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MicroRNA: a new and promising potential biomarker for diagnosis and prognosis of ovarian cancer

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Cancer Biology & Medicine 2015年第4期12卷 328-341页

作者： Manish K.Pal Shyam P.Jaiswar Vinaya N.dwivedi Amit K.Tripathi ashish dwivedi Pushplata Sankhwar Department of Obstetrics and Gynecology King George Medical University Biochemistry and Molecular Biology Laboratory Center for Advanced Study in Zoology Department of Zoology Banaras Hindu University Endocrinology Division Central Drug Research Institute Photobiology Division Indian Institute of Toxicology Research

Epithelial ovarian cancer(EOC) is the leading cause of death among all gynecological malignancies. Despite the technological and medical advances over the past four decades, such as the development of several biological markers(mRNA and proteins biomarkers), the mortality rate of ovarian cancer remains a challenge because of its late diagnosis, which is specifically attributed to low specificities and sensitivities. Under this compulsive scenario, recent advances in expression biology have shifted in identifying and developing specific and sensitive biomarkers, such as micro RNAs(miRNAs) for cancer diagnosis and prognosis. MiRNAs are a novel class of small non-coding RNAs that deregulate gene expression at the posttranscriptional level, either by translational repression or by mRNA degradation. These mechanisms may be involved in a complex cascade of cellular events associated with the pathophysiology of many types of cancer. MiRNAs are easily detectable in tissue and blood samples of cancer patients. Therefore, miRNAs hold good promise as potential biomarkers in ovarian cancer. In this review, we attempted to provide a comprehensive profile of key miRNAs involved in ovarian carcinoma to establish mi RNAs as more reliable non-invasive clinical biomarkers for early detection of ovarian cancer compared with protein and DNA biomarkers.

关键词：生物标志物肿瘤诊断卵巢癌预后 miRNAs 开发基因表达癌症患者

DNACDS:Cloud IoE big data security and accessing scheme based on DNA cryptography

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Frontiers of Computer Science 2024年第1期18卷 157-170页

作者： ashish SINGH Abhinav KUMAR Suyel NAMASUDRA School of Computer Engineering KIIT Deemed to be UniversityBhubaneshwar 751024India Department of Computer Science and Engineering Indian Institute of Information Technology SuratSurat 394190India Department of Computer Science and Engineering National Institute of Technology AgartalaAgartala 799046India

The Internet of Everything(IoE)based cloud computing is one of the most prominent areas in the digital big data *** approach allows efficient infrastructure to store and access big real-time data and smart IoE services from the *** IoE-based cloud computing services are located at remote locations without the control of the data *** data owners mostly depend on the untrusted Cloud Service Provider(CSP)and do not know the implemented security *** lack of knowledge about security capabilities and control over data raises several security *** Acid(DNA)computing is a biological concept that can improve the security of IoE big *** IoE big data security scheme consists of the Station-to-Station Key Agreement Protocol(StS KAP)and Feistel cipher *** paper proposed a DNA-based cryptographic scheme and access control model(DNACDS)to solve IoE big data security and access *** experimental results illustrated that DNACDS performs better than other DNA-based security *** theoretical security analysis of the DNACDS shows better resistance capabilities.

关键词： IoE based cloud computing DNA cryptography IoE big data security StS KAP feistel cipher IoE big data access

Treat to target in Crohn’s disease:A practical guide for clinicians

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World Journal of Gastroenterology 2024年第1期30卷 50-69页

作者： ashish R Srinivasan Department of Gastroenterology Austin HealthVictoriaMelbourne 3083Australia Department of Gastroenterology Eastern HealthVictoriaMelbourne 3128Australia Department of Medicine University of MelbourneVictoriaMelbourne 3052Australia

A treat-to-target(T2T)approach applies the principles of early intervention and tight disease control to optimise long-term outcomes in Crohn's *** Selecting Therapeutic Targets in Inflammatory Bowel Disease(STRIDE)-II guidelines specify short,intermediate,and long-term treatment goals,documenting specific treatment targets to be achieved at each of these *** appraisal of Crohn’s disease activity against pre-defined treatment targets at these timepoints remains central to determining whether current therapy should be continued or *** treatment targets in Crohn’s disease comprise combination clinical and patient-reported outcome remission,in conjunction with biomarker normalisation and endoscopic *** the STRIDE-II guidelines endorse the pursuit of endoscopic healing,clinicians must consider that this may not always be appropriate,acceptable,or achievable in all *** underscores the need to engage patients at the outset in an effort to personalise care and individualise treatment *** use of non-invasive biomarkers such as faecal calprotectin in conjunction with cross-sectional imaging techniques,particularly intestinal ultrasound,holds great promise;as do emerging treatment targets such as transmural *** randomised clinical trials,namely,CALM and STARDUST,have evaluated the efficacy of a T2T approach in achieving endoscopic endpoints in patients with Crohn’s *** from these studies reflect that patient subgroups and Crohn’s disease characteristics likely to benefit most from a T2T approach,remain to be ***,outside of clinical trials,data pertaining to the real-world effectiveness of a T2T approach remains scare,highlighting the need for pragmatic real-world *** the obvious promise of a T2T approach,a lack of guidance to support its integration into real-world clinical practice has the potential to limit its *** highlights the need to describe st

关键词： Treat to target Inflammatory bowel disease Crohn’s disease Treatment targets Endoscopic remission Transmural healing Time to response Intestinal ultrasound

Improved simultaneous quantitation of candesartan and hydrochlorthiazide in human plasma by UPLC–MS/MS and its application in bioequivalence studies

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Journal of Pharmaceutical Analysis 2014年第2期4卷 144-152页

作者： Bhupinder Singh Rama S.Lokhandae ashish dwivedi Sandeep Sharma Naveen Dubey Jubiliant Clinsys Limited NoidaNew DelhiIndia Jaipur National University JaipurIndia

A validated ultra-performance liquid chromatography mass spectrometric method （UPLC-MS/MS） was used for the simultaneous quantitation of candesartan （CN） and hydrochlorothiazide （HCT） in human plasma. The analysis was performed on UPLC-MS/MS system using turbo ion spray interface. Negative ions were measured in multiple reaction monitoring （MRM） mode. The analytes were extracted using a liquid-liquid extraction （LLE） method by using 0.1 mL of plasma volume. The lower limit of quantitation for CN and HCT was 1.00 ng/mL whereas the upper limit of quantitation was 499.15 ng/mL and 601.61 ng/mL for CN and HCT respectively. CN d4 and HCT-13Cd2 were used as the internal standards for CN and HCT respectively. The chromatography was achieved within 2.0 min run time using a C18 Pheno-menex, Gemini NX （100 mm ~ 4.6 mm, 5 mm） column with organic mixture：buffer solution （80：20, v/v） at a flow rate of 0.800 mL/min. The method has been successfully applied to establish the bioequivalence of candesartan cilexetil （CNC） and HCT immediate release tablets with reference product in human subjects.

关键词： Candesartan cilexetil Hydrochlorothiazide UPLC MS/MS Bioequivalence Candcsartan cilexetil-hydrochlorothiazide(ATACAND HCT)

Ultra-performance liquid chromatography electrospray ionization-tandem mass spectrometry method for the simultaneous determination of itraconazole and hydroxy itraconazole in human plasma

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Journal of Pharmaceutical Analysis 2014年第5期4卷 316-324页

作者： ashish dwivedi Bhupinder Singh Sandeep Sharma R.S.Lokhandae Naveen Dubey Bioanalytical Department Jubilant Life SciencesC-46Sector 62Noida 201307India Jaipur National University JaipurIndia

A highly sensitive, selective, and precise ultra-performance liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous quantification of itraconazole and hydroxy itraconazole in human plasma by a single liquid-liquid extraction step. The precursor to product ion transitions of m/z 705.3/392.3, m/z 721.2/408.3 and m/z 708.2/435.4 were used to detect and quantify itraconazole, hydroxy itraconazole and itraconazole-d3 respectively. The lower limit of quantitation was found to be 0.500 ng/mL for itraconazole and 1.00 ng/mL for hydroxy itraconazole. The mean recoveries for itraconazole and hydroxy itraconazole were found to be 100.045% and 100.021%, respectively. This developed method with a chromatographic run time of 2.0 min was successfully applied to a bioequivalence study of 100 mg itraconazole capsule.

关键词： Itraconazole,Hydroxy itraconazole,Ultra-performance liquidchromatography, Human plasma Simultaneous analysis

Current perspective on amyloid aggregation accelerating properties of the artificial butter flavoring,diacetyl

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Neural Regeneration Research 2024年第10期19卷 2113-2114页

作者： ashish P.Vartak Swati S.More Center for Drug Design College of PharmacyUniversity of MinnesotaMinneapolisMNUSA

The amyloid—what peptide can resist its entropic bliss?Without kinetic barricades and chaperones,most peptides would simply tumble down that *** amyloid-β(Aβ) peptides are understood to underlie the hallmark pathology of Alzheimer's disease(AD) and are considered one of the causative factors for neurodegeneration and cognitive *** affects critical connected structures within the brain that are responsible for memory,language,and social behavior.

关键词： amyloid Alzheimer Aβ

Experiences with Rice Grown on Permanent Raised Beds: Effect of Crop Establishment Techniques on Water Use, Productivity, Profitability and Soil Physical Properties

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Rice science 2014年第3期21卷 170-180页

作者： R.K.NARESH S.S.TOMAR Dipender KUMAR Samsher Purushottam S.P.SINGH ashish dwivedi Vineet KUMAR Department of Agronomy SardarVallabhbhai Patel University of Agriculture & Technology Department of Agronomy Punjab Agricultural University Department Food Processing &Engeering SardarVallabhbhai Patel University of Agriculture & Technology Department of Pathology & Microbiology SardarVallabhbhai Patel University of Agriculture & Technology Department of Soil Science SardarVallabhbhai Patel University of Agriculture & Technology

In recent years, conventional rice production technologies have been leading to deterioration of soil health and declining farm profitability due to high inputs of water and labor. Conservation agriculture （CA） based resource-conserving technologies i.e. zero-tillage （ZT）, raised-bed planting and direct-seeded rice （DSR） have shown promise as alternatives to conventional production technologies to overcome these problems. Present study was undertaken during 2009-2012 to establish an understanding of how permanent raised bed cropping system could be practiced to save water at the field application level to improve water productivity and also have the capability to enhance productivity, profitability and soil physical quality. The results showed that among different crop establishment techniques, conventional-tilled puddle transplanted rice （CT-TPR） required 14%-25% more water than other techniques. Compared with the CT-TPR system, zero till direct-seeded rice （ZT-DSR） consumed 6%-10%less water with almost equal system productivity and demonstrated higher water productivity. Wide raised beds saved about 15%-24% water and grain yield decrease of about 8%. Direct-seeded rice after ZT or reduced tillage or on unpuddled soil provided more net income than CT-TPR. The CT-TPR system had higher bulk density and penetration resistance due to compaction caused by the repeated wet tillage in rice. The steady-state infiltration rate and soil aggregation （〉 0.25 mm） were higher under permanent beds and ZT and lower in the CT-TPR system. Under CT-TPR, soil aggregation was static across seasons, whereas it improved under no-till and permanent beds. Similarly, mean weight diameter of aggregates was higher under ZT and permanent beds and increased over time. The study reveals that to sustain the rice productivity, CA-based planting techniques can be more viable options. However, the long-term effects of these alternative technologies need to be studied under varying agro-ecologies in

关键词： permanent raised bed water productivity profitability yield water saving crop establishment technique

Optimizing Biodiesel Production from Karanja and Algae Oil with Nano Catalyst:RSMand ANN Approach

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Energy Engineering 2024年第9期121卷 2363-2388页

作者： Sujeet Kesharvani Sakhi Katre Suyasha Pandey Gaurav dwivedi Tikendra Nath Verma Prashant Baredar Energy Centre Maulana Azad National Institute of TechnologyBhopal462003India Department of Mechanical Engineering Maulana Azad National Institute of TechnologyBhopal462003India

This study delves into biodiesel synthesis from non-edible oils and algae oil sources using Response Surface Methodology(RSM)and an Artificial Neural Network(ANN)model to optimize biodiesel *** of *** and Karanja oils is utilized,aiming to reduce free fatty acid content to 1%through single-step *** reveals peak biodiesel yield conditions:1%catalyst quantity,91.47 min reaction time,56.86℃reaction temperature,and 8.46:1 methanol to oil molar *** ANN model outperforms RSM in yield prediction *** impact assessment yields an E-factor of 0.0251 at maximum yield,indicating responsible production with minimal *** analysis reveals significant cost savings:30%-50%reduction in raw material costs by using non-edible oils,10%-15%increase in production efficiency,20%reduction in catalyst costs,and 15%-20%savings in energy *** optimized process reduces waste disposal costs by 10%-15%,enhancing overall economic ***,the widespread adoption of biodiesel offers economic,environmental,and social benefits to a diverse range of stakeholders,including farmers,producers,consumers,governments,environmental organizations,and the transportation *** among these stakeholders is essential for realizing the full potential of biodiesel as a sustainable energy solution.

关键词： Non-edible oil algae RSM ANN optimization environmental factor

Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2885-2900页

作者： Porkizhi Arjunan Durga Kathirvelu Gokulnath Mahalingam ashish Kumar Goel Uday George Zacharaiah Alok Srivastava Srujan Marepally Center for Stem Cell Research(A Unit of inStem Bengaluru)Christian Medical College CampusBagayamVellore 632002Tamil NaduIndia Manipal academy for higher education Mangalore 576104KarnatakaIndia Department of Hematology Christian Medical College&HospitalVellore 632004Tamil NaduIndia Department of Hepatology Christian Medical College&HospitalVellore 632004Tamil NaduIndia

Inherited genetic disorders of the liver pose a significant public health *** transplantation is often limited by the availability of donor livers and the exorbitant costs of immunosuppressive *** overcome these limitations,nucleic acid therapy provides a hopeful alternative that enables gene repair,gene supplementation,and gene silencing with suitable *** viral vectors are the most efficient and preferred for gene therapy,pre-existing immunity debilitating immune responses limit their *** a potential alternative,lipid nanoparticle-mediated vectors are being explored to deliver multiple nucleic acid forms,including pDNA,mRNA,siRNA,and ***,we discuss the broader applications of lipid nanoparticles,from protein replacement therapy to restoring the disease mechanism through nucleic acid delivery and gene editing,as well as multiple preclinical and clinical studies as a potential alternative to liver transplantation.

关键词： Lipid nanoparticle Liver disorders Gene therapy Gene editing Nucleic acid delivery pDNA mRNA siRNA ASO Clinical trials