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Clinical Significance of Liver Function Abnormality in Patients with COVID-19:A Single-center Experience from Western India

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Journal of Clinical and Translational Hepatology 2021年第6期9卷 878-888页

作者： Chetan R.Kalal Harshad Joshi Vivek Kumar Divya Gopal Darshana Rathod ashish shukla Tarang Gianchandani Chetan Bhatt Department of Gastroenterology Hepatology and Liver TransplantSir HN Reliance Foundation Hospital and Research Cen-treMumbaiMaharashtraIndia Department of Critical Care Sir HN Reliance Foundation Hospital and Research CentreMumbaiMaharashtraIndia Department of Administration Sir HN Reliance Foundation Hospital and Research CentreMumbaiMaharashtraIndia

Background and Aims:The impact of coronavirus disease-2019(COVID-19)on liver function remains to be fully *** study was designed to investigate such and determine the clinical significance in determining mortality ***:A retrospective study was conducted in patients with COVID-19 from March 2020 to July *** details were retrieved from electronic medical records to obtain clinical characteristics,medical history,laboratory tests,therapeutic intervention,and outcome ***:A total of 184 patients with COVID-19 were included(median age:45.5 years),comprised of 62.5%*** total,22(12.0%)patients had severe infection and 162(88.0%)had mild to moderate ***,95(51.6%)showed abnormal liver function test(LFT)and 17(9.2%)showed normal LFT at *** median age,hospital stay,and LFT were significantly higher in severe ***-severe infection(p<0.001).Out of 12 deaths,the majority were due to severe infection(n=11).Deaths were also due to acute respiratory distress syndrome(n=5),cardiac reasons(n=3),and sepsis with multiorgan failure(n=3).The median age,hospital stay and number of intensive care unit admissions were higher in patients having abnormal LFT compared to normal *** of elevated aspartate aminotransferase(42.8%and 40.4%),alanine transaminase(43.7%and 41.6%),and hypoalbuminemia(71.4%and72.7%)at admission and discharge were more common in severe *** mean survival was significantly lower in severe infection compared to those with non-severe disease(17.2 vs.52.3 days;p<0.001).Conclusions:Incidence of abnormal liver function was higher in patients with severe COVID-19 and was associated with prolonged hospital stay;mortality was associated with severity of *** ruling out the risk of liver injury,it is crucial to vigilantly monitor the liver function parameters in patients with COVID-19 admitted to hospital.

关键词： ALT/AST Hospital stay Hypoalbuminemia Liver injury Severe disease

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Clinical profile of febrile encephalopathy patients at a tertiary care hospital in India:A retrospective study

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Journal of Acute Disease 2023年第4期12卷 145-150页

作者： Sanjeev Sengupta ashish Kumar shukla Kunal Kishore Jitesh Goel Amlan Ghosh Department of Cardiology Command HospitalEastern CommandKolkata-700064West BengalIndia Department of Medicine Command HospitalEastern CommandKolkata-700064West BengalIndia Department of Neurology Command HospitalEastern CommandKolkata-700064West BengalIndia

Objective:To investigate demography,etiology,and clinical profile and to analyze the outcomes of patients presenting with febrile encephalopathy at a tertiary care center in Eastern ***:This retrospective,observational study included a total of 50 patients(>18 years)who presented with fever and *** patients underwent blood analysis;culture test for blood,urine,sputum,cerebrospinal fluid,and other body fluids;chest and abdominal ultrasonography;neuroimaging;polymerase chain reaction test,and other relevant tests as and when ***:The mean age of all enrolled patients was(58.0±16.0)years with male to female ratio of 1.27꞉*** encephalitis was diagnosed in 16(32%)patients,sepsis-associated encephalitis in 14(28%),bacterial meningoencephalitis in 8(16%)and tuberculosis meningoencephalitis in 5(10%).The mean hospital stay was 10(4,17)*** 6-month follow-up,10(20%)patients died,10(20%)patients recovered with sequelae(cognitive impairment,critical care neuropathy,etc.),and 30(60%)patients recovered without sequelae.A statistically significant association was noted between Glasgow Coma Scale(<8)and mortality rate(P=0.02).Conclusions:Primary central nervous system infection is the most frequent etiology of febrile encephalopathy and viral encephalitis is the most common etiological ***,systematic,timely diagnosis and management are prime factors to reduce mortality and morbidity.

关键词： Encephalopathy Fever Acute syndrome Etiology Infection

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Recognition and quality mapping of traditional herbal drugs:way forward towards artificial intelligence

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Traditional Medicine Research 2025年第1期10卷 12-26页

作者： Sanyam Sharma Subh Naman ashish Baldi Faculty of Pharmacy Pacific Academy of Higher Education and Research UniversityUdaipur 313024India Pharma Innovation Lab Department of Pharmaceutical Sciences and TechnologyMaharaja Ranjit Singh Punjab Technical UniversityBathinda 151001India Faculty of Pharmaceutical Sciences The ICFAI UniversityBaddi 174103India.

The use of traditional herbal drugs derived from natural sources is on the rise due to their minimal side effects and numerous health ***,a major limitation is the lack of standardized knowledge for identifying and mapping the quality of these herbal *** article aims to provide practical insights into the application of artificial intelligence for quality-based commercialization of raw herbal *** focuses on feature extraction methods,image processing techniques,and the preparation of herbal images for compatibility with machine learning *** article discusses commonly used image processing tools such as normalization,slicing,cropping,and augmentation to prepare images for artificial intelligence-based *** also provides an overview of global herbal image databases and the models employed for herbal plant/drug *** will gain a comprehensive understanding of the potential application of various machine learning models,including artificial neural networks and convolutional neural *** article delves into suitable validation parameters like true positive rates,accuracy,precision,and more for the development of artificial intelligence-based identification and authentication techniques for herbal *** article offers valuable insights and a conclusive platform for the further exploration of artificial intelligence in the field of herbal drugs,paving the way for smarter identification and authentication methods.

关键词： artificial intelligence Ayurveda machine learning models herbal drugs image pre-processing medicinal plants

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Multifunctional hopeite nanocoating on Ti64 substrates by pulsed laser deposition and radio frequency magnetron sputtering for orthopedic implant applications:A comparative study

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Journal of Central South University 2020年第8期27卷 2198-2209页

作者： ashish DAS Mukul shukla Department of Mechanical Engineering Motilal Nehru National Institute of TechnologyAllahabad 211004India Department of Production and Industrial Engineering National Institute of TechnologyJamshedpur 831014India School of Mechanical and Aerospace Engineering Queen’s UniversityBelfast BT71NNUnited Kingdom Department of Mechanical Engineering Technology University of JohannesburgJohannesburg PO Box 524South Africa

Functionalized implants demonstrate an upgraded approach in orthopedic implants,aiming to achieve long term success through improved bio *** coatings with multifunctionality have arisen as an effective substitute for conventional coatings,owing to their combination of various properties that are essential for bio-implants,such as osteointegration and antibacterial *** the present study,thin hopeite coatings were produced by Pulsed laser deposition(PLD)and radio frequency magnetron sputtering(RFMS)on Ti64 *** obtained hopeite coatings were annealed at 500°C in ambient air and studied in terms of surface morphology,phase composition,surface roughness,adhesion strength,antibacterial efficacy,apatite forming ability,and surface wettability by scanning electron microscope(SEM),X-ray diffraction(XRD),atomic force microscope(AFM),tensometer,fluorescence-activated cell sorting(FACS),simulated body fluid(SBF)immersion test and contact angle goniometer,***,based on promising results obtained in the present work it can be summarized that the new generation multifunctional hopeite coating synthesized by two alternative new process routes of PLD and RFMS on Ti64 substrates,provides effective alternatives to conventional coatings,largely attributed to strong osteointegration and antibacterial character of deposited hopeite coating ensuring the overall stability of metallic orthopedic implants.

关键词： hopeite Ti64 alloy pulsed laser deposition magnetron sputtering coating implant

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MODELING THE ROLE OF DISSOLVED OXYGEN- DEPENDENT BACTERIA ON BIODEGRADATION OF ORGANIC POLLUTANTS

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International Journal of Biomathematics 2014年第1期7卷 145-160页

作者： J. B. shukla ashish GOYAL P. K. TIWARI A. K. MISRA BIT BIIFRED Bhabha Group of Institutions Kanpur (Rural) 209204 India The University of New South Wales Sydney NSW 2052 Australia Department of Mathematics BHU Varanasi India

In this paper, a nonlinear mathematical model is proposed and analyzed to study the role of dissolved oxygen （DO）-dependent bacteria on biodegradation of one or two organic pollutant（s） in a water body. In the case of two organic pollutant（s）, it is assumed that the one is fast degrading and the other is slow degrading and both are discharged into the water body from outside with constant rates. The density of bacteria is assumed to follow logistic model and its growth increases due to biodegradation of one or two organic pollutant（s） as well as with the increase in the concentration of DO. The model is analyzed using the stability theory of differential equations and by simulation. The model analysis shows that the concentration（s） of one or both organic pollutant（s） decrease（s） as the density of bacteria increases. It is noted that for very large density of bacteria, the organic pollutant（s） may be removed ahnost completely from the water body. It is found that simulation analysis confirms the analytical results. The results obtained in this paper are in line with the experimental observations published in literature.

关键词： Organic pollutants bacteria dissolved oxygen mathematical model.

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Polymer Nanocomposites in Sensor Applications: A Review on Present Trends and Future Scope

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Chinese Journal of Polymer Science 2021年第6期39卷 665-691,I0005页

作者： Prashant shukla Pooja Saxena Amity Institute for Advanced Research and Studies(Materials&Devices) Amity UniversitySector-125Noida 201303India G L Bajaj Institute of Technology and Management Greater Noida-201306Uttar PradeshIndia

Polymers are crucial constituents of modern electronic *** can be used in their pristine,composite or nanocomposite forms for several domestic and industrial applications with innumerable unique *** nanocomposites have gained wide theoretical interest and numerous practical applications in diverse fields of science and technology as they bestow the materials not only with virtuous processability but also with exceptional *** is evidenced that the electrical conductance of polymer nanocomposite is governed by the conductive filler networks within the polymer ***,insignificant variation in the conductive networks can result in noteworthy variations in the output electric signal of polymer *** this stimuli-responsive performance of conductive networks to the physical parameters,polymer nanocomposites can be harnessed to fabricate novel sensitive sensors to detect vital physical parameters ***/stress,pressure,temperature,solvent or *** and phenomenological studies on polymer nanocomposites are still *** explanations are being sought but the mechanisms governing the formation of several polymer nanocomposites are still topics of debate in the material science *** in-depth investigation requires copious scientific *** review analytically sketches the synthesis,microstructures,physiochemical properties and the underlying mechanisms for stimuli-responsiveness to the physical parameters of the polymer nanocomposites as well as their applications in various sensitive sensors and ***,it became evocative for this review to focus on their processing methodologies,physiochemical physiognomies,classification and probable potentials of polymer *** review primarily presents the current literature survey on polymer composites and the gap areas in the study encourages the objective of the present review ***,the status,perspec

关键词： Polymers Polymer nanocomposites Sensors CNT Graphene

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Tracking Control of Uncertain Nonlinear Systems With Unknown Constant Input Delay

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IEEE/CAA Journal of Automatica Sinica 2020年第2期7卷 420-425页

作者： ashish Kumar Jain Shubhendu Bhasin Department of Electrical Engineering Indian Institute of Technology DelhiNew Delhi-110016India

A robust delay compensator has been developed for a class of uncertain nonlinear systems with an unknown constant input *** control law consists of feedback terms based on the integral of past control values and a novel filtered tracking error,capable of compensating for input *** Lyapunov-Krasovskii functionals are used to prove global uniformly ultimately bounded(GUUB)tracking,provided certain sufficient gain conditions,dependent on the bound of the delay,are *** results illustrate the performance and robustness of the controller for different values of input delay.

关键词： Global uniformly ultimately bounded stability Lyapunov-Krasovskii functionals nonlinear systems tracking control unknown input delay

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A review on anode materials for lithium/sodium-ion batteries

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Journal of Energy Chemistry 2023年第8期83卷 509-540,I0013页

作者： Abhimanyu Kumar Prajapati ashish Bhatnagar Department of Physics and Materials Science and Engineering Jaypee Institute of Information TechnologyNoida 201309Indid

Since lithium-ion batteries(LIBs) have been substantially researched in recent years, they now possess exceptional energy and power densities, making them the most suited energy storage technology for use in developed and developing industries like stationary storage and electric cars, etc. Concerns about the cost and availability of lithium have prompted research into alternatives, such as sodium-ion batteries(SIBs), which use sodium instead of lithium as the charge carrier. This is especially relevant for stationary applications, where the size and weight of battery are less important. The working efficiency and capacity of these batteries are mainly dependent on the anode, cathode, and electrolyte. The anode,which is one of these components, is by far the most important part of the rechargeable *** of its characteristics and its structure, the anode has a tremendous impact on the overall performance of the battery as a whole. Keeping the above in view, in this review we critically reviewed the different types of anodes and their performances studied to date in LIBs and SIBs. The review article is divided into three main sections, namely:(i) intercalation reaction-based anode materials;(ii) alloying reaction-based anode materials;and(iii) conversion reaction-based anode materials, which are further classified into a number of subsections based on the type of material used. In each main section, we have discussed the merits and challenges faced by their particular system. Afterward, a brief summary of the review has been discussed. Finally, the road ahead for better application of Li/Na-ion batteries is discussed, which seems to mainly depend on exploring the innovative materials as anode and on the inoperando characterization of the existing materials for making them more capable in terms of application in rechargeable batteries.

关键词： Lithium/Sodium-ion batteries Anode materials Nanomaterials Metal-organic framework Conversion materials Intercalated materials Alloying materials

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Liposome based drug delivery as a potential treatment option for Alzheimer’s disease

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Neural Regeneration Research 2022年第6期17卷 1190-1198页

作者： Carely Hernandez Surabhi shukla Department of Pharmaceutical Sciences College of PharmacyLarkin UniversityMiamiFLUSA

Alzheimer’s disease is a neurodegenerative condition leading to atrophy of the brain and robbing nearly 5.8 million individuals in the United States age 65 and older of their cognitive ***’s disease is associated with dementia and a progressive decline in memory,thinking,and social skills,eventually leading to a point that the individual can no longer perform daily activities *** available drugs on the market temporarily alleviate the symptoms,however,they are not successful in slowing down the progression of Alzheimer’s *** and cures have been constricted due to the difficulty of drug delivery to the blood-brain *** studies have led to identification of vesicles to transport the necessary drugs through the blood-brain barrier that would typically not achieve the targeted area through systemic delivered ***,liposomes have emerged as a viable drug delivery agent to transport drugs that are not able to cross the blood-brain *** are being used as a component of nanoparticle drug delivery;due to their biocompatible nature;and possessing the capability to carry both lipophilic and hydrophilic therapeutic agents across the blood brain barrier into the brain *** indicate the importance of liposomal based drug delivery in treatment of neurodegenerative *** idea is to encapsulate the drugs inside the properly engineered liposome to generate a response of *** are engineered to target specific diseased moieties and also several surface modifications of liposomes are under research to create a clinical path to the management of Alzheimer’s *** review deals with Alzheimer’s disease and emphasize on challenges associated with drug delivery to the brain,and how liposomal drug delivery can play an important role as a drug delivery method for the treatment of Alzheimer’s *** review also sheds some light on variation of ***

关键词： Alzheimer’s disease beta-amyloid blood-brain barrier brain delivery drug delivery systems encapsulated drugs liposomes nanoparticles neurodegenerative diseases PEGylation targeted delivery tau

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Study of plasma parameters of coaxial plasma source using triple Langmuir probe and Faraday cup diagnostics

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Plasma Science and Technology 2024年第4期26卷 94-100页

作者： Sunil KANCHI Rohit shukla Archana SHARMA Pulsed Power and Electromagnetics Division Bhabha Atomic Research CentreVisakhapatnam 531011India Homi Bhabha National Institute Mumbai 400085India Beam Technology Development Group Bhabha Atomic Research CentreMumbai 400085India

Coaxial plasma guns are a type of plasma source that produces plasma which propagates radially and axially controlled by the shape of the ground electrode, which has attracted much interest in several applications. In this work, a 120° opening angle of CPG nozzle is used as a plasma gun configuration that operates at the energy of 150 J. The ionization of polyethylene insulator between the electrodes of the gun produces a cloud of hydrogen and carbon *** triple Langmuir probe and Faraday cup are used to measure plasma density and plasma temperature. These methods are used to measure the on-axis and off-axis plasma divergence of the coaxial plasma gun. The peak values of ion densities measured at a distance of 25 mm on-axis from the plasma gun are(1.6±0.5)×10^(19)m^(-3)and(2.8±0.6)×10^(19)m^(-3)for hydrogen and carbon plasma respectively and the peak temperature is 3.02±0.5 eV. The mean propagation velocity of plasma is calculated using the transit times of plasma at different distances from the plasma gun and is found to be 4.54±0.25 cm/μs and 1.81±0.18 cm/μs for hydrogen and carbon plasma respectively. The Debye radius is obtained from the measured experimental data that satisfies the thin sheath approximation. The shot-to-shot stability of plasma parameters facilitates the use of plasma guns in laboratory experiments. These types of plasma sources can be used in many applications like plasma opening switches, plasma devices, and as plasma sources.

关键词： coaxial plasma source triple Langmuir probe Faraday cup plasma density plasma temperature

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