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Treat to target in Crohn’s disease:A practical guide for clinicians

World Journal of Gastroenterology 2024年第1期30卷 50-69页

作者： ashish r.sr.nivasan Department of Gastroenterology Austin HealthVictoriaMelbourne 3083Australia Department of Gastroenterology Eastern HealthVictoriaMelbourne 3128Australia Department of Medicine University of MelbourneVictoriaMelbourne 3052Australia

A treat-to-target(T2T)approach applies the principles of early intervention and tight disease control to optimise long-term outcomes in Crohn's *** Selecting Therapeutic Targets in Inflammatory Bowel Disease(STrIDE)-II guidelines specify short,intermediate,and long-term treatment goals,documenting specific treatment targets to be achieved at each of these *** appraisal of Crohn’s disease activity against pre-defined treatment targets at these timepoints remains central to determining whether current therapy should be continued or *** treatment targets in Crohn’s disease comprise combination clinical and patient-reported outcome remission,in conjunction with biomarker normalisation and endoscopic *** the STrIDE-II guidelines endorse the pursuit of endoscopic healing,clinicians must consider that this may not always be appropriate,acceptable,or achievable in all *** underscores the need to engage patients at the outset in an effort to personalise care and individualise treatment *** use of non-invasive biomarkers such as faecal calprotectin in conjunction with cross-sectional imaging techniques,particularly intestinal ultrasound,holds great promise;as do emerging treatment targets such as transmural *** randomised clinical trials,namely,CALM and STArDUST,have evaluated the efficacy of a T2T approach in achieving endoscopic endpoints in patients with Crohn’s *** from these studies reflect that patient subgroups and Crohn’s disease characteristics likely to benefit most from a T2T approach,remain to be ***,outside of clinical trials,data pertaining to the real-world effectiveness of a T2T approach remains scare,highlighting the need for pragmatic real-world *** the obvious promise of a T2T approach,a lack of guidance to support its integration into real-world clinical practice has the potential to limit its *** highlights the need to describe st

关键词： Treat to target Inflammatory bowel disease Crohn’s disease Treatment targets Endoscopic remission Transmural healing Time to response Intestinal ultrasound

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DNACDS:Cloud IoE big data security and accessing scheme based on DNA cryptography

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Frontiers of Computer Science 2024年第1期18卷 157-170页

作者： ashish SINGH Abhinav KUMAr Suyel NAMASUDrA School of Computer Engineering KIIT Deemed to be UniversityBhubaneshwar 751024India Department of Computer Science and Engineering Indian Institute of Information Technology SuratSurat 394190India Department of Computer Science and Engineering National Institute of Technology AgartalaAgartala 799046India

The Internet of Everything(IoE)based cloud computing is one of the most prominent areas in the digital big data *** approach allows efficient infrastructure to store and access big real-time data and smart IoE services from the *** IoE-based cloud computing services are located at remote locations without the control of the data *** data owners mostly depend on the untrusted Cloud Service Provider(CSP)and do not know the implemented security *** lack of knowledge about security capabilities and control over data raises several security *** Acid(DNA)computing is a biological concept that can improve the security of IoE big *** IoE big data security scheme consists of the Station-to-Station Key Agreement Protocol(StS KAP)and Feistel cipher *** paper proposed a DNA-based cryptographic scheme and access control model(DNACDS)to solve IoE big data security and access *** experimental results illustrated that DNACDS performs better than other DNA-based security *** theoretical security analysis of the DNACDS shows better resistance capabilities.

关键词： IoE based cloud computing DNA cryptography IoE big data security StS KAP feistel cipher IoE big data access

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Promoting rigor in blockchain energy and environmental footprint research:A systematic literature review

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Blockchain(research and Applications) 2024年第1期5卷 133-151页

作者： ashish rajendra Sai Harald Vranken Department of Computer Science Open UniversiteitHeerlen6419 ATthe Netherlands Department of Advanced Computing Sciences Maastricht UniversityMaastricht6211 LKthe Netherlands Institute for Computing&Information Sciences Radboud UniversityNijmegen6525 XZthe Netherlands

There is a growing interest in understanding the energy and environmental footprint of digital currencies,specifically in cryptocurrencies such as Bitcoin and *** cryptocurrencies are operated by a geographically distributed network of computing nodes,making it hard to estimate their energy consumption *** studies,both in academia and industry,attempt to model cryptocurrency energy consumption often based on a number of assumptions,for instance,about the hardware in use or the geographic distribution of the computing nodes.A number of these studies have already been widely criticized for their design choices and subsequent over-or under-estimation of energy *** this study,we evaluate the reliability of prior models and estimates by leveraging existing scientific literature from fields cognizant of blockchain,such as social energy sciences and information *** first design a quality assessment framework based on existing research,and we then conduct a systematic literature review examining scientific and non-academic literature demonstrating common issues and potential avenues of addressing these *** goal with this article is to advance the field by promoting scientific rigor in studies focusing on blockchain energy *** that end,we provide a novel set of codes of conduct for the five most widely used research methodologies:Quantitative energy modeling,literature reviews,data analysis and statistics,case studies,and *** envision that this code of conduct would assist in standardizing the design and assessment of studies focusing on blockchain-based systems’energy and environmental footprint.

关键词： Blockchain Energy consumption Environmental footprint Scientific rigor reliability

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Examining dietary interventions in Crohn’s disease

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World Journal of Gastroenterology 2024年第34期30卷 3868-3874页

作者： Lynna Chen ashish srinivasan Abhinav Vasudevan Department of Gastroenterology and Hepatology Eastern HealthBox Hill 3128Australia Eastern Clinical School Monash UniversityBox Hill 3128Australia

This editorial builds on the article by Shakhshir et *** conducted an overview of evidence-based dietary interventions in adults with inflammatory bowel disease(IBD).In the IBD population,there may be a role for the Mediterranean diet due to its anti-inflammatory effects,long-term sustainability,and role in improving cardiovascular *** active Crohn’s disease,the use of exclusive enteral nutrition,the Crohn’s disease exclusion diet,or the specific carbohydrate diet may be used as a short-term adjunct to medical therapy and may improve mucosal *** low-FODMAP diet can assist in reducing symptoms for patients without evidence of active bowel *** interest in nutritional therapy increases amongst clinicians and patients alike,it is integral that dietary therapies are understood and discussed in routine management of patients with IBD as part of holistic care,ideally through a multidisciplinary setting with involvement of experienced *** serves to improve clinician-patient engagement and reduce complications of IBD including micro and micronutrient deficiencies.

关键词： Inflammatory bowel disease Nutrition Dietary therapies Inflammation Malnutrition

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Prostate cancer genotyping for risk stratification and precision treatment

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Current Urology 2024年第2期18卷 87-97页

作者： ashish A.Kumar Department of Urology York&Scarborough Teaching Hospitals NHS Foundation TrustYorkUK

Prostate cancer(PC)is the most frequently diagnosed cancer and second leading cause of cancer-related deaths in *** is heterogeneous,as is evident from the wide spectrum of therapeutic *** patients with PC are initially responsive to androgen deprivation therapy;however,themajority of cases are either hormone-sensitive PC or castration-resistant *** therapeutic protocols follow the evolution of PC,a continuously progressive process involving a combination of widespread genomic *** genomic alterations are either hereditary germline mutations,such as mutations in BrCA2,or specific only to tumor cells(somatic).Tumor-specific genomic spectra include genomic structural rearrangements,canonical androgen response genes,andmany other specific genes such as TMPrSS2-ErG fusion,SPOP/FOXA1,TP53/rB1/PTEN,*** evidence indicates the involvement of signaling pathways including PI3K,WNT/β-catenin,srC,and IL-6/STAT,which have been shown to promote epithelial-mesenchymal transition cancer stem cell–like features/stemness,and neuroendocrine differentiation in *** the last decade,our understanding of the genotype-phenotype relationships has been enhanced *** genetic background of PC related to canonical genetic alterations and signaling pathway activation genes has shed more insight into the molecular subtype and disease landscape,resulting in a more flexible role of individual therapies targeting diverse genotypes and phenotypes.

关键词： Prostate cancer Prostate cancer treatment Prostate cancer genomics Hereditary prostate cancer Androgen deprivation therapy Hormone sensitive prostate cancer Kinase signaling

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Microstructure transformations and improving wear resistance of austenitic stainless steel additively fabricated by arc-based DED process

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Defence Technology（防务技术） 2024年第8期38卷 194-204页

作者： ashish Yadav Manu srivastava Prashant K.Jain Sandeep rathee Hybrid Additive Manufacturing Laboratory Mechanical Engineering DepartmentPDPM Indian Institute of Information TechnologyDesign&ManufacturingJabalpur482005Madhya PradeshIndia FFF Laboratory Mechanical Engineering DepartmentPDPM Indian Institute of Information TechnologyDesign&ManufacturingJabalpur482005Madhya PradeshIndia Department of Mechanical Engineering National Institute of TechnologySrinagarIndia

In this study, austenitic stainless steel(ASS) was additively fabricated by an arc-based direct energy deposition(DED) technique. Macrostructure, microstructure, mechanical characteristics at different spatial orientations(0°, 90°, and 45°), and wear characteristics were evaluated at the deposited structure top, middle, and bottom regions. results show that austenite(γ) and delta-ferrite(δ) phases make up most of the microstructure of additively fabricated SS316LSi steel. Within γ matrix, δ phase is dispersed both(within and along) grain boundaries, exhibiting a fine vermicular morphology. The bottom, middle,and top regions of WAAM deposited ASS exhibit similar values to those of wrought SS316L in the tensile and impact test findings. Notably, a drop in hardness values is observed as build height increases. During SEM examinations of fractured surfaces from tensile specimen, closed dimples were observed, indicating good ductility of as-built structure. Wear test findings show signs of mild oxidation and usual adhesive wear. By depositing a mechanically mixed composite layer, an increase in the oxidation percentage was discovered to facilitate healing of worn surfaces. The findings of this study will help in design, production and renovation of products/components that are prone to wear. WAAM-deposited ASS has remarkable strength and ability to withstand impacts;it can be used in the production of armour plates for defence applications, mainly military vehicles and aircraft.

关键词： Metal additive deposition Defence applications Arc-based DED Characterization Wear behaviour Fractography

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Current perspective on amyloid aggregation accelerating properties of the artificial butter flavoring,diacetyl

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Neural regeneration research 2024年第10期19卷 2113-2114页

作者： ashish P.Vartak Swati S.More Center for Drug Design College of PharmacyUniversity of MinnesotaMinneapolisMNUSA

The amyloid—what peptide can resist its entropic bliss?Without kinetic barricades and chaperones,most peptides would simply tumble down that *** amyloid-β(Aβ) peptides are understood to underlie the hallmark pathology of Alzheimer's disease(AD) and are considered one of the causative factors for neurodegeneration and cognitive *** affects critical connected structures within the brain that are responsible for memory,language,and social behavior.

关键词： amyloid Alzheimer Aβ

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Influence of imidazolium ionic liquids as organic filler dispersant on electrical properties of chitin/epoxy composites

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High Voltage 2024年第4期9卷 930-938页

作者： Kai Yin Qihong Fan Jing Li Taqi ur rahman Tianyin Zhang ashish Paramane Xiangrong Chen School of Information and Electrical Engineering Hangzhou City UniversityHangzhouChina College of Electrical Engineering Zhejiang UniversityHangzhouChina State Grid Tianjin Power Chengnan District Supply Company TianjinChina Electrical Engineering Department National Institute of TechnologySilcharAssamIndia

Ionic liquid(IL)as the dispersant can help disperse the organic nanofillers to improve the performance of epoxy resin ***,the effect of IL on the electrical properties of epoxy composites is not well *** comprehensive study consists of the preparation,material characterisation and systematical investigation of electrical properties of 1-Butyl-3-methylimidazole hexafluorophosphate-modified chitin fibre/epoxy *** findings show that introducing IL into a chitin/epoxy composite can minimise porosity defects and improve the compatibility between filler and ***,a high concentration of IL induces severe charge injection into chitin/epoxy composites and internal electric field *** addition of 0.75%–1.5%mass fraction IL results in maximum enhancement in the AC breakdown strength of the chitin/epoxy composite(by~71%)compared with the non-IL *** nonlinear conductivity and non-uniform charge injection phenomena of IL-modified composites can be attributed to the movement of radicals and anions due to the decomposition of *** this study,it is highly expected that the organic filler dispersion in the epoxy matrix can be optimised by tuning IL to improve the insulation properties.

关键词： composites composite filler

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Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2885-2900页

作者： Porkizhi Arjunan Durga Kathirvelu Gokulnath Mahalingam ashish Kumar Goel Uday George Zacharaiah Alok srivastava srujan Marepally Center for Stem Cell research(A Unit of inStem Bengaluru)Christian Medical College CampusBagayamVellore 632002Tamil NaduIndia Manipal academy for higher education Mangalore 576104KarnatakaIndia Department of Hematology Christian Medical College&HospitalVellore 632004Tamil NaduIndia Department of Hepatology Christian Medical College&HospitalVellore 632004Tamil NaduIndia

Inherited genetic disorders of the liver pose a significant public health *** transplantation is often limited by the availability of donor livers and the exorbitant costs of immunosuppressive *** overcome these limitations,nucleic acid therapy provides a hopeful alternative that enables gene repair,gene supplementation,and gene silencing with suitable *** viral vectors are the most efficient and preferred for gene therapy,pre-existing immunity debilitating immune responses limit their *** a potential alternative,lipid nanoparticle-mediated vectors are being explored to deliver multiple nucleic acid forms,including pDNA,mrNA,sirNA,and ***,we discuss the broader applications of lipid nanoparticles,from protein replacement therapy to restoring the disease mechanism through nucleic acid delivery and gene editing,as well as multiple preclinical and clinical studies as a potential alternative to liver transplantation.

关键词： Lipid nanoparticle Liver disorders Gene therapy Gene editing Nucleic acid delivery pDNA mrNA sirNA ASO Clinical trials

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Development of Accident Prediction Model under Mixed Traffic Conditions:A Case Study

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Journal of Traffic and Transportation Engineering 2024年第4期12卷 187-195页

作者： ashish Dhamaniya Civil Engineering Department Indian Institute of Technology(IIT)RoorkeeUttarakhand 247667India

Accident prediction models are developed under mixed traffic *** models have been *** first model is a city based traffic accident prediction *** population and vehicle ownership are the two parameters used to develop the model.A case study of Surat city in Gujarat is taken *** accident occurred in the city are regressed with population and vehicle *** model is the urban arterial based accident prediction *** accident record of ring road of Surat city shows that there are eight different locations on a ten kilometer stretch of ring road where the accidents took place *** locations are picked up as accident *** there are many contributing factors and causes to road accidents.A comprehensive study of road safety found that human error was the sole cause in 57%of all accidents and was a contributing factor in over 90%.Keeping this in view a new term driver-pedestrian index is used to develop this *** function of Microsoft excel is used for model *** the models are checked with r-statistics and t-statistics further the models are validated by using statistical goodness of fit(chi square test).Hence these models can be used to predict number of accidents in future subjected to the same geometric *** this in mind improvement measures can be taken up by the district authorities.

关键词： Traffic accidents regression population and vehicle ownership driver-pedestrian index

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