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中国生物工程学会第六次全国会员代表大会暨第九届学术年会

作者： Tanguy Y.Seiwert Zhixiang Zuo Michaela K.Keck Arun Khattri chandra S.Pedamallu Thomas Stricker Christopher Brown Trevor J.Pugh Petar Stojanov Juok Cho Michael S.Lawrence Gad Getz Johannes Br?gelmann Rebecca DeBoer Ralph R.Weichselbaum Alexander Langerman Louis Portugal Elizabeth Blair Kerstin Stenson Mark W.Lingen Ezra E.W.Cohen Everett E.Vokes Kevin P.White Peter S.Hammerman Section of Hematology/Oncology Department of MedicineThe University of Chicago The University of Chicago Comprehensive Cancer Center Institute for Genomics and Systems Biology University of Chicago Broad Institute of Harvard and MIT Department of Medical Oncology Dana Farber Cancer Institute Department of Pathology Microbiologyand ImmunologyVanderbilt University Department of Genetics University of Pennsylvania Department of Radiation Oncology The University of Chicago Department of Otolaryngology/Head and Neck Surgery The University of Chicago Department of Pathology University of Chicago

Purpose:The genetic differences between human papilloma virus(HPV)–positive and –negative head and neck squamous cell carcinomas(HNSCC) remain largely *** identify differential biology and novel therapeutic targets for both entities,we determined mutations and copy-number aberrations in a large cohort of locoregionally advanced *** Design:We performed massively parallel sequencing of 617 cancer-associated genes in 120 matched tumor/normal samples(42.5% HPV-positive).Mutations and copy-number aberrations were determined and results validated with a secondary ***:The overall mutational burden in HPV-negative and HPV-positive HNSCC was similar with an average of 15.2 versus14.4 somatic exonic mutations in the targeted cancer-associated ***-negative tumors showed a mutational spectrum concordant with published lung squamous cell carcinoma analyses with enrichment for mutations in TP53,CDKN2 A,MLL2,CUL3,NSD1,PIK3 CA,and NOTCH ***-positive tumors showed unique mutations in DDX3 X,FGFR2/3 and aberrations in PIK3 CA,KRAS,MLL2/3,and NOTCH1 were enriched in HPVpositive *** targetable genomic alterations were identified in FGFR1,DDR2,EGFR,FGFR2/3,EPHA2,and PIK3 ***,CCND1,and FGFR1 amplifications occurred in HPV-negative tumors,whereas 17.6% of HPV-positive tumors harbored mutations in fibroblast growth factor receptor genes(FGFR2/3),including six recurrent FGFR3 S249 C ***-positive tumors showed a 5.8% incidence of KRAS mutations,and DNArepair gene aberrations,including 7.8% BRCA1/2 mutations,were ***:The mutational makeup of HPV-positive and HPV-negative HNSCC differs significantly,including targetable *** harbors multiple therapeutically important genetic aberrations,including frequent aberrations in the FGFR and PI3K pathway genes.

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CT结肠成像:计算机辅助检测作为第二与同步阅片者对具有一定CT结肠成像经验的普通放射科医生诊断结肠息肉的影响

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国际医学放射学杂志 2014年第5期 491-491页

作者： T.Mang L.Bogoni V.X.Anand D.chandra A.J.Curtin A.S.Lev-Toaff 孔祥 Department of Biomedical Imaging and Image-guided Therapy Medical University of ViennaWaehringer Guertel 18-201090ViennaAustria

摘要目的评估运用计算机辅助检测(CAD)作为第二和同步阅片者来帮助具一定的CT结肠成像(CTC)经验的放射科医生诊断结肠息肉的有效性。方法 7名具有一定CTC

关键词：结肠成像 CTC 放射科结肠息肉辅助检测 CT 计算机

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全球重要经济害虫橘小实蝇的种群结构和入侵路径

全球重要经济害虫橘小实蝇的种群结构和入侵路径

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第五届全国入侵生物学大会——入侵生物与生态安全

作者：秦誉嘉 Matthew N.Krosch Mark K.Schutze 张岳王小雪 chandra Shekhar Prabhakar Agus Susanto Alvin K.W.Hee Sunday Ekesi Kemo BADJI Mahfuza Khan 黄毓斌吴佳教王巧铃严格朱立桓赵紫华柳丽君 Anthony R.Clarke 李志红中国农业大学植物保护学院 School of Earth Environmental and Biological SciencesQueensland University of Technology(QUT) Department of Entomology Bihar Agricultural University Faculty of Agriculture Padjadjaran University Department of Biology Faculty of Science Universiti Putra Malaysia International Centre of Insect Physiology and Ecology Fruit Fly Control Project-ECOWAS Responsable Composante Surveillance.Projet Lutte contre les Mouches des Fruits-CEDEAO CRSA Insect Biotechnology Division Institute of Food and Radiation BiologyAtomic Energy Research Establishment 台湾农业研究所广东检验检疫中心

橘小实蝇Bactrocera dorsalis,又名东方果实蝇,是全球重要农业入侵性害虫并严重阻碍果蔬产品国际贸易。近年来的相关报道显示,木瓜实蝇***、菲律宾实蝇***、入侵实蝇***是橘小实蝇的同物异名,该虫分布范围从亚太地区扩展到了非洲大多数... 详细信息

橘小实蝇Bactrocera dorsalis,又名东方果实蝇,是全球重要农业入侵性害虫并严重阻碍果蔬产品国际贸易。近年来的相关报道显示,木瓜实蝇***、菲律宾实蝇***、入侵实蝇***是橘小实蝇的同物异名,该虫分布范围从亚太地区扩展到了非洲大多数国家,其全球种群结构和入侵路径亟待研究。本研究在收集橘小实蝇全球63个种群样品的基础上,利用微卫星、线粒体基因cox1、nad6两种分子标记和翅形态测量学数据,探究橘小实蝇的宏观地理种群结构和入侵路径。结果表明,橘小实蝇亚洲种群表现出较高的遗传多样性且遗传结构不明显,南亚可能是其他亚洲种群的来源地,非洲和夏威夷的种群推断为南亚起源的单一入侵种群,我国中部地区的橘小实蝇为多次重复入侵的结果,很可能与果蔬贸易有关。因此,应大力加强针对橘小实蝇的全球入侵防控工作,特别是严防该虫通过果蔬贸易和人员往来传入亚洲中北部地区、欧洲、大洋洲及美洲大部分国家和地区。

关键词： Bactrocera dorsalis 形态测量学微卫星线粒体基因种群结构入侵路径

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Systematic and other reviews: Criteria and complexities

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第3期7卷 236-239页

作者： Robert T.Sataloff Matthew L.Bush Rakesh chandra Douglas Chepeha Brian Rotenberg Edward W.Fisher David Goldenberg Ehab Y.Hanna Joseph E.Kerschner Dennis H.Kraus John H.Krouse Daqing Li Michael Link Lawrence R.Lustig Samuel H.Selesnick Raj Sindwani Richard J.Smith James R.Tysome Peter C.Weber D.Bradley Welling Department of Otolaryngology-Head and Neck Surgery Drexel University College of MedicinePhiladelphiaPennsylvaniaUSA Department of Otolaryngology University of KentuckyLexingtonKentuckyUSA Department of Otolaryngolosy Vanderbilt University Medical CenterNashvilleTennesseeUSA Faculty of Medicine Deportment of Otolaryngology-Head and Neck SurseryUniversity of TorontoTorontoOntarioCanada Department of Otolaryngology·Head and Neck Surgery Western UniversityTorontoOntarioCanada Department of Otolaryngology Cambridge University PressCambridgeUK Department of Otolaryngology-Head and Neck Surgery Pennsylvania State University College of MedicineHersheyPennsylvaniaUSA Department of Head and Neck Surgery The University of Texas M.D.Anderson Cancer CenterHoustonTexasUSA Department of Otolaryngology Medical College of WisconsinMilwaukeeWisconsinUSA Department of Otolaryngology-Head and Neck Surgery Northwell HealthNew YorkNew YorkUSA Department of Otolaryngology University of Texas Rio Grande Valley School of MedicineBrownsvilleTexasUSA Department of Otorhinolaryngology·Head and Neck Surgery Hospital of the University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Radiation Oncology Mayo ClinicRochesterMinnesotaUSA Department of Otolaryngology Columbia University Medical CenterNew YorkNew YorkUSA Department of Otolarynsology Weill Cornell Medical College of Cornell UniversityNew YorkNew YorkUSA Cleveland Clinic Head and Neck InstituteClevelandOhioUSA Department of Otolaryngology·Head and Neck Surgery The University of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Otolarynsolosy Cambridge University Hospitals NHS Foundation TrustCambridgeUK Mount Sinai Health System New YorkNew YorkUSA Department of Otolaryngology·Head and Neck Surgery Harvard UniversityCambridgeMassachusettsUSA

Review articles can be extremely *** synthesize information for readers,often provide clarity and valuable insights into a topic;and good review articles tend to be cited *** articles do not require Institutional Review Board(IRB)approval if the data reviewed are public(including private and government databases)and if the articles reviewed have received IRB approval previously.

关键词： approval insight valuable

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与影像相关的眼球运动神经控制

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国际医学放射学杂志 2016年第5期 585-585页

作者： M.Agarwal J.L.Ulmer T.chandra A.P.Klein L.P.Mark S.Mohan 周艳玲 Department of Radiology Medical College of Wsconsin

摘要眼球运动的目的是使视网膜上呈现清晰的图像,简而言之,需要几种不同的眼部运动及反射使感兴趣物影聚焦于视网膜中央凹上,只有该处可产生清晰锐利的视觉。完成此任务的运动及反射包括扫视、平稳追踪、凝视、调节、视动及前庭-眼反射... 详细信息

摘要眼球运动的目的是使视网膜上呈现清晰的图像,简而言之,需要几种不同的眼部运动及反射使感兴趣物影聚焦于视网膜中央凹上,只有该处可产生清晰锐利的视觉。完成此任务的运动及反射包括扫视、平稳追踪、凝视、调节、视动及前庭-眼反射。大脑、小脑、脑干、丘脑诸多不同中枢通过不同途径控制这些运动。这些机制对于放射科医生也许极为

关键词：眼球运动神经控制放射科

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经皮冠状动脉介入后阻塞性睡眠呼吸暂停与心血管事件的关系

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中华高血压杂志 2016年第5期24卷 499-499页

作者： Lee CH Sethi R Li R Ho HH Hein T Jim MH Loo G Koo CY Gao XF chandra S Yang XX Furlan SF Ge Z Mundhekar A Zhang WW Ucha CH Kharwar RB Chan PF Chen SL Chan MY Richards A Tan HC Ong TH Roldan G Tai BC Drager LF Zhang JJ 刘莉叶鹏

目前关于阻塞性睡眠呼吸暂停（obstructive sleepapnea，OSA）对冠状动脉疾病患者的预后意义的大型队列研究数据匮乏。该研究假设OSA可预测行经皮冠状动脉介入治疗（percutaneous coronary ***）患者未来主要不良心脏和脑血管事件（majo... 详细信息

目前关于阻塞性睡眠呼吸暂停（obstructive sleepapnea，OSA）对冠状动脉疾病患者的预后意义的大型队列研究数据匮乏。该研究假设OSA可预测行经皮冠状动脉介入治疗（percutaneous coronary ***）患者未来主要不良心脏和脑血管事件（major adverse cardiac and cerebrovascularevents，MACCE）。方法：睡眠及支架研究是一项前瞻性、多中心注册研究，纳入2011年12月和2014年4月来自5个国家经PCI治疗成功的患者1748例。

关键词：经皮冠状动脉介入治疗阻塞性睡眠呼吸暂停心血管事件冠状动脉疾病脑血管事件队列研究患者 OSA

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SONIC-新一代快恢复二极管

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电气技术 2006年第7期7卷 87-90,81页

作者： S.博斯 L.伊姆列 H.欧斯特曼 P.英格拉姆王培清 IXYS半导体公司拉姆帕泽德国d68623 清华大学电力电子厂

在这篇文章中,介绍了平面型SONIC软恢复二极管的新系列,电压范围从600V到1800V,并有不同的额定电流。采用从硅片背面进行深的磷扩散和控制轴向寿命抑制剂的办法开发出了带有拖尾电流的快恢复及软恢复二极管。被提及的二极管在整个工作... 详细信息

在这篇文章中,介绍了平面型SONIC软恢复二极管的新系列,电压范围从600V到1800V,并有不同的额定电流。采用从硅片背面进行深的磷扩散和控制轴向寿命抑制剂的办法开发出了带有拖尾电流的快恢复及软恢复二极管。被提及的二极管在整个工作温度范围内性能稳定,并且对于温度的变化正向电压降的变化可以忽略不计。SONIC二极管是为高频应用而设计的,在高频应用方面需要稳定的开关特性。文章还比较了SONIC二极管和用铂或金作为寿命抑制剂的标准快恢复外延二极管(FRED)在25℃到125℃下的开关损耗。

关键词： SONIC二极管快恢复二极管软恢复开关损耗

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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