检索结果-南通市图书馆

Food Bioscience 2022年第3期47卷 881-888页

作者： Borkwei Ed Nignpense sajid Latif Nidhish Francis Christopher Blanchard Abishek Bommannan Santhakumar School of Dentistry and Medical Sciences Charles Sturt UniversityLocked Bag 588Wagga WaggaNSW 2678Australia National Life Sciences Research Hub Charles Sturt UniversityWagga WaggaNSW 2795Australia School of Agricultural Environment and Veterinary SciencesCharles Sturt UniversityWagga WaggaNSW 2650Australia Gulbali Institute Charles Sturt UniversityWagga WaggaNSW 2650Australia Australian Research Council (ARC) Industrial Transformation Training Centre (ITTC) for Functional GrainsGraham Centre for Agricultural InnovationCharles Sturt UniversityWagga WaggaNSW 2650Australia

Polyphenol-rich purple rice has been shown to exhibit a wide range of health properties including antioxidant *** study aimed to determine the impact that gastrointestinal digestion of purple rice had on its phenolic bioaccessibility and antioxidant *** results demonstrated a significant difference(p<0.01)in bioaccessible phenolic content level and antioxidant activity between simulated gastric and intestinal ***,mass spectrometry and ultra-high-performance liquid chromatography(UHPLC)coupled with online ABTS•+scavenging activity demonstrated a significant loss in the number of polyphenols that were bioaccessible after ***,substantial free radical scavenging activity was retained after digestion due to the bioaccessibility of bioactive compounds such as tryptophan and protocatechuic ***,purple rice may be considered as a source of bioaccessible phenolic and antioxidant compounds.

关键词： Antioxidant Bioaccessibility Gastrointestinal digestion Polyphenols Purple rice

Recent advances in diverse nanosystems for nitric oxide delivery in cancer therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第4期13卷 1498-1521页

作者： Dan Gao sajid Asghar Rongfeng Hu Su Chen Ruixin Niu Jia Liu Zhipeng Chen Yanyu Xiao State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Faculty of Pharmaceutical Sciences Government College University FaisalabadFaisalabad 38000Pakistan Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application Hefei 230012China Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine Jiangyin 214499China Department of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China

Gas therapy has been proven to be a promising and advantageous treatment option for *** have shown that nitric oxide(NO)is one of the smallest structurally significant gas molecules with great potential to suppress ***,there is controversy and concern about its use as it exhibits the opposite physiological effects based on its levels in the ***,the anti-cancer mechanism of NO is the key to cancer treatment,and rationally designed NO delivery systems are crucial to the success of NO biomedical *** review summarizes the endogenous production of NO,its physiological mechanisms of action,the application of NO in cancer treatment,and nano-delivery systems for delivering NO ***,it briefly reviews challenges in delivering NO from different nanoparticles and the issues associated with its combination treatment *** advantages and challenges of various NO delivery platforms are recapitulated for possible transformation into clinical applications.

关键词： Nitric oxide Nitric oxide donor Nitric oxide-based delivery system Anti-cancer Binding mechanisms Synergistic treatment strategy Inorganic platforms Organic platforms

Interleukin-1 receptor antagonist:From synthesis to therapeutic applications

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2023年第4期47卷 809-823页

作者： KANWAL REHMAN AMMARA AFZAAL MUHAMMAD sajid HAMID AKASH MUHAMMAD IMRAN MOHAMMED A.ASSIRI Department of Pharmacy The Women UniversityMultan60000Pakistan Department of Pharmaceutical Chemistry Government College UniversityFaisalabad38000Pakistan Research Center for Advanced Materials Science(RCAMS) King Khalid UniversityAbha62413Saudi Arabia Department of Chemistry Faculty of ScienceKing Khalid UniversityAbha62413Saudi Arabia

The cytokine channel’s mechanism for self-regulation involves the application of antagonistic cytokines that are synthesized to connect to the receptors and release soluble cytokine *** very first receptor antagonist of cytokine that was naturally present was interleukin-1 receptor antagonist(IL-1Ra).The IL-1Ra protein forms are disinfected from supernatants of cultured monocytes on stacked *** family of IL-1 consists of IL-1α,IL-1βand *** monocytes regulate the production of ***-Ra takes part in normal physiological functions by using specific antibodies,and acts as an anti-inflammatory ***-Ra is synthesized in the tissues during the period of active disease and can be systematically measured and/or *** of the levels of IL-Ra and IL-1 is the main factor for host resistance in patients during diseased conditions,as IL-Ra acts as an inherent regulator of various inflammatory *** this article,we focuse on how IL-Ra is synthesized and performs its functions once the inflammatory responses are activated.

关键词： IL-Ra Synthesis Therapeutic applications Functions of IL-1Ra

Deep Learning with a Novel Concoction Loss Function for Identification of Ophthalmic Disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2023年第9期76卷 3763-3781页

作者： Sayyid Kamran Hussain Ali Haider Khan Malek Alrashidi sajid Iqbal Qazi Mudassar Ilyas Kamran Shah Department of Computer Science TIMES InstituteMultan60000Pakistan Department of Software Engineering Faculty of Computer ScienceLahore Garrison UniversityLahore54000Pakistan Department of Computer Science Applied CollegeUniversity of TabukTabukSaudi Arabia Department of Information Systems College of Computer Sciences and Information TechnologyKing Faisal UniversityAl Hofuf31982Saudi Arabia Department of Mechanical Engineering College of EngineeringKing Faisal UniversityAl HofufSaudi Arabia

As ocular computer-aided diagnostic(CAD)tools become more widely accessible,many researchers are developing deep learning(DL)methods to aid in ocular disease(OHD)*** eye diseases like cataracts(CATR),glaucoma(GLU),and age-related macular degeneration(AMD)are the focus of this study,which uses DL to examine their *** imbalance and outliers are widespread in fundus images,which can make it difficult to apply manyDL algorithms to accomplish this analytical *** creation of efficient and reliable DL algorithms is seen to be the key to further enhancing detection *** the analysis of images of the color of the retinal fundus,this study offers a DL model that is combined with a one-of-a-kind concoction loss function(CLF)for the automated identification of *** study presents a combination of focal loss(FL)and correntropy-induced loss functions(CILF)in the proposed DL model to improve the recognition performance of classifiers for biomedical *** is done because of the good generalization and robustness of these two types of losses in addressing complex datasets with class imbalance and *** classification performance of the DL model with our proposed loss function is compared to that of the baseline models using accuracy(ACU),recall(REC),specificity(SPF),Kappa,and area under the receiver operating characteristic curve(AUC)as the evaluation *** testing shows that the method is reliable and efficient.

关键词： Deep learning multi-classification focal loss CNN eye disease

A Fused Machine Learning Approach for Intrusion Detection System

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2023年第2期74卷 2607-2623页

作者： Muhammad sajid Farooq Sagheer Abbas Atta-ur-Rahman Kiran Sultan Muhammad Adnan Khan Amir Mosavi School of Computer Science National College of Business Administration and EconomicsLahore54000Pakistan Department of Computer Science College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam 31441Saudi Arabia Department of CIT The Applied CollegeKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Software Gachon UniversitySeongnam13120Korea John von Neumann Faculty of Informatics Obuda UniversityBudapest1034Hungary Institute of Information Engineering Automation and MathematicsSlovak University of Technology in BratislavaBratislava81107Slovakia Faculty of Civil Engineering TU-DresdenDresden01062Germany

The rapid growth in data generation and increased use of computer network devices has amplified the infrastructures of *** interconnectivity of networks has brought various complexities in maintaining network availability,consistency,and *** learning based intrusion detection systems have become essential to monitor network traffic for malicious and illicit *** intrusion detection system controls the flow of network traffic with the help of computer *** deep learning algorithms in intrusion detection systems have played a prominent role in identifying and analyzing intrusions in network *** this purpose,when the network traffic encounters known or unknown intrusions in the network,a machine-learning framework is needed to identify and/or verify network *** Intrusion detection scheme empowered with a fused machine learning technique(IDS-FMLT)is proposed to detect intrusion in a heterogeneous network that consists of different source networks and to protect the network from malicious *** proposed IDS-FMLT system model obtained 95.18%validation accuracy and a 4.82%miss rate in intrusion detection.

关键词： Fused machine learning heterogeneous network intrusion detection

A Cost-Effective Approach for NDN-Based Internet of Medical Things Deployment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2022年第1期70卷 233-249页

作者： Syed sajid Ullah Saddam Hussain Abdu Gumaei Mohsin SAlhilal Bader Fahad Alkhamees Mueen Uddin Mabrook Al-Rakhami Department of Information Technology Hazara University MansehraKPK21120Pakistan Research Chair of Pervasive and Mobile Computing Department of Information SystemsKing Saud UniversityRiyadh11543Saudi Arabia Department of Computer Science Faculty of Applied SciencesTaiz UniversityTaiz6803Yemen Department of Information Systems College of Computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia Digital Science Faculty of ScienceUniversiti Brunei DarussalamJln Tungku linkGadongBruneiBE1410Darussalam

Nowadays,healthcare has become an important area for the Internet of Things(IoT)to automate healthcare facilities to share and use patient data anytime and anywhere with Internet *** present,the host-based Internet paradigm is used for sharing and accessing healthcare-related ***,due to the location-dependent nature,it suffers from latency,mobility,and *** this purpose,Named Data Networking(NDN)has been recommended as the future Internet paradigm to cover the shortcomings of the traditional host-based Internet ***,the novel breed lacks a secure framework for *** article constructs an NDN-Based Internet of Medical Things(NDN-IoMT)framework using a lightweight certificateless(CLC)*** adopt the Hyperelliptic Curve Cryptosystem(HCC)to reduce cost,which provides strong security using a smaller key size compared to Elliptic Curve Cryptosystem(ECC).Furthermore,we validate the safety of the proposed scheme through *** cost-efficiency,we compare the designed scheme with relevant certificateless signature *** final result shows that our proposed scheme uses minimal network ***,we deploy the given framework on NDN-IoMT.

关键词： Internet of Medical Things healthcare Named Data Networking

Hemodynamic Response Detection Using Integrated EEG-fNIRS-VPA for BCI

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2022年第1期70卷 535-555页

作者： Arshia Arif M.Jawad Khan Kashif Javed Hasan sajid Saddaf Rubab Noman Naseer Talha Irfan Khan National University of Sciences and Technology(NUST) IslamabadPakistan Intelligent Robotics Lab National Center of Artificial IntelligenceNational University of Sciences and Technology(NUST)IslamabadPakistan Department of Mechatronics Engineering Air UniversityIslamabadPakistan Institute of Space Technology IslamabadPakistan

For BCI systems,it is important to have an accurate and less complex architecture to control a device with enhanced *** this paper,a novel methodology for more accurate detection of the hemodynamic response has been developed using a multimodal brain-computer interface(BCI).An integrated classifier has been developed for achieving better classification accuracy using two *** integrated EEG-fNIRS-based vector-phase analysis(VPA)has been *** open-source dataset collected at the TechnischeUniversit鋞Berlin,including simultaneous electroencephalography(EEG)and functional near-infrared spectroscopy(fNIRS)signals of 26 healthy participants during n-back tests,has been used for this *** and physiological noise removal has been done using preprocessing techniques followed by individually detecting activity in both *** resting state threshold circle,VPA has been used to detect a hemodynamic response in fNIRS signals,whereas phase plots for EEG signals have been constructed using Hilbert Transform to detect the activity in each *** threshold circles are drawn in the vector plane,where each circle is drawn after task completion in each trial of EEG ***,both processes are integrated into one vector-phase plot to get combined detection of hemodynamic response for *** of this study illustrate that the combined EEG-fNIRS VPA yields considerably higher average classification accuracy,that is 91.35%,as compared to other classifiers such as support vector machine(SVM),convolutional neural networks(CNN),deep neural networks(DNN)and VPA(with dual-threshold circles)with classification accuracies 82%,89%,87%and 86%*** of this research demonstrate that improved classification performance can be feasibly achieved using multimodal VPA for EEG-fNIRS hybrid data.

关键词： EEG-fNIRS hybrid BCI vector-phase analysis hemodynamic response detection

Novel LaFe_(2)O_(4)spinel structure with a large oxygen reduction response towards protonic ceramic fuel cell cathode

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rare Earths 2023年第3期41卷 413-421,I0004页

作者： Jinping Wang Yuzheng Lu Naveed Mushtaq M.A.K Yousaf Shah sajid Rauf Peter D.Lund Muhammad Imran Asghar School of Energy and Power Engineering Nanjing Institute of TechnologyNanjing 211167China School of Electronic Engineering Nanjing Xiao Zhuang UniversityNanjing 211171China Jiangsu Provincial Key Laboratory of Solar Energy Science and Technology/Energy Storage Joint Research Center School of Energy and EnvironmentSoutheast UniversityNanjing 210096China College of Electronics and Information Engineering Shenzhen UniversityShenzhen 518000China New Energy Technologies Group Department of Applied PhysicsAalto University School of ScienceP.O.Box.15100FI00076AaltoEspooFinland Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Faculty of Physics and Electronic ScienceHubei UniversityWuhan 430062China

Highly active and stable electrocatalysts are mandatory for developing high-performance and longlasting fuel *** current study demonstrates a high oxygen reduction reaction(ORR)electrocatalytic activity of a novel spinel-structured LaFe_(2)O_(4)via a self-doping *** LaFe_(2)O_(4)demonstrates excellent ORR activity in a protonic ceramic fuel cell(PCFC)at temperature range of 350-500℃.The high ORR activity of LaFe_(2)O_(4)is mainly attributed to the facile release of oxide and proton ions,and improved synergistic incorporation abilities associated with interplay of multivalent Fe^(3+)/Fe^(2+)and La^(3+)*** LaFe_(2)O_(4)as cathode over proton conducting BaZr_(0.4)Ce_(0.4)Y_(0.2)O_(3)(BZCY)electrolyte,the fuel cell has delivered a high-power density of 806 mW/cm^(2)operating at 500℃.Different spectroscopic and calculations methods such as UV-visible,Raman,X-ray photoelectron spectroscopy and density functional theory(DFT)calculations were performed to screen the potential application of LaFe_(2)O_(4)as *** study would help in developing functional cobalt-free ORR electrocatalysts for low temperature-PCFCs(LT-PCFCs)and solid oxide fuel cells(SOFCs)applications.

关键词： LaFe_(2)O_(4)cathode Facile Fe^(3+/2+)ions resale Oxygen reductionreaction(ORR) Excellent electrocatalyst Protonic ceramicfuel cell(PCFC) Rare earths

3D ball-type self-assemble CeO_(2) nanostructure produced by facile hydrothermal strategy for catalytic wet air oxidation of N,N-dimethylformamide

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2023年第8期41卷 1179-1188,I0003页

作者： sajid Ali Yue Jiang Zhirong Lai Peipei Zhang Songshou Ye Jiexiang Wang Jile Fu Nuowei Zhang Jinbao Zheng Binghui Chen National Engineering Laboratory for Green Productions of Alcohols-Ethers-Esters Department of Chemical and Biochemical EngineeringCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China School of Energy and Chemical Engineering Xiamen University Malaysia CampusJalan SunsuriaBandar Sunsuria43900SepangMalaysia

CeO_(2)plays an important role in heterogeneous catalysis,and its performance is highly dependent on the oxygen vacancies and surface defects,which can be easily tuned by manipulating the particle dimensions and *** this article,we report a facile strategy to synthesize a new type of CeO_(2)with modified surface property which can improve its ability to active *** obtained ball-type 3D selfassemble CeO_(2)(M-CeO_(2)) is composed of large amounts of small 1D crystals which are stro ngly connected with each *** characterizations confirm its morphology,particle size and improved reducibility with abundant fraction of Ce^(3+)and more surface active oxygen when compared with CeO_(2)-nanorods and CeO_(2)-*** the catalytic wet air oxidation(CWAO)of N,N-dimethylfo rmamide,the total organic carbon(TOC)and total nitrogen(TN)conversion of M-CeO_(2)at 180℃in 3 h are 68%and 46%,respectively,which are higher than that of CeO_(2)-nanorods and CeO_(2)-***,M-CeO_(2) presents the lowest activation energy,which is related to its modified surface *** good stability with consecutive four reactions of M-CeO_(2)in catalytic reactions suggests its potential application in CWAO processes for industrial wastewater treatment.

关键词： Ethylene glycol Neutralization 3D self-assemble CeO_(2) Ce^(3+)fraction N,N-dimethylformamide Rare earths

Call for action:Increased healthcare utilization with growing use of percutaneous cholecystectomy tube over initial cholecystectomy in cirrhotics

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 56-62页

作者： Srikanth Vedachalam sajid Jalil Somashaker G Krishna Kyle Porter Na Li Sean G Kelly Lanla Conteh Khalid Mumtaz Department of Internal Medicine The Ohio State University Wexner Medical CenterColumbusOH 43210USA Division of Gastroenterology Hepatology and NutritionThe Ohio State University Wexner Medical CenterColumbusOH 43210USA Center for Biostatistics Department of Biomedical InformaticsThe Ohio State University Wexner Medical CenterColumbusOH 43210USA

Background:Acute calculous cholecystitis(ACC)is frequently seen in cirrhotics,with some being poor candidates for initial ***,these patients may undergo percutaneous cholecystostomy tube(PCT)*** studied the healthcare utilization and predictors of cholecystectomy and PCT in patients with ***:The National Database was queried to study all cirrhotics and non-cirrhotics with ACC between 2010-2014 who underwent initial PCT(with or without follow-up cholecystectomy)or *** patients were divided into compensated and decompensated *** predictors and outcomes of initial PCT and failure to undergo subsequent cholecystectomy were ***:Out of 919189 patients with ACC,13283(1.4%)had *** cirrhotics,cholecystec-tomy was performed in 12790(96.3%)and PCT in the remaining 493(3.7%).PCT was more frequent in cirrhotics(3.7%)than in non-cirrhotics(1.4%).Multivariate analyses showed increased early readmis-sions[odds ratio(OR)=2.12,95%confidence interval(CI):1.43-3.13,P<0.001],length of stay(effect ratio=1.39,95%CI:1.20-1.61,P<0.001),calendar-year hospital cost(effect ratio=1.34,95%CI:1.28-1.39,P<0.001)and calendar-year mortality(hazard ratio=1.89,95%CI:1.07-3.29,P=0.030)in cir-rhotics undergoing initial PCT compared to *** cirrhosis(OR=2.25,95%CI:1.67-3.03,P<0.001)had the highest odds of getting initial ***,regardless of compensated(OR=0.56,95%CI:0.34-0.90,P=0.020)or decompensated(OR=0.28,95%CI:0.14-0.59,P<0.001),reduced the chances of getting a subsequent ***:Cirrhotic patients undergo fewer cholecystectomy incurring initial PCT ***,the rates of follow-up cholecystectomy are lower in *** healthcare utilization is seen with initial PCT amongst cirrhotic *** situation reflects suboptimal management of ACC in cirrhotics and a call for action.

关键词： National Healthcare Cholecystectomy Percutaneous cholecystostomy Cirrhosis Decompensated cirrhosis