a new era of second-line treatment and was quickly followed by ramucirumab,cabozantinib,and the most influential,immune checkpoint inhibitors(iCis).Over the same period combination therapies,including anti-angiogenesis agents with iCis,dual iCis and targeted agents in conjunction with surgery or other loco-regional therapies,have been extensively investigated and have shown promise and provided the basis for exciting clinical *** continues to develop additional novel therapeutic agents which could potentially augment the presently available options and understand the underlying mechanisms responsible for drug resistance,with the goal of improving the survival of patients with HCC.

关键词： hepatocellular treatment subsequent

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导航波流体力学

力学进展 2021年第1期51卷 155-177页

作者： John W.M.bush 王展(译) 韦小丁(校) 麻省理工学院数学系马萨诸塞州剑桥02139 中国科学院力学研究所北京大学

Yves Couder,Emmanuel Fort和同事们最近发现能够维持在振荡液体表面的毫米液滴可以通过与自身诱导波场的共振作用自我推进.这篇文章针对实验结果进行了综述,发现行走的液滴呈现出某些以往被认为只属于微观量子领域的特征.文章接着回顾... 详细信息

Yves Couder,Emmanuel Fort和同事们最近发现能够维持在振荡液体表面的毫米液滴可以通过与自身诱导波场的共振作用自我推进.这篇文章针对实验结果进行了综述,发现行走的液滴呈现出某些以往被认为只属于微观量子领域的特征.文章接着回顾了这种流体动力导航波系统的理论描述,从而深入了解其类量子行为的起源.量子化源于导波场施加在液滴上的动态约束,而多模态统计似乎是混沌导航波动力学的一个特征.在此,尝试评估此流体力学系统作为量子比拟的可能性和局限性.该流体力学系统与量子导航波理论的比较表明,他明显不同于玻姆力学,而与德布罗意(de Broglie)最初的量子动力学概念密切相关,这包括德布罗意的双解理论及其后研究者们在随机电动力学领域的拓展.

关键词：行走的液滴法拉第波量子比拟

incidental seminal vesicle amyloidosis observed in diagnostic prostate biopsies--are routine investigations for systemic amyloidosis warranted？

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Asian Journal of Andrology 2013年第1期15卷 149-151页

作者： Zichu Yang Alexander Laird ashley Monaghan Morag Seywright imran Ahmad Hing Y Leung institute of Cardiovascular and Medical Sciences College of Medical Veterinary and Life Sciences University of Glasgow Glasgow Scotland G12 8QQ UK Department of Urology Gartnavel General Hospital NHS Great Glasgow and Clyde Glasgow Scotland G12 OYN UK pathology NHSGGC Southern General Hospital Glasgow Scotland G51 4TF UK The Beatson institute for Cancer Research Glasgow Scotland G61 1BD UK

Seminal vesicle （SV） amyloidosis is a well-documented histological entity, but it is observed infrequently. its incidence is on the rise, which is probably related to the increasing use of prostate biopsies to investigate patients with elevated serum prostate-specific antigen levels. Here, we report seven cases of incidental SV amyloidosis over a 3-year period and consider their relationship to the previously suggested aetiological factors. Based on our series, we conclude that incidental localized SV amyloidosis observed in diagnostic prostate biopsies does not warrant formal investigations for systemic amyloidosis.

关键词： accessory sex organs male prostate biopsies prostate cancer prostate diseases prostatitis seminal vesicle amyloidosis

A revisit to staining reagents for neuronal tissues

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Annals of Eye Science 2022年第1期7卷 51-65页

作者： Alexandra Rosario ashley Howell Sanjoy K.Bhattacharya Miami integrative Metabolomics Research Center Bascom Palmer Eye InstituteUniversity of MiamiMiamiFloridaUSA

in the early days of deciphering the injured neuronal tissues led to the realization that contrast is necessary to discern the parts of the recovering tissues from the damaged *** attempts relied on available(and often naturally occurring)staining ***,the active ingredients of most of them were small *** the advent of time,the knowledge of chemistry helped identify compounds and conditions for *** staining reagents were even found to enhance the visibility of the *** impregnation identification of Golgi bodies was discovered in owl optic *** reagents since the late 1800s were widely used across all disciplines and for nerve tissue and became a key contributor to advancement in nerve-related *** use of these reagents provided insight into the organization of the neuronal tissues and helped distinguish nerve degeneration from *** neuronal staining reagents have played a fundamental role in the clinical research facilitating the identification of biological mechanisms underlying eye and neuropsychiatric *** found a lack of systematic description of all staining reagents,whether they had been used historically or currently *** is a lack of readily available information for optimal staining of different neuronal tissues for a given *** present here a grouping of the reagents based on their target location:(i)the central nervous system(CNS),(ii)the peripheral nervous system(PNS),or(iii)*** biochemical reactions of most of the staining reagents is based on acidic or basic pH and specific reaction partners such as organelle or biomolecules that exists within the given tissue *** present here a summary of the chemical composition,optimal staining condition,use for given neuronal tissue and,where possible,historic *** biomolecules such as lipids and metabolites lack specific *** being non-specific the reagents enhance contrast a

关键词： Staining reagent neuroregeneration silver impregnation method Mallory staining hematoxylin-eosin staining

Bilateral renal cortical necrosis associated with smoking synthetic cannabinoids

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World Journal of Clinical Cases 2017年第6期5卷 234-237页

作者： Kanaan Mansoor ashley Zawodniak Tibor Nadasdy Zeid J Khitan internal Medicine Department Joan C Edwards School of Medicine Marshall University Department of Renal and Transplant Pathology the Ohio State University

Synthetic cannabinoids have become a common drug of abuse in recent years and their toxicities have come to light as well. They are known to be notorious for the kidneys, with acute tubular necrosis, acute interstitial nephritis and rhabdomyolysis induced renal injury being the frequent nephrotoxic outcomes in users. We report a case of bilateral renal cortical necrosis, leading to irreversible renal damage and lifelong dialysis dependency.

关键词： Synthetic cannabinoids Renal cortical necrosis Dialysis

Mitigation of Hypoxic Ecosystems Using Hemolymph Analysis of Callinectes sapidus and Procambarus clarkii in Relation to Spartina Grasses

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Open Journal of Ecology 2016年第8期6卷 484-495页

作者： Natalie bush Edward bush Christopher Green Julie Anderson Pamela Blanchard Nathan bush Jennifer Conover St. Joseph’s Academy Baton Rouge LA USA LSU AgCenter Baton Rouge LA USA LSU AgCenter Aquaculture Research Station Baton Rouge LA USA LSU AgCenter and Louisiana Sea Grant Baton Rouge LA USA Health and Human Resources Baton Rouge LA USA Department of Mathematics Texas A & M University College Station TX USA Louisiana Universities Marine Consortium Chauvin LA USA

in the past 80 years, Louisiana has lost over one million acres in land, affecting plants and crustaceans that live in these environments. The first objective of this research was to determine the relationship between diffused oxygen in water and time with the behavioral and physiological health of Callinectes sapidus (blue crab) and Procambarus clarkii (crawfish). After 24 hours, manual dexterity, or the amount of time it takes for a crustacean to flip itself over increased under hypoxic conditions. Hemolymph was extracted and tested for lactate, glucose, and protein. Crawfish were also exposed to this same procedure. An additional crawfish study comparing Spartina plants to assimilate oxygen for aeration compared to mechanical aeration was conducted. The hypoxic groups for all three studies at the 0.05 level had a significantly greater manual dexterity time and greater amounts of lactate and glucose. The protein was significantly higher in hypoxia-exposed crawfish. Time and aeration affect the health of crustaceans, and plants were shown to effectively provide normoxic oxygen levels at a similar level as mechanical aeration. These studies support the importance of marsh grasses for the coast and crustacean viability.

关键词： Coastal Restoration Barrier island Mitigation Marine Ecology

Summarizing the evidence for robotic-assisted bladder neck reconstruction: Systematic review of patency and incontinence outcomes

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Asian Journal of Urology 2024年第3期11卷 341-347页

作者： Tenny R.Zhang ashley Alford Lee C.Zhao Department of Urology NewYork-Presbyterian Hospital/Weill Cornell MedicineNew YorkNYUSA Department of Urology NYU Langone Medical CenterNew YorkNYUSA

Objective:Bladder neck contracture and vesicourethral anastomotic stenosis are difficult to manage endoscopically,and open repair is associated with high rates of *** recent years,there have been increasing reports of robotic-assisted bladder neck reconstruction in the ***,existing studies are small,heterogeneous case *** objective of this study was to perform a systematic review of robotic-assisted bladder neck reconstruction to better evaluate patency and incontinence ***:We performed a systematic review of PubMed from first available date to May 2023 for all studies evaluating robotic-assisted reconstructive surgery of the bladder neck in adult *** in non-English,author replies,editorials,pediatric-based studies,and reviews were *** of interest were patency and incontinence rates,which were pooled when ***:After identifying 158 articles on initial search,we included only ten studies that fit all aforementioned criteria for robotic-assisted bladder neck *** were case series published from March 2018 to March 2022 ranging from six to 32 men,with the median follow-up of 5e23 months.A total of 119 patients were included in our analysis.A variety of etiologies and surgical techniques were *** rates ranged from 50%to 100%,and pooled patency was 80%(95/119).De novo incontinence rates ranged from 0%to 33%,and pooled incontinence was 17%(8/47).Our findings were limited by small sample sizes,relatively short follow-ups,and heterogeneity between studies.

关键词： Bladder neck Continence incontinence Patency Posterior urethra Reconstructive surgery Robotic surgery Stenosis Stricture Surgical outcome