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Design and preparation of a new multi-targeted drug delivery system using multifunctional nanoparticles for co-delivery of siRNA and paclitaxel

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Journal of Pharmaceutical Analysis 2021年第2期11卷 163-173页

作者： Sara Hosayni Nasab Amin amani Hossein Ali Ebrahimi Ali asghar Hamidi Department of Agronomy and Plant Breeding Faculty of Agriculture and Natural ResourcesUniversity of Mohaghegh ArdabiliArdabilIran Biotechnology Research Center Tabriz University of Medical SciencesTabrizIran Department of Pharmaceutics School of PharmacyArdabil University of Medical SciencesArdabilIran Department of Medicinal Chemistry Faculty of PharmacyTabriz University of Medical SciencesTabrizIran

Drug resistance is a great challenge in cancer therapy using chemotherapeutic agents. Administration of these drugs with siRNA is an efficacious strategy in this battle. Here, the present study tried to incorporate siRNA and paclitaxel(PTX) simultaneously into a novel nanocarrier. The selectivity of carrier to target cancer tissues was optimized through conjugation of folic acid(FA) and glucose(Glu) onto its surface. The structure of nanocarrier was formed from ternary magnetic copolymers based on FeCopolyethyleneimine(FeCo-PEI) nanoparticles and polylactic acid-polyethylene glycol(PLA-PEG) gene delivery system. Biocompatibility of FeCo-PEI-PLA-PEG-FA(NPsA), FeCo-PEI-PLA-PEG-Glu(NPsB) and FeCo-PEI-PLA-PEG-FA/Glu(NPsAB) nanoparticles and also influence of PTX-loaded nanoparticles on in vitro cytotoxicity were examined using MTT assay. Besides, siRNA-FAM internalization was investigated by fluorescence microscopy. The results showed the blank nanoparticles were significantly less cytotoxic at various concentrations. Meanwhile, siRNA-FAM/PTX encapsulated nanoparticles exhibited significant anticancer activity against MCF-7 and BT-474 cell lines. NPsAB/siRNA/PTX nanoparticles showed greater effects on MCF-7 and BT-474 cells viability than NPsA/siRNA/PTX and NPsB/siRNA/***, they induced significantly higher anticancer effects on cancer cells compared with NPsA/siRNA/PTX and NPsB/siRNA/PTX due to their multi-targeted properties using FA and Glu. We concluded that NPsAB nanoparticles have a great potential for co-delivery of both drugs and genes for use in gene therapy and chemotherapy.

关键词： Paclitaxel siRNA Targeted drug delivery Magnetic nanoparticles Polymeric drug delivery

Recrystallization and mechanical properties of WE43 magnesium alloy processed via cyclic expansion extrusion

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International Journal of Minerals,Metallurgy and Materials 2018年第6期25卷 672-681页

作者： Soheil amani Ghader Faraji School of Mechanical Engineering College of Engineering University of Tehran

In this study, cyclic expansion extrusion（CEE）, as a relatively new severe plastic deformation（SPD） process, is applied to a rare earth（RE） containing Mg alloy WE43. The effects of the processing temperature and the number of passes are also investigated. The results showed that dynamic recrystallization（DRX） occurred after CEE processing at 400°C, and a bimodal structure with ultrafine DRXed grains surrounded the unrecrystallized grains. However, the DRX at 330°C was retarded because of the existence of RE elements. The tensile tests showed that a simultaneous increase in the strength and the ductility of WE43 is obtained after CEE processing at 400°C via two passes. Furthermore, the highest ultimate tensile strength of 440 MPa was achieved after the second pass of CEE at 330°C, and the highest ductility of 21% was attained after the second pass of CEE at 400°C. The microhardness measurements showed that the hardness increased from HV 80 to HV 114 and HV 98 after two passes of CEE processing at 330 and 400°C, respectively. In conclusion, increasing the processing passes could increase the mechanical properties and the volume fraction of the recrystallized grains. Moreover, increasing the temperature reduced the strength and the microhardness even if the elongation increased.

关键词： severe plastic deformation (SPD) grain refinement mechanical properties WE43 microhardness deformation behavior

Design aspect of a novel L-shaped pulsed column for liquid–liquid extraction applications: Energy consumption and the characteristics velocity concept

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Chinese Journal of Chemical Engineering 2018年第4期26卷 723-730页

作者： Pouria amani Elham Mohammadi Sahar Akhgar School of Chemical Engineering College of Engineering University of Tehran Chemical Engineering Department Tarbiat Modares University

This article deals with the evaluation of the consumption of energy for a steady state solvent extraction in a novel L-shaped pulsed sieve-plate column, which is highly required for design and optimization of the periodic flow processes for industrial applications. In this regard, a comprehensive evaluation on the energy consumption in case of a pulsed flow for three different chemical systems is conducted and besides the influence of pulsation intensity, the effect of geometrical parameters including the plate spacing and the plate free area is investigated as well. Moreover, the concept of characteristic velocity models at flooding points is evaluated with respect to the variation of pressure drop along the column at different operational conditions.

关键词： Solvent extraction Pulsed plate column Pressure drop Energy consumption Pulsed flow Characteristic velocity

Massive Dirac particles based on gapped graphene with Rosen-Morse potential in a uniform magnetic field

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Chinese Physics B 2024年第8期33卷 170-178页

作者： A.Kalani Alireza amani M.A.Ramzanpour Department of Physics Ayatollah Amoli BranchIslamic Azad UniversityAmolIran

We explore the gapped graphene structure in the two-dimensional plane in the presence of the Rosen-Morse potential and an external uniform magnetic *** order to describe the corresponding structure,we consider the propagation of electrons in graphene as relativistic fermion quasi-particles,and analyze it by the wave functions of two-component spinors with pseudo-spin symmetry using the Dirac ***,to solve and analyze the Dirac equation,we obtain the eigenvalues and eigenvectors using the Legendre differential *** that,we obtain the bounded states of energy depending on the coefficients of Rosen-Morse and magnetic potentials in terms of quantum numbers of principal n and spin-orbit ***,the values of the energy spectrum for the ground state and the first excited state are calculated,and the wave functions and the corresponding probabilities are plotted in terms of coordinates *** what follows,we explore the band structure of gapped graphene by the modified dispersion relation and write it in terms of the two-dimensional wave vectors K_(x) and K_(y).Finally,the energy bands are plotted in terms of the wave vectors K_(x) and K_(y) with and without the magnetic term.

关键词： massive Dirac equation Rosen–Morse potential Legendre polynomial gapped graphene pseudospin symmetry

A novel combined baffle-cavity micro-combustor configuration for Micro-Thermo-Photo-Voltaic applications

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Chinese Journal of Chemical Engineering 2020年第2期28卷 403-413页

作者： E.amani A.Daneshgar A.Hemmatzade Mechanical Engineering Dept. Amirkabir University of TechnologyTehranIran

The major issues of Micro-Thermo-Photo-Voltaic(MTPV) micro-combustors are flame instabilities, which narrow the operational range, and non-uniform wall temperature, which lowers the overall efficiency. The purpose of the present research is to propose a novel micro-combustor with combined baffle and cavity configuration to address these issues. For this aim, a numerical modeling approach is validated and used. The performance of the improved combustor is compared with another recent baffle-bluff configuration. It is shown that the novel design improves the average wall temperature by 36.4 K and mitigates its standard deviation by 13.4 K. Moreover, using the optimal baffle thickness, these enhancements can be augmented by 4% raise of average wall temperature, 62%increase of temperature uniformity, and 20% reduction in overall emission. The baffle length of 0.6 times the combustor length and thickness of 0.0625 times the baffle spacing result in the optimal operation due to the flame lift-off in the upstream direction. According to the sensitivity analysis, the most effective geometrical parameters are the baffle length and thickness. It is expected that using this novel micro-combustor with optimized design parameters improves the overall efficiency of MTPV systems.

关键词： Microscale Computational Fluid Dynamics(CFD) Reaction Micro-combustion Micro-Thermo-Photo-Voltaic(MTPV) Emission

Synthesis and Crystal Structure of 2-(4-Chlorophenyl)-1,4,5-triphenyl-1H-imidazole

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Chinese Journal of Structural Chemistry 2012年第4期31卷 574-576页

作者： Ali Mohammad amani Kazem Barati Young Researchers Club Shiraz BranchIslamic Azad University Young Researchers Club Yasooj BranchIslamic Azad University

The compound 2-（4-chlorophenyl）-1,4,5-triphenyl-1H-imidazole（1,C27H19ClN2） has been synthesized and its crystal structure was determined by single-crystal X-ray *** crystal of 1 belongs to the triclinic system,space group P with a = 10.3350（19）,b = 10.238（2）,c = 11.201（2） ,α = 85.957（16）,β = 83.148（15）,γ = 66.467（15）°,V = 1078.5（4） 3,Mr = 406.89,Z = 2,F（000） = 422,Dc = 1.257 g/cm3,μ = 0.193 mm-1,T = 298（2） K,S = 1.092,R = 0.0702 and wR = *** imidazole ring system is planar and makes a dihedral angle of 40.3° with the chlorobenzene ring.

关键词： crystal structure imidazole triclinic system

Pattern recognition and data mining software based on artificial neural networks applied to proton transfer in aqueous environments

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Chinese Physics B 2014年第4期23卷 410-421页

作者： amani Tahat Jordi Marti Ali Khwaldeh Kaher Tahat Department of Physics and Nuclear Engineering Technical University of Catalonia-Barcelona Tech B4-B5North Campus UPC08034 Barcelona Catalonia Spain Department of Computer Engineering Faculty of Engineering Philadelphia University Department of Graduate Business Studies Waterford Institute of TechnologyMain Campus Cork RoadWaterford Ireland

In computational physics proton transfer phenomena could be viewed as pattern classification problems based on a set of input features allowing classification of the proton motion into two categories： transfer ＇occurred＇ and transfer ＇not occurred＇. The goal of this paper is to evaluate the use of artificial neural networks in the classification of proton transfer events, based on the feed-forward back propagation neural network, used as a classifier to distinguish between the two transfer cases. In this paper, we use a new developed data mining and pattern recognition tool for automating, controlling, and drawing charts of the output data of an Empirical Valence Bond existing code. The study analyzes the need for pattern recognition in aqueous proton transfer processes and how the learning approach in error back propagation （multilayer perceptron algorithms） could be satisfactorily employed in the present case. We present a tool for pattern recognition and validate the code including a real physical case study. The results of applying the artificial neural networks methodology to crowd patterns based upon selected physical properties （e.g., temperature, density） show the abilities of the network to learn proton transfer patterns corresponding to properties of the aqueous environments, which is in turn proved to be fully compatible with previous proton transfer studies.

关键词： pattern recognition proton transfer chart pattern data mining artificial neural network empiricalvalence bond

Logarithmic Entropy Corrected Holographic Dark Energy with F(R, T ) Gravity

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Communications in Theoretical Physics 2015年第10期64卷 485-490页

作者： Ali R.amani A.Samiee-Nouri Faculty of Sciences Department of Physics Ayatollah Amoli Branch Islamic Azad University Department of Physics Central Tehran Branch Islamic Azad University

In this paper, we consider F(R,T) gravity as a linear function of the curvature and torsion scalars and interact it with logarithmic entropy corrected holographic dark energy to evaluate cosmology solutions. The model is investigated by FRW metric, and then the energy density and the pressure of dark energy are calculated. Also we obtain equation of state(EoS) parameter of dark energy and plot it with respect to both variable of redshift and e-folding number. Finally, we describe the scenario in three status: early, late and future time by e-folding number.

关键词： equation of state parameter F(R T) gravity logarit

AJAC: Atomic data calculation tool in Python

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Chinese Physics B 2013年第4期22卷 545-557页

作者： amani Tahat Jordi Marti Kaher Tahat Ali Khwaldeh Department of Physics and Nuclear Engineering Technical University of Catalonia Barcelona Spain Saudi Grown Investment Company Quai du Seujet 30 Geneva 1201 Switzerland Department of Computer Engineering Faculty of Engineering Philadelphia University Amman Jordan

In this work, new features and extensions of a currently used online atomic database management system are reported. A multiplatform flexible computation package is added to the present system, to allow the calculation of various atomic radiative and collisional processes, based on simplifying the use of some existing atomic codes adopted from the literature. The interaction between users and data is facilitated by a rather extensive Python graphical user interface working online and could be installed in personal computers of different classes. In particular, this study gives an overview of the use of one model of the package models （i.e., electron impact collisional excitation model）. The accuracy of computing capability of the electron impact collisional excitation in the adopted model, which follows the distorted wave approximation approach, is enhanced by implementing the Dirac R-matrix approximation approach. The validity and utility of this approach are presented through a comparison of the current computed results with earlier available theoretical and experimental results. Finally, the source code is made available under the general public license and being distributed freely in the hope that it will be useful to a wide community of laboratory and astrophysical plasma diagnostics.

关键词： software engineering atomic data atomic databases