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Effect of Lifestyle Modification and Oral Anti-Diabetic Drugs on Metabolic Parameters in Recently Diagnosed Patientswith Uncomplicated Type 2 Diabetes Mellitus in Eastern India

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Journal of Diabetes Mellitus 2018年第2期8卷 9-19页

作者： Nikhilesh Pradhan Sidhartha Das Anoj Kumar Baliarsinha ashirbad parhi Bijan Patnaik Pramod Kumar Rout Department of Medicine S.C.B Medical College Cuttack India Department of Endocrinology S.C.B Medical College Cuttack India

BACKGROUND: Oral anti-diabetic drugs (OADs) are often advised for initial treatment for patients with Type 2 Diabetes Mellitus (T2DM). Their effects on glycemic control, lipid profile, insulin resistance and beta cell function has not been systematically studied in India. The objective of this study was to evaluate the effect of lifestyle modification and OADs on metabolic parameters in recently diagnosed uncomplicated T2DM patients. MATERIAL METHODS: A total of consecutive sixty four (64) cases of recently diagnosed uncomplicated T2DM in the age group of 30 - 60 years were studied. They were evaluated for weight, body mass index (BMI), fasting plasma glucose (FPG), 2hr post glucose plasma glucose (2hrPGPG), HbA1c, lipid profile, serum fasting insulin, c-peptide, HOMA-IR and HOMA-β. They were divided into four groups according to increasing order of HbA1c values (6.5% - 6.9%, 7% - 7.5%, 7.6% - 8.5%, 8.6% - 8.9%). These four groups were subjected to lifestyle modification (LSM), monotherapy with metformin (1 g) and LSM, dual drug therapy i.e. metformin (1 g), glimepiride (1 mg) and LSM, triple drug therapy i.e. metformin (1 g), glimepiride 1 mg, sitagliptin 100 mg) and LSM respectively. These patients were followed up after three months of therapy. They were evaluated for the same metabolic parameters and compared with their baseline value. Fourteen (14) patients were lost to follow up. RESULTS: We found 91%, 92.8%, 53.3% and 60% of our patients from above four different groups achieved target glycemic control (HbA1c ≤ 6.5%). In all the four groups, significant improvement in glycemic status, lipid profile, HOMA-IR and HOMA-β were observed (p value CONCLUSION: In our study, early Initiation of LSM along with OADs either as monotherapy or in combination therapy according to HbA1c value showed significant improvement in glycemic control, insulin resistance and beta cell function.

关键词： Type 2 Diabetes Mellitus Metformin Glimepiride Sitagliptin HOMA-IR HOMA-β

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The Level and Role of Interleukin-17 in Patients of Type 2 Diabetes Mellitus with and without Complications

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Journal of Diabetes Mellitus 2019年第4期9卷 176-185页

作者： ashirbad parhi Sidhartha Das Srikrushna Mahapatra Nikhilesh Pradhan Manoranjan Behera Bijan Patnaik Roma Rattan Department of Cardiology SCBMCH Cuttack India Department of Medicine SCBMCH Cuttack India Department of Biochemistry SCBMCH Cuttack India

Background: Type 2 Diabetes Mellitus (T2DM) is the most prevalent metabolic disorder in the world. Recent evidence however suggests that T2DM is not only a disease of metabolism, but also an inflammatory disorder and that inflammation also plays an important role in the pathogenesis of Diabetic complications. Our aim was to study the level of interleukin-17 (IL 17) in Indian populations with T2DM as an inflammatory marker and analyze its role in different diabetic complications. Methods: A total of consecutive 67 patients of T2DM were evaluated for clinical parameters fasting blood glucose (FBG), 2hr-post-prandial blood glucose (PPBG), lipid profile, HbA1c and plasma IL 17. They were divided into three groups—Patients of T2DM without any complications (group A;n = 24), T2DM with acute complications (group B;n = 20), T2DM with chronic complications (group C;n = 23) and compared with 23 healthy controls (group D). Results: Diabetic patients had a higher level of IL 17 as compared to the healthy controls. The level of IL 17 in complicated diabetics was higher than the patients with T2DM without complications. Multiple logistic regression analysis showed positive correlation of IL 17 with Diabetic Retinopathy and Diabetic Neuropathy. IL 17 also showed a positive Pearsons correlation with systolic blood pressure (SBP), diastolic blood pressure (DBP), serum triglycerides (TG), serum total cholesterol (TC), very low density lipoproteins (VLDL), low density lipoproteins (LDL), HbA1c and a negative correlation with HDL. Conclusion: Indian subjects with T2DM with or without complications had higher values of IL 17 as compared to healthy controls. Also diabetic neuropathy and diabetic retinopathy were positively correlated to levels of IL 17. Further levels of IL 17 were positively correlated to hypertension and dyslipidemia indicating a prevalent inflammatory state in our population of T2DM with and without complications.

关键词： IL-17 Inflammation Interleukins

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Optimum path planning of mobile robot in unknown static and dynamic environments using Fuzzy-Wind Driven Optimization algorithm

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Defence Technology（防务技术） 2017年第1期13卷 47-58页

作者： Anish Pandey Dayal R.parhi Mechanical Engineering Department N.I.T.RourkelaOrissaIndia

This article introduces a singleton type-1 fuzzy logic system(T1-SFLS) controller and Fuzzy-WDO hybrid for the autonomous mobile robot navigation and collision avoidance in an unknown static and dynamic environment. The WDO(Wind Driven Optimization) algorithm is used to optimize and tune the input/output membership function parameters of the fuzzy controller. The WDO algorithm is working based on the atmospheric motion of infinitesimal small air parcels navigates over an N-dimensional search domain. The performance of this proposed technique has compared through many computer simulations and real-time experiments by using Khepera-Ⅲ mobile robot. As compared to the T1-SFLS controller the Fuzzy-WDO algorithm is found good agreement for mobile robot navigation.

关键词： Singleton type-1 fuzzy Navigation Wind driven optimization Membership function Atmospheric motion

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Reactive Navigation of Underwater Mobile Robot Using ANFIS Approach in a Manifold Manner

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International Journal of Automation and computing 2017年第3期14卷 307-320页

作者： Shubhasri Kundu Dayal R. parhi Robotics Lab Department of Mechanical Engineering Rourkela National Institute of Technology Rourkela 769008 India

Learning and self-adaptation ability is highly required to be integrated in path planning algorithm for underwater robot during navigation through an unspecified underwater environment. High frequency oscillations during underwater motion are responsible for nonlinearities in dynamic behavior of underwater robot as well as uncertainties in hydrodynamic coefficients. Reactive behaviors of underwater robot are designed considering the position and orientation of both target and nearest obstacle from robot s current position. Human like reasoning power and approximation based learning skill of neural based adaptive fuzzy inference system（ANFIS）has been found to be effective for underwater multivariable motion control. More than one ANFIS models are used here for achieving goal and obstacle avoidance while avoiding local minima situation in both horizontal and vertical plane of three dimensional *** error gradient approach based on input-output training patterns for learning purpose has been promoted to spawn trajectory of underwater robot optimizing path length as well as time taken. The simulation and experimental results endorse sturdiness and viability of the proposed method in comparison with other navigational methodologies to negotiate with hectic conditions during motion of underwater mobile robot.

关键词： Adaptive fuzzy inference system(ANFIS) error gradient optimal path obstacle avoidance behavior steering angle target seeking behavior

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An Approach to Optimize the Path of Humanoids using Adaptive Ant Colony Optimization

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Journal of Bionic Engineering 2018年第4期15卷 623-635页

作者： Chinmaya Sahu Dayal R. parhi Priyadarshi Biplab Kumar Robotics Laboratory Mechanical Engineering Department National Institute of Technology Rourkela-769008 Odisha India

In the emerging area of humanoid robotics, path planning and autonomous navigation have evolved as one of the most promising area of research. This paper deals with the design and development of a novel navigational controller to guide humanoids in cluttered envi- ronments. The basic parameters of the ant colony optimization technique have been modified to have enhanced control as Adaptive Ant Colony Optimization （AACO）. The controller that has been implemented in the humanoids receives sensory information about obstacle distances as inputs and provides required turning angle as output to reach the specified target position. The proposed controller has been tested in both simulated and experimental environments created trader laboratory conditions, and a good agreement has been observed between the simulation and experiment results. Here, both static and dynamic path planning have been attempted. Finally, the proposed controller has also been tested against other existing techniques to validate the efficiency of the AACO in path planning problems.

关键词： navigation path planning humanoid robot AACO Petri-net bionics

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A new efficient optimal path planner for mobile robot based on Invasive Weed Optimization algorithm

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Frontiers of Mechanical Engineering 2014年第4期9卷 317-330页

作者： Prases K. MOHANTY Dayal R. parhi Robotics Laboratory National Institute of Technology Rourkela769008 India

Planning of the shortest/optimal route is essential for efficient operation of autonomous mobile robot or vehicle. In this paper Invasive Weed Optimization （IWO）, a new meta-heuristic algorithm, has been imple- mented for solving the path planning problem of mobile robot in partially or totally unknown environments. This meta-heuristic optimization is based on the colonizing property of weeds. First we have framed an objective function that satisfied the conditions of obstacle avoidance and target seeking behavior of robot in partially or completely unknown environments. Depending upon the value of objective function of each weed in colony, the robot avoids obstacles and proceeds towards destination. The optimal trajectory is generated with this navigational algorithm when robot reaches its destination. The effec- tiveness, feasibility, and robustness of the proposed algorithm has been demonstrated through series of simulation and experimental results. Finally, it has been found that the developed path planning algorithm can be effectively applied to any kind of complex situation.

关键词： mobile robot obstacle avoidance InvasiveWeed Optimization navigation

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A review:On path planning strategies for navigation of mobile robot

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Defence Technology（防务技术） 2019年第4期15卷 582-606页

作者： B.K. Patle Ganesh Babu L Anish Pandey D.R.K. parhi A. Jagadeesh Department of Mechanical Engineering CVR College of Engineering Hyderabad India Department of Mechatronics Engineering Tishik International University Erbil Iraq Department of Mechanical Engineering KITS University Bhubaneshwar India Department of Mechanical Engineering NIT Rourkela India Department of Mechanical Engineering KL University Guntur India

This paper presents the rigorous study of mobile robot navigation techniques used so *** step by step investigations of classical and reactive approaches are made here to understand the development of path planning strategies in various environmental conditions and to identify research *** classical approaches such as cell decomposition(CD),roadmap approach(RA),artificial potential field(APF);reactive approaches such as genetic algorithm(GA),fuzzy logic(FL),neural network(NN),firefly algorithm(FA),particle swarm optimization(PSO),ant colony optimization(ACO),bacterial foraging optimization(BFO),artificial bee colony(ABC),cuckoo search(CS),shuffled frog leaping algorithm(SFLA)and other miscellaneous algorithms(OMA)are considered for *** navigation over static and dynamic condition is analyzed(for single and multiple robot systems)and it has been observed that the reactive approaches are more robust and perform well in all terrain when compared to classical *** is also observed that the reactive approaches are used to improve the performance of the classical approaches as a hybrid ***,reactive approaches are more popular and widely used for path planning of mobile *** paper concludes with tabular data and charts comparing the frequency of individual navigational strategies which can be used for specific application in robotics.

关键词： Mobile robot navigation Path planning Classical approaches Reactive approaches Artificial intelligence

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Path planning in uncertain environment by using firefly algorithm

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Defence Technology（防务技术） 2018年第6期14卷 691-701页

作者： B.K.Patle Anish Pandey A.Jagadeesh D.R.parhi Department of Mechanical Engineering CVR College of Engineering School of Mechanical Engineering KIIT University Department of Mechanical Engineering Audisankara Group of Institutions Department of Mechanical Engineering NIT Rourkela

Autonomous mobile robot navigation is one of the most emerging areas of research by using swarm intelligence. Path planning and obstacle avoidance are most researched current topics like navigational challenges for mobile robot. The paper presents application and implementation of Firefly Algorithm(FA)for Mobile Robot Navigation(MRN) in uncertain environment. The uncertainty is defined over the changing environmental condition from static to dynamic. The attraction of one firefly towards the other firefly due to variation of their brightness is the key concept of the proposed study. The proposed controller efficiently explores the environment and improves the global search in less number of iterations and hence it can be easily implemented for real time obstacle avoidance especially for dynamic environment. It solves the challenges of navigation, minimizes the computational calculations, and avoids random moving of fireflies. The performance of proposed controller is better in terms of path optimality when compared to other intelligent navigational approaches.

关键词： Mobile robot navigation Firefly algorithm Path planning Obstacle avoidance

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REMnO_(3)(RE=Pr,Nd,Sm,Eu,Gd) perovskite as efficient catalysts for oxygen reduction reaction

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Journal of Rare Earths 2024年第11期42卷 2078-2087,I0003页

作者： Rakesh Ranjan Mahalik Siba Soren Ipsha Hota A.K.Debnath K.P.Muthe Purnendu parhi Department of Chemistry Ravenshaw UniversityCuttackOdisha753003India Technical Physics Division Bhabha Atomic Research CentreMumbai400085India

Rare earth metal based perovskite emerges as important catalytic material for energy production and *** ABO_(3) type materials are now the focus of research in the field of oxygen reduction and evolution ***,in this work we evaluated the oxygen reduction properties of the synthesized one-dimensional REMnO_(3)(RE=Pr,Nd,Sm,Eu and Gd).The one-dimensional REMnO_(3) prepared by the hydrothermal synthesis route results in pure phase perovskite on *** perovskite was characte rized with X-ray diffraction,Fourier transform-infrared(FT-IR),field emission-scanning electron microscopy(FE-SEM),transmission electron microscopy(TEM) and X-ray photoelectron spectroscopy(XPS).The oxygen reduction reaction activities were investigated with the help of electrochemical workstation that consists of three-electrode system immersed in 0.1 mol/L KOH electrolyte solution saturated with *** Koutechy-Levich plot obtained from rotating ring disk electrode shows all the prepared catalysts follow 4e^(-)processes during oxygen *** effect of "A" site cation variation in REMnO3 on oxygen reduction reaction is ***_(3) showed better onset potential for oxygen reduction reaction among the prepared rare earth ***_(3) having high RE:Mn ratio(A-site rich co mpositions) promotes oxygen reduction reaction(ORR) *** the perovs kites showed good oxygen reduction property with high stability and methanol tolerance.

关键词： REMnO_(3) Perovskite Oxygen reduction reaction(ORR) Electrocatalytic activity SmMnO_(3) Rare earths

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Liquid-liquid extraction and separation of total rare earth(RE) metals from polymetallic manganese nodule leaching solution

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Journal of Rare Earths 2015年第2期33卷 207-213页

作者： P.K.parhi K.H.Park C.W.Nam J.T.Park Mineral Resources Research Division Korea Institute of Geoscience & Mineral Resources (KIGAM)Daejeon 305-350 Republic of Korea School of Applied Science and Center of Industrial Technology KIIT UniversityBhubaneswar 751024 Odisha India

The study on the solvent extraction for quantitative and selective separation of total rare earth metals from the polymetallic nodule leach liquor was investigated. The typical leach liquor bearing 0. 094 g/L total rare earth, 0. 23 g/L Mn, 0.697 g/L Cu, 0.2 g/L Fe, 0.01 g/L Co and 0.735 g/L Ni was subjected to the removal iron content by precipitation method using Ca（OH）2 at pH 3.95, prior to solvent extraction of rare earth metals. Three different organo-phosphoric acid reagents（D2EHPA, PC88 A, Cyanex 272） were used to ascertain their performances and selectivity towards the loading of rare earth metals in presence of other base metals. Based on the results of eq. pH effect, the performances of above three extractants followed the order as： D2EHPA〉PC88A〉Cyanex 272. To ensure the absence of extraction of base metals（Cu, Co, Ni）, the eq. pH of the solution was optimized at the level of 2.21, though higher rare earth metal extraction efficiency was observed at higher eq. pH with either of the extractants. The complete process flow diagram for substantial recovery of total rare earth was developed using D2 EHPA. Extraction isotherm plot was constructed at A：O=12：1, 3-stages and pHe=2.21, using 0.8 mol/L D2 EHPA and the predicted condition of this study was further confirmed by 6-Cycles Counter Current Simulation（CCS） study. The stripping of total rare earth from loaded organic phase（LO） was conducted using HCl solution. Mc-Cabe Thiele diagram study carried out at A：O=1：5 using 4 mol/L HCl showed that three theoretical stages were needed for quantitative stripping of total rare earth. The subsequent stripped solution resulted thus led to contain total rare earth of 5.6 g/L indicating a very high enrichment of total metals by solvent extraction（SX） process.

关键词： total rare earth (RE) metals SX D2EHPA HCl deep sea nodule

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