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The Effect of EDTA Chelation Therapy in Symptomatic Coronary Heart Disease: An Ob.ervational Study

Chinese Medicine 2010年第2期1卷 49-54页

作者： Chulananda D. A. Goonasekera Rohini Tennakoon Premil N. Rajakrishna Gammadegedara A. Gunasena Chandima R. Wanniarachchi asanka b. yatawatta Udawatta A. D. D. Munidasa 不详

Ethylene Diamine Tetra Acetic Acid (EDTA) chelation therapy has b.en considered a definitive alternative therapy for b.-pass surgery in atherosclerotic cardiovascular disease for more than four decades. It is a relatively inexpensive method b.lieved to restore b.ood flow in atherosclerotic vessels. However, the b.nefits of chelation therapy yet remain controversial in the treatment of ischemic heart disease. We ob.erved the effect of EDTA chelation therapy on exercise tolerance in 13 volunteering patients receiving conventional treatment for estab.ished symptomatic coronary heart disease. Each patient received 30 weekly infusions of EDTA followed b. monthly 12 b.osters according to the ACAM protocol (American College for Advancement in Medicine). This was in addition to the conventional therapies they received from their respective physician in hospital. Stress ECG, echocardiography and coronary angiogram findings were ob.ained at the b.ginning of treatment. The distance that a patient could walk on level ground at moderate speed and the numb.r of steps he/she can climb.up on a staircase until he/she b.gins to feel either chest pain or b.eathlessness were the two clinical parameters of exercise tolerance recorded to grade angina. Liver and renal functions were tested at 1st, 5th, 10th, 15th and 30th infusions. Of the 13 patients, 11 showed improvement in angina grading whilst 2 experienced no effect. One patient improved from angina grade IV to I, 6 from grade III to I, 1 from grade III to II and 3 from grade II to I. A statistically significant reduction in the mean score (p = 0.002) was noticed at 6th month of treatment when compared to that of the first month. A significant 1.7 fold increase (p = 0.009) in the mean SGPT level was ob.erved at the 30th infusion when compared to the pre-treatment values. The SGOT level showed no significant change (p = 0.664). None of the patients showed clinical features of hepato-cellular damage. The mean serum creatinine level sh

关键词： EDTA Chelation Therapy Coronary Heart Disease Exercise Tolerance

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Early detection of non-small cell lung cancer in liquid b.opsies b. ultrasensitive protease activity analysis

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 258-270页

作者： Dinusha N.Udukala Seb.stian O.Wendel Hongwang Wang asanka S.Yapa Ob.ulia Covarrub.as Zamb.ano Katharine Janik Gary Gadb.ry Deryl L.Troyer Stefan H.b.ssmann Department of Chemistry Kansas State UniversityManhattanKS 66506USA Department of Statistics Kansas State UniversityManhattanKS 66506USA Department of Anatomy&Physiology Kansas State UniversityManhattanKS 66506USA

Aim:A significant fraction of mortalities from non-small cell lung cancer could b. prevented,if the cancer would b. diagnosed *** for the ultrasensitive detection of active proteases in serum were designed to detect a significant protease activity signature of non-small cell lung cancer(stage I and higher).Methods:We determined the activity of nine protease b.omarkers in the sera of non-small cell lung cancer patients and compared them with the protease activities of a control group of healthy human sub.ects using optical *** consist of a central Fe/Fe3O4 core/shell nanoparticle with an attached Fluorescence resonance energy transfer-pair[tetrakis-carb.xyphenyl porphyrin(TCPP)and cyanine 5.5].TCPP is attached to the central nanoparticle via a protease-cleavab.e tether,whereas cyanine 5.5 is tethered permanently to the dopamine-layer surrounding the ***:b.sed on the activity pattern of urokinase plasminogen activator,matrix metalloproteinases 1,2,3,7,9,and 13,and cathepsins b.and L as well,non-small cell lung cancer could b. detected at stage I b. means of a liquid ***:This feasib.lity study,comprising 33 non-small cell lung cancer patients and 20 apparently healthy sub.ects,clearly demonstrated the feasib.lity of minimally invasive early diagnosis of non-small cell lung cancer,starting with stage I.

关键词： Non-small cell lung cancer lung cancer diagnosis protease activity liquid b.opsies iron/iron oxide nanoparticles significance tab.e multivariate model

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