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Preoperative therapy in locally advanced esophageal cancer

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World Journal of Gastroenterology 2016年第39期22卷 8750-8759页

作者： Pankaj kumar Garg Jyoti Sharma ashish Jakhetiya Aakanksha goel Manish kumar Gaur Department of Surgery University College of Medical Sciences and Guru Teg Bahadur Hospital University of Delhi Department of Surgical Oncology Sawai Man Singh Medical College Department of Surgical Oncology Dr BRA Institute Rotary Cancer Hospital All India Institute of Medical Sciences

Esophageal cancer is an aggressive malignancy associated with dismal treatment outcomes. Presence of two distinct histopathological types distinguishes it from other gastrointestinal tract malignancies. Surgery is the cornerstone of treatment in locally advanced esophageal cancer(T2 or greater or node positive); however, a high rate of disease recurrence(systemic and loco-regional) and poor survival justifies a continued search for optimal therapy. Various combinations of multimodality treatment(preoperative/perioperative, or postoperative; radiotherapy, chemotherapy, or chemoradiotherapy) are being explored to lower disease recurrence and improve survival. Preoperative therapy followed by surgery is presently considered the standard of care in resectable locally advanced esophageal cancer as postoperative treatment may not be feasible for all the patients due to the morbidity of esophagectomy and prolonged recovery time limiting the tolerance of patient. There are wide variations in the preoperative therapy practiced across the centres depending upon the institutional practices, availability of facilities and personal experiences. There is paucity of literature to standardize the preoperative therapy. Broadly, chemoradiotherapy is the preferred neo-adjuvant modality in western countries whereas chemotherapy alone is considered optimal in the far East. The present review highlights the significant studies to assist in opting for the best evidence based preoperative therapy(radiotherapy, chemotherapy or chemoradiotherapy) for locally advanced esophageal cancer.

关键词： Esophageal cancer Preoperative therapy Multimodality treatment Chemotherapy Radiotherapy Chemoradiotherapy

Recent progress and perspective on batteries made from nuclear waste

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Nuclear Science and Techniques 2023年第3期34卷 1-8页

作者： Nirmal kumar Katiyar Saurav goel School of Engineering London South Bank UniversityLondonSE10 AAUK University of Petroleum and Energy Studies Dehradun248007India

Sustainable energy sources are an immediate need to cope with the imminent issue of climate change the world is facing *** particular,the long-lasting miniatured power sources that can supply energy continually to power handheld gadgets,sensors,electronic devices,unmanned airborne vehicles in space and extreme mining are some of the examples where this is an acute *** is known from basic physics that radioactive materials decay over few years and some nuclear materials have their half-life until thousands of *** past five decades of research have been spent harnessing the decay energy of the radioactive materials to develop batteries that can last until the radioactive reaction ***,an emergent opportunity of industrial symbiosis to make use of nuclear waste by using radioactive waste as raw material to develop bat-teries with long shelf life presents a great opportunity for sustainable energy resource ***,the current canon of research on this topic is *** perspective draws fresh discussions on the topic while highlighting future directions in this wealthy arena of *** abstract A long-lasting miniaturised nuclear battery utilising 14C radioactive isotope as fuel.

关键词： Sustainable energy Nuclear waste battery Nano-diamond

Gastroprotective effect of Acacia nilotica young seedless pod extract:Role of polyphenolic constituents

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Asian Pacific Journal of Tropical Medicine 2012年第7期5卷 523-528页

作者： Vijay kumar Bansal Rajesh kumar goel Department of Pharmaceutical Sciences NIMS UniversityJaipurIndia Department of Pharmaceutical Sciences and Drug Research Punjabi University PatialaIndia

Objective:To systematically evaluate antiulcer potential of Acacia nilotica in different ulcer models in ***:Different extracts[ethanolie,50%hydroethanolic(50:50),70% hydroethanolic(70:30) and aqueous]of young seedless pods were examined in pylorus ligation induced gastric ulcers in *** parameters like,volume of gastric acid secretion,pH,free acidity,total acidity,ulcer index,mucin content and antioxidant studies were determined and were compared between extract treated,standard and vehicle control following ulcer induction. The most active extract was also evaluated in swimming stress induced and NSAID induced gastric ***:Among different extracts of young seedless pods only hydroethanolic extracts showed significant antiulcer activity in pyloric ligation induced *** more the 70%hydroethanolic extract showed better protection as compared to 50%hydroethanolic *** 70%hydroethanolic extract also showed significant mucoprotection in swimming stress induced and nonsteroidal antiinflammatory drugs induced gastric ***: The results of present study concluded that the hydroethanolic extract of young seedless pods of Acacia nilotica has antiulcer activity in pylorus ligation,swimming stress and NSAID induced rat ulcer *** extract containing more amount of phenolic components show high antiulcer activity,indicating the phenolic component of the extract to be responsible for the activity of the extracts.

关键词： Peptic ulcer Acacia nilotica Ulcer index Tannins Flavonoids

Anthrax: A disease of biowarfare and public health importance

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World Journal of Clinical Cases 2015年第1期3卷 20-33页

作者： Ajay kumar goel Biotechnology Division Defence Research and Development Establishment Gwalior 474002 India

Bioterrorism has received a lot of attention in the first decade of this century. Biological agents are considered attractive weapons for bioterrorism as these are easy to obtain, comparatively inexpensive to produce and exhibit widespread fear and panic than the actual potential of physical damage. Bacillus anthracis(B. anthracis), the etiologic agent of anthrax is a Gram positive, spore forming, non-motile bacterium. This is supposed to be one of the most potent BW agents because its spores are extremely resistant to natural conditions and can survive for several decades in the environment. *** spores enter the body through skin lesion(cutaneous anthrax), lungs(pulmonary anthrax), or gastrointestinal route(gastrointestinal anthrax) and germinate, giving rise to the vegetative form. Anthrax is a concern of public health also in many countries where agriculture is the main source of income including India. Anthrax has been associated with human history for a very long time and regained its popularity after Sept 2001 incidence in United States. The present review article describes the history, biology, life cycle, pathogenicity, virulence, epidemiology and potential of B. anthracis as biological weapon.

关键词： Anthrax Bacillus anthracis Biological warfare Epidemiology Infection Public health

Kalman filtering for linear singular systems subject to round-robin protocol

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Control Theory and Technology 2024年第4期22卷 543-551页

作者： Ashna goel Shovan Bhaumik Nutan kumar Tomar Department of Mathematics Indian Institute of Technology PatnaPatnaBihar801106India Department of Electrical Engineering Indian Institute of Technology PatnaPatnaBihar801106India

This paper introduces a Kalman-type recursive state estimator for a class of discrete-time stochastic linear singular systems where the measurements are carried part by part periodically following a scheduling *** consider that the system is in a network with limited allotted bandwidth,which refers to a situation where the total available bandwidth for data transmission through the network is *** limitation can occur for various reasons,such as network congestion,resource allocation policies,or bandwidth limitations imposed by network *** such networks,the entire measurement vector cannot be transmitted to the estimator ***,managing a network with a limited allotted bandwidth requires careful planning,monitoring,and implementing some scheduling strategies to optimize the use of measured data while estimating the system *** show that a scheduling method,namely,round-robin protocol,is suitable for singular systems to deal with such a *** upper bound of the prior error covariance is studied via a periodic Riccati equation(PRE).To retain the boundedness of prior error covariance,the stability of the PRE is examined by the observability properties of the round-robin-induced ***,a simulation example is presented to show the effectiveness of the designed filtering scheme.

关键词： Networked control systems Communication constraints Round-robin protocol Singular systems Filtering

Effect of Ocimum sanctum on the development of protective immunity against Salmonella typhimurium infection through cytokines

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Asian Pacific Journal of Tropical Medicine 2010年第9期3卷 682-686页

作者： Anjana goel Sandeep kumar Ashok kumar Bhatia Department of Microbiology & Immunology College of Veterinary Sciences & Animal HusbandryU.P.Pt Deen Dayal Upadhyay Pasu Chikitsa Vigyan Vishwavidyalaya evam Go Anusandhan Sansthan(DUVASU)Mathura281001U.P.India

Objective:To investigate the protective role of Ocimum sanctum（***） leaves against Salmonella ***（***） infection in rats by inducing TNF-α,IFN-γ& IL-2 ***:Wistar albino rats were fed with aqueous extract of *** leaves using 250 mg/kg body weight dose once a day for 20 consecutive *** rats were fed with *** were infected with LD50 dose of *** infection and monitored for their *** blood burden in both the groups was compared and numbers of activated peritoneal macrophages were *** of TNF-α,IFN-γand IL-2 cytokines in serum during different time intervals was assayed by sandwich ***:Rats of control group showed a high mortality rate and had higher bacterial blood burden when compared with *** extract fed *** was a significant increase in the number of *** engulfed peritoneal macrophages in the peritoneal fluid of *** fed *** protective control against bacterial infection in O,sanctum fed rats was associated with elevated level of TNF-α,IFN-γand IL-2 cytokines in ***:These findings suggest that orally administered *** leaves extract effectively enhanced activation in macrophage and lymphocytes,depicted by the elevated serum concentration of TNF-α,IFN-γand IL-2 cytokines,leading to induce a protective resistance against Salmonella typhimurium infection.

关键词： Ocimum sanctum Salmonella typhimurium TNF-α IFN-γ IL-2

Immunomodulating property of Ocimum sanctum by regulating the IL-2 production and its mRNA expression using rat's splenocytes

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Asian Pacific Journal of Tropical Medicine 2010年第1期3卷 8-12页

作者： Anjana goel Dilip kumar Singh Sandeep kumar Ashok kumar Bhatia Department of Microbiology & Immunology College of Veterinary Sciences & Animal HusbandryU.P.Pt Deen Dayal Upadhyay Pasu Chikitsa Vigyan Vishwavidyalaya evam Go Anusandhan Sansthan(DUVASU)Mathura281001U.P.India

Objective:To investigate the regulatory effect of aqueous extract of leaves of Ocimum sanctum on IL-2 cytokine production in vivo and in vitro,and the effect of leaves extract on general blood picture including T& B ***:For in vivo studies albino Wistar rats were treated with aqueous crude leaves extract of Ocimum sanctum for 20 consecutive *** cells were harvested and assayed for IL-2 production by using sandwich enzyme-linked immunosorbent assay(ELISA) and mRNA expression *** in vitro study aqueous Ocimum sanctum leaves extract= in different concentrations(25-500μ/mL) was added into culture plates containing ConA stimulated *** study the overall effect on blood picture,density gradient purified lymphocytes analysis and conventional methodology for total and differential leukocyte count and hemoglobin level were also ***:It indicated that the rats treated with Ocimum sanctum leaves extract had significantly enhanced(P<0.001) ability of spleen cells to secrete *** in vitro also showed regulation of IL-2 *** study exhibited leucocytosis and augmentation of T& B lymphocytes by 25%approximately.4-5%increase in Hemoglobin value was also ***:Aqueous Ocimum sanctum leaves extract may have stimulatory effect on T & B lymphocytes particularly on Th 1 subset of lymphocytes as shown by enhancement in IL-2 production.

关键词： B lymphocytes IL-2 Ocimum sanctum Splenocytes T lymphocytes

Pharmacokinetic, pharmacodynamic, and neurochemical investigations of lamotrigine-pentylenetetrazole kindled mice to ascertain it as a reliable model for clinical drug-resistant epilepsy

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Animal Models and Experimental Medicine 2020年第3期3卷 245-255页

作者： Sandeep kumar Rajesh K.goel Department of Pharmaceutical Sciences&Drug Research Punjabi UniversityPatialaPunjabIndia

Background:Pentylenetetrazole kindling has long been used for the screening of investigational antiseizure *** presence of lamotrigine,at a very low dose,does not hamper kindling in mice;rather it modifies this epileptogenesis process into drug-resistant *** lamotrigine-pentylenetetrazole kindled mice show resistance to lamotrigine,phenytoin,and *** may also be possible that other licensed antiseizure drugs,like the mentioned drugs,remain ineffective in this model;therefore,this was the subject of this ***:Swiss albino mice were kindled with pentylenetetrazole for 35 days in the presence of either methylcellulose vehicle or lamotrigine(subtherapeutic dose,ie,5 mg/kg).Vehicle vs lamotrigine-kindled mice were compared in terms of(a)resistance/response toward nine antiseizure drugs applied as monotherapies and two drug combinations;(b)lamotrigine bioavailability in blood and brain;(c)blood-brain barrier integrity;and(d)amino acids and monoamines in the cerebral cortex and ***:Lamotrigine vs vehicle-kindled mice are similar(or not significantly different P>.05 from each other)in terms of(a)response toward drug combinations;(b)lamotrigine bioavailability;and(c)blood-brain barrier integrity except for,significantly(P<.05)reduced taurine and increased glutamate in the cerebral cortex and *** from these,lamotrigine-kindled mice show significant(P<.05)resistant to lamotrigine(15 mg/kg),levetiracetam(40 mg/kg);carbamazepine(40 mg/kg),zonisamide(100 mg/kg),gabapentin(224 mg/kg),pregabalin(30 mg/kg),phenytoin(35 mg/kg),and topiramate(300 mg/kg).Conclusion:Lamotrigine-pentylenetetrazole kindling takes longer to develop(~5 weeks)in comparison to lamotrigine-amygdale(~4 weeks)and lamotriginecorneal(~2 weeks)kindling ***,drug screening through this model may yield superior drugs with novel antiseizure mechanisms.

关键词： animal models drug-resistant epilepsy kindling lamotrigine refractory epilepsy

Analytical modeling of subthreshold current and subthreshold swing of Gaussiandoped strained-Si-on-insulator MOSFETs

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Journal of Semiconductors 2014年第8期35卷 52-59页

作者： Gopal Rawat Sanjay kumar Ekta goel Mirgender kumar Sarvesh Dubey S.Jit Department of Electronics Engineering Indian Institute of Technology (BHU) Varanasi India Faculty of Electronics and Communication Engineering Shri Ramswaroop Memorial University Lucknow-Deva Road India

This paper presents the analytical modeling of subthreshold current and subthreshold swing of short- channel fully-depleted （FD） strained-Si-on-insulator （SSOI） MOSFETs having vertical Gaussian-like doping pro- file in the channel. The subthreshold current and subthreshold swing have been derived using the parabolic approx- imation method. In addition to the effect of strain on silicon layer, various other device parameters such as channel length （L）, gate-oxide thickness （tox）, strained-Si channel thickness （ts_Si）, peak doping concentration （Np）, project range （Rp） and straggle （op） of the Gaussian profile have been considered while predicting the device characteris- tics. The present work may help to overcome the degradation in subthreshold characteristics with strain engineering. These subthreshold current and swing models provide valuable information for strained-Si MOSFET design. Ac- curacy of the proposed models is verified using the commercially available ATLASTM, a two-dimensional （2D） device simulator from SILVACO.

关键词： strained-Si-on-insulator (SSOI) Poisson's solution short-channel-effects