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Effect of ankle versus thigh tourniquets on post-operative pain in foot and ankle surgery

World Journal of Orthopedics 2024年第2期15卷 163-169页

作者： ashish Mishra Ahmed Barakat Jitendra Mangwani Jakub Kazda Sagar Tiwatane Sana Mohammed Aamir Shaikh Linzy Houchen-Wolloff Vipul Kaushik Department of Trauma and Orthopedics University Hospitals LeicesterLeicester LE15WWUnited Kingdom Department of Trauma and Orthopedics Leicester University Hospitals-NHS TrustLeicester LE15WWLeicestershireUnited Kingdom Academic Team of Musculoskeletal Surgery University Hospitals of Leicester NHS TrustLeicester LE39QPUnited Kingdom Department of Anaesthesia York&Scarborough Teaching Hospitals NHS Foundation TrustNorth Yorkshire YO318HEUnited Kingdom Department of Anaesthesia Royal Free London NHS TrustLondon NW32QGUnited Kingdom Department of Trauma&Orthopaedics Breach Candy Hospital TrustMumbai 400026India Department of Physiotherapy University Hospitals of Leicester NHS TrustLeicester LE39QPUnited Kingdom Department of Anasthesia University Hospitals of Leicester NHS TrustLeicester LE15WWUnited Kingdom

BACKGROUND Tourniquets are commonly used in elective extremity orthopaedic surgery to reduce blood loss,improve visualization in the surgical field,and to potentially reduce surgical *** is a lack of consensus in existing guidelines regarding the optimal tourniquet pressure,placement site,and duration of *** is a paucity of data on the relationship between the site of a tourniquet and postoperative pain in foot and ankle *** To explore the relationship between tourniquet site and intensity of post-operative pain scores in patients undergoing elective foot and ankle *** Retrospective analysis of prospectively collected data on 201 patients who underwent foot and ankle surgery in a single institution was *** tourniquet duration,tourniquet pressure and site,and postoperative pain scores using Visual Analogue Score were collected in immediate recovery,at six hours and at 24 h *** plots were used to analyse the data and to assess for the statistical correlation between tourniquet pressure,duration,site,and pain scores using Pearson correlation *** All patients who underwent foot and ankle surgery had tourniquet pressure of 250 mmHg for ankle tourniquet and 300 mmHg for *** was no correlation between the site of the tourniquet and pain scores in recovery,at six hours and after 24 *** was a weak correlation between tourniquet time and Visual Analogue Score immediately post-op(r=0.14,P=0.04)but not at six or 24 h *** This study shows that there was no statistically significant correlation between tourniquet pressure,site and postop pain in patients undergoing foot and ankle *** choice of using a tourniquet is based on the surgeon's preference,with the goal of minimizing the duration of its application at the operative site.

关键词： Lower limb surgery Tourniquet time Tourniquet pressure Tourniquet site Post-operative pain Pain scores

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Low testing rates and high BRCA prevalence: Poly (ADP-ribose) polymerase inhibitor use in Middle East BRCA/homologous recombination deficiency-positive cancer patients

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World Journal of Clinical Oncology 2024年第7期15卷 848-858页

作者： Naveed Syed ashish Vittalrao Chintakuntlawar Deepti Vilasini Aisha Mohamed Al Salami Riad Al Hasan Imrana Afrooz Kanishka Uttam Chandani Ashok Uttam Chandani Aref Chehal Department of Hematology and Oncology Sheikh Shakbout Medical CityAbu Dhabi 11001United Arab Emirates Department of Oncology Mayo ClinicRochesterNY 790339United States Department of Oncology Sheikh Shakbout Medical CityAbu Dhabi 11001United Arab Emirates Clinical Research Sheikh Shakbout Medical CityAbu Dhabi 11001United Arab Emirates Department of Internal Medicine Landmark Medical CenterRhode IslandRI 02895United States

BACKGROUND Poly(ADP-ribose)polymerase inhibitors(PARPis)are approved as first-line therapies for breast cancer gene(BRCA)-positive,human epidermal growth factor receptor 2-negative locally advanced or metastatic breast *** are also effective for new and recurrent ovarian cancers that are BRCA-or homologous recombination deficiency(HRD)-***,data on these mutations and PARPi use in the Middle East are *** To assess BRCA/HRD prevalence and PARPi use in patients in the Middle East with breast/ovarian *** This was a single-center retrospective study of 57 of 472 breast cancer patients tested for BRCA mutations,and 25 of 65 ovarian cancer patients tested for *** adult patients participated in at least four visits to the oncology service at our center between August 2021 and May *** were summarized using descriptive statistics and compared using counts and *** to treatment was assessed using Response Evaluation Criteria in Solid Tumors *** Among the 472 breast cancer patients,12.1%underwent BRCA testing,and 38.5%of 65 ovarian cancer patients received HRD *** mutations were found in 25.6%of the tested patients:26.3%breast cancers had germline BRCA(gBRCA)mutations and 24.0%ovarian cancers showed ***,40.0%of gBRCA-positive breast cancers and 66.0%of HRD-positive ovarian cancers were Middle Eastern and Asian patients,*** treatment was used in 5(33.3%)gBRCA-positive breast cancer patients as first-line therapy(n=1;7-months progression-free),for maintenance(n=2;>15-months progression-free),or at later stages due to compliance issues(n=2).Four patients(66.6%)with HRD-positive ovarian cancer received PARPi and all remained *** Lower testing rates but higher BRCA mutations in breast cancer were *** reflected United Arab Emirates demographics,with breast cancer in Middle Eastern and ovarian cancer in Asian patients.

关键词： Homologous recombination repair BRCA1 BRCA2 Homologous recombination deficiency Ovarian cancer Breast cancer Poly(ADP-ribose)polymerase inhibitors Olaparib DNA double-strand breaks

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Salp Swarm Algorithm for Solving Optimal Power Flow Problem with Thyristor-Controlled Series Capacitor

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Journal of Electronic Science and Technology 2022年第2期20卷 111-119页

作者： Balasubbareddy Mallala Divyanshi dwivedi the Department of Electrical and Electronics Engineering Chaitanya Bharathi Institute of TechnologyHyderabad 500075 the Department of Electrical and Electronics Engineering Indian Institute of TechnologyHyderabad 502284

In this paper, a salp swarm algorithm(SSA) is proposed for solving the optimal power flow(OPF)problem of a power system with the incorporation of the thyristor-controlled series capacitor(TCSC). The proposed methodology is implemented for determining the optimal setting of control variables for the OPF problem, which includes the real power of generators buses, voltages of generator buses, reactive power injected by shunt compensators, and tap changing transformer ratios. The performance of the proposed approach is validated and tested on the standard IEEE-30 bus system and single-objective functions, including transmission line losses. The severity factor has been minimized and the result obtained is compared with the existing algorithms. Simulation results achieved with the proposed SSA approach demonstrate that it results in an effective and better solution for the OPF problem.

关键词： optimal Optimal power

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The Dallas Donation after Circulatory Death Transplantation Summit:expanding donation after circulatory death procedures through process improvement,broader utilization,and innovation

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 824-836,I0009页

作者： Michele Finotti Anji Wall Anthony D’Alessandro Gary Schwartz Chris Sonnenday David Goldberg ashish Shah Peter Friend Jeff P.Orlowski Greg McKenna Steve Newton Brad Adams William C.Chapman Amit Mathur Marwan Abouljoud Tim Pruett Amelia Hessheimer James F.Trotter Sumeet K.Asrani Giuliano Testa Simmons Transplant Institute Baylor University Medical CenterDallasTXUSA Hepatobiliary and General Surgery Unit Regional Hospital TrevisoDISCOGUniversity of PaduaPaduaItaly Division of Transplantation Department of SurgeryUniversity of Wisconsin School of Medicine and Public HealthMadisonWIUSA Department of Thoracic Surgery and Lung Transplantation Baylor University Medical CenterCenter for Advanced Heart and Lung DiseaseDallasTXUSA Department of Surgery University of MichiganAnn ArborMIUSA Division of Digestive Health and Liver Diseases Department of MedicineUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Cardio-Thoracic Surgery Vanderbilt University Medical CenterNashvilleTNUSA Nuffield Department of Surgical Sciences University of OxfordOxfordUK LifeShare Transplant Donor Services of Oklahoma Oklahoma CityOKUSA Administration Baylor University Medical CenterDallasTXUSA Southwest Transplant Alliance DallasTXUSA Department of Surgery/Transplantation Washington UniversitySt.LouisMOUSA Division of Transplant Surgery Department of SurgeryMayo Clinic ArizonaAlix School of MedicinePhoenixAZUSA Divisions of Transplant and Hepatobiliary Surgery Henry Ford HospitalDetroitMIUSA Department of Surgery University of MinnesotaMinneapolisMNUSA General and Digestive Surgery Hospital Universitario La PazIdiPAZMadridSpain

Despite a significant increase in utilization over the past decade,the number of donation after circulatory death(DCD)organs that are procured and transplanted in the United States(US)remains well below its *** is still room for expansion,as utilizing DCD organs to the fullest extent is currently the most viable solution to the persistent mismatch between supply and demand in *** convened a multidisciplinary transplantation summit to examine various aspects of DCD,with faculty members from around the world with clinical and academic interest in DCD donation and transplantation,including abdominal and cardiothoracic surgeons,organ procurement organization directors,hepatologists,and *** conference focused on identifying barriers to DCD organ utilization and strategies to overcome these *** divide the barriers to DCD utilization into three mains categories:(Ⅰ)policy and process variation;(II)logistical and transportation challenges;and(Ⅲ)higher risk perceptions related to DCD *** each barrier,we proposed a variety of solutions,providing an overview of the status of DCD donation in the US and suggestions on how to increase the use of *** is a specific focus on ex situ machine perfusion,normothermic regional perfusion,and other opportunities to expand DCD utilization without negatively impacting recipient outcomes.

关键词： Donation after circulatory death donation(DCD donation) marginal graft donor pool machine perfusion(MP)

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Local and biglobal linear stability analysis of parallel shear flows

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Computer Modeling in Engineering & Sciences 2017年第2期113卷 219-237页

作者： Sanjay Mittal Anubhav dwivedi Department of Aerospace Engineering Indian Institute of Technology KanpurUP 208016India

Linear Stability Analysis(LSA)of parallel shear flows,via local and global approaches,is *** local analysis is carried out by solving the Orr-Sommerfeld(OS)equation using a spectral-collocation method based on Chebyshev polynomials.A stabilized finite element formulation is employed to carry out the global analysis using the linearized disturbance equations in primitive *** local and global analysis are *** per the Squires theorem,the two-dimensional disturbance has the largest growth ***,only two-dimensional disturbances are *** its very nature,the local analysis assumes the disturbance field to be spatially periodic in the streamwise *** global analysis permits a more general ***,to enable a comparison with the local analysis,periodic boundary conditions,at the inlet and exit of the domain,are imposed on the *** are carried out for the LSA of the Plane Poiseuille Flow(PPF).The relationship between the wavenumber,a,of the disturbance and the streamwise extent of the domain,L,in the global analysis is explored for Re=*** is found that a and L are related by L=2pn/a,where n is the number of cells of the instability along the streamwise direction within the domain length,*** procedure to interpret the results from the global analysis,for comparison with local analysis,is described.

关键词： Linear stability analysis local analysis plane Poiseuille flow Orr-Sommerfeld equation global analysis

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Synthesis and enhanced photoluminescence properties of red emitting divalent ion(Ca^(2+))doped Eu:Y_(2)O_(3)nanophosphors for optoelectronic applications

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Journal of Rare Earths 2022年第8期40卷 1187-1198页

作者： Arpita dwivedi Monika Srivastava Ankur dwivedi Amit Srivastava Anurag Mishra S.K.Srivastava Department of Physics Institute of ScienceBanaras Hindu University(BHU)Varanasi221005India School of Materials Science and Technology Indian Institute of Technology(BHU)Varanasi221005India Department of Mining Engineering Indian Institute of Technology(BHU)Varanasi221005India Department of Physics TDPG College VBS Purvanchal UniversityJaunpur222001India

This work presents the synthesis of Y_(2)O_(3):Eu^(3+),χCa^(2+)(χ=0 mol%,1 mol%,3 mol%,5 mol%,7 mol%,9 mol%,11 mol%)nanophosphors with enhanced photoluminescence properties through a facile solution combustion method for optoelectronic,display,and lighting *** X-ray diffraction(XRD)patterns of the proposed nanophosphor reveal its structural properties and crystalline *** transmission electron microscope(TEM)results confirm the change in the shape of the particle and aggregation of particles after co-doping with Ca^(2+).Fourier transform infrared spectroscopy(FTIR)and Raman vibrations also confirm the presence of Y-O vibration and subsequently explain the crystalline nature,structural properties,and purity of the *** the synthesized nanophosphors samples emit intense red emission at 613 nm(~5D_(0)→~7 F_(2))under excitation with 235,394 and 466 nm wavelengths of Eu^(3+)*** photoluminescence(PL)emission spectra excited with 235 nm illustrate the highest emission peak with two other emission peaks excited with 466 and 394 nm that is 1.4 times higher than 466 nm and 1.9 times enhanced by 394 nm wavelength,*** emission intensity of Y_(2)O_(3):Eu^(3+),χCa^(2+)(5 mol%)is increased 8-fold as compared to Eu:Y_(2)O_(3).Doping with Ca^(2+)ions enhances the emission intensity of Eu:Y_(2)O_(3)nanopho sphors due to an increase in energy transfer in Ca^(2+)→Eu^(3+)through asymmetry in the crystal field and by introduction of radiative defect centers through oxygen vacancies in the yttria *** is also observed that the optical band gap and the lifetime of the~5D_(0)level of Eu^(3+)ions in Y_(2)O_(3):Eu^(3+),xCa^(2+)nanophosphor sample gets changed with a doping conce ntration of Ca^(2+)*** also reveals high thermal stability and quantum yield as estimating activation energy of 0.25 eV and 81%,***,CCT,and color purity values(>98%)show an improved red-emitting nanophosphor in the warm region of light,which m

关键词： Red emission Photoluminescence(PL) Y_(2)O_(3):Eu^(3+),xCa^(2+) Rare earths Nanophosphors LEDs

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Computer aided design and analysis of a tunable muzzle brake

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Defence Technology（防务技术） 2019年第1期15卷 89-94页

作者： Ekansh Chaturvedi Ravi K.dwivedi Department of Mechanical Engineering Maulana Azad National Institute of Technology

This research work deals with the design of a tunable muzzle brake [10] for a rifle chambered in 5.56 x 45 NATO ammunition. It proposes to solve the problem of handling differences from shooter to shooter by incorporating the feature of tunability. Beside this, it also solves the problem of requirement of optimum recoil in short recoil weapons. This innovation gives this design an edge over its already existing counterparts in the market. The product is designed using the internal ballistics calculations and the investigations been performed using solidworks flow simulation tool and ANSYS static structural to check the parameters like velocity distribution, pressure growth, and muzzle brake force along the series of ports and comparison of the so found results with those devised by the authors of the documents mentioned in references. This assures the market adaptability of the product for satisfactory performance, when brought among its already existing counterpart, though with a slight edge over them due to tunability. The results so found shall be concluded satisfactory regarding the performance of muzzle brake.

关键词： Flow simulation Innovation Muzzle brake Tunability Set screws

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Modeling the Contemporary Stress Field and Deformation Pattern of Eastern Mediterranean

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Journal of Earth Science 2010年第4期21卷 365-381页

作者： S K dwivedi D Hayashi Simulation Tectonics Laboratory Faculty of ScienceUniversity of the Ryukyus

The contemporary stress field in the earth＇s crust is important and provides insights into mechanisms that drive plate motions. In this study, elastic plane stress finite element modeling incorporating realistic rock parameters was used to calculate the stress field, displacement field, and defor- mation of the plate interactions in the eastern Mediterranean. Modeled stress data for the African- Arabian-Anatolian plate interactions with fixed European platform correlate well with observed contemporary stress indicator from the world stress map （WSM） and focal mechanism of earthquakes; while displacement field agrees qualitatively well with GPS vectors and sense of motion indicated by focal mechanisms for large crustal earthquakes （Ms〉6） and plate motion models. Modeling result shows the direction of maximum horizontal compressive stress （σHmax） toward the direction of absolute motion of these plates. Large perturbations in σHmax orientations are shown to occur in and around tectonic boundaries between those plates. It is observed that, although the African plate acts mostly as indenter, which transmits the collisional motion from the Arabian plate to the Anatolian plate, in the current situation, the far-field stress, probably from the subduction in Aegean Arc, is needed to satisfy the contemporary stress field in Anatolia.

关键词： finite element model maximum horizontal stress seismieity crustal deformation Anatolia eastern Mediterranean.

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Blockchain-Based Secured IPFS-Enable Event Storage Technique With Authentication Protocol in VANET

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IEEE/CAA Journal of Automatica Sinica 2021年第12期8卷 1913-1922页

作者： Sanjeev Kumar dwivedi Ruhul Amin Satyanarayana Vollala Department of CSE Dr.Shyama Prasad Mukherjee International Institute of Information Technology Naya RaipurChhattisgarh 492002India

In recent decades,intelligent transportation systems(ITS)have improved drivers’safety and have shared information(such as traffic congestion and accidents)in a very efficient ***,the privacy of vehicles and the security of event information is a major *** problem of secure sharing of event information without compromising the trusted third party(TTP)and data storage is the main issue in *** technologies can resolve this problem.A work has been published on blockchain-based protocol for secure sharing of events and authentication of *** protocol addresses the issue of the safe storing of event ***,authentication of vehicles solely depends on the cloud *** a result,their scheme utilizes the notion of partially decentralized *** paper proposes a novel decentralized architecture for the vehicular ad-hoc network(VANET)without the cloud *** work also presents a protocol for securing event information and vehicle authentication using the blockchain *** this protocol,the registered user accesses the event information securely from the interplanetary file system(IPFS).We incorporate the IPFS,along with blockchain,to store the information in a fully distributed *** proposed protocol is compared with the *** comparison provides desirable security at a reasonable *** evaluation of the proposed smart contract in terms of cost(GAS)is also discussed.

关键词： Authentication blockchain interplanetary file system(IPFS) secure information sharing security

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A Cooperative Approach of Frequency Regulation Through Virtual Inertia Control and Enhancement of Low Voltage Ride-through in DFIG-based Wind Farm

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Journal of Modern Power Systems and Clean Energy 2022年第6期10卷 1519-1530页

作者： Preeti Verma Seethalekshmi K. Bharti dwivedi Department of Electrical Engineering Institute of Engineering and TechnologyLucknow 226021Uttar PradeshIndiawhich is a constituent institute of Dr.A.P.J.Abdul Kalam Technical UniversityLucknowUttar Pradesh(U.P.)India IEEE

Doubly-fed induction generator(DFIG)-based wind farms(WFs)are interfaced with power electronic *** interfaces are attributed to the low inertia generated in the WFs under high penetration and that becomes prevalent in a fault ***,transient stability enhancement along with frequency stability in DFIG-based WFs is a major concern in the present *** this paper,a cooperative approach consisting of virtual inertia control(VIC)and a modified grid-side converter(GSC)approach for low voltage ride-through(LVRT)is proposed to achieve fault ride-through(FRT)capabilities as per the grid code requirements(GCRs)while providing frequency support to the grid through a synthetic *** proposed approach provides LVRT and reactive power compensation in the *** participation of the VIC in a rotor-side converter(RSC)provides frequency support to the DFIG-based *** combined approach supports active power compensation and provides sufficient kinetic energy support to the system in a contingency *** studies are carried out in MATLAB/Simulink environment for symmetrical and unsymmetrical *** superiority of the proposed scheme is demonstrated through analysis of the performance of the scheme and that of a series resonance bridge-type fault current limiter(SR-BFCL).

关键词： Virtual inertia controller(VIC) doubly-fed induction generator(DFIG) fault ride-through(FRT)capability wind farm(WF) fault current limiter(FCL)

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