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Effectiveness of revascularization of the ulcerated foot in diabetic patients with peripheral artery disease for one year follow-up

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Frontiers in Biology 2018年第6期13卷 458-463页

作者： Mohammad Momen Gharibvand Mina Mounesi Arman Shahriari asghar sharif najafi Azim Motamed far Atefeh Roumi Department of Radiology school ofmedicineAhvaz Jundishapur University of Medical SciencesAhvazIran Department of Internal Medicin School of MedicineAhvaz Jundishapur University of Medical SciencesRazi HospitalAhvazIran

Diabetes is an important risk factor for atherosclerosis. The diabetic foot is characterized by the presence of arteriopathy and neuropathy. When ischemia is diagnosed, restoration of pulsatile blood flow by revascularization may be considered for salvaging the limb. The treatment options are angioplasty with or without stenting and surgical bypass or hybrid procedures combining the two. To evaluate the outcomes of severe ischemic diabetic foot ulcers for which percutaneous transluminal angioplasty (PTA) was considered as the first-line vascular procedure. Factors associated with successful PTA were also evaluated. In 80 consecutive diabetic patients with foot ulcers and severe limb ischemia, PTAwas performed if feasible. All patients were followed until healing or for one year. Clinical and angiographic factors in fluencing outcomes after PTA were sought by univariate and multivariate analysis. PTAwas done in 73 of the 80 (91.2%) patients, and considered clinically succe ssful in 58(79.9%). Successful PTA was significantly higher in patients with Superficial femoral artery, posterior Tibialis and dorsalis pedis arteries involvement in the univariate analysis. Seven patients were expired during the study follow up due to MI, pulmonary thromboembolism and GI bleeding. PTA in diabetic patients with severe ischemic foot ulcers provided favorable. Some parameters could be used for predicting PTA successfulness.

关键词： percutaneous transluminal angioplasty revascularization diabetes

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Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer

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World Journal of Gastroenterology 2006年第44期12卷 7104-7112页

作者： Ferdous Rastgar Jazii Zahra najafi Reza Malekzadeh Thomas P Conrads Abed Ali Ziaee Christian Abnet Mansour Yazdznbod Ali asghar Karkhane Ghasem H Salekdeh National Institute of Genetic Engineering and Biotechnology POBOX: 14155 6343 Tehran Iran Digestive Disease Research Center Shariati Hospital Medical University Tehran Iran Laboratory of Proteomics and Analytical Technologies SAIC -Frederick B Frederick MD 21702 United States Institute of Biochemistry and Biophysics Tehran University Tehran Iran NCI Center for Cancer Research CancerPrevention Studies Branch Bethesda United States Department of surgery Shariati Hospital Medical University Tehran Iran Agricultural Biotechnology ResearchInstitute of Iran Karaj Iran

AIM： To assess the proteome of normal versus tumor tissue in squamous cell carcinoma of the esophagus （SCCE） in Iranian patients and compare our results with former reports by using proteomics. METHODS： Protein was extracted from normal and tumor tissues. Two dimensional electrophoresis was carried out and spots with differential expression were identified with mass spectrometry. RNA extraction and RT-PCR along with immunodetection were performed. RESULTS： Fourteen proteins were found whose expression levels differed in tumor compared to normal tissues. Mass spectrometric analysis resulted in the identification of β-tropomyosin （TMβ）, myosin light chain 2 （and its isoform）, myosin regulatory light chain 2, peroxyredoxin 2, annexin I and an unknown polypeptide as the down regulated polypeptides in tumor tissue. Heat shock protein 70 （HSP70）, TPM4-ALK fusion oncoprotein 2, myosin light polypeptide 6, keratin I, GH16431p and calreticulin were the up-regulated polypeptides found in tumor tissue. Several of these proteins, such as TMβ, HSP70, annexin Ⅰ, calreticulin, TPM4-ALK and isoforms of myosins, have been well recognized in tumorigenesis of esophageal or other types of cancers. CONCLUSION： Our study not only supports the involvement of some of the formerly reported proteins in SCCE but also introduces additional proteins found to be lost in SCCE, including TMβ.

关键词： Squamous Cell Carcinoma Esophagus Esophageal Proteomics Two dimensional electrophoresis Polypeptide marker

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Congenital Microvillous Atrophy, Report of Two Consecutive Siblings with Complete Histologic, Immunohistochemical and Detailed Electron Microscopic Studies, First Report from Iran

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Open Journal of Pathology 2014年第2期4卷 64-67页

作者： Fatemeh Elham Mahjoub Seyedeh Nakisa Niknejad Mahnaz Sadeghian Afshin Abdirad Mehri najafi Sani Issa Jahanzad Elham Talachian 1Maternal Fetal and Neonatal Research Center Tehran University of Medical Sciences Tehran Iran 2Imam Khomeini Hospital Complex Affiliated with Tehran University of Medical Sciences Tehran Iran Ali-asghar Children Hospital Children Hospital Affiliated with Iran University of Medical Sciences Tehran Iran Markaze Tebbi Koodakan Children Hospital Affiliated with Tehran University of Medical Sciences Tehran Iran Maternal Fetal and Neonatal Research Center Tehran University of Medical Sciences Tehran Iran Tehran University of Medical Sciences Tehran Iran

Introduction: Microvillous inclusion disease (MVD) or microvillous atrophy disorder is a congenital disorder of the small intestinal epithelial cells that presents with persistent and severe diarrhea and it is characterized by enterocytes abnormalities [1] 08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F005200650066003300380035003800380033003700360030000000 . For these children, prognosis is generally poor due to metabolic acidosis with poor compensation. To our experiment, this disease is very rare in Iran and it is yet unreported, so we decided to report two consecutive siblings with the same disease from Iran. Report of Cases: Two siblings were born to healthy parents. Parents were cousins. Both siblings were hospitalized due to severe diarrhea starting shortly after breast feeding. The frequency of diarrhea in both cases was 10 to 17 times per day and their stools were loose and green. Histological studies of both siblings revealed duodenal mucosa with complete flattening of villi (total villous atrophy). Superficial lining cells showed atrophy. Crypts showed no hyperplasia, however it showed distortion and difference in size. By PAS staining and CD10 staining, a poorly developed brush border and typical inclusions were seen in apical boarder of enterocytes. Electron microscopy was performed for the second case and showed microvillous involution and inclusions in the apical part of the epithelial cells. Discussion: Microvillous congenital atrophy is a rare congenital disorder. Due to rareness of congenital microvillous atrophy (CMA), it is crucial to distinguish it from other diseases with persistent and severe diarrhea as soon as possible.

关键词： Congenital Microvillous Atrophy Pediatric Diarrhea Histopathological Findings Electron Microsopy

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